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The study of rare lung disorders enhances our understanding of common pulmonary diseases such as fibrosis and emphysema. Molecular Basis of Lung Disease: Insights from Rare Disorders brings together a panel of distinguished clinicians and molecular scientists who are experts in a range of rare lung diseases and their underlying molecular defects. Each chapter focuses on the pathogenic mechanisms and therapeutic targets suggested by basic research and follows an easy to read format: brief introduction followed by discussion of epidemiology, genetic basis and molecular pathogenesis, animal models, clinical presentation, diagnostic approaches, conventional management and treatment strategies, as well as future therapeutic targets and directions. Disorders ranging from the Marfan and Goodpasture's syndromes to Sarcoidosis and alpha one antitrypsin deficiency are treated in detail. Written for pulmonary clinicians and scientists alike, Molecular Basis of Lung Disease: Insights from Rare Disorders is a comprehensive and invaluable resource that sheds new light on the molecular mechanisms influencing the clinical presentation and treatment strategies for these debilitating disorders.
The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. "Bench to Bedside": A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development and diagnosis through to the treatment and care of cancer patients - essential for providing a broader view of cancer and its impact. The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field. For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information. Key highlights are listed below: An overview of the cancer cell and important new concepts. Selected human cancers: lung, breast, colorectal, prostate, renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a) traditionally important areas such as cell cycle control, growth regulation, oncogenes and tumour suppressors apoptosis, as well as (b) more highly topical areas of apoptosis, telomeres, DNA damage and repair, cell adhesion, angiogenesis, immunity, epigenetics, and the proteasome. Clinical oncology: In-depth coverage of important concepts such as screening, risk of cancer and prevention, diagnoses, managing cancer patients from start to palliative care and end-of-life pathways.Chapters highlighting the direct links between cancer research and clinical applications. New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested. Systems Biology and cutting edge research areas covered such as RNA interference (RNAi). Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review. Quotations have been used in each chapter to introduce basic concepts in an entertaining way.Supported by a dedicated website at www.blackwellpublishing.com/pelengaris We should list the great reviews we got for first edition which are on the back of the 2nd edition:"A capturing, comprehensive, clearly written and absolutely accurate introduction into cancer biology.....This book deserves great praise for the readable presentation of this complex field....the true synthesis of bench and bedside approaches is marvelously achieved." Christian Schmidt, Molecular Cell"Chapters address the issues of cancer diagnosis, treatment, and patient care and set the book apart from general molecular biology references....This book is applicable to both graduate and undergraduate students, and in the context of a research laboratory, this book would be an excellent resource as a reference guide for scientists at all levels." V.Emuss, Institute of Cancer Research, London.Also, from the first edition:"Pelengaris, Khan, and the contributing authors are to be applauded. The Molecular Biology of Cancer is a comprehensive and readable presentation of the many faces of cancer from molecular mechanisms to clinical therapies and diagnostics. This book will be welcomed by neophyte students, established scientists in other fields, and curious physicians." -Dean Felsher, Stanford University
For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book. * And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint(r) presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies animations, videos, and molecular models all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. * There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.
The first major collection of techniques for gene therapy and stem cell therapy for heart diseases. The methods include readily reproducible techniques for genetic dissection, signal transduction, and microarray analysis. The protocols include techniques for gene transfer to heart tissue using viral and nonviral vectors and for producing transgenic models of heart diseases, the novel and powerful tools for the study of heart disease pathogenesis. Many of the protocols employ not only molecular and cell biology techniques, but also in vivo approaches to myocardial repair using different types of stem cells, and include methods for expansion, purification, and genetic modification of stem cells. The techniques are at the center of the most recent advances in the study and treatment of genetic and acquired heart diseases.
The textbook, written for students enrolled for Clinical Laboratory Science/Medical Technology programs, explains the principles of molecular technology that are used for diagnostic purposes.
An international sensation, Molecular Gastronomy debunks a variety of time-honored rules and dictums about cooking, but also presents new knowledge from which readers can improve the preparation of a variety of dishes. Hervé This, a physical chemist, discusses the physiology of flavor and explores the brain's perception of tastes, the effect of chewing on food, and the reaction of the tongue to various stimuli. Bringing the instruments and techniques of the laboratory into the kitchen, Hervé's entertaining revelations are for cooks, gourmets, and scientists alike.
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual's specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy.
The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, medical oncologists, radiation oncologists, surgeons, pediatricians, family practice), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundamentals of molecular pathogenesis, diagnosis and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series the basic science and the technology is integrated with the medical perspective and clinical application. Each book in the series is divided according to neoplastic and non-neoplastic diseases for each of the organ systems traditionally associated with medical subspecialties. Each book in the series is organized to provide (1) a succinct background of the essential terminology, concepts and technology of molecular biology, (2) an overview of the broad application of molecular biology principles to disease and (3) specific application of molecular pathology to the pathogenesis, diagnosis and treatment of neoplastic and non-neoplastic diseases specific to each organ system. These broad section topics will be broken down into succinct chapters, averaging about 15 to 20 pages each, to cover a very specific disease entity. The chapters will be written by established authorities on the specific topic from academic centers around the world. In one book, diverse subjects are included that the reader would have to pursue from multiple sources in order to have a clear understanding of the molecular pathogenesis, diagnosis and treatment of specific diseases. Attempting to hunt for the full information from basic concept to specific applications for a disease from the varied sources is time-consuming and frustrating. By providing this quick and user-friendly reference, understanding and application of this rapidly growing field is made more accessible to both expert and generalist alike. As books that bridge the gap between basic science and clinical understanding and practice, the Molecular Pathology Series serves the basic scientist, the clinical researcher and the practicing physician or other health care provider who require more understanding of the application of basic research to patient care, from "bench to bedside." This series is unique and an invaluable resource. These books will be indispensable to physicians and health care providers in multiple disciplines as noted above, to residents and fellows in these multiple disciplines as well as their teaching institutions and to researchers who increasingly must justify the clinical implications of their research.
A revolution is underway in archaeology. Working at the cutting edge of genetic and molecular technologies, researchers have been probing the building blocks of ancient life-DNA, proteins, fats-to rewrite our understanding of the past. Their discoveries (including a Mitochondrial Eve, the woman from whom all modern humans descend) and analyses have helped revise the human genealogical tree and answer such questions as: How different are we from the Neanderthals? Who first domesticated horses and ancient grasses? What was life like for our ancestors? Here is science at its most engaging.
Two novels, The Molecule Men and The Monster of Loch Ness, by the father and son astronomer team.
Why do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from one another or do they function together as parts of an interconnected system? In this groundbreaking audiobook, Candace Pert -- a neuroscientist whose extraordinary career began with her 1972 discovery of the opiate receptor -- provides startling and decisive answers to these and other challenging questions that scientists and philosophers have pondered for centuries. From explaining the scientific basis of popular wisdom about phenomena like "gut feelings" to making comprehensible recent discoveries in cancer and AIDS research,Molecules of Emotionis an intellectual adventure of the highest order. Yet the journey Pert takes us on is one of personal as well as scientific discovery. Woven into her lucid explanations of the science underlying her work is the remarkable story of how -- faced with personal and professional obstacles -- she has grown as a woman and a mother, and how her personal and spiritual development has led to breakthroughs in her remarkable career. Molecules of Emotionis a landmark work. Full of insight and wisdom, it is among those rare audiobooks which possess the power to change the way we see the world and ourselves.
Why do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.
Set in sixteenth century; very funny story about the adventures of a cross-dressing thief.
Moll Flanders, Defoe's 18th Century classic novel, was "marketed" in its day in much the same way that a modern commercial novel might be - its title page promised the racy details of a woman's life spent in thievery and whoredom. The book is much more than this; it is a Puritan tale of sin, repentance, conversion, and redemption. It is also seen by many critics as a satirical and ironic picaresque novel with a twist (that being its female protagonist). On yet another level, it is a playful and beguiling social commentary set between the Puritan age (which saw humankind as fallen) and the Age of Reason in which humankind was seen as born innocent and good and corrupted by society. Taking center stage in this whorl of irony, humor, pathos, and religious faith is one Moll Flanders - both the most plausible sinner and the most pious repentant in English literature; arguably the most notorious heroine in the canon of fiction in the English language. She is as controversial today as when she first appeared in 1722.
After the death of her mother, Mollie Barnes is sent to live in her aunt and uncle's house and forced to endure her aunt's simmering resentment. One day, the tension explodes, leading to a shocking revelation about Mollie's parentage. Every day, Mollie had been working by the shore, under the shadow of a large and imposing house. Now she knows that the master of the house, James Grainger, is her real father, she vows that one day she will sit at his table. But her dreams of finding acceptance are shattered as she finds herself the unwilling object of her half-brother's affections . . .
Following the flight of one woman's factory job from the United States to Mexico, this compelling work offers a provocative and fresh perspective on the global economy -- at a time when downsizing is unraveling the American Dream for many working families. Mollie's Job is an absorbing and affecting narrative history that traces the postwar migration of one factory job as it passes from the cradle of American industry, Paterson, New Jersey, to rural Mississippi during the turmoil of the civil rights movement to the burgeoning border city of Matamoros, Mexico. This fascinating account follows the intersecting lives and fates of three women -- Mollie James in Paterson, Dorothy Carter in Mississippi, and Balbina Duque in Matamoros, all of whom work the same job as it winds its way south. Mollie's Job is the story of North American labor and capital during the latter half of the twentieth century and the dawn of the twenty-first. The story of these women, their company, and their communities provides an ideal prism through which William Adler explores the larger issues at the heart of the book: the decline of unions and the middle class, the growing gap between rich and poor, public policy that rewards companies for transferring U. S. jobs abroad, the ways in which "free trade" undermines stable businesses and communities, and how the global economy exploits workers on both sides of the border. At once a social and industrial history; a moving, personal narrative; and a powerful indictment of free trade at any cost, Mollie's Job puts a human face on the political and market forces shaping the world at the dawn of the new millennium and skillfully frames the current debate raging over future trade agreements. By combining a deft historian's touch with first-rate reporting, Mollie's Job is an unprecedented and revealing look at the flesh-and-blood consequences of globalization.
Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.
When Margaret Tobin Brown arrived in New York City shortly after her perilous night in Titanic's Lifeboat Six, a legend was born. Through magazines, books, a Broadway musical, and a Hollywood movie, she became "The Unsinkable Molly Brown," but in the process her life story was distorted beyond recognition. Even her name was changed-- she was never known as Molly during her lifetime. Kristen Iversen's Molly Brown: Unraveling the Myth is the first full-length biography of this American icon, and the story it tells is of a passionate and outspoken crusader for the rights of women, children, mine workers, and others struggling for their voice in the early twentieth century. In the end, the real "Molly" Brown was far more fascinating than her myth, and Kristen Iversen has captured her in all her brilliance.
Pacific islander Molly Cooper has house-swapped her way into London's exclusive Chelsea. It's her dream to explore Britain. . . ;and meet a perfect English gentleman! Patrick Knight is finding Molly's chatty emails strangely compelling. The onetime city banker thought swapping his London pad for Molly's idyllic cottage would help him write his first novel-but it's not quite working out. . . ; What do you do when you realize the one you want is half a world away, living inyourhome, sleeping inyourbed. . . ;?
Two novels of wedded bliss are in this volume for the price of one. In Christine Rimmer's "Double Dare", loyalty demands Joanna Vail marry Casey Clinton to secure custody of his nephew. And in Laurie Paige's "Molly Darling", Sam Frazier vows chaste Molly Clellend will stay that way--he just needs her to help raise his baby.
The Pee Wees are running for office! In the imaginary town of Peeweeville, the Scouts will be mayor, police chief, and even dogcatcher. Molly thinks she would be a good mayor, but Roger thinks he should be mayor--and he offers candy to anyone who votes for him. How can Molly top that? Promising to do a good job just can't compete with free candy. Mary Beth has some ideas that are sure to get Molly noticed, but will it be the kind of attention Molly needs? May the best candidate win! The Pee Wees goof around, do good deeds, take on projects and have fun and adventures. Find out all about what scouts do in the other 38 Pee Wee Scout books you can get from Bookshare including: #1 Cookies and Crutches, #2 Camp Ghost-Away, #3 Lucky Dog Days, #4 Blue Skies, French Fries, #5 Grumpy Pumpkins, #6 Peanut-Butter Pilgrims, #7 A Pee Wee Christmas, #8 That Mushy Stuff, #9 Spring Sprouts, #10 The Pooped Troop, # 11 The Pee Wee Jubilee, #12 Bad, Bad, Bunnies, #13 Rosy Noses, Frozen Toes, #14 Sonny's Secret, #15 Sky Babies, #16 Trash Bash, # 17 Pee Wees On Parade, #18 Lights, Action, Land-ho!, # 19 Piles of Pets, #20 Fishy Wishes, #21 Pee Wees On skis, #22 Greedy Groundhogs, #23 All Dads on Deck, #24 Tricks and Treats, #25 Pee Wees on First, #26 Super Duper Pee Wees, #27 Teeny Weeny Zucchinis, #28 Eggs With Legs, #29 Pee Wee Pool Party, #30 Bookworm Buddies, #31 Moans and Groans and Dinosaur Bones, #32 Stage Frightened, #33 Halloween Helpers, #34 Planet Pee Wee, #35 Pedal Power, #36 Computer Clues # 37 Wild, Wild West, and #38 Here Come the Clowns.
Surprise--Molly's in trouble again! Molly Zander and her best friend Morty get more surprises than they bargained for on their "surprise" class trip to the town's brand-new ice rink. Everyone tries to guess the secret destination, but when they get to the rink, Molly finds out she's not the only star athlete around anymore--she has some real competition in Florence, a talented figure skater. Though Molly risks her friendship with Morty by trying to be number one, in the end she decides that some things are more important than being the best.
From the book: "When the teacher announces the Lend-a-Hand Contest to help the war effort, Molly is determined that the third grade girls will plan the winning project. Instead, they choose an idea that Molly knows will never work out. So she talks two friends into planning their own project and keeping it a secret from the rest of the girls in the class. But the secret project turns out to be harder than Molly thought it would be. She begins to worry that it might not win after all and decides to spy on the other girls to see how they are doing. When Molly and her friends get caught peeking in a window, they learn some important lessons."
To keep the peace in the coal mines, the Pinkerton agency goes to war The Civil War is over, and the Union is rebuilding using the power of coal--black rock dug from deep beneath the Pennsylvania earth by men from all over the globe who are seeking their fortune in America. In the 1870s, the miners are unionizing to fight for better working conditions, but within their ranks lurks a secret society whose aim is not so pure. It calls itself the Mollie Maguires, and its adherents are ready to kill to get what they want. Fearing a bloodbath, the head of one of the coal-mining firms reaches out to Allan Pinkerton, founder of the famous detective agency, and begs him to break up the sinister ring. Pinkerton sends James McParlan undercover among the miners, the first soldier in a three-year battle against the radicals that will change the face of American labor forever. This ebook features a new introduction by Otto Penzler and has been professionally proofread to ensure accuracy and readability on all devices.