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Praise for the Second Edition:"...a grand feast for biostatisticians. It stands ready to satisfy the appetite of any pharmaceutical scientist with a respectable statistical appetite." --Journal of Clinical Research Best PracticesThe Third Edition of Design and Analysis of Clinical Trials provides complete, comprehensive, and expanded coverage of recent health treatments and interventions. Featuring a unified presentation, the book provides a well-balanced summary of current regulatory requirements and recently developed statistical methods as well as an overview of the various designs and analyses that are utilized at different stages of clinical research and development. Additional features of this Third Edition include:* New chapters on biomarker development and target clinical trials, adaptive design, trials for evaluating diagnostic devices, statistical methods for translational medicine, and traditional Chinese medicine* A balanced overview of current and emerging clinical issues as well as newly developed statistical methodologies* Practical examples of clinical trials that demonstrate everyday applicability, with illustrations and examples to explain key concepts* New sections on bridging studies and global trials, QT studies, multinational trials, comparative effectiveness trials, and the analysis of QT/QTc prolongation* A complete and balanced presentation of clinical and scientific issues, statistical concepts, and methodologies for bridging clinical and statistical disciplines* An update of each chapter that reflects changes in regulatory requirements for the drug review and approval process and recent developments in statistical design and methodology for clinical research and developmentDesign and Analysis of Clinical Trials, Third Edition continues to be an ideal clinical research reference for academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students.
Cutting edge high temperature materials include high temperature superconductors, solid oxide fuel cells, thermoelectric materials and ultrahigh temperature construction materials (including metals, cermets and ceramics) and have applications in key areas such as energy, transportation and space technologies.This book introduces the concepts which underpin research into these critical materials including thermodynamics, kinetics and various physical, chemical and modelling techniques with a focus on practical "how to" methods and covers:Introduction to High Temperature ResearchBasic Design of High Temperature FurnacesTemperature MeasurementRadiation PyrometryRefractory Materials in the LaboratoryVacuum in Theory and Practice The Design of Vacuum Furnaces and ThermobalancesWith highly detailed instrument illustrations and an emphasis on the control and measurement of the fundamental properties of temperature, pressure and mass, High Temperature Experiments in Chemistry and Materials Science provides a practical reference on high temperature measurements, for researchers, advanced students and those working in academic or industrial laboratories.Introduction to High Temperature ResearchBasic Design of High Temperature FurnacesTemperature MeasurementRadiation PyrometryRefractory Materials in the LaboratoryVacuum in Theory and Practice The Design of Vacuum Furnaces and Thermobalances
"In today's rapidly changing digital environment, Darwinism is alive and well. What's the Future of Business doesn't just explore trends and theories; it introduces a dynamic, actionable path to transformation."--Evan Greene, CMO, The Recording Academy, Producers of the GRAMMY AwardsRethink your business model to incorporate the power of "user" experiences What's the Future of Business? will galvanize a new movement that aligns the tenets of user experience with the vision of innovative leadership to improve business performance, engagement, and relationships for a new generation of consumerism. It provides an overview of real-world experiences versus "user" experiences in relation to products, services, mobile, social media, and commerce, among others. This book explains why experience is everything and how the future of business will come down to shared experiences. Aligns the tenets of user experience with the concepts of innovative leadership to improve business performance and engagement and to motivate readers to rethink business models and customer and employee relationshipsMotivates readers to rethink business models, products and services, marketing, and customer and employee relationships with desired experiences in mindBrian Solis is globally recognized as one of the most prominent thought leaders and published authors in new media, and is the author of Engage! and The End of Business as Usual! Discover how user experience design affects your business, and how you can harness its power for meaningful revenue growth
The coming financial apocalypse and what government and individuals can do to insulate themselves against the worst shocksIn this controversial book a noted adherent of Austrian School of Economics theories advances the thesis that the United States is fast approaching the end stage of the biggest asset bubble in history. He describes how the bursting of the bubble will cause a massive interest rate shock that will send the US consumer economy and the US government--pumped up by massive Treasury debt--into bankruptcy, an event that will send shockwaves throughout the global economy. Michael Pento examines how policies followed by both the Federal Reserve and private industry have contributed to the impending interest rate disaster and highlights the similarities between the US and European debt crisis. But the book isn't all doom and gloom. Pento also provides well-reasoned solutions that, government, industry and individuals can take to insulate themselves against the coming crisis.Paints an alarmingly vivid picture of the massive interest rate shock which soon will send consumers and the government into bankruptcyBacked by a wealth of historical and economic data, Pento explains how the bubble was created and what the U.S. can do to mitigate the impending crisisProvides investors with sound strategies for protecting themselves and their assets against the coming financial apocalypseExplains why retirees, in particular, will be at risk as real estate prices decline, pensions weaken, and the bond bubble bursts
Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help clinicians develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience.
Peter Hall's seminal Cities of Tomorrow remains an unrivalled account of the history of planning in theory and practice, as well as of the social and economic problems and opportunities that gave rise to it. Now comprehensively revised, the fourth edition offers a perceptive, critical, and global history of urban planning and design throughout the twentieth-century and beyond.A revised and updated edition of this classic text from one of the most notable figures in the field of urban planning and designOffers an incisive, insightful, and unrivalled critical history of planning in theory and practice, as well as of the underlying socio-economic challenges and opportunitiesComprehensively revised to take account of abundant new research published over the last decadeReviews the development of the modern planning movement over the entire span of the twentieth-century and beyondDraws on global examples throughout, and weaves the author's own fascinating experiences into the text to illustrate this authoritative story of urban growth
Praise for the Fourth Edition:"This book is . . . an excellent source of examples for regression analysis. It has been and still is readily readable and understandable."--Journal of the American Statistical Association Regression analysis is a conceptually simple method for investigating relationships among variables. Carrying out a successful application of regression analysis, however, requires a balance of theoretical results, empirical rules, and subjective judgment. Regression Analysis by Example, Fifth Edition has been expanded and thoroughly updated to reflect recent advances in the field. The emphasis continues to be on exploratory data analysis rather than statistical theory. The book offers in-depth treatment of regression diagnostics, transformation, multicollinearity, logistic regression, and robust regression.The book now includes a new chapter on the detection and correction of multicollinearity, while also showcasing the use of the discussed methods on newly added data sets from the fields of engineering, medicine, and business. The Fifth Edition also explores additional topics, including:Surrogate ridge regressionFitting nonlinear modelsErrors in variablesANOVA for designed experimentsMethods of regression analysis are clearly demonstrated, and examples containing the types of irregularities commonly encountered in the real world are provided. Each example isolates one or two techniques and features detailed discussions, the required assumptions, and the evaluated success of each technique. Additionally, methods described throughout the book can be carried out with most of the currently available statistical software packages, such as the software package R.Regression Analysis by Example, Fifth Edition is suitable for anyone with an understanding of elementary statistics.
Neurotrauma: Managing Patients with Head Injuries is a comprehensive, holistic, evidence-based approach to the primary, secondary and tertiary care of a person with neurotrauma.Using a patient-centred needs approach to enhance the quality of care of head injured patients, family and carers, this multidisciplinary book enables the reader to apply the knowledge, skills and attitudes learned to the practice of neurotrauma in all settings. It explores:Anatomy and physiology of the brainPharmacology for neurotrauma patientsAssessment of the patient with neurotraumaManagement of neurotrauma in a range of settings including at the scene, in the emergency department, and at the hospitalNeuro-rehabilitationCommunity careNursing management of the patientThis practical resource includes activities, exercises, and ethical and legal considerations throughout, making it ideal reading for all staff working in neuroscience, emergency, critical and rehabilitation settings.
Passing the FRACP Written Examination is the ideal study aid for candidates of the Fellow of the Royal Australasian College of Physicians (FRACP) examination. Written by a team of physicians based at Flinders Medical Centre, and covering the key components of the FRACP basic training syllabus, this guide presents over 500 multiple-choice questions on all major topics covered in the examination. It provides coverage of rapidly evolving topics such as healthcare in an ageing population, disparity in indigenous health outcomes, advances in molecular science and genetics, and the complexity of care arising from multiple chronic illnesses. Questions echo the written examination, including those on both 'Basic Sciences' and 'Clinical Practice'.Many of the questions are similar to those in the actual examination; others are designed to 'teach' particularly important issues or to draw attention to contemporary topics. Each question has an answer that fully explains the correct and incorrect responses.This study aid also includes: * Questions and answers linked to a reference that is usually the best and most contemporary review for further reading and as additional guide to study* QR code links to all the references* Hints and tips from previous candidates on examination strategies* A large number of the new style extended matching questions (EMQs).This brand new study aid gives all FRACP candidates a unique opportunity to practise for the examination and improve their medical knowledge of the syllabus as a whole.
The Social Change Model of Leadership Development particularly appeals to undergraduate students because it's an approach to leadership development that views leadership as a purposeful, collaborative, values-based process that uses multiple perspectives to enact positive social change. This accessible textbook engages the reader in understanding the nature of social change and the dimensions of leadership that help one become an effective change agent. It includes case studies, reflection questions, and learning activities to help facilitate engagement with the model. Written and edited by some of the country's most recognized and active scholars and educators in student leadership, the book has been field-tested by leadership faculty.
Addiction to drugs and alcohol is an increasing problem that all clinicians have to deal with. This Cochrane Handbook of Alcohol and Drug Misuse serves as a concise guide to the evidence base for relevant interventions, highlighting the key points of Cochrane reviews for the busy practitioner. It covers a wide range of pharmacological and psychosocial treatments for opioid, alcohol, cocaine and other stimulant and drug misuse, offering comprehensive coverage of interventions for drug and alcohol addiction.
The new edition of Girls, Delinquency, and Juvenile Justice combines cutting-edge research and expanded coverage of girls' delinquency, including coverage of girls in gangs and the sexual trafficking of girls, to provide students with an accessible, up-to-date, and globally oriented textbook.Including global perspectives and coverage of cutting-edge research, this is the only textbook to deal exclusively with girls and crimeOffers expanded coverage of girls in gangs and emerging literature on the sexual trafficking of girlsPulls together and analyzes all existing literature on the subject of female delinquencyBrings to light new research on a wide range of issues, including the conditions of confinement for girls incarcerated in juvenile jails and prisons, Latina girls, and gender responsive programmingExplores the moral panic around "violent," "bad," and "mean" girls
An accessible beginner's guide to the fundamentals of audit and assurance Audit and assurance is a basic and vital aspect of the financial world and a key element of all professional accountancy programs. Whereas professional training on the topic frequently immerses students in too much detail while glossing the basics, this book begins with the fundamentals and expands to cover the details in a more measured way. With practical examples and end-of-chapter examples, External Audit and Assurance Essentials breaks down a difficult and challenging field of professional accounting.
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.Visit the companion site to access supplementary materials including videos, editorial team details, downloadable figures, and more.
The easy way to get a grip on cost accountingCritical in supporting strategic business decisions and improving profitability, cost accounting is arguably one of the most important functions in the accounting field. For business students, cost accounting is a required course for those seeking an accounting degree and is a popular elective among other business majors.Cost Accounting For Dummies tracks to a typical cost accounting course and provides in-depth explanations and reviews of the essential concepts you'll encounter in your studies: how to define costs as direct materials, direct labor, fixed overhead, variable overhead, or period costs; how to use allocation methodology to assign costs to products and services; how to evaluate the need for capital expenditures; how to design a budget model that forecast changes in costs based on expected activity levels; and much more.Tracks to a typical cost accounting courseIncludes practical, real-world examplesWalks you though homework problems with detailed, easy-to-understand answersIf you're currently enrolled in a cost accounting course, this hands-on, friendly guide gives you everything you need to master this critical aspect of accounting.
Addressing the exploding interest in bioengineering for healthcare applications, this book provides readers with detailed yet easy-to-understand guidance on biomedical device engineering. Written by prominent physicians and engineers, Medical Devices: Surgical and Image-Guided Technologies is organized into stand-alone chapters covering devices and systems in diagnostic, surgical, and implant procedures.Assuming only basic background in math and science, the authors clearly explain the fundamentals for different systems along with such topics as engineering considerations, therapeutic techniques and applications, future trends, and more. After describing how to manage a design project for medical devices, the book examines the following:Instruments for laparoscopic and ophthalmic surgery, plus surgical roboticsCatheters in vascular therapy and energy-based hemostatic surgical devicesTissue ablation systems and the varied uses of lasers in medicineVascular and cardiovascular devices, plus circulatory support devicesUltrasound transducers, X-ray imaging, and neuronavigationAn absolute must for biomedical engineers, Medical Devices: Surgical and Image-Guided Technologies is also an invaluable guide for students in all engineering majors and pre-med programs interested in exploring this fascinating field.
The easy way to brush up on the math skills you need in real lifeNot everyone retains the math they learned in school. Like any skill, your ability to speak "math" can deteriorate if left unused. From adding and subtracting money in a bank account to figuring out the number of shingles to put on a roof, math in all of its forms factors into daily life. Math For Real Life For Dummies provides you with the simple formulas and theorems that you're likely to encounter in the workplace, the kitchen, and even when playing games.You can turn to Math For Real Life For Dummies to brush up on your math skills or to handle everyday encounters, like calculating restaurant tips, understanding interest rates, and figuring out percentages and odds. Packed with real-world examples that make sense, Math For Real Life For Dummies takes the stress out of your daily calculation encounters.Provides tips for understanding and using basic mathematical conceptsShows you how math helps the mind to reason and organize complicated situations or problems into clear, simple, and logical stepsCovers all of the math skills you're likely to need in everyday situationsIf you're looking for a practical, plain-English guide to mastering everyday math skills, Math For Real Life For Dummies has you covered.
Veterinary Periodontology is a comprehensive yet user-friendly reference on periodontal disease in dogs and cats, encompassing etiology, pathogenesis, and clinical features. Emphasizing clinical management of this common dental disease, this book covers basic as well as advanced treatments, offering practical instruction on therapeutic procedures. Veterinary Periodontology builds on existing human-based knowledge to provide veterinary-specific information on the periodontal disease process, therapies, patient management, and instrumentation.The book presents detailed information in an accessible format, including numerous step-by-step procedures for use in the clinic. Full-color images aid in comprehension. Veterinary Periodontology is beneficial for anyone who practices veterinary dentistry, including specialists, general practitioners, students, and technicians.
Small Animal Dental Procedures for Veterinary Technicians and Nurses is a comprehensive, procedures-based resource for technicians and nurses involved with all aspects of canine, feline, and exotic animal dentistry. Heavily illustrated and clinically oriented, this training manual provides step-by-step instructions on the oral exam, anesthesia, cleaning and radiology, as well as the necessary background on dental anatomy, common diseases and terminology. Each chapter includes learning objectives and key terms to promote retention, and a companion website provides review questions, training exercises, images from the book and additional images in PowerPoint, chapter glossaries, and forms available for download at www.wiley.com/go/perrone. Fully authored by Veterinary Technician Specialists in Dentistry, the book covers all aspects of veterinary dentistry that a technician will encounter in daily practice, with a special emphasis on the technician's role relative to dental procedures. With extensive full-color pictures, review questions and glossary terms, Small Animal Dental Procedures for Veterinary Technicians and Nurses is equally useful for veterinary technician or nursing students, technicians or nurses in practice, and those pursuing their specialty certification in veterinary dentistry.
Whilst inkjet technology is well-established on home and small office desktops and is now having increasing impact in commercial printing, it can also be used to deposit materials other than ink as individual droplets at a microscopic scale. This allows metals, ceramics, polymers and biological materials (including living cells) to be patterned on to substrates under precise digital control. This approach offers huge potential advantages for manufacturing, since inkjet methods can be used to generate structures and functions which cannot be attained in other ways.Beginning with an overview of the fundamentals, this bookcovers the key components, for example piezoelectric print-heads and fluids for inkjet printing, and the processes involved. It goes on to describe specific applications, e.g. MEMS, printed circuits, active and passive electronics, biopolymers and living cells, and additive manufacturing. Detailed case studies are included on flat-panel OLED displays, RFID (radio-frequency identification) manufacturing and tissue engineering, while a comprehensive examination of the current technologies and future directions of inkjet technology completes the coverage. With contributions from both academic researchers and leading names in the industry, Inkjet Technology for Digital Fabrication is a comprehensive resource for technical development engineers, researchers and students in inkjet technology and system development, and will also appeal to researchers in chemistry, physics, engineering, materials science and electronics.
Diagnostic Electron Microscopy: A Practical Guide to Interpretation and Technique summarises the current interpretational applications of TEM in diagnostic pathology. This concise and accessible volume provides a working guide to the main, or most useful, applications of the technique including practical topics of concern to laboratory scientists, brief guides to traditional tissue and microbiological preparation techniques, microwave processing, digital imaging and measurement uncertainty.The text features both a screening and interpretational guide for TEM diagnostic applications and current TEM diagnostic tissue preparation methods pertinent to all clinical electron microscope units worldwide. Containing high-quality representative images, this up-to-date text includes detailed information on the most important diagnostic applications of transmission electron microscopy as well as instructions for specific tissues and current basic preparative techniques.The book is relevant to trainee pathologists and practising pathologists who are expected to understand and evaluate/screen tissues by TEM. In addition, technical and scientific staff involved in tissue preparation and diagnostic tissue evaluation/screening by TEM will find this text useful.
The physician's guide to diagnosing and treating learning disabilities in children1 in 10 Canadians have a learning disability, and doctors must be able to identify, diagnose, treat, and manage children who are struggling in school. The first book specifically tailored for the needs of physicians working with kids with learning disabilities, Children With School Problems: A Physician's Manual covers such important areas as child development, diagnosing learning disabilities (including data gathering, screening and assessment, and physical examinations), management (medication, behavioral management, and educational interventions), and prevention (including literacy promotion).Written by trusted experts from the Canadian Paediatric Society, Children With School Problems is filled with practical tools and resources that physicians--including paediatricians, family physicians, and paediatric learners--can use to diagnose and treat children with learning disabilities.The only book on learning disabilities in children specifically designed for physiciansWritten by trusted experts from the Canadian Paediatric SocietyCovers important issues including literacy promotion, screening for disabilities, medication options, and much moreGives physicians the tools they need to help children with learning disabilitiesPhysicians want to know more about learning disabilities, and parents want their pediatricians and family physicians to provide more help when their kids struggle in school. Children with School Problems provides that information, making it an invaluable resource for any doctor working with kids.
Additional resources for this book can be found at: www.wiley.com/go/vandermaarelfranklin/vegetationecology. Vegetation Ecology, 2nd Edition is a comprehensive, integrated account of plant communities and their environments. Written by leading experts in their field from four continents, the second edition of this book:covers the composition, structure, ecology, dynamics, diversity, biotic interactions and distribution of plant communities, with an emphasis on functional adaptations; reviews modern developments in vegetation ecology in a historical perspective;presents a coherent view on vegetation ecology while integrating population ecology, dispersal biology, soil biology,ecosystem ecology and global change studies;tackles applied aspects of vegetation ecology, including management of communities and invasive species;includes new chapters addressing the classification and mapping of vegetation, and the significance of plant functional typesVegetation Ecology, 2nd Edition is aimed at advanced undergraduates, graduates and researchers and teachers in plant ecology, geography, forestry and nature conservation. Vegetation Ecology takes an integrated, multidisciplinary approach and will be welcomed as an essential reference for plant ecologists the world over.
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of 'trial and error' drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.Cutting Edge - highlights advances in pharmacogenomics and explores how an individual's genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Fully revised and restructured, this fresh edition offers students and trainee social workers an incisive and authoritative introduction to the subject. As well as entirely new sections on theory and practice, the expert contributions which have shaped the companion's leading reputation have been updated and now include innovative standalone essays on social work theory.Comprehensively reworked new edition comprising six substantive sections covering essential topics for trainee social workers - in effect, six books in oneIncludes an extensive introduction and chapters by leading experts on the focus and purpose of social workProvides a unified textbook for trainees and an invaluable professional reference volumeFeatures a wealth of new material on theory and practice alongside detailed expositions of the social and psychological framework, stages in the human life cycle, and the objectives and core components of social workEach chapter lists five key points to remember, questions for discussion, and recommendations for further reading