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This ready reference presents environmentally friendly and stereoselective methods of modern biocatalysis. The experienced and renowned team of editors have gathered top international authors for this book. They cover such emerging topics as chemoenzymatic methods and multistep enzymatic reactions, while showing how these novel methods and concepts can be used for practical applications. Multidisciplinary topics, including directed evolution, dynamic kinetic resolution, and continuous-flow methodology are also discussed. From the contents: * Directed Evolution of Ligninolytic Oxidoreductases: from Functional Expression to Stabilization and Beyond * New Trends in the In Situ Enzymatic Recycling of NAD(P)(H) Cofactors * Monooxygenase-Catalyzed Redox Cascade Biotransformations * Biocatalytic Redox Cascades Involving w-Transaminases * Multi-Enzyme Systems and Cascade Reactions Involving Cytochrome P450 Monooxygenases * Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates * Synergies of Chemistry and Biochemistry for the Production of Beta-Amino Acids * Racemizable Acyl Donors for Enzymatic Dynamic Kinetic Resolution * Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode * Perspectives on Multienzyme Process Technology * Nitrile Converting Enzymes Involved in Natural and Synthetic Cascade Reactions * Mining Genomes for Nitrilases * Key-Study on the Kinetic Aspects of the In-Situ NHase/AMase Cascade System of M. imperiale Resting Cells for Nitrile Bioconversion * Enzymatic Stereoselective Synthesis of Beta-Amino Acids * New Applications of Transketolase: Cascade Reactions for Assay Development * Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs * Enzymatic Generation of Sialoconjugate Diversity * Methyltransferases in Biocatalysis * Chemoenzymatic Multistep One-Pot Processes
Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
This new textbook is the successor to the volume "Side Reactions in Organic Synthesis - A Guide to Successful Synthesis Design" (2004), written by the same author. Whereas the predecessor mainly covered the limitations of aliphatic substitution reactions, this new volume focuses on the most important aromatic substitution reactions, both electrophilic and nucleophilic, such as amination reactions, halogenation reactions, Friedel-Crafts acylations, or transition metal-catalyzed arylation reactions. Each chapter not only describes the scope of a specific reaction type, but also reveals what cannot be achieved with this reaction, i.e. what type of side reactions are to be expected with certain starting materials or electrophiles/nucleophiles. With its unique approach, this is a must-have book for graduate students in organic chemistry and synthetic chemists both in academia and industry!
A first-look at radiative transfer in planetary atmospheres with a particular focus on the Earth's atmosphere and climate. The textbook covers the basics of the radiative transfer of sunlight, treating absorption and scattering, and the transfer of the thermal infrared appropriate for local thermodynamic equilibrium, absorption and emission. The examples included show how the solutions of the radiative transfer equation are used in remote sensing to probe the thermal structure and composition of planetary atmospheres. This motivates students by leading them to a better understanding of and appreciation for the computer-generated numerical results. Aimed at upper-division undergraduates and beginning graduate students in physics and atmospheric sciences, the book is designed to cover the essence of the material in a 10-week course, while the material in the optional sections will facilitate its use at the more leisurely pace and in-depth focus of a semester course.
Designed as the primary reference for the biotechnological use of macroalgae, this comprehensive handbook covers the entire value chain from the cultivation of algal biomass to harvesting and processing it, to product extraction and formulation. In addition to covering a wide range of product classes, from polysaccharides to terpenes and from enyzmes to biofuels, it systematically discusses current and future applications of algae-derived products in pharmacology, medicine, cosmetics, food and agriculture. In doing so, it brings together the expertise of marine researchers, biotechnologists and process engineers for a one-stop resource on the biotechnology of marine macroalgae. Benefit from the introductory offer, valid until 30 April 2015! Introductory price: £245.00.00 / $405.00 / 299.00 List price thereafter: £285.00 / $470.00 / 349.00
This is the first book to provide an integrated introduction to the nature, formation and occurrence, stability, propagation, and uses of the most common types of colloidal dispersion in the process-related industries. The primary focus is on the applications of the principles, paying attention to practical processes and problems. This is done both as part of the treatment of the fundamentals, where appropriate, and also in the separate sections devoted to specifi c kinds of industries. Throughout, the treatment is integrated, with the principles of colloid and interface science common to each dispersion type presented for each major physical property class, followed by separate treatments of features unique to emulsions, foams, or suspensions. The first half of the book introduces the fundamental principles, introducing readers to suspension formation and stability, characterization, and fl ow properties, emphasizing practical aspects throughout. The following chapters discuss a wide range of industrial applications and examples, serving to emphasize the diff erent methodologies that have been successfully applied. The author assumes no prior knowledge of colloid chemistry and, with its glossary of key terms, complete cross-referencing and indexing, this is a must-have for graduate and professional scientists and engineers who may encounter or use emulsions, foams, or suspensions, or combinations thereof, whether in process design, industrial production, or in related R&D fields.
Grace Reinhart Sachs is living the only life she ever wanted for herself. Devoted to her husband, a pediatric oncologist at a major cancer hospital, their young son Henry, and the patients she sees in her therapy practice, her days are full of familiar things: she lives in the very New York apartment in which she was raised, and sends Henry to the school she herself once attended. Dismayed by the ways in which women delude themselves, Grace is also the author of a book You Should Have Known, in which she cautions women to really hear what men are trying to tell them. But weeks before the book is published a chasm opens in her own life: a violent death, a missing husband, and, in the place of a man Grace thought she knew, only an ongoing chain of terrible revelations. Left behind in the wake of a spreading and very public disaster, and horrified by the ways in which she has failed to heed her own advice, Grace must dismantle one life and create another for her child and herself.
"I adore Kristen Ashley's books. Her stories grab you by the throat from page one and . . . continue to dwell in your mind days after you've finished the story."-Maya Banks, New York Times bestselling authorLanie Heron isn't looking for love-no surprise, considering her last serious relationship nearly got her killed. So when Lanie propositions Hop Kincaid, all she wants is one wild night with the hot-as-hell biker who patrols with the Chaos Motorcycle Club . . . For Hop, Lanie has always been untouchable. She's too polished and too classy for his taste. But when she gives Hop the once-over with her bedroom eyes and offers him a night in paradise, he can't say no. And he doesn't regret it when he finds that Lanie is the best thing that's ever happened to him-in or out of bed. Now the trick will be to convince her of that.
Get ready to ride . . . Tyra Masters has had enough drama to last a lifetime. Now, she's back on track and looking forward to her new, quiet life. Until she meets the man of her dreams. The tattooed, muscled biker plies her with tequila-and the best sex of her life. She knows it isn't the tequila and hot sex talking. He's the kind of man she's always wanted. Unfortunately, he's also her new boss . . . Kane "Tack" Allen has a rule. He doesn't employ someone he's slept with. So when he learns he spent last night in bed with his new office manager, he quickly fires Tyra. Yet when Tyra stands up to him and fights for her job, Tack is intrigued. He tells her she can keep her job on one condition: no more sex. Ever. But as things heat up between them, Tack finds that he'll be the one breaking all the rules...136,000 words
"I adore Kristen Ashley's books!" --- Maya Banks, New York Times bestselling authorWhen old friends become new lovers...anything can happen.Sexy, gifted, and loyal, PI Jacob Decker is a tall, cool drink of perfection who had Emmanuelle Holmes at "hello." His relationship with Emme's best friend kept them apart for years, but things have changed. Now that a case has brought him to Gnaw Bone, Colorado, the road is wide open for Emme and Deck to explore something hotter and deeper than Emme dreamed possible. So why is she sabotaging the best thing that's ever happened to her? It isn't easy to catch Deck off guard, but Emme does just that when she walks back into his life after nine long years. The curvy brunette had her charms back in the day, but now she's a bona fide knockout . . . and she wants to rekindle their friendship. Deck, however, wants more. Emme's always been the one; she excites Deck's body and mind like no other woman can. But a dark chapter from Emme's past overshadows their future together. Now only Deck can help her turn the page-if she'll let him . . .
Love is the greatest gamble of all . . . Nina Sheridan desperately needs a timeout vacation. With a fiancé who can't even remember how she takes her coffee, Nina wants some distance to rethink her engagement. Flying halfway around the world from England to a mountain town in Colorado should do the trick. But when she finds a gorgeous man at her rental cabin, Nina's cold, lonely adventure suddenly heats up.The owner of the house, Holden "Max" Maxwell is surprised by the beautiful woman who turns up at his door. But when Nina becomes ill, Max spends days nursing her back to health. A private man with a broken heart, Max finds himself drawn to the strong-willed woman. Soon it becomes impossible for Nina and Max to deny their growing attraction to one another. Yet even as these two wounded lovebirds think about taking a chance on a relationship, a dangerous secret from Max's past emerges-and threatens to end their love for good.203,000 words
The emotional rollercoaster of the USA TODAY bestselling Give &Take series by Kelli Maine continues! Praise for Kelli Maine! "TAKEN BY STORM is a passionate love story that grips you by the heart from the first page and doesn't let go. MJ and Maddie's love is soul-deep. Maine has written a masterpiece!" -- Kristen Proby, Bestselling Author of the With Me in Seattle series. "This book hooked me from the very beginning and glued me to every page. MJ stole my heart and quickly became one of my new favorite leading men. Loved it." -- Michelle Valentine, New York Times Bestselling Author of Rock the Heart
The emotional rollercoaster of the USA TODAY bestselling Give &Take series by Kelli Maine continues! Praise for Kelli Maine!"TAKEN BY STORM is a passionate love story that grips you by the heart from the first page and doesn't let go. MJ and Maddie's love is soul-deep. Maine has written a masterpiece!" -- Kristen Proby, Bestselling Author of the With Me in Seattle series. "This book hooked me from the very beginning and glued me to every page. MJ stole my heart and quickly became one of my new favorite leading men. Loved it." -- Michelle Valentine, New York Times Bestselling Author of Rock the Heart
The book Son of God is a tie-in with the major motion picture of the same title, slated for wide theatrical release (through 20th-Century Fox) on February 28, 2014. Like the movie, the book possesses an epic scope, providing a panoramic picture of first-century Judea as it recounts the events and reveals the meaning of Jesus's life, death, and resurrection. Though based on New Testament accounts, including the four Gospels as well as the book of Acts, Son of God reads like a contemporary novel, delving deeply into the character of Jesus and the personalities and motives all of those who surround him, both his followers and his enemies. Even minor Gospel characters (Mary Magdelene, the servant Malchus, the Jewish elder Nicodemus) come vividly to life in the book, and its portrayal of the political machinations behind Jesus's trial and death-the contest for power between the Roman governor Pontius Pilate and the high priest Caiaphas-is especially engaging. Beyond depicting the historical milieu in which Jesus lived, Son of God deftly explains the customs and culture of the Jewish people and the Roman officials and soldiers who oppress them, enhancing readers' understanding of the biblical record. In its final part, the book extends the Christian story past Jesus's resurrection to show how Jesus's followers, impassioned by their faith, began spreading his message of salvation throughout the wider world. Grittily realistic, Son of God pulls no punches in conveying the harsh realities of Jesus's era. But it is also inspirational, showing how Jesus transformed the lives of the humble and the powerful alike-and conveying Jesus's message of comfort and hope to present-day readers.
Everybody loves cowboys! Now in this special six-book box set, meet the best of the tall, dark, and handsome cowboys and get ready for the ride of your life . . . SOMEBODY LIKE YOU by Lynnette Austin: Cash thought he had plenty of time to find the right woman-until he learns that he must marry soon or lose his family's Texas farm. When Boston beauty Annelise enters his life, Cash wonders if she's what he's been looking for all along.AIN'T MISBEHAVING by Molly Cannon: After her ex-husband leaves her for another woman, Marla Jean won't settle for another lonely night. And her childhood crush, Jake, may just be the right man to help make this good girl go a little bad.THE SWEET SPOT by Laura Drake: Charla Rae thought she was over her ex-husband-they'd both been through too much together. But when the championship bull rider comes back into town and offers to help with her ranch, will he also convince her to give their love a second chance?LOOKING FOR TROUBLE by Erin Kern: Fleeing her rich, overbearing family, Avery makes her way to Trouble, Wyoming. She soon tries things the old Avery wouldn't dare, like having a sizzling affair with her sexy new boss, Noah-and discovering he's just the kind of trouble she needs.GOING COWBOY CRAZY by Katie Lane: When Faith is mistaken for her identical twin sister in Bramble, Texas, there's bound to be trouble-especially with her sister's ex-boyfriend Slate.MONTANA LEGACY by R. C. Ryan: When Amy left Jesse, she broke his heart. Now she's back in town and stirs his old desires, even as she promises to help him find his family's gold. But under the prairie skies an unseen enemy is closing in to threaten their love-and their lives.Approx. 500,000 words.
A free preview of David Baldacci's new blockbuster thriller... (Includes the first eight chapters) The President knows it's a perilous, high-risk assignment. If he gives the order, he has the opportunity to take down a global menace, once and for all. If the mission fails, he would face certain impeachment, and the threats against the nation would multiply. So the president turns to the one team that can pull off the impossible: Will Robie and his partner, Jessica Reel.Together, Robie and Reel's talents as assassins are unmatched. But there are some in power who don't trust the pair. They doubt their willingness to follow orders. And they will do anything to see that the two assassins succeed, but that they do not survive.As they prepare for their mission, Reel faces a personal crisis that could well lead old enemies right to her doorstep, resurrecting the ghosts of her earlier life and bringing stark danger to all those close to her. And all the while, Robie and Reel are stalked by a new adversary: an unknown and unlikely assassin, a woman who has trained her entire life to kill, and who has her own list of targets-a list that includes Will Robie and Jessica Reel.
All the information and compassion a cancer patient in search of spiritual answers needs Your doctor has given you, or a loved one, frightening medical news. You face surgery, difficult treatment, and questionable outcomes. What does this mean? What can you do? Fear and uncertainty dominate your thoughts, and that's where this book comes in: a dose of soul medicine, a tonic for frightened and weary spirits. Focusing on personal growth, the book explains personal spiritual choice and helps patients find meaning in illness. Anderson is an expert in the field of healing, and has conducted numerous seminars and retreats for the terminally ill and their families.
Nominated for the National Book Award: The story of a middle-aged American man searching for himself in the ruins of Mexico At the start of this vibrant and invigorating novel, Robert Brill has a farm, a law practice, a daughter in high school, a son fighting in Vietnam, and a wife who deep dives into the sherry bottle every night. What more can a typical midwesterner ask for in the late 1960s? A lot, thinks Brill. Tired of distracting himself with drinking, hunting, and sleeping around, Brill leaves Illinois and his family to join an archaeological dig in Puebla, Mexico. As he sifts through pre-Columbian artifacts, Brill considers the ruins of his life and imagines what might have been. One exhilarating fantasy involves a beautiful and free-spirited woman named Gabby. If there is a lesson to be learned from cataloging ancient pottery sherds, however, it is that the past never disappears, no matter how far you try to run from it. Hilarious, candid, and deeply felt, Brill Among the Ruins is considered by many critics to be Vance Bourjaily's finest novel.
"One of the very few good, ambitious and important novels to have been done by the writers of my generation." --Norman Mailer The lives of four Americans born between the world wars are intertwined to devastating effect in this gripping novel from one of the twentieth century's most acclaimed authors. Beautiful, sad Ellen Beniger; her younger brother, Tom, a scholar unhappily moonlighting as a TV writer; the athletic amorist Guy Cinturon; and tough little Eddie Bissle, ex-infantryman and Ellen's secret lover, struggle to come to grips with the limits of their futures and the scars of their pasts as they enter middle age. Will the physical, emotional, and spiritual violations they have endured remain with them forever, or can they be healed? As The Violated builds to its stunning climax, the story of four lost souls reveals heartbreaking truths about the dark side of post-World War II America.
In this masterwork of confessional literature, a man approaching middle age recalls his impetuous youth with fondness, remorse, and astonishment Spanning the years 1939 to 1946, this is the story of a defining era in one man's life and an exhilarating tribute to the entire generation that came of age during World War II. Quince's youthful adventures begin with his first sexual encounter, a night with a girl named Moomie in a one-room cabin in Virginia, and end with the twenty-four-year-old veteran settling down to his postwar future. In between, he falls in and out of love with dozens of women, drinks and drugs his way through two years of college and four years of military service, travels the world, and meets a dazzling array of colorful characters. In a voice both beguiling and sincere, an older, wiser Quince narrates his escapades in search of the truth about who he was and who he has become. One of the finest novels of mid-twentieth-century America, Confessions of a Spent Youth is poignant, witty, and profound.
Vance Bourjaily's classic novel of World War II dramatizes an entire generation's loss of innocence When Thomas "Skinner" Galt leaves Greenwich Village to volunteer as an ambulance driver with the British Army, he anticipates the adventure of a lifetime. What he fails to understand is that no matter where he comes from or how many books he has read, once he dons a military uniform, his life will cease to be his own. Stationed first in the Middle East and then in Italy, Skinner and his fellow American volunteers, Rod, Freak, and Benny, endure boredom, fear, and the exquisite frustration of following orders. They seek solace in their friendship with one another and in the debauched diversions available to men during wartime. But as the days and nights drag on, Skinner begins to drift away from his comrades--and from himself. Too late, he discovers that the path he has chosen leads only to tragedy. Inspired by Vance Bourjaily's experiences as an ambulance driver in the American Field Service and commissioned by legendary editor Maxwell Perkins, The End of My Life marked the arrival of a writer heralded by the New York Times as "a Dostoevsky of the generation that came of age in World War II." Elegant, spare, and fiercely honest, this is a timeless portrait of the devastating effects of war on the human spirit.
Katherine Anne Porter's first and only novel is a masterful allegory of the passions and prejudices that sparked World War II August 1931. An ocean liner bound for Germany sets out from the Mexican port city of Veracruz. The ship's first-class passengers include an idealistic young American painter and her lover; a Spanish dance troupe with a sideline in larceny; an elderly German couple and their fat, seasick bulldog; and a boisterous band of Cuban medical students. As the Vera journeys across the Atlantic, the incidents and intrigues of several dozen passengers and crew members come into razor-sharp focus. The result is a richly drawn portrait of the human condition in all its complexity and a mesmerizing snapshot of a world drifting toward disaster. Written over a span of twenty years and based on the diary Katherine Anne Porter kept during a similar ocean voyage, Ship of Fools was the bestselling novel of 1962 and the inspiration for an Academy Award-winning film starring Vivien Leigh. It is a masterpiece of American literature as captivating today as when it was first published more than a half century ago. This ebook features an illustrated biography of Katherine Anne Porter, including rare photos from the University of Maryland Libraries.
From the legendary front man of the Sex Pistols and Public Image Ltd comes the complete, unvarnished story of his life in his own wordsJohn Lydon is an icon--one of the most recognizable and influential cultural figures of the last forty years. As Johnny Rotten, he was the lead singer and lyricist of the Sex Pistols--the world's most notorious band. The Pistols shot to fame in the mid-1970s with songs such as "Anarchy in the UK" and "God Save the Queen." So incendiary was their impact at the time that in their native England the houses of Parliament questioned whether they violated the Traitors and Treasons Act, a crime that carries the death penalty to this day. The Pistols would inspire the formation of numerous other likeminded groups and Lydon would become the unlikely champion of a generation clamoring for change.Following on the heels of the Pistols, Lydon formed Public Image Ltd (PiL), expressing an equally urgent impulse in his character: the constant need to reinvent himself, to keep moving. From their beginnings in 1978, PiL set the groundbreaking template for a band that continually and compellingly challenges convention, while recording one of the eighties' most powerful anthems, "Rise," along with other cult classics such as "This is Not a Love Song" and "Disappointed." Lydon also found time for making innovative hip-hop and dance records with the likes of Afrika Bambaataa and Leftfield. By the nineties he'd broadened his reach into other media while maintaining his trademark invective and wit, most memorably hosting Rotten TV on VH1.Today, John Lydon remains a captivating and dynamic figure--both as a musician, and, thanks to his outspoken, controversial, and from-the-hip opinions, as a cultural commentator. In Anger Is an Energy--which also features rare and never-before-seen photographs--Lydon looks back on a life full of incident, from his start as a sickly child of Irish immigrants growing up in post-war London to his present status as a vibrant, alternative hero.
am I a partner?am I forgiving?am I a bad girl?am I resilient?am I enough?In the summer of 2013, lying in a hospital bed, her body riddled with parasites, Maria Bello realized that waiting to do something isn't always an option. In a moment, everything could end, and all of her stories would be lost--stories of love, family, miracles, and madness that filled the hundreds of journals she had been keeping since she was a child. She read through each one of those journals during her months of recovery, and in the process began to uncover who she was and who she had become. And instead of coming to any definitive answers, she found herself asking more and more questions. One of the biggest questions she was asking herself at the time was how to tell her son, then 12 years old, that she had fallen in love with a woman. Jack's response--simple and wise beyond his years--was "Whatever, Mom . . . love is love." Realizing that Jack didn't see traditional labels of partnership, Maria began to contemplate the labels she herself had worn during her life.Her essay "Coming Out as a Modern Family" was featured in the New York Times's Modern Love column and started a worldwide conversation about how so many of the labels we all know and still use today are simply outdated. Partnership, career, love, sexuality--all of these aspects of life are fluid now. We no longer fit into tidy little boxes, and neither do our lives. Questioning those labels is at the heart of Whatever . . . Love Is Love.Written as a series of provocative questions and thoughtful answers, this book is filled with deeply personal, often funny, and even passionate stories, stories in which Maria bares her soul and shares what she's learned--not only about romantic love, but also about her relationship with her parents, her feelings about spirituality, her sexual identity, the highs and lows of her career, her humanitarian work, and her worth as a mother. Using her experiences as a gateway to a larger conversation, Maria encourages you to think about the life you lead, who you love, what you do, what you believe in, and what you call yourself . . . and helps you to realize that the only labels that matter are the ones we place on and accept for ourselves, even if they don't fit the mold of "typical."
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