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Showing 37,701 through 37,725 of 119,006 results

Supply Chain Management in the Drug Industry

by Hedley Rees

This book bridges the gap between practitioners of supply-chain management and pharmaceutical industry experts. It aims to help both these groups understand the different worlds they live in and how to jointly contribute to meaningful improvements in supply-chains within the globally important pharmaceutical sector. Scientific and technical staff must work closely with supply-chain practitioners and other relevant parties to help secure responsive, cost effective and risk mitigated supply chains to compete on a world stage. This should not wait until a drug has been registered, but should start as early as possible in the development process and before registration or clinical trials. The author suggests that CMC (chemistry manufacturing controls) drug development must reset the line of sight - from supply of drug to the clinic and gaining a registration, to the building of a patient value stream. Capable processes and suppliers, streamlined logistics, flexible plant and equipment, shorter cycle times, effective flow of information and reduced waste. All these factors can and should be addressed at the CMC development stage.

Membrane Process Design Using Residue Curve Maps

by David Glasser Diane Hildebrandt Mark Peters Shehzaad Kauchali

Design and Synthesis of Membrane Separation Processes provides a novel method of design and synthesis for membrane separation. While the main focus of the book is given to gas separation and pervaporation membranes, the theory has been developed in such a way that it is general and valid for any type of membrane. The method, which uses a graphical technique, allows one to calculate and visualize the change in composition of the retentate (non-permeate) phase. This graphical approach is based on Membrane Residue Curve Maps. One of the strengths of this approach is that it is exactly analogous to the method of Residue Curve Maps that has proved so successful in distillation system synthesis and design.

Fiber-Optic Communication Systems

by Govind P. Agrawal

This book provides a comprehensive account of fiber-optic communication systems. The 3rd edition of this book is used worldwide as a textbook in many universities. This 4th edition incorporates recent advances that have occurred, in particular two new chapters. One deals with the advanced modulation formats (such as DPSK, QPSK, and QAM) that are increasingly being used for improving spectral efficiency of WDM lightwave systems. The second chapter focuses on new techniques such as all-optical regeneration that are under development and likely to be used in future communication systems. All other chapters are updated, as well.

ADMET for Medicinal Chemists

by Steven A. Kates Katya Tsaioun

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.

Regulated Bioanalytical Laboratories

by Michael Zhou

This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on qualification of certified standards and in-house reference material as well as on people qualification. Finally, it guides readers through stressless internal and third party laboratory audits and inspections. It takes account to most national and international regulations and quality and accreditation standards, along with corresponding interpretation and inspection guides. The author elaborates on highly comprehensive content, making it easy not only to learn the subject but also to quickly implement the recommendations.

Analytical Methods for Therapeutic Drug Monitoring and Toxicology

by Q. Alan Xu Timothy L. Madden

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Flow Cytometry in Drug Discovery and Development

by Virginia Litwin Philip Marder

This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.

Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles

by Nicholas L. Mills David E. Newby Flemming R. Cassee

This book assists scientists, toxicologists, clinicians, and public health regulators to understand the complex issues that determine the impact of air pollution on the cardiovascular system. It covers a range of relevant topics including particulate matter (PM) sources and characterization, methods of exposure, impact of PM on cells and systems, role of particles in the pathophysiology of cardiovascular disease, risk assessment, and potential environmental and therapeutic interventions.

Single-Use Technology in Biopharmaceutical Manufacture

by Regine Eibl Dieter Eibl

This book gives an overview of commonly-used disposables in the manufacture of biopharmaceuticals, their working principles, characteristics, engineering aspects, economics, and applications. With this information, readers will be able to come to an easier decision for or against disposable alternatives and to choose the appropriate system. The book is divided into two parts - the first is related to basic knowledge about disposable equipment; and the second discusses applications through case studies that illustrate manufacturing, quality assurance, and environmental influence.

Herbal Supplements

by Catherine A. Hammett-Stabler Amitava Dasgupta

This book focuses on efficacy, toxicity, drug interactions, and abnormal clinical laboratory tests resulting from the use of herbal remedies. Although a few herbal remedies are safe and have efficacy (for example saw palmetto), many herbal remedies are toxic. This book guides in the interpretation of abnormal test results in otherwise healthy subjects due to use of herbal remedies. Chapters focus on interactions between herbals and pharmaceuticals, sources of contamination in herbal supplements, and analytical techniques used in the investigation of herbal remedies.

The Dose Makes the Poison

by Patricia Frank M. Alice Ottoboni

This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys, and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected.

Pharmaceutical Toxicology in Practice

by Jeanne Stadler Alberto Lodola

This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to "traditional" toxicology in the risk assessment and risk management of pharmaceuticals.

Metabolic Syndrome

by Minghan Wang

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

Quantum Physics for Scientists and Technologists

by Paul Sanghera

Quantum Physics for Scientists and Technologists is a self-contained, comprehensive review of this complex branch of science. The book demystifies difficult concepts and views the subject through non-physics fields such as computer science, biology, chemistry, and nanotechnology. It explains key concepts and phenomena in the language of non-physics majors and with simple math, assuming no prior knowledge of the topic.This cohesive book begins with the wavefunction to develop the basic principles of quantum mechanics such as the uncertainty principle and wave-particle duality. Comprehensive coverage of quantum theory is presented, supported by experimental results and explained through applications and examples without the use of abstract and complex mathematical tools or formalisms. From there, the book:Takes the mystery out of the Schrodinger equation, the fundamental equation of quantum physics, by applying it to atomsShows how quantum mechanics explains the periodic table of elementsIntroduces the quantum mechanical concept of spin and spin quantum number, along with Pauli's Exclusion Principle regarding the occupation of quantum statesAddresses quantum states of molecules in terms of rotation and vibration of diatomic moleculesExplores the interface between classical statistical mechanics and quantum statistical mechanicsDiscusses quantum mechanics as a common thread through different fields of nanoscience and nanotechnologyEach chapter features real-world applications of one or more quantum mechanics principles. "Study Checkpoints" and problems with solutions are presented throughout to make difficult concepts easy to understand. In addition, pictures, tables, and diagrams with full explanations are used to present data and further explain difficult concepts.This book is designed as a complete course in quantum mechanics for senior undergraduates and first-year graduate students in non-physics majors. It also applies to courses such as modern physics, physical chemistry and nanotechnology. The material is also accessible to scientists, engineers, and technologists working in the fields of computer science, biology, chemistry, engineering, and nanotechnology.

Immunoassays in Agricultural Biotechnology

by Guomin Shan

A very broad range of professionals are using immunoassay technology daily to analyze genetically engineered (GE) crops and related areas, and many of these professionals are completely new to this technology. There is a great need for users to have a book containing technical and practical guidance, and describing limitations and pitfalls of applying immunoassay in agricultural biotechnology.This book focuses on the application of immunoassays to GE plants and related areas. A group of international experts from government agencies, academics and industries, who have many years of related experience, contribute high quality chapters in their areas of expertise. This book covers topics including principles of immunoassay, antibody engineering in AgBiotech, current technologies (formats, kit development, manufacturing and quality control), method validation, applications in trait discovery and product development, applications in grain products and food processing, applications in environmental monitoring, automation and high throughput, reference materials, data interpretation and source of error, and future perspectives and challenges. In addition, to meet the practical needs for a variety of readers from different backgrounds, methods and protocols are included as well.

Broadband Optical Access Networks

by Leonid G. Kazovsky Ning Cheng David Gutierrez Wei-Tao Shaw Shing-Wa Wong

Broadband optical access network is an ideal solution to alleviate the first/last mile bottleneck of current Internet infrastructures. Richly illustrated throughout to help clarify important topics, Broadband Optical Access Networks covers the architectures, protocols enabling technologies of broadband optical access networks, and all current and future competing technologies for access networks. This comprehensive work presents the evolution of optical access networks, including reach extension, bandwidth enhancement, and discusses the convergence of optical and wireless technologies for broadband access, making it an invaluable reference for researchers, electrical engineers, and graduate students.

Traditional Herbal Medicine Research Methods

by Willow J.H. Liu

This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic study and analysis of herbal medicines in general - including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products.

Brand Relevance

by David A. Aaker

Branding guru Aaker shows how to eliminate the competition and become the lead brand in your marketThis ground-breaking book defines the concept of brand relevance using dozens of case studies-Prius, Whole Foods, Westin, iPad and more-and explains how brand relevance drives market dynamics, which generates opportunities for your brand and threats for the competition. Aaker reveals how these companies have made other brands in their categories irrelevant. Key points: When managing a new category of product, treat it as if it were a brand; By failing to produce what customers want or losing momentum and visibility, your brand becomes irrelevant; and create barriers to competitors by supporting innovation at every level of the organization.Using dozens of case studies, shows how to create or dominate new categories or subcategories, making competitors irrelevantShows how to manage the new category or subcategory as if it were a brand and how to create barriers to competitorsDescribes the threat of becoming irrelevant by failing to make what customer are buying or losing energyDavid Aaker, the author of four brand books, has been called the father of brandingThis book offers insight for creating and/or owning a new business arena. Instead of being the best, the goal is to be the only brand around-making competitors irrelevant.

ASVAB for Dummies

by Rod Powers

Get fully briefed on the changes to the ASVAB and sharpen your test-taking skills Want to ace the ASVAB? This essential guide includes in-depth reviews of all nine test subjects with complete explanations for every question, proficiency exercises, and tips to help you pinpoint your weaknesses and hone your test taking skills. You'll discover the pros and cons of the paper and computer exams, which tests are important to your military career, and cutting-edge study techniques. Features four full-length practice ASVAB tests Includes a new sample Armed Forces Qualifying Test (AFQT) Presents a thorough review of foundational concepts for every section, including: building word knowledge, paragraph comprehension, solving math word problems, mechanical comprehension, assembling objects, and more Helps you conquer the subtests and compute your scores Packed with practice questions and proven study tips, ASVAB For Dummies, Third Edition is the only guide you need to score your best and find your place in the military!

Mastering Autodesk Inventor and Autodesk Inventor LT 2011

by Thom Tremblay Curtis Waguespack

Expert authors Curtis Waguespack and Thom Tremblay developed this detailed reference and tutorial with straightforward explanations, real-world examples, and practical tutorials that focus squarely on teaching Inventor tips, tricks, and techniques. The authors extensive experience across industries and their Inventor expertise allows them to teach the software in the context of real-world workflows and work environments. They present topics that are poorly documented elsewhere, such as design tactics for large assemblies, effective model design for different industries, strategies for effective data and asset sharing across teams, using 2D and 3D data from other CAD systems, and improving designs by incorporating engineering principles.Mastering Inventor 2011 begins with an overview of Inventor design concepts and application before exploring all aspects of part design, including sketching, basic and advanced modeling techniques, working with sheet metal, and part editing. The book then looks at assemblies and subassemblies, explaining real-world workflows and offering extensive detail on working with large assemblies.Weldment design is detailed next before the reader is introduced to the functional design using Design Accelerators and Design Calculators. The detailed documentation chapter then covers everything from presentation files to simple animations to documentation for exploded views, sheet metal flat patterns, and more. The following chapters explore crucial productivity-boosting tools, data exchange, the Frame Generator, and the Inventor Studio visualization tools. Finally, the book explores Inventor Professional's dynamic simulation and stress analysis features as well as the routed systems features (piping, tubing, cabling, and harnesses).Mastering Inventor's detailed discussions are reinforced with step-by-step tutorials, and readers can compare their work to the downloadable before-and-after tutorial files. It also features content to help readers pass the Inventor 2011 Certified Associate and Certified Professional exams and will feature instructor support materials appropriate for use in both the training and higher education channels. Mastering Inventor is the ultimate resource for those who want to quickly become proficient with Autodesk's 3D manufacturing software and prepare for the Inventor certification exams.

Introduction to Fixed Income Analytics

by Frank J. Fabozzi Steven V. Mann

A comprehensive introduction to the key concepts of fixed income analyticsThe First Edition of Introduction to Fixed Income Analytics skillfully covered the fundamentals of this discipline and was the first book to feature Bloomberg screens in examples and illustrations. Since publication over eight years ago, the markets have experienced cathartic change.That's why authors Frank Fabozzi and Steven Mann have returned with a fully updated Second Edition. This reliable resource reflects current economic conditions, and offers additional chapters on relative value analysis, value-at-risk measures and information on instruments like TIPS (treasury inflation protected securities).Offers insights into value-at-risk, relative value measures, convertible bond analysis, and much moreIncludes updated charts and descriptions using Bloomberg screens Covers important analytical concepts used by portfolio managersUnderstanding fixed-income analytics is essential in today's dynamic financial environment. The Second Edition of Introduction to Fixed Income Analytics will help you build a solid foundation in this field.

Management by Design

by Daniel W. Rasmus

A revealing look at work environments that lead to greater loyalty and an increase in productivityExploring the premise that the best way to attract and retain people, and their knowledge, will come from designing environments that turn today's increasingly virtual workplace into an attractive place for people to spend their time, Management by Design: Applying Design Principles to the Work Experience shows how the principles of design can be successfully applies to the work experience, making it a rewarding and productive.Reveals why the application of design to the workplace experience can improve the employee/employer relationshipWhy increased morale and employee loyalty start with a great work environmentExplains why it is more important than ever to manage work experiences, especially with the projected work shortages in the coming decadesOther titles by Rasmus: Listening to the Future: Why It's Everybody's BusinessThis innovative book helps managers and executives connect the dots between employee retention, positive brand expression, and lasting stories that reflect well on an organization.

Graphic Standards Field Guide to Home Inspections

by Stephen Gladstone

Quick, reliable answers to your most common on-site questionsWhen you're in the field, you never know what you'll come across. The Wiley Graphic Standards Field Guide to Home Inspections gives you fast access to the information you need when you're on-site and under pressure.Presented in a highly visual and easily portable format, the Graphic Standards Field Guide to Home Inspections is organized according to CSI's Masterformat standards of practice. It covers everything from inspection preparation to on-site safety, conveying the most common answers with practical instruction about home inspections that the professional inspector, architect, engineer, or contractor needs to access quickly out in the field to evaluate an existing residential property.The Field Guide to Home Inspections extends the Graphic Standards experience outside of the office and into the field, with:Quick access to essential information wherever you areGraphic Standards-quality details accompanied by real-world photographs of the common conditions you'll find in residential buildingsIllustrations that help you troubleshoot problems, along with on-the-spot solutionsCompact format that's easy to reference and carry alongThe Graphic Standards Field Guide to Home Inspections is the ideal companion for the on-the-go professional home inspector.

Getting Started in Mutual Funds

by Alvin D. Hall

A fresh look at the ever-changing world of mutual fundsLike all investment instruments, mutual funds continue to evolve. In the last decade however, there has been plenty of change, including market capitalization, the introduction of new types of funds, and the expansion of the mutual fund model to include investments in commodities.Getting Started in Mutual Funds, Second Edition offers a completely updated look at this popular investment vehicle, including everything from Morningstar's new matrix of evaluating a fund's investment style to implementing mutual funds into long-term investment strategies in retirement plans. Throughout the book, author Alvin Hall also focuses on the basics, like how to read a prospectus, how to evaluate ongoing fees and expenses, and how to gauge a fund's performance.Acquaints you with the various types of mutual funds and how they are structuredExplains important mutual fund terms and conceptsNew chapters include information on exchange-traded funds and how they compare to mutual funds in terms of performance, risk and feesReveals how to assess a fund manager's investment style and its impact on your returns Gain a better understanding of mutual funds and maximize your investment returns with Getting Started in Mutual Funds, Second Edition.

Reverse Mortgages and Linked Securities

by Vishaal B. Bhuyan

An institutional investor's guide to the burgeoning field of reverse mortgage securitizationReverse Mortgages and Linked Securities is a contributed title comprising many of the leading minds in the Home Equity Conversion Mortgages (HECM) industry, including reverse mortgage lenders, institutional investors, underwriters, attorneys, and regulators.This book begins with a brief history of reverse mortgages, and quickly moves on to discuss how the industry has evolved-detailing the players in these markets as well as the process. It discusses the securitization of reverse mortgages and other linked securities and includes coverage of pricing techniques and risk mitigation. This reliable resource also takes the time to cover the current regulatory environment of the HECM market, which is constantly changing due to the current state of the real estate market.Highlights specific strategies that will allow institutional investors to benefit from the resurgence of reverse mortgages and linked securitiesOne of the only guides to reverse mortgages and linked securities targeted towards institutional investors interested in securitized productsIf you want to make the most of reverse mortgages and linked securities, take the time to read this book.

Showing 37,701 through 37,725 of 119,006 results

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