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Bioisosteres in Medicinal Chemistry

by Nathan Brown Raimund Mannhold Gerd Folkers Hugo Kubinyi

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third partcovers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays ofprotein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

The Everything Krav Maga for Fitness Book

by Jeff Levine Nathan Brown

What can an ancient Israeli self-defense system can do for your body? Just ask J-Lo, who thanks Krav Maga for her celebrated derriere. But you don't have to be a movie star to have bootylicious behind-all you need is this book! The Everything fitness dream team has developed workouts that will transform your body into a lean, mean fighting machine-Krav Maga style! With more than 100 instructional photographs, this step-by-step guide shows you how to: Jab your way to a strong core; Power up your calves and quads; Amp your abs with power training; Maximize muscles with weight training; Start-and stick!-to a training regimen. Master these original, kick-ass work outs, and you'll have the body-and the defense moves-you've always wanted! With The Everything Krav Maga for Fitness Book, sweating has never been so much fun!

The Everything Paying For College Book

by Nathan Brown Sheryle A. Proper

Finding the right college-from filling out applications to getting accepted-should be one of the most thrilling times of your life. But it won't be if you're still figuring out how to pay for it come Labor Day. Whether you're a graduating high-school senior, a parent making financial investments for your child's future, or an adult returning to school, The Everything Paying for College Book is a valuable resource that provides the information you need to face the challenge of college tuition. With appendices listing organizations and other resources, you'll find smart ways to save and find extra cash for books and class.The Everything Paying for College Book helps you learn about: The difference between loans and grants Conditional cash Options for long-term investing When and how to fill out the forms Qualification guidelines Whom you should approach for money Easily accessible and highly informative, The Everything Paying for College Book takes the mystery out of myriad money sources, where to find grants and loans, and how to fill out the endless paper trail of forms so that you can spend less time thinking about your finances and more time hitting the books!

The Everything Paying for College Book: Grants, loans, scholarships, and financial aid--all you need to fund higher education

by Nathan Brown Sheryle A. Proper

Finding the right college-from filling out applications to getting accepted-should be one of the most thrilling times of your life. But it won't be if you're still figuring out how to pay for it come Labor Day. Whether you're a graduating high-school senior, a parent making financial investments for your child's future, or an adult returning to school,The Everything Paying for College Bookis a valuable resource that provides the information you need to face the challenge of college tuition. With appendices listing organizations and other resources, you'll find smart ways to save and find extra cash for books and class. The Everything Paying for College Bookhelps you learn about: The difference between loans and grants Conditional cash Options for long-term investing When and how to fill out the forms Qualification guidelines Whom you should approach for money Easily accessible and highly informative,The Everything Paying for College Booktakes the mystery out of myriad money sources, where to find grants and loans, and how to fill out the endless paper trail of forms so that you can spend less time thinking about your finances and more time hitting the books!

Scaffold Hopping in Medicinal Chemistry

by Nathan Brown

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

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