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The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Our research and experience have shown that there is, in fact, an extensive range of effective self-defense options for blind people. We have repeatedly seen that, given the opportunity to learn and practice a reliable system of self-defense, blind men and women meet these challenges with a sense of determination and a true fighting spirit. The purpose of this book is to give blind and visually impaired individuals the opportunity to learn how to avoid dangerous situations, or, if necessary, to fight back. The three of us founded Safe Without Sight in 1995 after discovering that each of us was interested in techniques that teach blind people how to defend themselves.
This book constitutes the refereed proceedings of the five workshops that were organized in conjunction with the International Conference on Business Information Systems, BIS 2014, which took place in Larnaca, Cyprus, in May 2014. The 27 papers in this volume were carefully reviewed and selected from 53 submissions and were revised and extended after the event. The workshop topics covered applications and economics of knowledge-based technologies (AKTB), business and IT alignment (BITA), digital currencies (DC), modern applications of business information systems (MODAPP), and tools for setting up and running a business in cloud computing (TSRB). In addition a keynote paper is included in this book.
Psychology of Success introduces the fundamental psychological principles of success--principles applicable to everyone regardless of age, background, or specialty. Unlike many psychology books, Psychology of Success doesn't take a one-size-fits-all approach. Instead, it asks you to take an active role in defining what is right for you as an individual. Psychology of Success calls on you to use self-awareness and critical thinking strategies to examine your dreams, values, interests, skills,needs, identity, self-esteem, and relationships. This will help you set and achieve goals that are in harmony with your personal vision of success.
The Kansas Journey is a 7th grade Kansas history textbook. The outline for this book is based on the 7th grade Kansas Standards for Social Studies and teaches history and government, economics and geography. The book enables students to gain a working knowledge and understanding of Kansas's history in the context of American history.
Welcome to the Edupress Text Structure Reading Comprehension Book. This resource is an effective tool for instruction, practice, and evaluation of student understanding. It includes ideas on how to introduce different text structures to students, as well as activities to help teach and practice the concepts.
This book describes recent advances on fuzzy logic augmentation of nature-inspired optimization metaheuristics and their application in areas such as intelligent control and robotics, pattern recognition, time series prediction and optimization of complex problems. The book is organized in two main parts, which contain a group of papers around a similar subject. The first part consists of papers with the main theme of theoretical aspects of fuzzy logic augmentation of nature-inspired optimization metaheuristics, which basically consists of papers that propose new optimization algorithms enhanced using fuzzy systems. The second part contains papers with the main theme of application of optimization algorithms, which are basically papers using nature-inspired techniques to achieve optimization of complex optimization problems in diverse areas of application.
This book constitutes the thoroughly refereed post-workshop proceedings of the 10th International Workshop on Web Services and Formal Methods, WS-FM 2013, held in Beijing, China, in August 2013. The 8 papers presented were carefully reviewed and selected from 19 submissions. They cover aspects such as control-flow relations using Petri nets, consistency of cloud stores, model checking, model-drives design, analysis of context-aware systems.
This book focuses on the use of farm level, micro- and macro-data of cooperative systems and networks in developing new robust, reliable and coherent modeling tools for agricultural and environmental policy analysis. The efficacy of public intervention on agriculture is largely determined by the existence of reliable information on the effects of policy options and market developments on farmers' production decisions and in particular, on key issues such as levels of agricultural and non-agricultural output, land use and incomes, use of natural resources, sustainable-centric management, structural change and the viability of family farms. Over the last years, several methods and analytical tools have been developed for policy analysis using various sets of data. Such methods have been based on integrated approaches in an effort to investigate the above key issues and have thus attempted to offer a powerful environment for decision making, particularly in an era of radical change for both agriculture and the wider economy.
This concise text is based on a series of lectures held only a few years ago and originally intended as an introduction to known results on linear hyperbolic and parabolic equations. Yet the topic of differential equations on graphs, ramified spaces, and more general network-like objects has recently gained significant momentum and, well beyond the confines of mathematics, there is a lively interdisciplinary discourse on all aspects of so-called complex networks. Such network-like structures can be found in virtually all branches of science, engineering and the humanities, and future research thus calls for solid theoretical foundations. This book is specifically devoted to the study of evolution equations - i. e. , of time-dependent differential equations such as the heat equation, the wave equation, or the Schrödinger equation (quantum graphs) - bearing in mind that the majority of the literature in the last ten years on the subject of differential equations of graphs has been devoted to elliptic equations and related spectral problems. Moreover, for tackling the most general settings - e. g. encoded in the transmission conditions in the network nodes - one classical and elegant tool is that of operator semigroups. This book is simultaneously a very concise introduction to this theory and a handbook on its applications to differential equations on networks. With a more interdisciplinary readership in mind, full proofs of mathematical statements have been frequently omitted in favor of keeping the text as concise, fluid and self-contained as possible. In addition, a brief chapter devoted to the field of neurodynamics of the brain cortex provides a concrete link to ongoing applied research.
This collected volume deals with emerging issues related to climate variation, climate change and adaptation technologies, with a special focus on Latin American countries. Presenting a variety of adaptation strategies and projects currently being undertaken and implemented, the book showcases how Latin American nations are struggling to meet the challenges of climate change. Latin America as a whole and Central America in particular is one of the most vulnerable regions of the world and is severely affected by recurrent extreme climate-related events. This volume documents and analyzes the main challenges and lessons learned, serving to disseminate knowledge beyond the region and enhance international research and policy cooperation.
Each passing year bears witness to the development of ever more powerful computers, increasingly fast and cheap storage media, and even higher bandwidth data connections. This makes it easy to believe that we can now - at least in principle - solve any problem we are faced with so long as we only have enough data. Yet this is not the case. Although large databases allow us to retrieve many different single pieces of information and to compute simple aggregations, general patterns and regularities often go undetected. Furthermore, it is exactly these patterns, regularities and trends that are often most valuable. To avoid the danger of "drowning in information, but starving for knowledge" the branch of research known as data analysis has emerged, and a considerable number of methods and software tools have been developed. However, it is not these tools alone but the intelligent application of human intuition in combination with computational power, of sound background knowledge with computer-aided modeling, and of critical reflection with convenient automatic model construction, that results in successful intelligent data analysis projects. Guide to Intelligent Data Analysis provides a hands-on instructional approach to many basic data analysis techniques, and explains how these are used to solve data analysis problems. Topics and features: guides the reader through the process of data analysis, following the interdependent steps of project understanding, data understanding, data preparation, modeling, and deployment and monitoring; equips the reader with the necessary information in order to obtain hands-on experience of the topics under discussion; provides a review of the basics of classical statistics that support and justify many data analysis methods, and a glossary of statistical terms; includes numerous examples using R and KNIME, together with appendices introducing the open source software; integrates illustrations and case-study-style examples to support pedagogical exposition. This practical and systematic textbook/reference for graduate and advanced undergraduate students is also essential reading for all professionals who face data analysis problems. Moreover, it is a book to be used following one's exploration of it. Dr. Michael R. Berthold is Nycomed-Professor of Bioinformatics and Information Mining at the University of Konstanz, Germany. Dr. Christian Borgelt is Principal Researcher at the Intelligent Data Analysis and Graphical Models Research Unit of the European Centre for Soft Computing, Spain. Dr. Frank Höppner is Professor of Information Systems at Ostfalia University of Applied Sciences, Germany. Dr. Frank Klawonn is a Professor in the Department of Computer Science and Head of the Data Analysis and Pattern Recognition Laboratory at Ostfalia University of Applied Sciences, Germany. He is also Head of the Bioinformatics and Statistics group at the Helmholtz Centre for Infection Research, Braunschweig, Germany.
Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement of imaging techniques, and key multi-disciplinary approaches including aspects of organic chemistry, biochemistry, molecular biology, electrophysiology, and behavioral science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Pheromone Signaling: Methods and Protocols details the key methodologies utilized in laboratories all over the world, making them accessible to those who want to begin investigation in the area of pheromone research.
Providing current diverse approaches and techniques used to study the immunoproteome, Immunoproteomics: Methods and Protocols collects chapters from key researchers that deliver information to be used in diagnostics, disease progression, and vaccine correlates of protection analysis, to name but a few. This detailed volume includes techniques used for the study of the antibody targets of bacterial pathogens, viruses, and cancer, mass spectrometry-based approaches to characterize T-cell epitopes, chapters on detection and relative quantification of cytokines in serum, as well as in silico prediction of epitopes using sequence-based or modeling approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Immunoproteomics: Methods and Protocols aids researchers in transferring these techniques to their own laboratories in addition to providing a reference to guide researchers toward appropriate techniques.
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and ToxicologyTM series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
The theory of numbers continues to occupy a central place in modern mathematics because of both its long history over many centuries as well as its many diverse applications to other fields such as discrete mathematics, cryptography, and coding theory. The proof by Andrew Wiles (with Richard Taylor) of Fermat's last theorem published in 1995 illustrates the high level of difficulty of problems encountered in number-theoretic research as well as the usefulness of the new ideas arising from its proof. The thirteenth conference of the Canadian Number Theory Association was held at Carleton University, Ottawa, Ontario, Canada from June 16 to 20, 2014. Ninety-nine talks were presented at the conference on the theme of advances in the theory of numbers. Topics of the talks reflected the diversity of current trends and activities in modern number theory. These topics included modular forms, hypergeometric functions, elliptic curves, distribution of prime numbers, diophantine equations, L-functions, Diophantine approximation, and many more. This volume contains some of the papers presented at the conference. All papers were refereed. The high quality of the articles and their contribution to current research directions make this volume a must for any mathematics library and is particularly relevant to researchers and graduate students with an interest in number theory. The editors hope that this volume will serve as both a resource and an inspiration to future generations of researchers in the theory of numbers.
This valuable collection aims to provide a collection of frequently used statistical methods in the field of proteomics. Although there is a large overlap between statistical methods for the different 'omics' fields, methods for analyzing data from proteomics experiments need their own specific adaptations. To satisfy that need, Statistical Analysis in Proteomics focuses on the planning of proteomics experiments, the preprocessing and analysis of the data, the integration of proteomics data with other high-throughput data, as well as some special topics. Written for the highly successful Methods in Molecular Biology series, the chapters contain the kind of detail and expert implementation advice that makes for a smooth transition to the laboratory. Practical and authoritative, Statistical Analysis in Proteomics serves as an ideal reference for statisticians involved in the planning and analysis of proteomics experiments, beginners as well as advanced researchers, and also for biologists, biochemists, and medical researchers who want to learn more about the statistical opportunities in the analysis of proteomics data.
This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology. Chapters in this book cover methods to help illuminate the assembly, trafficking, molecular composition and subcellular location of iGluRs; approaches used to understand the atomic organization of iGluRs; and techniques to monitor receptor activity in real time. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Ionotropic Glutamate Receptor Technologies aims to facilitate the implementation of specific methods to iGluR investigations.
This volume aims to bring together a variety of protocols useful for DNA-based typing of blood cell antigens. Protocols range from simple approaches with low technical complexity to highly sophisticated modern developments. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Molecular Typing of Blood Cell Antigens summarizes contributions from leading scientist in the field DNA typing for blood cell antigens.
"The editors. . . have done an outstanding job of presenting. . . complex information in a lucid manner - this book is a must-read for the global community of aspiring students and neuro-oncology practitioners. " Amar Gajjar, MD in the Foreword This is a succinct introduction to pediatric neuro-oncology. It summarizes the key advances in molecular biology that have helped transform this rapidly evolving field and provides up-to-date coverage of major and emerging treatment modalities as well as supportive care. Separate chapters present each kind of pediatric brain cancer and its diagnosis and treatment. As more children survive brain cancer, the importance of quality of life issues and helping survivors to cope with the neuropsychological impact and long-term effects of current therapies has come into sharper focus; these topics are also addressed in the book, as are palliative care and pediatric neuro-oncology in countries with limited resources. The book is aimed at trainees and practitioners who seek an up-to-date text in pediatric neuro-oncology that is both comprehensive and concise.
Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians. Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication? How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms? Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology, this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists on the application of physics-based experiment and analysis, together with appropriate modeling, in the understanding and interpretation of the pervasive phenomenon of microbial quorum communication.
Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules: Methods and Protocols aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.
Primary Care Sleep Medicine - A Practical Guide was among the first books to address sleep medicine for a primary care audience. It remains the primary text oriented to the primary care physician with an interest in sleep disorders medicine Since this title published, there have been many changes in the sleep field A new text oriented towards supporting the primary care physician in the practice of sleep medicine is needed; an updated second edition of Primary Care Sleep Medicine - A Practical Guide could fill this knowledge gap. This second edition will include updated information on insomnia medications, post-traumatic stress disorders, home sleep testing protocols, complex sleep apnea and the defined role for primary care physicians in sleep medicine.
FOUNDATIONS OF LEGAL RESEARCH AND WRITING, Fifth Edition is the ideal resource for paralegals. The book's up-to-the-minute coverage tackles the ever-evolving areas of computer-assisted research and Cyber law, in addition to traditional legal research, analysis, and writing. Extensive research chapters address primary and secondary sources, citating, Lexis/Nexis, the Internet, and more, while writing sections center on drafting client opinion letters, pleadings, contracts, office memos, memoranda of law, and appellate briefs. Every chapter gives you practice writing opportunities, as well as traditional and computer-assisted research assignments to help develop your skills. Detailed case excerpts, samples, tips, and discussions further support the assignments, and illustrate the many perils of inadequate research and poor legal writing. Readers everywhere agree that FOUNDATIONS OF LEGAL RESEARCH AND WRITING, Fifth Edition delivers the concepts you need for success in the most demanding law firms and legal departments today.
Daily instruction on the reading strategies and comprehension skills your students need to improve reading comprehension and raise test scores! Engage your students in reading, thinking about, and responding to a variety of passages and texts!
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