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This timely volume presents a range of critical topics on the use of composite materials in civil engineering; industrial, commercial, and residential structures; and historic buildings. Structural strengthening techniques based on composite materials, including, but not limited to, fiber-reinforced polymers, fiber-reinforced glasses, steel-reinforced polymers, and steel-reinforced glasses represent a practice employed internationally and have become an important component in the restoration of buildings impacted by natural hazards and other destructive forces. New Composite Materials: Selection, Design, and Application stands as a highly relevant and diverse effort, distinct from other technical publications dealing with building issues. The book focuses extensively on characterization of techniques employed for structural restoration and examines in detail an assortment of materials such as concrete, wood, masonry, and steel.
This book is a unique collection of challenging geometry problems and detailed solutions that will build students' confidence in mathematics. By proposing several methods to approach each problem and emphasizing geometry's connections with different fields of mathematics, Methods of Solving Complex Geometry Problems serves as a bridge to more advanced problem solving. Written by an accomplished female mathematician who struggled with geometry as a child, it does not intimidate, but instead fosters the reader's ability to solve math problems through the direct application of theorems. Containing over 160 complex problems with hints and detailed solutions, Methods of Solving Complex Geometry Problems can be used as a self-study guide for mathematics competitions and for improving problem-solving skills in courses on plane geometry or the history of mathematics. It contains important and sometimes overlooked topics on triangles, quadrilaterals, and circles such as the Menelaus-Ceva theorem, Simson's line, Heron's formula, and the theorems of the three altitudes and medians. It can also be used by professors as a resource to stimulate the abstract thinking required to transcend the tedious and routine, bringing forth the original thought of which their students are capable. Methods of Solving Complex Geometry Problems will interest high school and college students needing to prepare for exams and competitions, as well as anyone who enjoys an intellectual challenge and has a special love of geometry. It will also appeal to instructors of geometry, history of mathematics, and math education courses.
The papers in this book cover issues related to the development of novel statistical models for the analysis of data. They offer solutions for relevant problems in statistical data analysis and contain the explicit derivation of the proposed models as well as their implementation. The book assembles the selected and refereed proceedings of the biannual conference of the Italian Classification and Data Analysis Group (CLADAG), a section of the Italian Statistical Society.
In medical practice there are often complex cases that make extraordinary demands on a clinician's knowledge and ingenuity. In Challenging Cases in Allergy and Immunology, the authors provide these types of fascinating, and informative cases to complement a basic knowledge of diagnosis and management in these fields. As such, this novel title will be of interest to a wide array of allergists and clinical immunologists, as well as all students of medicine and allied health. Written by a multidisciplinary group of national and international experts, the book covers in detail two or more challenging, real-life cases in each disorder discussed. Each case is followed by a work-up, treatment plan, and discussion that includes a differential diagnosis, up-to-date references, and up to ten thought-provoking, multiple-choice questions that enhance the book's value as a comprehensive reference and teaching text. The cases include not only the common allergic diseases such as allergic rhinitis, asthma, and food allergy, but also disorders in immune regulation, autoimmunity, and immunodeficiencies. There are chapters on subjects as wide-ranging as anaphylaxis, occupational asthma, and immune-mediated rheumatic diseases. State-of-the-art and evidence-based, Challenging Cases in Allergy and Immunology is an important resource for all clinicians searching for ways to improve their ability to diagnose and manage patients with allergic and immunologic problems.
Expert practitioners combine the traditional basic techniques of membrane isolation and analysis with modern advances in molecular biology, immunology, and clinical sciences to devise analytical techniques that are successful for expert and novice alike. The techniques are used in the isolation and compositional analysis of membranes and address animal, plant, and microbial cells. The topics covered in this first volume include the isolation of subcellular fractions, centrifugation, the extraction and quantitation of lipids, the separation and analysis of proteins, and the isolation and characterization of glycosylated molecules, glycoproteins, proteoglycans, and glycolipids.
This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.
Reflecting a vast amount of new information concerning the functional characteristics of the various 5-HT receptor subtypes and the Na+-dependent serotonin transporter (SERT), this volume provides state of the art methodologies currently applied in serotonin research from leading experts in the field. Serotonin Receptor Technologies describes approaches that vary from molecular biological and biochemical techniques (e. g. , regarding receptor dimerization), fluorescence microscopy and imaging applications, flow cytometry, the use of organotypic slice and cell cultures to the generation of genetically modified animal models and the development of sophisticated behavioral tests, thus covering a wide spectrum of techniques to study serotonergic signaling in detail. Written for the popular Neuromethods series, chapters include the kind of detail and practical advice that ensures successful results in the lab. Authoritative and convenient, Serotonin Receptor Technologies serves to foster both basic and translational research aiming to further deepen our understanding of the various facets of aminergic systems, as well as to aid research on similar problems with related GPCRs and neurotransmitter transporters.
Nuclear Reprogramming: Methods and Protocols, Second Edition includes not only classic methods to perform nuclear transfer in different species but also several techniques to assess the early and late development of the reconstructed embryos, at the cellular, molecular, and epigenetic level. Over the past several years, many technical improvements have been made to improve somatic cell nuclear transfer (SCNT) efficiency, all of which are reflected in the detailed chapters of this fully revised collection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nuclear Reprogramming: Methods and Protocols, Second Edition will be of interest not only to cloners but also to researchers concerned with studying the development of embryos.
The Handbook of Simulation Optimization presents an overview of the state of the art of simulation optimization, providing a survey of the most well-established approaches for optimizing stochastic simulation models and a sampling of recent research advances in theory and methodology. Leading contributors cover such topics as discrete optimization via simulation, ranking and selection, efficient simulation budget allocation, random search methods, response surface methodology, stochastic gradient estimation, stochastic approximation, sample average approximation, stochastic constraints, variance reduction techniques, model-based stochastic search methods and Markov decision processes. This single volume should serve as a reference for those already in the field and as a means for those new to the field for understanding and applying the main approaches. The intended audience includes researchers, practitioners and graduate students in the business/engineering fields of operations research, management science, operations management and stochastic control, as well as in economics/finance and computer science.
This book provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. It discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer. Chapters explain the basic cancer biology and how cancer develops, including the many potential survival routes. The examination of gene-expression patterns uncovers commonalities across multiple cancers and specific characteristics of individual cancer types. The authors also treat cancer as an evolving complex system, explore future case studies, and summarize the essential online data sources. Cancer Bioinformatics is designed for practitioners and researchers working in cancer research and bioinformatics. It is also suitable as a secondary textbook for advanced-level students studying computer science, biostatistics or biomedicine.
Taking into account the major recent studies, this volume presents an updated analysis of the life of the black slave--his African heritage, culture, family, acculturation, behavior, religion, and personality.
Everyone's an Author focuses on writing as it really is today-with words, images, and sounds, in print and online-and encourages students to see the connections between their everyday writing and academic writing. It covers the genres college students need to learn to write-and teaches them to do so across media. It bridges the gap between Facebook and academic writing, showing how the strategies students use instinctively in social media can inform their academic writing. And it provides a strong rhetorical framework that guides students in the decisions they need to make as authors today.
This 2007 book considers how agencies are currently figured at the human-machine interface, and how they might be imaginatively and materially reconfigured. Contrary to the apparent enlivening of objects promised by the sciences of the artificial, the author proposes that the rhetorics and practices of those sciences work to obscure the performative nature of both persons and things. The question then shifts from debates over the status of human-like machines, to that of how humans and machines are enacted as similar or different in practice, and with what theoretical, practical and political consequences. Drawing on scholarship across the social sciences, humanities and computing, the author argues for research aimed at tracing the differences within specific sociomaterial arrangements without resorting to essentialist divides. This requires expanding our unit of analysis, while recognizing the inevitable cuts or boundaries through which technological systems are constituted.
Wootton's translation brings out the liveliness of More's work and offers an accurate and reliable version of a masterpiece of social theory. His edition is further distinguished by the inclusion of a translation of Erasmus's 'The Sileni of Alcibiades,' a work very close in sentiment to Utopia, and one immensely influential in the sixteenth century. This attractive combination suits the edition especially well for use in Renaissance and Reformation courses as well as as for Western Civilization survey courses. Woottons Introduction simultaneously provides a remarkably useful guide to anyones first reading of Mores mysterious work and advances an original argument on the origins and purposes of Utopia which no one interested in sixteenth-century social theory will want to miss.
Through the lives of a variety of Texans who put a human face on the state's history, this work presents the history of the 'Lone Star State'.
Over the past twenty years, transgender studies has emerged as a vibrant field of interdisciplinary scholarship. In 2006, Routledge's The Transgender Studies Reader brought together the first definitive collection of the field. Since its publication, the field has seen an explosion of new work that has expanded the boundaries of inquiry in many directions. The Transgender Studies Reader 2 gathers these disparate strands of scholarship, and collects them into a format that makes sense for teaching and research. Complementing the first volume, rather than competing with it, The Transgender Studies Reader 2 consists of fifty articles, with a general introduction by the editors, explanatory head notes for each essay, and bibliographical suggestions for further research. Unlike the first volume, which was historically based, tracing the lineage of the field, this volume focuses on recent work and emerging trends. To keep pace with this rapidly changing area, the second reader has a companion website, with images, links to blogs, video, and other material to help supplement the book. For more information, visit the companion website at www. routledge. com/cw/stryker
One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences and medicine. The Computational Biomechanics for Medicine series provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This 5th edition comprises nine of the latest developments in both fundamental science and patient-specific applications, from researchers in Australia, New Zealand, USA, UK, France, Ireland and China. Some of the interesting topics discussed are: cellular mechanics; tumor growth and modeling; medical image analysis and both patient-specific fluid dynamics and solid mechanics simulations.
Whether caused by illness, accident, or incident, brain injury requires multi-tiered resources for the patient and considerable external care and support. When recovery is sidelined by depression, anger, grief, or turmoil, family members and the support network have critical roles to play and need their own guidance and compassionate therapeutic interventions. Psychotherapy for Families after Brain Injury offers theoretical frameworks and eclectic techniques for working effectively with adult patients and their families at the initial, active and post-treatment phases of rehabilitation. This practical reference clarifies roles and relationships of the support network in interfacing with the loved one and addresses the understandably devastating and sometimes derailing emotions and psychosocial adversities. The content promotes psychoeducation and guided exercises, delineates "helpful hints" and coping tools and proffers multimedia resources to overcome hurdles Constructs of awareness, acceptance and realism for all parties are woven throughout, along with ideas to enhance the support network's commitment, adjustment, positivity, hope and longevity. Case excerpts, instructive quotes from caregivers and nuggets of clinical advice assist in analyzing these and other topics in salient detail: The impact of brain injury on different family members. Treatment themes in early family sessions. Family therapy for moderate to severe brain injury, concussion and postconcussion syndrome. Family therapy after organic brain injury: stroke, anoxia, tumor, seizure disorders. Family group treatment during active rehabilitation. End-of-life and existential considerations and positive aspects of care giving. Aftercare group therapy for long-term needs. The hands-on approach demonstrated in Psychotherapy for Families after Brain Injury will enhance the demanding work of a range of professionals, including neuropsychologists, clinical psychologists, rehabilitation psychologists, family therapists, marriage and family counselors, psychiatrists, behavioral/mental health counselors, clinical social workers, rehabilitation specialists such as speech-language pathologists, physical and occupational therapists, and graduate students in the helping professions.
Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U. S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.
Emacs, the world's most powerful text editor-based work environment, is easy to use, but far from easy to learn. As such, integrating Emacs into your personal world of thinking and creating is a long-term process. Harley Hahn, one of the most respected technical authors in the world, makes learning fun and stimulating. In this book, Hahn demystifies Emacs for programmers, students, and everyday users. The first part of the book carefully creates a context for your work with Emacs. What exactly is Emacs? How does it relate to your personal need to work quickly and to solve problems? Hahn then explains the technical details you need to understand to work with your operating system, the various interfaces, and your file system. In the second part of the book, Hahn provides an authoritative guide to the fundamentals of thinking and creating within the Emacs environment. You start by learning how to install and use Emacs with Linux, BSD-based Unix, Mac OS X, or Microsoft Windows. Written with Hahn's clear, comfortable, and engaging style, Harley Hahn's Emacs Field Guide will surprise you: an engaging book to enjoy now, a comprehensive reference to treasure for years to come. What you'll learn Special Emacs keys Emacs commands Buffers and windows Cursor, point, and region Kill/delete, move/copy, correcting, spell checking, and filling Searching, including regular expressions Emacs major modes and minor modes Customizing using your . emacs file Built-in tools, including Dired Games and Diversions Who this book is for Harley Hahn's Emacs Field Guide' is for programmers, students, and everyday users, who want an engaging and authoritative introduction to the complex and powerful Emacs working environment.
Learn what it takes to build large scale, mission critical applications -hardened applications- on the Azure cloud platform. This 208 page book covers the techniques and engineering principles that every architect and developer needs to know to harden their Azure/. NET applications to ensure maximum reliability and high availability when deployed at scale. While the techniques are implemented in . NET and optimized for Azure, the principles here will also be valuable for users of other cloud-based development platforms. Applications come in a variety of forms, from simple apps that can be built and deployed in hours to mega-scale apps that need significantly higher engineering rigor and robust organizations to deliver them. How do you build such massively scalable applications to keep pace with traffic demands while always being 'online' with five 9's availability? The authors take you step by step through the process of evaluating and building applications with the appropriate hardness attributes. For example, it is easy to say that an application should be available "all the time", but it is very important to understand what each level of 9 for availability means and the resulting implications on engineering and resources. The book explains the details required for developers and IT Pros to get it right in Azure. What you'll learn Why it is important to harden Azure/. NET applications and ensure they are always available. Characteristics of advanced applications Design for failure - how to avoid common mistakes and prevent failure Design for scale - prepared to scale up and scale down the application to fully leverage the best of Cloud infrastructure Techniques to secure the applications without restricting the business goals of the company How to train teams and people to run such hardened services Who this book is for Developers creating high reliability Azure applications in . NET plus most other popular environments like Java, PHP, node. JS, Python, Apache, etc. Architects and CIOs. Table of Contents 1. Overview of Azure 2. Cloud applications and their spectrum 3. Hardened cloud applications 4. Service fundamentals - Instrumentation, Telemetry and Monitoring 5. Key Application experiences - Latency, Scalability and Throughput 6. Failures and their inevitability 7. Failure detection and recovery oriented computing 8. High Availability, Scalability and Disaster Recovery 9. Availability and economics of 9s 10. Security 11. Modernization of software organizations
Python Algorithms, Second Edition explains the Python approach to algorithm analysis and design. Written by Magnus Lie Hetland, author of Beginning Python, this book is sharply focused on classical algorithms, but it also gives a solid understanding of fundamental algorithmic problem-solving techniques. The book deals with some of the most important and challenging areas of programming and computer science in a highly readable manner. It covers both algorithmic theory and programming practice, demonstrating how theory is reflected in real Python programs. Well-known algorithms and data structures that are built into the Python language are explained, and the user is shown how to implement and evaluate others.
This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The contributors are world-renown leaders in the field. They describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging. They discuss HLA typing, PCR-SSP typing, and HLA antigens. This volume is an invaluable source for biochemists, molecular biologists, and clinicians.
This unique book provides a bridge between digital control theory and vehicle guidance and control practice. It presents practical techniques of digital redesign and direct discrete-time design suitable for a real-time implementation of controllers and guidance laws at multiple rates and with and computational techniques. The theory of digital control is given as theorems, lemmas, and propositions. The design of the digital guidance and control systems is illustrated by means of step-by-step procedures, algorithms, and case studies. The systems proposed are applied to realistic models of unmanned systems and missiles, and digital implementation.
Topics in Matroid Theory provides a brief introduction to matroid theory with an emphasis on algorithmic consequences. Matroid theory is at the heart of combinatorial optimization and has attracted various pioneers such as Edmonds, Tutte, Cunningham and Lawler among others. Matroid theory encompasses matrices, graphs and other combinatorial entities under a common, solid algebraic framework, thereby providing the analytical tools to solve related difficult algorithmic problems. The monograph contains a rigorous axiomatic definition of matroids along with other necessary concepts such as duality, minors, connectivity and representability as demonstrated in matrices, graphs and transversals. The author also presents a deep decomposition result in matroid theory that provides a structural characterization of graphic matroids, and show how this can be extended to signed-graphic matroids, as well as the immediate algorithmic consequences.
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