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Biostatistics and Epidemiology

by Jordan Smoller Sylvia Wassertheil-Smoller

Since the publication of the first edition, Biostatistics and Epidemiology has attracted loyal readers from across specialty areas in the biomedical community. Not only does this textbook teach foundations of epidemiological design and statistical methods, but it also includes topics applicable to new areas of research. Areas covered in the fourth edition include a new chapter on risk prediction, risk reclassification and evaluation of biomarkers, new material on propensity analyses, and a vastly expanded chapter on genetic epidemiology, which is particularly relevant to those who wish to understand the epidemiological and statistical aspects of scientific articles in this rapidly advancing field. Biostatistics and Epidemiology was written to be accessible for readers without backgrounds in mathematics. It provides clear explanations of underlying principles, as well as practical guidelines of "how to do it" and "how to interpret it. " Key features include a philosophical and logical explanation at the beginning of the book, subsections that can stand alone or serve as reference, cross-referencing, recommended reading, and appendices covering sample calculations for various statistics in the text.

The Other Side of Normal

by Jordan Smoller

Psychiatry has ignored the normal. The focus on defining abnormal behavior has obscured what turns out to be a more fundamental question-how does the biology of the brain give rise to the mind, which in turn gives rise to everything we care about: thoughts, feelings, desires, and relationships? In The Other Side of Normal, Harvard psychiatrist Jordan Smoller shows us that understanding what the mind was designed to do in the first place demystifies mental illness and builds a new foundation for defining psychiatric disorders-from autism to depression. Smoller argues there are no bright lines between normal and abnormal. Psychiatric disorders are variations of the same brain systems that evolved to help us solve the challenges of everyday life. How do we become who we are? Smoller explains where our personalities come from, and how the temperaments we had as infants actually stay with us into adulthood. Why do we choose to date, love, and marry the people we do? Why do some of us form healthy relationships while others form unstable ones? Our relationships are shaped by the biology that drives two imperatives: maternal-child bonding and child-parent attachment. Along the way, Smoller tackles an even greater question-what do we mean by "normal"?-as he explores the puzzles behind the epidemics of multiple personalities and koro, the shocking phobia that one's penis is shrinking. He also looks at the controversial history of psychiatric classification and the explosive debates over how much early experiences influence our minds and to what degree genetics affect our temperaments, personalities, and emotional lives. Throughout this examination, Smoller explores the hidden sides of such questions as: How are trust and love rooted in biology? How much does sexual attraction stem from biology rather than culture? And what can the scientific study of normal behavior tell us about what it means to be human? Based on the author's groundbreaking research and personal experiences treating psychological disorders, The Other Side of Normal changes the way we think about the human condition.

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