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Somatic genome manipulation is required when a sexual crossing approach cannot be used in breeding or genetic treatment of an individual organism. Examples can include gene- or cell-therapy of a person to correct disease, genetic improvement of vegetatively propagated plants, and genetic replacement of cytoplasm without significantly modifying the nuclear genome. The advantage of somatic genome manipulation is maintenance of the general genotype while correcting one or more traits. Somatic genome manipulation is also an option for genetic improvement of sexually propagated plants in polyploidy breeding or in overcoming issues of sexual incompatibility. Recent novel technologies in somatic genome manipulation are developing quickly but much of this literature is fragmented and difficult or inconvenient to access. This book represents the first attempt to assemble updated reviews, detailed protocols, and their applications in all fields in which somatic genome manipulation has thrived. This is a truely one-of-a-kind work that brings together the most important and relevant advances in somatic genome manipulation in plants, algae, microorganisms, humans and animals, and demonstrates where the science interacts and where it diverges. The chapters are written by experts on the topic with ready-to-use protocols that were originally developed or adapted from the literature in their laboratories. We expect that this book will be useful for students, researchers, and teachers in both plant and animal research as a resource for the latest information on somatic genome manipulation and for its useful laboratory methods.
#Holy Trinity - A Tweet-a-logue is a tweet format discussion of the Trinity between a skeptic and a Trinitarian. Christians shy away from the doctrine because of its seeming complexity. Yet it is the most fundamental truth of their faith and of reality. It tells us what God is like, why we live, how to be happy. Rightly understood it makes sense of our everyday experience and the experience of humanity. The book asks and addresses tough questions: is the doctrine contradictory? what about science? evil and suffering? Incredibly, we see precursors of the truth in the three kinds of pre-Christian religions: the cyclic-mystical of India, the unity-in-multiplicity of China and the historical-linear of Israel. In the end, it is only because of the Trinity that we can truly say that love is the ultimate reality.
Gothika: Volume FiveSince ancient times, humankind has looked into the night sky and wondered: Are we alone? Are there other civilizations beyond the stars? Will we ever encounter these beings? Who are they, what are they like, and what might they want with us? These questions are about to be answered, but those who discover the truth might wish they had never asked. On the other hand, some might find salvation in visitors from other planets. For while some aliens are hostile, others are benevolent. Some have little in common with humans, but for others, the need for love and acceptance is universal. Lives will intersect and otherworldly passions will ignite as four acclaimed authors of gay romance explore first contact--and where it can lead.
The Disordered Mind: An Introduction to Philosophy of Mind and Mental Illness, second edition examines and explains, from a philosophical standpoint, what mental disorder is: its reality, causes, consequences, and more. It is also an outstanding introduction to philosophy of mind from the perspective of mental disorder. Revised and updated throughout, this second edition includes new discussions of grief and psychopathy, the problems of the psychophysical basis of disorder, the nature of selfhood, and clarification of the relation between rationality and mental disorder. Each chapter explores a central question or problem about mental disorder, including: what is mental disorder and can it be distinguished from neurological disorder? what roles should reference to psychological, cultural, and social factors play in the medical/scientific understanding of mental disorder? what makes mental disorders undesirable? Are they diseases? mental disorder and the mind-body problem is mental disorder a breakdown of rationality? What is a rational mind? addiction, responsibility and compulsion ethical dilemmas posed by mental disorder, including questions of dignity and self-respect. Each topic is clearly explained and placed in a clinical and philosophical context. Mental disorders discussed include clinical depression, dissociative identity disorder, anxiety, religious delusions, and paranoia. Several non-mental neurological disorders that possess psychological symptoms are also examined, including Alzheimer's disease, Down's syndrome, and Tourette's syndrome. Containing chapter summaries and suggestions for further reading at the end of each chapter, The Disordered Mind, second edition is a superb introduction to the philosophy of mental disorder for students of philosophy, psychology, psychiatry, and related mental health professions.
Erika Fischer-Lichte's introduction to the discipline of Theatre and Performance Studies is a strikingly authoritative and wide ranging guide to the study of theatre in all of its forms. Its three-part structure moves from the first steps in starting to think about performance, through to the diverse and interrelated concerns required of higher-level study: Part 1 - Central Concepts for Theatre and Performance Research - introduces the language and key ideas that are used to discuss and think about theatre: concepts of performance; the emergence of meaning; and the theatrical event as an experience shared by actors and spectators. Part 1 contextualizes these concepts by tracing the history of Theatre and Performance Studies as a discipline. Part 2 - Fields, Theories and Methods - looks at how to analyse a performance and how to conduct theatre-historiographical research. This section is concerned with the 'doing' of Theatre and Performance Studies: establishing and understanding different methodological approaches; using sources effectively; and building theoretical frameworks. Part 3 - Pushing Boundaries - expands on the lessons of Parts 1 and 2 in order to engage with theatre and performance in a global context. Part 3 introduces the concept of 'interweaving performance cultures'; explores the interrelation of theatre with the other arts; and develops a transformative aesthetics of performance. Case studies throughout the book root its theoretical discussion in theatrical practice. Focused accounts of plays, practitioners and performances map the development of Theatre and Performance Studies as an academic discipline, and of the theatre itself as an art form. This is the most comprehensive and sophisticated introduction to the field available, written by one of its foremost scholars.
This new text offers a unique developmental focus on gender. Gender development is examined from infancy through adolescence, integrating biological, socialization, and cognitive perspectives. The book's current empirical focus is complemented by a lively and readable style that includes anecdotes about children's everyday experiences. The book's accessibility is further enhanced with the use of bold face to highlight key terms when first introduced along with a complete glossary of these terms. All three of the authors are respected researchers in divergent areas of children's gender role development and each of them teaches a course on the topic. The book's primary focus is on gender role behaviors - how they develop and the roles biological and experiential factors play in their development. The first section of the text introduces the field and outlines its history. Part 2 focuses on the differences between the sexes, including the biology of sex and the latest research on behavioral sex differences, including motor and cognitive behaviors and personality and social behaviors. Contemporary theoretical perspectives on gender development - biological, social and environmental, and cognitive approaches - are explored in Part 3 along with the research supporting these models. The social agents of gender development, including children themselves, family, peers, the media, and schools are addressed in the final part. Cutting-edge and comprehensive, this is the perfect text for those who have been searching for an advanced undergraduate and/or graduate book for courses in gender development, the psychology of sex roles and/or gender and/or women or men, taught in departments of psychology, human development, and educational psychology. Although chapters have been designed to be read sequentially, a full author citation is included the first time a reference is used within an individual chapter rather than only the first time it is used in the book, making it easy to assign chapters in a variety of orders. This referencing system will also appeal to scholars interested in using the book as a resource to review a particular content area.
Based on significant new research from multiple sources, Richard Barrett creates a compelling narrative about why values-driven organizations are the most successful organizations on the planet. According to Barrett, understanding employee's needs--what people value--is the key to creating a high performing organization. When you support employees in satisfying their needs, they respond with high levels of employee engagement and willingly bring their commitment and creativity to their work. This book updates and brings together in one volume, two of Richard Barrett's previous publications, Liberating the Corporate Soul (1998) and Building a Values-Driven Organisation (2006), to provide a reference manual for leaders and change agents who wish to create a values-driven organization. The text provides both a leadership approach, and a language, for organizational transformation and culture change that incorporates concepts such as cultural entropy, values alignment and whole system change. With an updated set of cultural diagnostic tools and a wide range of new and exciting case studies on culture and leadership development, The Values-Driven Organization will be essential reading for students, researchers and practitioners in the fields of organizational change, leadership and ethics.
Fully revised and updated, the third edition of EU Law provides an exhaustive, yet easily readable, account of the complex and ever changing subject of EU law. The author gives thorough, authoritative, and up-to-the-minute treatment to the institutional, constitutional and substantive elements of EU Law. The book is unique in that it successfully combines depth of coverage with an excellent selection of supporting case law, making this challenging subject accessible and easy to follow. Case summaries and judgments are highlighted in colour-tinted boxes for ease of reference, and are accompanied by key facts and analysis, often in the light of subsequent developments. The student-friendly approach is enhanced by market-driven pedagogical features, including:* Concise outlines, at the beginning of each chapter describing its content;* An aide-mémoire, often presented in diagrammatic form, at the end of each chapter to highlight and reinforce key points;* End of chapter recommended reading lists to facilitate further research;* End of chapter problem and essay questions testing the students' ability to apply what they have learnt; and,* A map identifying EU Member States, and their accession dates; acceding States; candidate States; and, potential candidate States. The book's companion website offers a range of teaching and learning resources including an interactive timeline of the EU, useful web links, self-test questions and much more. This book is essential reading for those studying EU law on both undergraduate and postgraduate courses and will be of interest to students of political science, social science and business studies. It also provides comprehensive coverage of substantive and procedural EU competition law and thus has its place as a textbook for introductory courses on EU competition law.
A New History of Asian America is a fresh and up-to-date history of Asians in the United States from the late eighteenth century to the present. Drawing on current scholarship, Shelley Lee brings forward the many strands of Asian American history, highlighting the distinctive nature of the Asian American experience while placing the narrative in the context of the major trajectories and turning points of U.S. history. Covering the history of Filipinos, Koreans, Asian Indians, and Southeast Indians as well as Chinese and Japanese, the book gives full attention to the diversity within Asian America. A robust companion website features additional resources for students, including primary documents, a timeline, links, videos, and an image gallery. From the building of the transcontinental railroad to the celebrity of Jeremy Lin, people of Asian descent have been involved in and affected by the history of America. A New History of Asian America gives twenty-first-century students a clear, comprehensive, and contemporary introduction to this vital history.
Women, Science, and Technology is an ideal reader for courses in feminist science studies. This third edition fully updates its predecessor with a new introduction and twenty-eight new readings that explore social constructions mediated by technologies, expand the scope of feminist technoscience studies, and move beyond the nature/culture paradigm.
This book provides a comprehensive and up-to-date introduction to criminological theory for students taking courses in criminology at both undergraduate and postgraduate level. Building on previous editions, which broadened the debate on criminological theory, this book presents the latest research and theoretical developments. The text is divided into five parts, the first three of which address ideal type models of criminal behaviour: the rational actor, predestined actor and victimized actor models. Within these, the various criminological theories are located chronologically in the context of one of these different traditions, and the strengths and weaknesses of each theory and model are clearly identified. The fourth part of the book looks closely at more recent attempts to integrate theoretical elements from both within and across models of criminal behaviour, while the fifth part addresses a number of key recent concerns of criminology: postmodernism, cultural criminology, globalization and communitarianism. All major theoretical perspectives are considered, including: classical criminology, biological and psychological positivism, labelling theories, feminist criminology, critical criminology and left realism, social control theories, the risk society. The new edition also features comprehensive coverage of recent developments in criminology, including situation action theory, desistance theory, peacemaking criminology, Loïc Wacquant's thesis of the penal society, critical race theory and Southern theory. This revised and expanded fourth edition of An Introduction to Criminological Theory includes chapter summaries, critical thinking questions, a full glossary of terms and theories and a timeline of criminological theory, making it essential reading for those studying criminology.
Criminological Research for Beginners is a comprehensive and engaging guide to research methods in Criminology. Written specifically for undergraduate students and novice researchers, this book has been designed as a practical guide to planning, conducting, and reporting research in the subject. By first inviting readers to consider the importance of criminological research, the book places related methodology firmly in the context of students' broader study of Criminology, before moving on to provide a detailed guide to the practical processes of research. It is common for Criminology undergraduates to feel intimidated at the prospect of conducting their own research, and these students typically struggle to see the relevance of research methods to their own studies. This book speaks directly to the needs of such students, and includes contemporary examples and case studies that bring a topic that is often thought of as dry to life, providing a thorough and accessible practical guide that students can return to at each stage of their research, all the way through to their dissertation. This book covers: an examination of the theoretical, political, and ethical debates in criminological research; a complete guide to planning criminological research, assisting student researchers in identifying their research questions, choosing their research methods, and critiquing the available literature; guidance on the practicalities and processes of collecting data, a discussion of the process of analysing data and writing up research, Including an extensive glossary and an integrated companion website with extra examples, exercises, and videos to further develop students' understanding, this book is essential reading for any undergraduate on a Criminological Research Methods course, or for anyone in need of practical guidance on any or every of the various stages involved in conducting thorough and effective criminological research.
Fountas and Pinnell Leveled Literacy Intervention Green System -- 1st Grade
Fountas and Pinnell Leveled Literacy Intervention Green System -- 1st Grade
Fountas and Pinnell Leveled Literacy Intervention Green System -- 1st Grade
Growing up in California, Yoshi knew her family looked different from their neighbors. Still, she felt like an American. But everything changed when America went to war against Japan. Along with all the other Japanese-Americans on the West Coast, Yoshi's family were rounded up and imprisoned in a crowded. badly built camp in the desert because they "looked like the enemy." Yoshiko Uchida grew up to be an award-winning author. This memoir of her childhood gives a personal account of a shameful episode in American history.
This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors' laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer's diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.
This book covers a wide range of issues in fire safety engineering in tunnels, describes the phenomena related to tunnel fire dynamics, presents state-of-the-art research, and gives detailed solutions to these major issues. Examples for calculations are provided. The aim is to significantly improve the understanding of fire safety engineering in tunnels. Chapters on fuel and ventilation control, combustion products, gas temperatures, heat fluxes, smoke stratification, visibility, tenability, design fire curves, heat release, fire suppression and detection, CFD modeling, and scaling techniques all equip readers to create their own fire safety plans for tunnels. This book should be purchased by any engineer or public official with responsibility for tunnels. It would also be of interest to many fire protection engineers as an application of evolving technical principles of fire safety.
This volume is the most recent installment of the Progress in Motor Control series. It contains contributions based on presentations by invited speakers at the Progress in Motor Control IX meeting held in at McGill University, Montreal, in July, 2013. Progress in Motor Control is the official scientific meeting of the International Society of Motor Control (ISMC). The Progress in Motor Control IXI meeting, and consequently this volume, provide a broad perspective on the latest research on motor control in humans and other species.
This book discusses in detail the analysis and monitoring of the most important analytes in the environmental field. It also reviews the implementation, realization and application of sensor designs mentioned in the first volume of this set, dividing the coverage into global parameters, sensors of organics and sensors of inorganics.
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e. g. , Alzheimer's disease, Parkinson's disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
Engineering Multicellular Systems: Methods and Protocols, focuses on laboratory procedures used in recent efforts for constructing synthetic multicellular systems and their applications. In particular, constructing multicellular systems to form various microbial ecosystems has been extensively explored to examine evolution and interactions of microbial ecosystems, while co-cultures have emerged as an efficient tool to produce some complex chemical molecules. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Engineering Multicellular Systems: Methods and Protocols provide a comprehensive laboratory protocol reference for constructing multicellular systems for various applications.
This handbook focuses on Data Envelopment Analysis (DEA) applications in operations analytics which are fundamental tools and techniques for improving operation functions and attaining long-term competitiveness. In fact, the handbook demonstrates that DEA can be viewed as Data Envelopment Analytics. Chapters include a review of cross-efficiency evaluation; a case study on measuring the environmental performance of OECS countries; how to select a set of performance metrics in DEA with an application to American banks; a relational network model to take the operations of individual periods into account in measuring efficiencies; how the efficient frontier methods DEA and stochastic frontier analysis (SFA) can be used synergistically; and how to integrate DEA and multidimensional scaling. In other chapters, authors construct a dynamic three-stage network DEA model; a bootstrapping based methodology to evaluate returns to scale and convexity assumptions in DEA; hybridizing DEA and cooperative games; using DEA to represent the production technology and directional distance functions to measure band performance; an input-specific Luenberger energy and environmental productivity indicator; and the issue of reference set by differentiating between the uniquely found reference set and the unary and maximal types of the reference set. Finally, additional chapters evaluate and compare the technological advancement observed in different hybrid electric vehicles (HEV) market segments over the past 15 years; radial measurement of efficiency for the production process possessing multi-components under different production technologies; issues around the use of accounting information in DEA; how to use DEA environmental assessment to establish corporate sustainability; a summary of research efforts on DEA environmental assessment applied to energy in the last 30 years; and an overview of DEA and how it can be utilized alone and with other techniques to investigate corporate environmental sustainability questions.
Learn how to form and execute an enterprise information strategy: topics include data governance strategy, data architecture strategy, information security strategy, big data strategy, and strategy to move data warehouses to the cloud. Manage information like a pro, to achieve much better financial results for the enterprise, more efficient processes, and multiple advantages over competitors. As you''ll discover in Enterprise Information Management in Practice, EIM deals with both structured data (e. g. sales data and customer data) as well as unstructured data (like customer satisfaction forms, emails, documents, social network sentiments, and so forth). With the deluge of information that enterprises face given their global operations and complex business models, as well as the advent of big data technology, it is not surprising that making sense of the large piles of data is of paramount importance. Enterprises must therefore put much greater emphasis on managing and monetizing both structured and unstructured data. As Saumya Chaki--an information management expert and consultant with IBM--explains in Enterprise Information Management in Practice, it is now more important than ever before to have an enterprise information strategy that covers the entire life cycle of information and its consumption while providing security controls. With Fortune 100 consultant Saumya Chaki as your guide, Enterprise Information Management in Practice covers each of these and the other pillars of EIM in depth, which provide readers with a comprehensive view of the building blocks for EIM. Enterprises today deal with complex business environments where information demands take place in real time, are complex, and often serve as the differentiator among competitors. The effective management of information is thus crucial in managing enterprises. Enterprise Information Management (EIM) has evolved as a specialized discipline in the business intelligence and enterprise data warehousing space to address the complex needs of information processing and delivery--and to ensure the enterprise is making the most of its information assets. What you''ll learn The structure of your enterprise information management (EIM) program What kinds of data management strategies you need in place as part of the EIM program The key benefits of an EIM program The solution components in an EIM program The incremental roadmap to building an EIM organization and leverage the benefits Who this book is for All practitioners of information management including business information analysts, data scientists, IT professionals, IT managers, database administrators, senior information executives, and many others. While there are numerous books on data management and big data, there are very few books that tie up all the concepts in a holistic manner. Table of Contents Chapter 1: Enterprise Information Management : Definition, Scope, and History Chapter 2: Lifecycle of Enterprise Information Management Chapter 3: Components of Enterprise Information Management Chapter 4: Pillar #1: Information Sourcing Chapter 5: Pillar #2: Information Integration and Exchange Chapter 6: Pillar #3: Information Governance and Quality Chapter 7: Pillar #4: Master Information Management Chapter 8: Pillar #5: Information Warehousing Chapter 9: Pillar #6: Information Delivery and Consumption Chapter 10: Pillar #8: Metadata Management Chapter 11: Pillar #9: Big Data Components Chapter 12: Building an Enterprise Information Management Solution Chapter 13: EIM in Today''s Business Environment Appendix A - Glossary Appendix B - EIM Tools in the Marketplace
This new edition is a hands-on guide for developers and administrators who want to use the power and flexibility of Couchbase Server 4. 0 in their applications. The second edition extends coverage of N1QL, the SQL-like query language for Couchbase. It also brings coverage of multiple new features, including the new generation of client SDKs, security and LDAP integration, secondary indexes, and multi-dimensional scaling. Pro Couchbase Server covers everything you need to develop Couchbase solutions and deploy them in production. The NoSQL movement has fundamentally changed the database world in recent years. Influenced by the growing needs of web-scale applications, NoSQL databases such as Couchbase Server provide new approaches to scalability, reliability, and performance. Never have document databases been so powerful and performant. With the power and flexibility of Couchbase Server, you can model your data however you want, and easily change the data model any time you want. Pro Couchbase Server shows what is possible and helps you take full advantage of Couchbase Server and all the performance and scalability that it offers. Helps you design and develop a document database using Couchbase Server. Covers the latest features such as the N1QL query language. Gives you the tools to scale out your application as needed. What you'll learn Install and configure Couchbase Server Design a good data model for your application. Build mobile applications on the Xamarin platform. Deploy advanced query techniques in your application. Make use of the new and powerful N1 Query Language. Integrate Elastic Search for full-text access to your data. Manage Couchbase Server in a production environment. Scale your application as needed. Who this book is for Pro Couchbase Server is a comprehensive guide for developers looking to build scalable, high-performance application solutions. Written from hands-on experience, the book also provides detailed information for administrators on deploying, maintaining, and scaling out of Couchbase Server. Whether you want to build an application from scratch or migrate an existing application to a document database, Pro Couchbase Server has your back with solid guidance written from experienced practitioners who have experienced repeated success in deploying Couchbase Server in production environments. Table of Contents Introduction Part I: Getting Started Chapter 1: Getting Started with Couchbase Server Chapter 2: Designing Document-Oriented Databases with Couchbase Part II: Development Chapter 3: The Couchbase Client Libraries Chapter 4: CRUD and Key-Based Operations Chapter 5: Working with Views Chapter 6: The N1QL Query Language Chapter 7: Advanced Couchbase Techniques Chapter 8: ElasticSearch Integration Part III: Under the Hood Chapter 9: Security Chapter 10: Secondary Indexes Part IV: Couchbase at Scale Chapter 11: Sizing and Deployment Considerations Chapter 12: Basic Administration Chapter 13: Monitoring and Best Practices Chapter 14: Couchbase Server in the Cloud Chapter 15: Cross-Datacenter Replication Part V: Mobile Development with Couchbase Chapter 16: Couchbase Lite on Android
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