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Showing 26 through 50 of 13,581 results

Cryopreservation and Freeze-Drying Protocols, 3rd Edition (Methods in Molecular Biology #1257)

by Willem F. Wolkers Harriëtte Oldenhof

This volume provides a variety of standard protocols used to cryopreserve or freeze-dry different types of specimens. In addition, it provides chapters focused on the fundamental principles of cryopreservation, vitrification, and freeze-drying. Several state of the art microscopic, spectroscopic as well as calorimetric methods are highlighted that can be used to study cellular and macromolecular changes in response to freezing or drying. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. <P><P> Authoritative and practical, Cryopreservation and Freeze-Drying Protocols, Third Edition serves as a practical guideline for studies on freezing and drying processes as well as preservation strategies for biological specimens.

Communication Challenges and Solutions in the Smart Grid (SpringerBriefs in Computer Science)

by Fayҫal Bouhafs Michael Mackay Madjid Merabti

This SpringerBrief discusses the rise of the smart grid from the perspective of computing and communications. It explains how current and next-generation network technology and methodologies help recognize the potential that the smart grid initiative promises. Chapters provide context on the smart grid before exploring specific challenges related to communication control and energy management. Topics include control in heterogeneous power supply, solutions for backhaul and wide area networks, home energy management systems, and technologies for smart energy management systems. Designed for researchers and professionals working on the smart grid, Communication Challenges and Solutions in the Smart Grid offers context and applications for the common issues of this developing technology. Advanced-level students interested in networking and communications engineering will also find the brief valuable.

BRAF Targets in Melanoma: Biological Mechanisms, Resistance, and Drug Discovery (Cancer Drug Discovery and Development #82)

by Ryan J. Sullivan

This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

Biostatistics and Epidemiology: A Primer for Health and Biomedical Professionals

by Jordan Smoller Sylvia Wassertheil-Smoller

Since the publication of the first edition, Biostatistics and Epidemiology has attracted loyal readers from across specialty areas in the biomedical community. Not only does this textbook teach foundations of epidemiological design and statistical methods, but it also includes topics applicable to new areas of research. Areas covered in the fourth edition include a new chapter on risk prediction, risk reclassification and evaluation of biomarkers, new material on propensity analyses, and a vastly expanded chapter on genetic epidemiology, which is particularly relevant to those who wish to understand the epidemiological and statistical aspects of scientific articles in this rapidly advancing field. Biostatistics and Epidemiology was written to be accessible for readers without backgrounds in mathematics. It provides clear explanations of underlying principles, as well as practical guidelines of "how to do it" and "how to interpret it. " Key features include a philosophical and logical explanation at the beginning of the book, subsections that can stand alone or serve as reference, cross-referencing, recommended reading, and appendices covering sample calculations for various statistics in the text.

Bayesian Networks in Educational Assessment (Statistics for Social and Behavioral Sciences)

by Russell G. Almond Robert J. Mislevy Linda S. Steinberg Duanli Yan David M. Williamson

Bayesian inference networks, a synthesis of statistics and expert systems, have advanced reasoning under uncertainty in medicine, business, and social sciences. This innovative volume is the first comprehensive treatment exploring how they can be applied to design and analyze innovative educational assessments. Part I develops Bayes nets' foundations in assessment, statistics, and graph theory, and works through the real-time updating algorithm. Part II addresses parametric forms for use with assessment, model-checking techniques, and estimation with the EM algorithm and Markov chain Monte Carlo (MCMC). A unique feature is the volume's grounding in Evidence-Centered Design (ECD) framework for assessment design. This "design forward" approach enables designers to take full advantage of Bayes nets' modularity and ability to model complex evidentiary relationships that arise from performance in interactive, technology-rich assessments such as simulations. Part III describes ECD, situates Bayes nets as an integral component of a principled design process, and illustrates the ideas with an in-depth look at the BioMass project: An interactive, standards-based, web-delivered demonstration assessment of science inquiry in genetics. This book is both a resource for professionals interested in assessment and advanced students. Its clear exposition, worked-through numerical examples, and demonstrations from real and didactic applications provide invaluable illustrations of how to use Bayes nets in educational assessment. Exercises follow each chapter, and the online companion site provides a glossary, data sets and problem setups, and links to computational resources.

Additive Manufacturing Technologies: 3D Printing, Rapid Prototyping, and Direct Digital Manufacturing

by David Rosen Ian Gibson Brent Stucker

This book covers in detail the various aspects of joining materials to form parts. A conceptual overview of rapid prototyping and layered manufacturing is given, beginning with the fundamentals so that readers can get up to speed quickly. Unusual and emerging applications such as micro-scale manufacturing, medical applications, aerospace, and rapid manufacturing are also discussed. This book provides a comprehensive overview of rapid prototyping technologies as well as support technologies such as software systems, vacuum casting, investment casting, plating, infiltration and other systems. This book also: Reflects recent developments and trends and adheres to the ASTM, SI, and other standards Includes chapters on automotive technology, aerospace technology and low-cost AM technologies Provides a broad range of technical questions to ensure comprehensive understanding of the concepts covered

Atlas of Implantable Therapies for Pain Management

by Jason E. Pope Timothy R. Deer

From reviews of the First Edition: "For the practitioner new to the field of implantable therapies, this book shows the scope of this particular branch of pain medicine. It is full of good advice on techniques and how to avoid complications. " British Journal of Clinical Pharmacology "All practicing pain physicians, whether their background is in anesthesia or neurosurgery, will find [this atlas] very useful. . . beautifully written and well-illustrated with x-ray images and pictures. . . a must-read for every pain fellow and a very useful one for every pain physician. " Doody's Review Service Now in its Second Edition, this atlas remains an essential guide to the treatment of pain using neuromodulation and is written for all implanters, from beginners to the most advanced practitioners. It has been significantly expanded with many brand new chapters and figures and thoroughly updated to address new techniques, targets, waveforms, and concepts that have emerged since publication of the last edition and now provides even more detailed coverage of patient safety, including infection control and reduction of bleeding risks. The new and returning physicians who have collaborated on the Second Edition are world-class in their research, clinical expertise, and ethics of practice. They have endeavored to make each segment of the atlas a great learning event through careful integration of extensive photographs, illustrations, and detailed instructions and to create a resource that helps to improve practice and enhance outcomes while complementing fellowship training, peer-to-peer experiences, and hands-on continuing medical education.

A Systems Biology Approach to Blood (Advances in Experimental Medicine and Biology #844)

by Marek Kimmel Seth Joel Corey Joshua N. Leonard

The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.

Advanced Fluorescence Microscopy: Methods and Protocols (Methods in Molecular Biology #1251)

by Peter J. Verveer

This volume provides an overview of advanced fluorescence microscopy, covering a broad range of methods. Each chapter focuses on a different method and provides a practical guide for application in biological systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Advanced Fluorescence Microscopy: Methods and Protocols seeks to provide scientists with methods for biological systems that are of interest.

Cased-Hole Log Analysis and Reservoir Performance Monitoring

by Richard M. Bateman

This book addresses vital issues, such as the evaluation of shale gas reservoirs and their production. Topics include the cased-hole logging environment, reservoir fluid properties; flow regimes; temperature, noise, cement bond, and pulsed neutron logging; and casing inspection. Production logging charts and tables are included in the appendices. The work serves as a comprehensive reference for production engineers with upstream E&P companies, well logging service company employees, university students, and petroleum industry training professionals.

Complex Fluids in Biological Systems: Experiment, Theory, and Computation (Biological and Medical Physics, Biomedical Engineering)

by Saverio E. Spagnolie

This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world's foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solutions in the numerical simulation of biologically relevant complex fluid flows This volume will be accessible to advanced undergraduate and beginning graduate students in engineering, mathematics, biology, and the physical sciences, but will appeal to anyone interested in the intricate and beautiful nature of complex fluids in the context of living systems.

A Case-Based Guide to Clinical Endocrinology (Contemporary Endocrinology Ser.)

by Terry F. Davies

In A Case-Based Guide to Clinical Endocrinology, Second Edition, a renowned group of distinguished clinicians once again provides stimulating instruction and insights into a wide variety of endocrine topics, teaching readers modern management of the conditions described and offering targeted entry into the literature. Importantly, many of the important elements in the current curriculum for clinical endocrine training as recommended by the Association of Program Directors in Clinical Endocrinology, Diabetes and Metabolism are covered in this text. Thoroughly updated, this new edition not only covers new treatment approaches but also emphasizes the latest investigative advances in both imaging and molecular diagnostics. To reinforce learning and retention of knowledge, a question-based approach is used in many of the case studies. Students, residents, fellows, and practitioners will find this reference to be an efficient way to review their understanding and increase their skills and abilities in patient investigation and management. An invaluable contribution to the field, A Case-Based Guide to Clinical Endocrinology, Second Edition, offers the same comprehensive volume of thought-provoking case-studies that made the first edition of significant importance to all clinicians who treat patients with endocrine disorders.

Cervical Cancer: Methods and Protocols (Methods in Molecular Biology #1249)

by Daniel Keppler Athena W. Lin

Representing the most relevant procedures and technologies aiding the advance of the field of HPV-mediated carcinogenesis of the cervix and other anatomical regions of squamocolumnar transition, such as the anorectum, penis, and oropharynx, Cervical Cancer: Methods and Protocols compiles a detailed collection of practical chapters. The first half of the book covers HPV types, pathogenesis of cervical cancer (CxCA), prevention, and novel potential drug targets, while the second half explores pathology, genomics, modeling of CxCA, and experimental therapeutic strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and vital, Cervical Cancer: Methods and Protocols serves as a valuable resource to both bench scientists and clinicians who step into the realm of high-risk HPVs and CxCA for the first time or those who wish to learn novel approaches or expand their toolbox for the study of CxCA.

Chronic Abdominal Pain: An Evidence-Based, Comprehensive Guide to Clinical Management

by Leonardo Kapural

Chronic Abdominal Pain is a comprehensive resource focused on the management of chronic abdominal pain. Chapters begin with an overview of pain generation, adaptive mechanisms and various diagnostic approaches. A complete range of novel, conservative, minimally invasive and surgical therapeutic options and their proper selection are then discussed along with evidence-based and practical clinical aspects of patient care. Authored by a team of world-renowned physicians and researchers, this definitive guide provides novel algorithms for contemporary treatment of chronic abdominal pain, giving pain medicine clinicians and practitioners the knowledge needed to assess and treat patients with abdominal pain.

Data Mining in Clinical Medicine (Methods in Molecular Biology #1246)

by Carlos Fernández-Llatas Juan Miguel García-Gómez

This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologiesAuthoritative and practical, Data Mining in Clinical Medicine seeks to aid scientists with new approaches and trends in the field.

Chronic Kidney Disease and Hypertension (Clinical Hypertension and Vascular Diseases)

by Edgar V. Lerma Matthew R. Weir

The treatment of hypertension has become the most important intervention in the management of all forms of chronic kidney disease. Chronic Kidney Disease and Hypertension is a current, concise, and practical guide to the identification, treatment and management of hypertension in patients with chronic kidney disease. In depth chapters discuss many relevant clinical questions and the future of treatment through medications and or novel new devices. Written by expert authors, Chronic Kidney Disease and Hypertension provides an up-to-date perspective on management and treatment and how it may re-shape practice approaches tomorrow.

Cognitive and Behavioral Interventions in the Schools: Integrating Theory and Research into Practice

by Rosemary Flanagan Korrie Allen Eva Levine

This book offers a new framework for providing psychological services in schools at the individual, group, and systemic levels. It examines a variety of disorders common to school children, including anxiety, depression, ADHD, and conduct disorder, and outlines treatment options from evidence-based cognitive and cognitive-behavioral methods. The accessible real-world guidelines enable readers to design, implement, and evaluate interventions relevant to diverse student needs. Ethical, competency, and training concerns facing school practitioners in the new therapeutic environment are reviewed as well. Featured areas of coverage include: Behavioral assessment in school settings. PTSD and secondary trauma in children and adolescents. Transdiagnostic behavioral therapy for anxiety and depression in school. CBT for children with autism spectrum and other developmental disorders. Implementation, technological, and professional issues. The Practitioner's Toolkit: evidence-based cognitive and behavioral interventions. Cognitive and Behavioral Interventions in the Schools is an essential resource for professionals and scientist-practitioners in child and school psychology, social work, behavioral therapy, psychotherapy and counseling, and educational psychology.

Analysis and Modeling of Coordinated Multi-neuronal Activity (Springer Series in Computational Neuroscience #12)

by Masami Tatsuno

Since information in the brain is processed by the exchange of spikes among neurons, a study of such group dynamics is extremely important in understanding hippocampus dependent memory. These spike patterns and local field potentials (LFPs) have been analyzed by various statistical methods. These studies have led to important findings of memory information processing. For example, memory-trace replay, a reactivation of behaviorally induced neural patterns during subsequent sleep, has been suggested to play an important role in memory consolidation. It has also been suggested that a ripple/sharp wave event (one of the characteristics of LFPs in the hippocampus) and spiking activity in the cortex have a specific relationship that may facilitate the consolidation of hippocampal dependent memory from the hippocampus to the cortex. The book will provide a state-of-the-art finding of memory information processing through the analysis of multi-neuronal data. The first half of the book is devoted to this analysis aspect. Understanding memory information representation and its consolidation, however, cannot be achieved only by analyzing the data. It is extremely important to construct a computational model to seek an underlying mathematical principle. In other words, an entire picture of hippocampus dependent memory system would be elucidated through close collaboration among experiments, data analysis, and computational modeling. Not only does computational modeling benefit the data analysis of multi-electrode recordings, but it also provides useful insight for future experiments and analyses. The second half of the book will be devoted to the computational modeling of hippocampus-dependent memory.

An Introductory Course in Functional Analysis (Universitext)

by Adam Bowers Nigel J. Kalton

Based on a graduate course by the celebrated analyst Nigel Kalton, this well-balanced introduction to functional analysis makes clear not only how, but why, the field developed. All major topics belonging to a first course in functional analysis are covered. However, unlike traditional introductions to the subject, Banach spaces are emphasized over Hilbert spaces, and many details are presented in a novel manner, such as the proof of the Hahn-Banach theorem based on an inf-convolution technique, the proof of Schauder's theorem, and the proof of the Milman-Pettis theorem. With the inclusion of many illustrative examples and exercises, An Introductory Course in Functional Analysis equips the reader to apply the theory and to master its subtleties. It is therefore well-suited as a textbook for a one- or two-semester introductory course in functional analysis or as a companion for independent study.

Branched Chain Amino Acids in Clinical Nutrition: Volume 2 (Nutrition and Health)

by Victor R. Preedy Vinood B. Patel Rajkumar Rajendram

This is the first volume in a 2-volume compendium that is the go-to source for both research- and practice-oriented information on the importance of branched chain amino acids in maintaining the nutritional status and overall health of individuals, especially those with certain disease conditions. Over 150 well recognized and respected contributors have come together to compile these up-to-date and well-referenced works. The volumes will serve the reader as the benchmarks in this complex area of interrelationships between dietary protein intakes and individual amino acid supplementation, the unique role of the branched chain amino acids in the synthesis of brain neurotransmitters, collagen formation, insulin and glucose modulation and the functioning of all organ systems that are involved in the maintenance of the body's metabolic integrity. Moreover, the physiological, genetic and pathological interactions between plasma levels of branched chain amino acids and aromatic amino acids are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Branched Chain Amino Acids in Clinical Nutrition: Volume 1 covers basic processes at the cellular level, inherited defects in branched chain amino acid metabolism, and experimental models of growth and disease states.

Cloud Computing for Data-Intensive Applications

by Xiaolin Li Judy Qiu

This book presents a range of cloud computing platforms for data-intensive scientific applications. It covers systems that deliver infrastructure as a service, including: HPC as a service; virtual networks as a service; scalable and reliable storage; algorithms that manage vast cloud resources and applications runtime; and programming models that enable pragmatic programming and implementation toolkits for eScience applications. Many scientific applications in clouds are also introduced, such as bioinformatics, biology, weather forecasting and social networks. Most chapters include case studies. Cloud Computing for Data-Intensive Applications targets advanced-level students and researchers studying computer science and electrical engineering. Professionals working in cloud computing, networks, databases and more will also find this book useful as a reference.

Context in Computing: A Cross-Disciplinary Approach for Modeling the Real World

by Patrick Brézillon Avelino J. Gonzalez

This volume explores how context has been and can be used in computing to model human behaviors, actions and communications as well as to manage data and knowledge. It addresses context management and exploitation of context for sharing experience across domains. The book serves as a user-centric guide for readers wishing to develop context-based applications, as well as an intellectual reference on the concept of context. It provides a broad yet deep treatment of context in computing and related areas that depend heavily on computing. The coverage is broad because of its cross-disciplinary nature but treats topics at a sufficient depth to permit a reader to implement context in his/her computational endeavors. The volume addresses how context can be integrated in software and systems and how it can be used in a computing environment. Furthermore, the use of context to represent the human dimension, individually as well as collectively is explained. Contributions also include descriptions of how context has been represented in formal as well as non-formal, structured approaches. The last section describes several human behavior representation paradigms based on the concept of context as its central representational element. The depth and breadth of this content is certain to provide useful as well as intellectually enriching information to readers of diverse backgrounds who have an interest in or are intrigued by using context to assist in their representation of the real world.

Cross-Sectional Imaging of the Abdomen and Pelvis: A Practical Algorithmic Approach

by Khaled M. Elsayes

This book offers concise descriptions of cross-sectional imaging studies of the abdomen and pelvis, supplemented with over 1100 high-quality images and discussion of state-of-the-art techniques. It is based on the most common clinical cases encountered in daily practice and uses an algorithmic approach to help radiologists arrive first at a working differential diagnosis and then reach an accurate diagnosis based on imaging features, which incorporate clinical, laboratory, and other underlying contexts. The book is organized by anatomical organ of origin and each chapter provides a brief anatomical background of the organ under review; explores various cross-sectional imaging techniques and common pathologies; and presents practical algorithms based on frequently encountered imaging features. Special emphasis is placed on the role of computed tomography (CT) and magnetic resonance imaging (MRI). In addition to algorithmic coverage of many pathological entities in various abdominopelvic organs, unique topics are also examined, such as imaging of organ transplant (including kidney, liver and pancreas), evaluation of perianal fistula, and assessment of rectal carcinoma and prostate carcinoma by MRI. Cross-Sectional Imaging of the Abdomen and Pelvis: A Practical Algorithmic Approach is a unique and practical resource for radiologists, fellows, and residents.

Computational Methods in Synthetic Biology (Methods in Molecular Biology #1244)

by Mario Andrea Marchisio

This volume provides complete coverage of the computational approaches currently used in Synthetic Biology. Chapters focus on computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and practical, Computational Methods in Synthetic Biology serves as a guide to plan in silico the in vivo or in vitro construction of a variety of synthetic bio-circuits.

Clinical Proteomics: Methods and Protocols (Methods in Molecular Biology #1243)

by Antonia Vlahou Manousos Makridakis

This second edition expands upon the previous edition with current, detailed developments in the field and brings together a multi-disciplinary team of leading researchers to provide their latest protocols for clinical proteomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and Practical, Clinical Proteomics: Methods and Protocols, Second Edition presents approaches that will serve as a reliable guide to researchers, including clinicians, chemists, molecular biologists, bioinformaticians and computational, biologists, and investigators working on biomarker development.

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Showing 26 through 50 of 13,581 results