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Directed Enzyme Evolution: Advances and Applications

by Miguel Alcalde

This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection.

Candida albicans: Cellular and Molecular Biology

by Rajendra Prasad

This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host-pathogen interactions, virulence, host immune system modulation, etc. , in the last two decades. This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host-pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.

The Hippocampus from Cells to Systems

by Melissa C. Duff Deborah E. Hannula

The hippocampus has long been considered a critical substrate in the neurobiology, neuropsychology, and cognitive neuroscience of memory. Over the past few decades, a number of ground-breaking theoretical and methodological advances have radically enhanced our understanding of the structure and function of the hippocampus and revolutionized the neuroscientific study of memory. Cutting across disciplines and approaches, these advances offer novel insights into the molecular and cellular structure and physiology of the hippocampus, the role of hippocampus in the formation, (re)consolidation, enhancement, and retrieval of memory across time and development, and permit investigators to address questions about how the hippocampus interacts, functionally and anatomically, with other neural systems in service of memory. In addition, recent investigations also suggest that the mechanistic properties and functional processing features of the hippocampus permit broader contributions to cognition, beyond memory, to the domains of attention, decision-making, language, social cognition, and a variety of other capacities that are critical for flexible cognition and behavior. These advances have profound implications for the neurobiology and cognitive neuroscience of hippocampus dependent cognition and for the numerous psychiatric and neurological diseases and disorders for which hippocampal pathology is a hallmark such as Alzheimer's disease and schizophrenia. The goal of this book is to bring together in a single source an integrated review of these advances providing state of the art treatment on the structure and function of the hippocampus. Contributors will examine the hippocampus from a variety of levels (from cells to systems) using a wide range of methods (from neurobiological approaches in non-human animals to neuroimaging and neuropsychological work in humans).

Peripheral Ulcerative Keratitis

by Manotosh Ray Virender Singh Sangwan Anat Galor Radhika Tandon

A handy manual for cornea specialists, this book provides detailed practical information about a complex, sight-threatening disease that can be challenging to diagnose and manage. This text features chapters dedicated to outlining all facets of diagnosis and management while covering both medical and surgical treatment options. Peripheral Ulcerative Keratitis, supplemented with useful references and appendices to provide simple step by step algorithms, is written by internationally renowned authors who are experts in the field. Including practical tips and guidelines for diagnosis and therapy of these disorders, Peripheral Ulcerative Keratitis is designed to serve as a guide for comprehensive ophthalmologists and should find itself on the bookshelves of ophthalmology clinics, corneal practices and training programs across the country.

Preparing Informal Science Educators

by Patricia G. Patrick

This book provides a diverse look at various aspects of preparing informal science educators. Much has been published about the importance of preparing formal classroom educators, but little has been written about the importance, need, and best practices for training professionals who teach in aquariums, camps, parks, museums, etc. The reader will find that as a collective the chapters of the book are well-related and paint a clear picture that there are varying ways to approach informal educator preparation, but all are important. The volume is divided into five topics: Defining Informal Science Education, Professional Development, Designing Programs, Zone of Reflexivity: The Space Between Formal and Informal Educators, and Public Communication. The authors have written chapters for practitioners, researchers and those who are interested in assessment and evaluation, formal and informal educator preparation, gender equity, place-based education, professional development, program design, reflective practice, and science communication. Readers will draw meaning and usefulness from the array of professional perspectives and be stimulated to begin a quest to scaffold programs and professional development around the frameworks described in this book.

Robust Resource Allocation in Future Wireless Networks

by Nader Mokari Ahmad Reza Sharafat Saeedeh Parsaeefard

This book presents state-of-the-art research on robust resource allocation in current and future wireless networks. The authors describe the nominal resource allocation problems in wireless networks and explain why introducing robustness in such networks is desirable. Then, depending on the objectives of the problem, namely maximizing the social utility or the per-user utility, cooperative or competitive approaches are explained and their corresponding robust problems are considered in detail. For each approach, the costs and benefits of robust schemes are discussed and the algorithms for reducing their costs and improving their benefits are presented. Considering the fact that such problems are inherently non-convex and intractable, a taxonomy of different relaxation techniques is presented, and applications of such techniques are shown via several examples throughout the book. Finally, the authors argue that resource allocation continues to be an important issue in future wireless networks, and propose specific problems for future research.

Complete Organ Method: A Classic Text on Organ Technique

by F. Flaxington Harker John Stainer

This classic method for beginners provides a brief history of the instrument followed by an explanation of organ construction, a thorough discussion of the various stops and their management, and a major section devoted to practical study -- including detailed pedal techniques, precision in manual touch, hand-foot independence, pedal scales, trios, and finger substitution to achieve a perfect legato. With the author's meticulous explanations and accompanying illustrations, students can actually teach themselves to play! Seven organ pieces complete the original edition, including five of Stainer's own works and two pieces by Guilmant; three additional works have been added to round out this Dover edition.

Patterns for Guernseys, Jerseys & Arans

by Gladys Thompson

For hundreds of years the fishermen of the British Isles have gone to the sea wearing Guernsey and Jersey sweaters. Among landlubbers as well, these sweaters are perennially popular, but, especially in this country, it is often hard to find practical instructions for the patterns that are traditional in Britain. Here is a book that presents fully 82 different genuine folk patterns for both the lighter weight Jerseys and the heavier Guernseys, and diagrams many more patterns that you can use in your knitting. The author gives the names of the stitches and patterns traditionally used in making Jerseys and Guernseys, and she tells you exactly how to knit every sweater in this book using those patterns and stitches. Here you will find patterns taken from sweaters found in Yorkshire, Norfolk, the west coast of Ireland, the Scottish Hebrides, and the Aran Islands. These are sweaters that have often been handed down from father to son for several generations, they wear so well. Instructions for these sturdy sweaters are given row by row for knitting fronts, backs, sleeves, and necks, in the traditional fashion. Each set of instructions is accompanied by a diagram of the pattern and, often, by a photograph of the finished sweater. All of these sweaters can be worn by either men or women, but the author has also provided full directions for making two sets of sweaters and cardigans expressly adapted for ladies' wear. Mrs. Thompson also includes interesting information about the people who gave her the patterns for this book.


by George Gamow

A distinguished physicist and teacher, George Gamow also possessed a special gift for making the intricacies of science accessible to a wide audience. In Gravity, he takes an enlightening look at three of the towering figures of science who unlocked many of the mysteries behind the laws of physics: Galileo, the first to take a close look at the process of free and restricted fall; Newton, originator of the concept of gravity as a universal force; and Einstein, who proposed that gravity is no more than the curvature of the four-dimensional space-time continuum.Graced with the author's own drawings, both technical and fanciful, this remarkably reader-friendly book focuses particularly on Newton, who developed the mathematical system known today as the differential and integral calculus. Readers averse to equations can skip the discussion of the elementary principles of calculus and still achieve a highly satisfactory grasp of a fascinating subject.Starting with a chapter on Galileo's pioneering work, this volume devotes six chapters to Newton's ideas and other subsequent developments and one chapter to Einstein, with a concluding chapter on post-Einsteinian speculations concerning the relationship between gravity and other physical phenomena, such as electromagnetic fields.

Foundations of Hardware IP Protection

by Lionel Torres Lilian Bossuet

This book provides a comprehensive and up-to-date guide to the design of security-hardened, hardware intellectual property (IP). Readers will learn how IP can be threatened, as well as protected, by using means such as hardware obfuscation/camouflaging, watermarking, fingerprinting (PUF), functional locking, remote activation, hidden transmission of data, hardware Trojan detection, protection against hardware Trojan, use of secure element, ultra-lightweight cryptography, and digital rights management. This book serves as a single-source reference to design space exploration of hardware security and IP protection.

Sinus Headache, Migraine, and the Otolaryngologist

by Mark E. Mehle

This volume will serve as a comprehensive and useful guide for ENT physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text will serve to expand management options to physicians already operating on sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.

Avant-garde Orientalism

by David Lehardy Sweet

This study explores the work of Western avant-garde writers who traveled to and wrote about Asia and North Africa. Though exoticist in outlook, many of these writers were also anti-colonialist and thus avoided some of the pitfalls of academic orientalism by assuming an aesthetics of diversity while employing strategies of provocation and reciprocity. As a survey of works on travel (including essays, novels, poems, and plays), the book challenges or modifies many postcolonial assumptions about Western writers on the Orient: from the French Surrealists to the American Beats and even transnational authors of the new millennium. Through a synthesis of avant-garde, postcolonial, and travel literature theories, Avant-garde Orientalism works in the best tradition of comparative literary study to identify and analyze a distinct category of world literature.

Macro Innovation Dynamics and the Golden Age

by Paul J. J. Welfens

This book takes a new look at the golden age in neoclassical growth theory and explores in detail sustainability and optimum growth in China, the US and Europe. Innovation, foreign direct investment, trade and growth dynamics are key elements in modern economies - including perspectives on green growth and aspects of the knowledge production function in the context of multinational companies. As such the book considers the role of foreign direct investment in a modified growth model and discusses innovation in an enhanced Mundell-Fleming macro model. Moreover, for the first time it directly links a knowledge production function to the macro production function in a broader context, including real money balances in the production function. It shows - also with empirical relevance - that FDI inward stocks relative to the GDP of host countries, the number of researchers and per capita income are relevant drivers of new knowledge and the stock of knowledge, respectively. This new Schumpeterian theoretical approach lends itself to important policy conclusions for both OECD members and newly industrialized countries.

100 years of European Philosophy Since the Great War

by Jack Reynolds Rory Jeffs Matthew Sharpe

This book is a collection of specifically commissioned articles on the key continental European philosophical movements since 1914. It shows how each of these bodies of thought has been shaped by their responses to the horrors set in train by World War I, and considers whether we are yet 'post-post-war'. The outbreak of World War I in August 1914,set in chain a series of crises and re-configurations, which have continued to shape the world for a century: industrialized slaughter, the end of colonialism and European empires, the rise of the USA, economic crises, fascism, Soviet Marxism, the gulags and the Shoah. Nearly all of the major movements in European thinking (phenomenology, psychoanalysis, Hegelianism, Marxism, political theology, critical theory and neoliberalism) were forged in, or shaped by, attempts to come to terms with the global trauma of the World Wars. This is the first book to describe the development of these movements after World War I, and as such promises to be of interest to philosophers and historians of philosophy around the world.

Reflections on Ethics and Responsibility

by Zachary J. Goldberg

The original essays in this book address the influential writings of Peter A. French on the nature of responsibility, ethics, and moral practices. French's contributions to a wide spectrum of philosophical discussions have made him a dominant figure in the fields of normative ethics, meta-ethics, applied ethics, as well as legal and political philosophy. Many of French's deepest insights come from identifying and exploring the scope and nature of moral responsibility and human agency as they appear in actual events, real social and cultural practices, as well as in literature and film. This immediacy renders French's scholarship vital and accessible to a wide variety of audiences. The authors, recognized for their own contributions to the understanding of the nature of morality and moral practices offer new and unique positions while exploring, expanding and responding to those of French. The final chapter is written by French, in which he provides both new philosophical insight as well as some reflection on his own work and its influence. This book will appeal to philosophers, as well as advanced students and researchers in the humanities, social sciences, law, and political science.

Learning and Intelligent Optimization

by Joaquin Vanschoren Meinolf Sellmann Paola Festa

This book constitutes the thoroughly refereed post-conference proceedings of the 10th International Conference on Learning and Optimization, LION 10, which was held on Ischia, Italy, in May/June 2016. The 14 full papers presented together with 9 short papers and 2 GENOPT papers were carefully reviewed and selected from 47 submissions. The papers address all fields between machine learning, artificial intelligence, mathematical programming and algorithms for hard optimization problems. Special focus is given to new ideas and methods; challenges and opportunities in various application areas; general trends, and specific developments.

Interactive Collaborative Learning

by James Uhomoibhi David Guralnick Michael E. Auer

This book presents the proceedings of the 19th International Conference on Interactive Collaborative Learning, held 21-23 September 2016 at Clayton Hotel in Belfast, UK. We are currently witnessing a significant transformation in the development of education. The impact of globalisation on all areas of human life, the exponential acceleration of developments in both technology and the global markets, and the growing need for flexibility and agility are essential and challenging elements of this process that have to be addressed in general, but especially in the context of engineering education. To face these topical and very real challenges, higher education is called upon to find innovative responses. Since being founded in 1998, this conference has consistently been devoted to finding new approaches to learning, with a focus on collaborative learning. Today the ICL conferences have established themselves as a vital forum for the exchange of information on key trends and findings, and of practical lessons learned while developing and testing elements of new technologies and pedagogies in learning.

Interactive Collaborative Learning

by James Uhomoibhi David Guralnick Michael E. Auer

This book presents the proceedings of the 19th International Conference on Interactive Collaborative Learning, held 21-23 September 2016 at Clayton Hotel in Belfast, UK. We are currently witnessing a significant transformation in the development of education. The impact of globalisation on all areas of human life, the exponential acceleration of developments in both technology and the global markets, and the growing need for flexibility and agility are essential and challenging elements of this process that have to be addressed in general, but especially in the context of engineering education. To face these topical and very real challenges, higher education is called upon to find innovative responses. Since being founded in 1998, this conference has consistently been devoted to finding new approaches to learning, with a focus on collaborative learning. Today the ICL conferences have established themselves as a vital forum for the exchange of information on key trends and findings, and of practical lessons learned while developing and testing elements of new technologies and pedagogies in learning.

The Isle of Blood (Monstrumologist #3)

by Rick Yancey

When Dr. Warthrop goes hunting for the “Holy Grail of Monstrumology” with his eager new assistant, Arkwright, he leaves Will Henry in Victorian New York. Finally, Will can enjoy something that always seemed out of reach: a normal life with a real family. But part of Will can’t let go of Dr. Warthrop, and when Arkwright returns, claiming that the doctor is dead, Will is devastated—and not convinced.<P><P> Determined to discover the truth, Will travels to London, knowing that if he succeeds, he will be plunging into depths of horror worse than anything he has experienced so far. His journey takes him to Socotra, the Isle of Blood, where human beings are used to make nests and blood rains from the sky—and puts Will Henry’s loyalty to the ultimate test.

An Atlas of Anatomy for Artists

by Fritz Schider

In this expanded edition of a classic work, Schider's complete, historical text is accompanied by a wealth of anatomical illustrations. A variety of plates showcasing master artists -- including Leonardo, Rubens, Michelangelo, Muybridge, and Vesalius -- and their classic works on anatomy are also included. Features 593 illustrations.

On the Sensations of Tone

by Hermann Helmholtz

On the Sensations of Tone is one of the world's greatest scientific classics. It bridges the gap between the natural sciences and music theory and, nearly a century after its first publication, it is still a standard text for the study of physiological acoustics -- the scientific basis of musical theory. It is also a treasury of knowledge for musicians and students of music and a major work in the realm of aesthetics, making important contributions to physics, anatomy, and physiology in its establishment of the physical theory of music. Difficult scientific concepts are explained simply and easily for the general reader.The first two parts of this book deal with the physics and physiology of music. Part I explains the sensation of sound in general, vibrations, sympathetic resonances, and other phenomena. Part II cover combinational tones and beats, and develops Helmholtz's famous theory explaining why harmonious chords are in the ratios of small whole numbers (a problem unsolved since Pythagoras).Part III contains the author's theory on the aesthetic relationship of musical tones. After a survey of the different principles of musical styles in history (tonal systems of Pythagoras, the Church, the Chinese, Arabs, Persians, and others), he makes a detailed study of our own tonal system (keys, discords, progression of parts).Important points in this 576-page work are profusely illustrated with graphs, diagrams, tables, and musical examples. 33 appendices discuss pitch, acoustics, and music, and include a very valuable table and study of the history of pitch in Europe from the fourteenth to the nineteenth centuries.<P><P>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. To explore further access options with us, please contact us through the Book Quality link on the right sidebar. Benetech is actively working on projects to improve accessibility issues such as these.

11 Harrowhouse

by Gerald A. Browne

The classic New York Times-bestselling tale of suspense and intrigue that takes readers behind the scenes of the secretive billion-dollar diamond business From a centuries-old building on a narrow street in the heart of London, a firm known as the System, the world's most lucrative and least-known cartel, maintains a stranglehold on the world's diamonds. The company selects the stones a customer can buy and decides how much he must pay for the privilege. One dealer is tired of the game, and so he sets out to destroy the System forever. With the help of his mistress, Chesser sketches a plan to infiltrate the offices at 11 Harrowhouse--and make off with every diamond the System owns. But this billion-dollar heist is not as simple as it seems, for the System is always watching.

Manual of 3D Echocardiography

by José Luis Zamorano Covadonga Fernandez-Golfin Eduardo Casas Rojo

This book is a practical guiding manual to explain critical clinical practice in three-dimensional (3D) echocardiography. The use of this technology has been limited to certain pioneer imaging units, but with the advent of lower cost hardware it is spreading and reaching more users that will start to use it often without previous experience or formal academic training. This title provides these readers with a full review of the features, clinical indications and methodological aspects of 3D echo in a practical, "how-to-do-it" way. 3D-echocardiography techniques are becoming more diverse, as they are applied to transthoracic and transesophageal studies, 3D-wall motion tracking, fusion of echocardiographic and fluoroscopy navigation, fusion of wall motion tracking and coronary tomography. All these aspects are described and explained deeply in this book.

The Amazing Language of Medicine

by Robert B. Taylor

This book tells the intriguing and often colorful stories of the medical words we use. The origins of clinical and scientific terms can be found in Greek and Latin myths, in places such as jungles of Uganda and the islands of the Aegean Sea, in the names of medicine's giants such as Hippocrates and Osler, and in some truly unlikely sources. In this book you will learn the answers to questions such as: * What disease was named for an American space flight? * Do you know the echoic word for elephantine rumbling of the bowels? * What drug name was determined by drawing chemists' notes out of a hat? * What are surfer's eye, clam digger's itch, and hide porter's disease? This book can give you new insights into the terms we use every day in the clinic, hospital, and laboratory. Knowing a word's history assists in understanding not only what it means, but also some of the connotative subtleties of terms used in diagnosis and treatment. The Amazing Language of Medicine is intended for the enrichment of physicians, other health professionals, students, and anyone involved in clinical care and medical science.

Mimicry and Meaning: Structure and Semiotics of Biological Mimicry

by Timo Maran

The present book analyses critically the tripartite mimicry model (consisting of the mimic, model and receiver species) and develops semiotic tools for comparative analysis. It is proposed that mimicry has a double structure where sign relations in communication are in constant interplay with ecological relations between species. Multi-constructivism and toolbox-like conceptual methods are advocated for, as these allow taking into account both the participants' Umwelten as well as cultural meanings related to specific mimicry cases. From biosemiotic viewpoint, mimicry is a sign relation, where deceptively similar messages are perceived, interpreted and acted upon. Focusing on living subjects and their communication opens up new ways to understand mimicry. Such view helps to explain the diversity of mimicry as well as mimicry studies and treat these in a single framework. On a meta-level, a semiotic view allows critical reflection on the use of mimicry concept in modern biology. The author further discusses interpretations of mimicry in contemporary semiotics, analyses mimicry as communicative interaction, relates mimicry to iconic signs and focuses on abstract resemblances in mimicry. Theoretical discussions are illustrated with detailed excursions into practical mimicry cases in nature (brood parasitism, eyespots, myrmecomorphy, etc. ). The book concludes with a conviction that mimicry should be treated in a broader semiotic-ecological context as it presumes the existence of ecological codes and other sign conventions in the ecosystem.

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