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Hired as the temporary companion to young Victoria Kent, who is distantly in line for the British throne, Mary Anne has trouble getting the girl to open up to her.
When her troubles in school culminate in her being dropped back to the seventh grade, Claudia struggles with feelings of failure while adjusting to classmates outside of the Baby-sitters Club.
In the landmark one-hundredth book in the series, Kristy disbands the club because of a combination of outside pressures and internal tension.
Hired for a week-long baby-sitting job in New York City, Stacey finds her enthusiasm quelled by her boyfriend's strange behavior, and begins to fear that he may be seeing another girl.
Welcome to Grimm Academy, where beloved fairy tale characters are BFFs -- and saving the world from the E.V.I.L. Society, one magical adventure at a time! Once upon a time, in faraway Grimmlandia . . . Goldilocks is so eager to make friends at Grimm Academy, she's even tempted to accept an invitation to join E.V.I.L. -- it's just nice to be included! But she doesn't want to be a villain. Can Goldie get inside the secret society and do some good?
Sage is used to being the fastest runner, the quickest climber, and the strongest swimmer around. And she's also used to taking charge. But when the second race course has the red team diving underwater to explore the Great Barrier Reef, it's trusting her teammates that matters most. It's sink or swim time.... Each chapter in this action-packed adventure series is bursting with totally true facts about wild and wonderful creatures, dangerous habitats, maps, and more!
When Russell entered the race, he knew it was going to be a wild ride. Especially the first race course! He'd been studying up on the Amazon's animals and culture forever. But nothing could prepare him or his teammates for what they'd find in the rain forest: raging rapids, poisonous venom, and sneaky competitors who'd do anything to win. Can the red team work together to make it to the finish line in one piece? Each chapter in this action-packed adventure series is bursting with totally true facts about wild and wonderful creatures, dangerous habitats, maps, and more!
Action packed and authentic, Charley Sunday's Texas Outfit is a vivid portrait of the men whose true grit left its mark on the American West.Charley Sunday. Bloody Sunday.In the lawless frontier town of Brownsville, Texas, a boy and his parents ride a carriage down a crowded street--when a kill crazy band of kidnappers strike suddenly. Now, to rescue his family, veteran rancher Charley Sunday cobbles together a ragtag posse that starts with an outlaw and an Indian--and picks up recruits, weapons, and a lot of trouble all the way down into Mexico. Because his grandson has escaped, Charley and his loyal band of misfits know who they are hunting for--but they don't know why the family was targeted, or what living nightmare lies ahead: from Indian raiders to Mexican bandits and nature's own fury. By the time Charley finds his family in the most brutally lawless part of Mexico there will only be one way out: through a hail fire of bullets and a mad, galloping bloody battle for survival.
1. Always step out camera ready. 2. Never, ever, fight over a boy. 3. Serve 'em grace 'n' face. Fiona Madison has being popular on lock. She's everywhere everyone wants to be--and she knows just how to keep frenemies, haters, and admirers guessing. Fiona keeps it cute and knows how to turn a party out no matter how tough things get at home--or how lonely she really is. The only relationship a guy can have with her is BWB (Boo-With-Benefits). Anything more is a major not-going-to-happen...Until someone Fiona never sees coming is suddenly too close, understands her all too well--and is turning this diva's life upside down...
Springtime may be for lovers, but for one of the ladies of the Cumberland Creek Scrapbook Crop, it's turning into a season of conflict. Still smarting from her divorce, Vera can't decide whether to accept a marriage proposal. She doesn't want to spoil a good thing by putting another ring on her finger. On the other hand, her mother Beatrice has flown off to France with the man of her dreams. But when folks claim to have seen Bea around town and Vera can't reach her, she starts to search for her mother. Is Bea still in France? And if not, what has happened to her? As Vera tries to solve the mystery of her missing mother, other problems crop up for the scrapbookers, including a health crisis in Sheila's family and a surprise announcement from Paige's son. If only life could be as neat and pretty as a scrapbook album! Some of the answers to their recent dilemmas will bring surprises that the croppers could never have predicted!Includes tips and a glossary of terms for the modern scrapbooker!
How do you tell identical twins Steven and Scotty apart?Hint: One of them is dead. Steven is the sensible twin with a sensible job, sensible clothes, sensible haircut, and sensible girlfriend. He works as a sommelier and has annoyingly good taste. Scotty is the wild one, a free spirit who travels the world, gets drunk, gets laid, then gets in trouble. They haven't spoken in three years. And now Scotty is dead. Upon hearing the news of his brother's fatal aneurism, Steven hops on a plane to Singapore to retrieve the body. He discovers that his twin had a hot local girlfriend, which isn't surprising. With Scotty, there was always a girl--usually young and pretty, but not the kind of woman to die for. Dania is another story. She's sexy, smart, sings in a cocktail bar, and notices a striking similarity between Steven and his twin: "You look like trouble, too." She must be right because, over the next few days, Steven finds himself shirking his staid life back home, talking to Scotty's ashes--and becoming dangerously involved with the one woman who might know the truth about his brother's death. . .
In a heartfelt story set in a picturesque small town in Virginia, Mary McDonough portrays three generations of women in a modern Irish-American family as they navigate marriage, motherhood, and independence. . .The Fitzgibbons--especially the women--have long been the backbone of Oliver's Well, Virginia. Matriarch Mary Bernadette is still striking and tireless at seventy-five, with a generous heart that belies her sometimes sharp tongue. Her husband, Paddy, owns the local landscaping business, daughter Grace is a nun, and son Pat and his wife Megan are successful lawyers. Her grandson, PJ, and his new wife, Alexis, live in a charming cottage behind the main house. Church, family, tradition, and the local historical society--everything Mary Bernadette cherishes is in Oliver's Well. But below the surface, there are fractures. Megan sees the strained relationship between her husband and Mary Bernadette, who has never quite recovered from the painful loss of her first-born son. Megan too is torn between gaining her mother-in-law's approval and living life on her own terms. Alexis loves PJ deeply yet chafes against his grandmother's influence in their marriage. Then a looming scandal brings unexpected tragedy, compelling the Fitzgibbons to determine the depth of their loyalty, find their strength--and repair the bonds that have held a town, and a family, together for so long. With warmth and an abundance of insight, Mary McDonough artfully captures the shifting dynamics of family life--and the revelations they may bear just in time.
No One Expects a CurveballFor Rylan Cates, the gloriously sunny beachside town of Barefoot William may be home, but the pro baseball player needs to focus on spring training. Hiring a personal assistant to keep him and his four dogs organized for the next eight weeks is the first step--and Beth Avery is the perfect pinch hitter. Beth is still looking for her place in the world, and a couple months caring for Rylan's two dachshunds, his golden retriever, and a Great Dane named Atlas should shore up her finances before she moves on. Except it's Atlas who won't budge, pushing her toward tanned, scruffy, sexy Rylan every chance he gets. One more strike and she's calling the dog out--unless she and Rylan admit that the attraction they're feeling is a game-winning grand slam. . .
Two Women. One Nightmare.Except for their gorgeous faces, identical twins Mercedes and Marcie Calder are nothing alike. Mercedes is a movie star in L.A. with a sexy husband, two beautiful children, and an exciting, glamorous lifestyle; Marcie is an art teacher in Minnesota with a shy disposition and a quiet life alone. But when Mercedes is found dead--mysteriously drowned in her swimming pool--Marcie is the only person who can step into her shoes and finish her latest movie. On a Hollywood sound stage, she will take on her sister's greatest role. In her Beverly Hills mansion, she will play mother to her children. In her sister's bed, she will make love to her husband. But there is one part of Mercedes' life that Marcie isn't prepared for--until it's too late. . . A deranged psychopath is hiding in the wings. Watching her every move. Waiting for his chance to kill. . .and kill again.
The busy summer tourist season is winding down in Busman's Harbor, Maine, but Julia Snowden senses trouble simmering for the Snowden Family Clambake Company. Shifty David Thwing--the "Mussel King" of upscale seafood restaurants--is sniffing around town for a new location. But serving iffy clams turns out to be the least of his troubles. . .When Thwing is found sleeping with the fishes beneath a local lobsterman's boat, the police quickly finger Julia's brother-in-law Sonny as the one who cooked up the crime. Sure, everyone knows Sonny despised the Mussel King. . .but Julia believes he's innocent. Proving it won't be easy, though. It seems there's a lot more than murder on the menu, and Julia needs to act fast. . .Includes Traditional Maine Clambake Recipes!
Many economic theories depend on the presence or absence of a unit root for their validity, and econometric and statistical theory undergo considerable changes when unit roots are present. Thus, knowledge on unit roots has become so important, necessitating an extensive, compact, and nontechnical book on this subject. This book is rested on this motivation and introduces the literature on unit roots in a comprehensive manner to both empirical and theoretical researchers in economics and other areas. By providing a clear, complete, and critical discussion of unit root literature, In Choi covers a wide range of topics, including uniform confidence interval construction, unit root tests allowing structural breaks, mildly explosive processes, exuberance testing, fractionally integrated processes, seasonal unit roots and panel unit root testing. Extensive, up to date, and readily accessible, this book is a comprehensive reference source on unit roots for both students and applied workers.
Glass is a material with essentially unlimited application possibilities. This second edition of a comprehensive reference in glass science, points out the correlation between the performance of industrial processes and practice-relevant properties, such as strength and optical properties. Interdisciplinary in his approach, the author discusses both the science and technology, starting with an outline of history and applications, glass structure, and rheology. The sections on properties include mechanical strength and contact resistance, ageing, mechanics of glass processes, the production and control of residual stresses, high-tech products, and current research and development. Applications include glazing, packaging, optical glass, glass fibers for reinforcement, and abrasive tools. The development of touchscreen technology showed how important were the design and resistance of thin flexible glass and these new thin aluminosilicate glasses are also discussed.
This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.
This second edition of the successful ready reference is updated and revised with approximately 30% new content to reflect the numerous instrumental developments and improvements, as well as the significant expansion of this rapidly developing field. For example, the combination of IR imaging with AFM has enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers, thus launching a multiplicity of new applications in material science. Furthermore, Raman and IR spectroscopic imaging have become key technologies for the life sciences and today contribute tremendously to a better and more detailed understanding of numerous biological and medical research topics. The topical structure of this new edition is now subdivided into four parts. The first treats the fundamentals of the instrumentation for infrared and Raman imaging and mapping and an overview on the chemometric tools for image analysis. The second part describes a wide varie-ty of applications ranging from biomedical via food, agriculture and plants to polymers and pharmaceuticals. This is followed by a description of imaging techniques operating beyond the diffraction limit, while the final part covers special methodical developments and their utility in specific fields.With its many valuable practical tips, this is a must-have overview for researchers in academic and industrial laboratories wishing to obtain reliable results with this method.
This first book on emerging applications for this innovative material gives an up-to-date account of the many opportunities graphene offers high-end optoelectronics. The text focuses on potential as well as already realized applications, discussing metallic and passive components, such as transparent conductors and smart windows, as well as high-frequency devices, spintronics, photonics, and terahertz devices. Also included are sections on the fundamental properties, synthesis, and characterization of graphene. With its unique coverage, this book will be welcomed by materials scientists, solid-state chemists and solid-state physicists alike.
The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Covering the various aspects of this fast-evolving field, this comprehensive book includes the fundamentals and a comparison of current applications, while focusing on the latest, novel achievements and future directions. The introductory chapters explore the thermodynamic and electrochemical processes to better understand how electrolysis cells work, and how these can be combined to build large electrolysis modules. The book then goes on to discuss the electrolysis process and the characteristics, advantages, drawbacks, and challenges of the main existing electrolysis technologies. Current manufacturers and the main features of commercially available electrolyzers are extensively reviewed. The final chapters then present the possible configurations for integrating water electrolysis units with renewable energy sources in both autonomous and grid-connected systems, and comment on some relevant demonstration projects. Written by an internationally renowned team from academia and industry, the result is an invaluable review of the field and a discussion of known limitations and future perspectives.
Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.
This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.
Highlighting the key aspects and latest advances in the rapidly developing field of molecular catalysis, this book covers new strategies to investigate reaction mechanisms, the enhancement of the catalysts' selectivity and efficiency, as well as the rational design of well-defined molecular catalysts. The interdisciplinary author team with an excellent reputation within the community discusses experimental and theoretical studies, along with examples of improved catalysts, and their application in organic synthesis, biocatalysis, and supported organometallic catalysis. As a result, readers will gain a deeper understanding of the catalytic transformations, allowing them to adapt the knowledge to their own investigations.With its ideal combination of fundamental and applied research, this is an essential reference for researchers and graduate students both in academic institutions and in the chemical industry.With a foreword by Nobel laureate Roald Hoffmann.
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