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The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.
The secrets locked in our genes are being revealed, and we find ourselves both enthused and frightened about what that portends. We look forward to curing disease and alleviating suffering--for our children as well as for ourselves--but we also worry about delving too deeply into the double helix. Abuses perpetrated by eugenicists--from involuntary sterilization to murder--continue to taint our feelings about genetic screening. Yet, as Ruth Schwartz Cowan reveals, modern genetic screening has been practiced since 1960, benefiting millions of women and children all over the world. She persuasively argues that new forms of screening--prenatal, newborn, and carrier testing--are both morally right and politically acceptable. Medical genetics, built on the desire of parents and physicians to reduce suffering and increase personal freedom, not on the desire to "improve the human race," is in fact an entirely different enterprise from eugenics. Cowan's narrative moves from an account of the interwoven histories of genetics and eugenics in the first half of the twentieth century, to the development of new forms of genetic screening after mid-century. It includes illuminating chapters on the often misunderstood testing programs for sickle cell anemia, and on the world's only mandated premarital screening programs, both of them on the island of Cyprus. Neither minimizing the difficulty of the choices that modern genetics has created for us nor fearing them, Cowan bravely and compassionately argues that we can improve the quality of our own lives and the lives of our children by using the modern science and technology of genetic screening responsibly.
Throughout your study of science, you will learn a variety of terms, facts, figures, and concepts. Each new topic you encounter will provide its own collection of words and ideas--which, at times, you may think seem endless. But each of the ideas within a particular topic is related in some way to the others. No concept in science is isolated. Thus it will help you to understand the topic if you see the whole picture; that is, the interconnectedness of all the individual terms and ideas. This is a much more effective and satisfying way of learning than memorizing separate facts.
This book examines the wide range of scientific and social arenas in which the concept of inheritance gained relevance in the late nineteenth and early twentieth centuries. Although genetics emerged as a scientific discipline during this period, the idea of inheritance also played a role in a variety of medical, agricultural, industrial, and political contexts. The book, which follows an earlier collection, Heredity Produced (covering the period 1500 to 1870), addresses heredity in national debates over identity, kinship, and reproduction; biopolitical conceptions of heredity, degeneration, and gender; agro-industrial contexts for newly emerging genetic rationality; heredity and medical research; and the genealogical constructs and experimental systems of genetics that turned heredity into a representable and manipulable object. Taken together, the essays in Heredity Explored show that a history of heredity includes much more than the history of genetics, and that knowledge of heredity was always more than the knowledge formulated as Mendelism. It was the broader public discourse of heredity in all its contexts that made modern genetics possible.ContributorsCaroline Arni, Christophe Bonneuil, Christina Brandt, Luis Campos, Jean-Paul Gaudillière, Bernd Gausemeier, Jean Gayon, Veronika Lipphardt, Ilana Löwy, J. Andrew Mendelsohn, Staffan Müller-Wille, Diane B. Paul, Theodore M. Porter, Alain Pottage, Hans-Jörg Rheinberger, Marsha L. Richmond, Helga Satzinger, Judy Johns Schloegel, Alexander von Schwerin, Hamish G. Spencer, Ulrike Vedder
Follow the adventures of six-year-old William, an adopted boy nicknamed Penny for his copper-colored hair, as he attends a Halloween party, adopts kittens, and finds an older brother to join his family.
From Carolyn Haywood, author of the beloved Betsy series, here are four more classics for young readers. These adorable stories of childhood adventures are as fresh today as when they were written more than a half century ago. And now, thanks to dynamic new covers, they're ready to charm a whole new generation of readers.Penny's name is really William, but when he was adopted as a baby, he had hair the color of a new copper penny. Adopted or not, Penny decides to prove his friend Patsy wrong when she says he doesn't truly have a family!
here's how i see it Rave reviews, an endless request for autographs, my name in lights on Broadway. here's how it is The audience is half empty, I spend zero time onstage, my dad's midlife crisis is about to ruin the playhouse...and my family. Junebug dreams of being a leading lady someday. A serious actress, a stage actress, a real actress. And it should be easy for her to get her start -- her parents own the Blue Moon Playhouse, after all, and her dad performed on Broadway (once). But the truth is, at (almost) thirteen, she's not even a supporting actress or a stand-in or an understudy or even a child actor has-been. In the current Blue Moon production, her role is this: thunder, props...and stagehand (gopher, actually). And lately it seems like maybe the stagehand mindset -- go unnoticed, don't say a word -- is rubbing off on Junebug's personality. She's starting to feel as though her opinions never count, her worries aren't taken seriously, that she's becoming the ultimate stagehand: invisible. And that's not a role she's happy with. From author and former playhouse insider Heather Henson comes a novel about growing up, standing out, and what it means to live your life just outside of the spotlight.
Welcome to the wonderful world of Lily Robbins! In this fun, entertaining story about growing up, you'll meet an awkward sixth-grader named Lily. After getting a compliment about her looks from a woman in the modeling business, Lily becomes obsessed with becoming a model and sets her sights on winning the "model search" fashion show. She packs away her rock and feather collection in exchange for pictures of teen models and fashion magazines. However, when the unthinkable happens the night before the fashion show, Lily learns a valuable lesson about real beauty.
Grow with the spirited, sometimes awkward, but always charming Lily as she learns what real beauty is.In this fun, entertaining story, readers meet awkward sixth grader Lily Robbins who, after receiving a compliment about her looks from a woman in the modeling business, becomes obsessed with her appearance and with becoming a model. As she sets her sights on winning the model search fashion show, she exchanges her rock and feather collection for lip gloss, fashion magazines, and a private "club" with her closest friends. But when the unthinkable happens the night before the fashion show, Lily learns a valuable lesson about real beauty.This best-selling, biblically based fiction series for girls--with a fresh new look and updated content--addresses social issues and coming-of-age topics, all with the spunk and humor of Lily Robbins as she fumbles her way through unfamiliar territory. As readers come to love Lily and her stories, they'll also benefit from the companion nonfiction books that will help them through their own growing pains.
Golf... Tennis... Scouting... No wonder Snoopy is tired! Despite what Charlie Brown thinks, Snoopy keeps busy. In this book Snoopy explains his day.
Do clouds truly have silver linings? Betty Rollin answers with a resounding yes in this wise, moving, and funny book about the surprising upsides to life's most challenging, painful, and seemingly insurmountable low blows. Rollin has been there. After being diagnosed with breast cancer more than thirty years ago-and again nine years later-she managed to find an astonishingly bright side to the darkness. She shares her often zany and unpredictable personal experiences of turning the worst into the best, and shows how others have done the same-thriving in adversity to a remarkable degree and coming to recognize their various blessings in disguise.Steve Jobs describes how being fired from Apple, the company he founded, was one of the best things that ever happened to him. Homemaker Sally Fleming made a better life for herself and her family after a fire. Only when workaholic CEO Eugene O'Kelly was diagnosed with a terminal illness did he really begin to live his life to the fullest. Bill Clinton, Charles Colson, and others describe life changes after adversity. Rollin reveals the science behind the theory of adversarial, or post-traumatic, growth. This paradox is not about denying hardship but about finding a way to benefit from it. Seeing the bright enables us to find the good, whatever form it takes, within the bad and proceed from there. Poignant, timely, universal, and inspiring, Here's the Bright Side proves that amid life's struggles and losses, there is much to be gained-wisdom, strength, and, perhaps most important, gratitude. "Try feeling gloomy and grateful all at once," says Rollin. "You can't. Gratitude picks you up and puts you in a place where gloom cannot thrive."From the Hardcover edition.
A frank, funny, no-holds-barred memoir that reveals the Deal or No Deal host's ongoing struggle with OCD and ADHD--and how it has shaped his life and career. Howie Mandel is one of the most recognizable names in entertainment--respected by his peers and beloved by audiences as the host of the enormously popular prime-time game show Deal or No Deal. With a career that spans three decades and many different show-business platforms--he's a renowned stand-up comedian who continues to perform more than 150 sold-out shows a year, he created the award-winning TV show Bobby's World, he's starred in feature films and the hit TV series St. Elsewhere, and he's also hosted his own daytime talk show--he's one of the most versatile performers anywhere. But there are aspects of his personal and professional life he's never talked about publicly--until now. Eleven years ago, Mandel first told the world about his "germophobia. " He's recently started discussing his adult ADHD as well. Now, for the first time, he reveals the details of his struggle with these challenging disorders. He catalogs his numerous fears and neuroses and shares entertaining stories about how he has tried to integrate them into his act. "If I'm making myself laugh," he writes, "then I'm distracted from all the other things going on in my head that are, at times, torturous. " And he speaks frankly and honestly about the ways his condition has affected his personal life--as a son, husband, and father of three. Fans who've been dying to know "the deal" behind Mandel's remarkable rise through the show-business ranks will be rewarded with many never-before-told anecdotes, each one generously leavened with Mandel's trademark humor. There are tales from every phase of his colorful career--from his early days as a teenage carpet salesman and aspiring stand-up comic to his stint opening for Diana Ross, his six years on St. Elsewhere, and beyond. As heartfelt as it is hilarious, Here's the Deal: Don't Touch Me is the story of one man's effort to draw comic inspiration out of his darkest, most vulnerable places. It's sure to please Howie Mandel's legion of fans--and provide hope to the millions who strive to succeed in spite of OCD and ADHD.
Advice for every pitch situation a modern day entrepreneur will encounterWhether you're pitching for funding, the media, or to potential customers and partners, to survive and succeed as an entrepreneur, you have to know how to deliver a high-impact pitch. Here's the Pitch reveals powerful proven techniques to get your audience to take the action you want. You'll learn the same strategies and tactics that have been used by entrepreneurs to raise millions of dollars, secure partnerships, and win big sales contracts.Here's the Pitch provides advice for every possible pitch situation, including virtual and Web 2.0 pitches. This book:Demonstrates proven, effective pitch techniquesOffers step-by-step advice for preparing your pitchHelps you develop a confident, winning mind-setExamines a range of pitch scenarios entrepreneurs frequently encounterDon't lose out on your next big sale, bid for exposure, or investment proposal for lack of skills. Here's the Pitch provides a complete toolkit that will enable you to deliver a confident, engaging, and successful pitch.
Marcia! Marcia! Marcia! Marcia Brady, eldest daughter on television's The Brady Bunch, had it all-style, looks, boys, brains, and talent. No wonder her younger sister Jan was jealous! For countless adolescents across America who came of age in the early 1970s, Marcia was the ideal American teenager. Girls wanted to be her. Boys wanted to date her. But what viewers didn't know about the always-sunny, perfect Marcia was that offscreen, her real-life counterpart, Maureen McCormick, the young actress who portrayed her, was living a very different-and not-so-wonderful-life. Now, for the very first time, Maureen tells the shocking and inspirational true story of the beloved teen generations have invited into their living rooms-and the woman she became. In Here's the Story, Maureen takes us behind the scenes of America's favorite television family, the Bradys. With poignancy and candor, she reveals the lifelong friendships, the hurtful jealousies, the offscreen romance, the loving support her television family provided during a life-or-death moment, and the inconsolable loss of a man who had been a second father. But The Brady Bunch was only the beginning. Haunted by the perfection of her television alter ego, Maureen landed on the dark side, caught up in a fast-paced, drug-fueled, star-studded Hollywood existence that ultimately led to the biggest battle of her life. Moving from drug dens on Wonderland Avenue to wild parties at the Playboy mansion and exotic escapades on the beaches of Hawaii, this candid, hard-hitting memoir exposes a side of a beloved pop-culture icon the paparazzi missed. Yet it is also a story of remarkable success. After kicking her drug habit, Maureen battled depression, reconnected with her mother, whom she nursed through the end of her life, and then found herself in a pitched battle for her family in which she ultimately triumphed. There is no question: Maureen McCormick is a survivor. After fifty years, she has finally learned what it means to love the person you are, insight that has brought her peace in a happy marriage and as a mother. Here's the Story is the empowering, engaging, shocking, and emotional tale of Maureen McCormick's courageous struggle over adversity and her lifelong battle to come to terms with the idea of perfection-and herself.
Autobiography of the actress who played Marcia Brady on the TV show The Brady Bunch in the 60s and 70s.
Once upon a time in a little town on the Oregon coast lived four Lindas--all in the same first-grade classroom. So they decided to go by their middle names. And form a club. And be friends forever. Decades later, they're all back home in Clifden and reinventing their lives, but the holidays bring a whole new set of challenges. Abby's new B&B is getting bad reviews and husband Paul is acting strange. Still grieving for her mom, Caroline is remodeling the family home, but boyfriend Mitch keeps pressuring her to go away with him. Artist Marley, distracted by a friend's family drama (and a touch of jealousy), can't find her creative groove. And Janie's drug-addicted daughter has just appeared up on her doorstep! When a long-planned New Year's cruise turns into a bumpy ride, they learn once again that, in your fifties, friends aren't just for fun--they're a necessity!
Jesusa is a tough, fiery character based on a real working-class Mexican woman whose life spanned some of the seminal events of early twentieth-century Mexican history. Having joined a cavalry unit during the Mexican Revolution, she finds herself at the Revolution's end in Mexico City, far from her native Oaxaca, abandoned by her husband and working menial jobs. So begins Jesusa's long history of encounters with the police and struggles against authority. Mystical yet practical, undaunted by hardship, Jesusa faces the obstacles in her path with gritty determination. Here in its first English translation, Elena Poniatowska's rich, sensitive, and compelling blend of documentary and fiction provides a unique perspective on history and the place of women in twentieth-century Mexico.
In recent years the distinction between heresy and orthodoxy has come under fire by those eager to reject the formal boundaries of sanctioned beliefs about God, Jesus, and the church. In a timely corrective to this trend, renowned church historian Alister McGrath argues that the categories of heresy and orthodoxy must be preserved. Remaining faithful to Jesus's mission and message is still the mandate of the church despite increasingly popular cries that traditional dogma is outdated and restricts individual freedom. Overturning misconceptions throughout the book, McGrath exposes: how many of the heretical beliefs and practices rejected by the church were actually more stringent and oppressive than rival orthodox claims. that many theological alternatives were rejected when the church had no power to enforce one view over another, long before Constantine made Christianity the official religion of the Roman Empire. In Heresy, McGrath explains why no heresy has ever been eradicated-rival beliefs only go underground and resurface in different forms. McGrath presents a powerful, compassionate, and deeply attractive orthodoxy that will equip the church to meet the challenge from renewed forms of heresy today.
Masterfully blending true events with fiction, this blockbuster historical thriller delivers a page-turning murder mystery set on the sixteenth-century Oxford University campus.Giordano Bruno was a monk, poet, scientist, and magician on the run from the Roman Inquisition on charges of heresy for his belief that the Earth orbits the sun and that the universe is infinite. This alone could have got him burned at the stake, but he was also a student of occult philosophies and magic. In S. J. Parris's gripping novel, Bruno's pursuit of this rare knowledge brings him to London, where he is unexpectedly recruited by Queen Elizabeth I and is sent undercover to Oxford University on the pretext of a royal visitation. Officially Bruno is to take part in a debate on the Copernican theory of the universe; unofficially, he is to find out whatever he can about a Catholic plot to overthrow the queen. His mission is dramatically thrown off course by a series of grisly murders and a spirited and beautiful young woman. As Bruno begins to discover a pattern in these killings, he realizes that no one at Oxford is who he seems to be. Bruno must attempt to outwit a killer who appears obsessed with the boundary between truth and heresy. Like The Dante Club and The Alienist, this clever, sophisticated, exceptionally enjoyable novel is written with the unstoppable narrative propulsion and stylistic flair of the very best historical thrillers.From the Hardcover edition.
8th in the Catherine LeVendeur mystery series set in 12th-century France. Catherine and Margaret go to the council at Reims to defend Astrolabe against charges of murder.
This interdisciplinary volume of essays brings together a team of leading early modern historians and literary scholars in order to examine the changing conceptions, character, and condemnation of 'heresy' in sixteenth- and seventeenth-century England. Definitions of 'heresy' and 'heretics' were the subject of heated controversies in England from the English Reformation to the end of the seventeenth century. These essays illuminate the significant literary issues involved in both defending and demonising heretical beliefs, including the contested hermeneutic strategies applied to the interpretation of the Bible, and they examine how debates over heresy stimulated the increasing articulation of arguments for religious toleration in England. Offering fresh perspectives on John Milton, Thomas Hobbes, John Locke and others, this volume should be of interest to all literary, religious and political historians working on early modern English culture.
Is Islam A Religion of Peace?In what is sure to be her most controversial book to date, Ayaan Hirsi Ali makes a powerful case that a religious Reformation is the only way to end the terrorism, sectarian warfare, and repression of women and minorities that each year claim thousands of lives throughout the Muslim world. With bracing candor, the brilliant, charismatic, and uncompromising author of the bestselling Infidel and Nomad argues that it is foolish to insist, as our leaders habitually do, that the violent acts of Islamic extremists can be divorced from the religious doctrine that inspires them. Instead we must confront the fact that they are driven by a political ideology embedded in Islam itself.Today, Hirsi Ali argues, the world's 1.6 billion Muslims can be divided into a minority of extremists, a majority of observant but peaceable Muslims, and a few dissidents who risk their lives by questioning their own religion. But there is only one Islam, and as Hirsi Ali shows, there is no denying that some of its key teachings--not least the duty to wage holy war--inspire violence not just in the Muslim world but in the West as well.For centuries it has seemed that Islam is immune to historical change. But Hirsi Ali is surprisingly optimistic. She has come to believe that a Muslim "Reformation"--a revision of Islamic doctrine aimed at reconciling the religion with modernity--is at hand, and may even already have begun.Partly in response to the barbaric atrocities of Islamic State and Boko Haram, Muslims around the world have at last begun to speak out for religious reform. Meanwhile, events in the West, such as the shocking Charlie Hebdo massacre, have forced Western liberals to recognize that political Islam poses a mortal threat to free speech. Yet neither Muslim reformers nor Western liberals have so far been able to articulate a coherent program for a Muslim Reformation.This is where Heretic comes in. Boldly challenging centuries of theological orthodoxy, Ayaan Hirsi Ali proposes five key amendments to Islamic doctrine that Muslims must make if they are to bring their religion out of the seventh century and into the twenty-first. She also calls upon the Western world to end its appeasement of radical Islamists--and to drop the bogus argument that those who stand up to them are guilty of "Islamophobia." It is the Muslim reformers who need our backing, she argues, not the opponents of free speech.Interweaving her own experiences, historical analogies, and powerful examples from contemporary Muslim societies and cultures, Heretic is not so much a call to arms as a passionate plea for peaceful change and a new era of global tolerance. As jihadists kill thousands, from Nigeria to Syria to Pakistan, this book offers an answer to what is fast becoming the world's number one problem.
An ode to tolerance and the liberty of conscience, The Heretic is an unforgettable story of a man and the passions that move him to action. In this winner of the Premio Nacional de Narrativa, Spain's most prestigious literary prize, Miguel Delibes takes us into the heart of sixteenth-century Spain. At the very moment Martin Luther nails his ninety-five theses to a church door and launches the movement that will divide the Roman Catholic Church, a child is born, his fate marked by the political and religious upheaval taking root in Europe. His mother having perished in childbirth, his father alienated and disconnected, Cipriano Salcedo's only source of affection is his wet nurse and foster mother, Minerva. He grows up to become a prosperous merchant and joins the Reformation movement, which is secretly advancing on the Iberian Peninsula, the historical bastion of the Catholic church. But before long, the Spanish Inquisition will drive the Reformers to put their lives at stake. Through the story of Cipriano Salcedo, Delibes paints a masterful portrait of the time of Spain's Charles V and recreates with uncanny accuracy and unparalleled artistry the social and intellectual atmosphere of Europe at one of history's most pivotal moments.
The second title in a series that peers into a mysterious new area of the Magic® world. Heretic: Betrayers of Kamigawa continues a series that will explore a new and mysterious area of the Magic: The Gathering world that fans have never seen before. This novel previews the newest trading card game set to be released in February, giving fans a sneak peek at the new elements of the game.
Already a seasoned veteran of King Edward's army, young Thomas of Hookton possesses the fearlessness of a born leader and an uncanny prowess with the longbow. Now, at the head of a small but able band of soldiers, he has been dispatched to capture the castle of Astarac. But more than duty to his liege has brought him to Gascony, home of his forebears and the hated black knight who brutally slew Thomas's father. It is also the last place where the Holy Grail was reported seen. Here, also, a beautiful and innocent, if not pious, woman is to be burned as a heretic. Saving the lady, Genevieve, from her dread fate will brand Thomas an infidel, forcing them to flee together across a landscape of blood and fire. And what looms ahead is a battle to the death that could ultimately shape the future of Christendom.