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Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine.
Ceramic Transactions, Volume 242; Biomaterials Science - Processing, Properties and Applications IIISusmita Bose, Roger Narayan, and Amit Bandyopadhyay, EditorsThis CT Volume contains14 contributed papers from the following 2012 Materials Science and Technology (MS&T'12) symposia: Next Generation BiomaterialsSurface Properties of Biomaterials
By providing mechanics before functional anatomy, the book helps students understand forces and their effects before studying how body structures deal with forces. Students will learn to appreciate the consequences of external forces, how the body generates internal forces to maintain position, and how forces create movement in physical activities. Rather than presenting the principles as isolated and abstract, the text enables students to discover the principles of biomechanics for themselves through observation. By examining ordinary activities firsthand, students will develop meaningful explanations resulting in a deeper understanding of the underlying mechanical concepts. This practical approach combines striking visual elements with clear and concise language to encourage active learning and improved comprehension.
Biomechanics of the Brain will present an introduction to brain anatomy for engineers and scientists. Experimental techniques such as brain imaging and brain tissue mechanical property measurement will be discussed, as well as computational methods for neuroimage analysis and modeling of brain deformations due to impacts and neurosurgical interventions. Brain trauma between the different sexes will be analyzed. Applications will include prevention and diagnosis of traumatic injuries, such as shaken baby syndrome, neurosurgical simulation and neurosurgical guidance, as well as brain structural disease modeling for diagnosis and prognosis. This book will be the first book on brain biomechanics. It will provide a comprehensive source of information on this important field for students, researchers, and medical professionals in the fields of computer-aided neurosurgery, head injury, and basic biomechanics.
This book will review work from a number of researchers who have produced open source software addressing the need for data management, integration, analysis, and visualization to aid cancer research. With the advent of high-throughput technologies in biomedicine, the need for data management and appropriate data analysis tools in genomics has increased dramatically, joining clinical trials data as a major driver of informatics at cancer research centers. The gathering of this data requires careful encoding of metadata, usually through the use of controlled vocabularies or ontologies, as well as the linking of data from model organisms, done at both a physiological level (e.g., anatomy) and at a molecular level (e.g., orthology). This data will then find use within computational and statistical models, which require data pipelines and analysis systems, as well as algorithms, visualization methods, and computational modeling systems. We will introduce open source tools available for these aspects of the problem. The editors plan to divide the book into five sections, beginning with a section containing high level overviews of the field and key issues. This will include an introductory review of informatics in cancer research, followed by five overviews addressing issues in authentication and authorization, data management, data pipelines and annotations, algorithms and models, and the NCI caBIG initiative. This will be followed by sections dedicated to data systems, data pipelines, algorithms for analysis and visualization, and modeling systems. Each of these areas has seen publication of open source tools, ranging from the widely known R/Bioconductor package to little known but powerful systems such as SImmune for biochemical modeling. The area of laboratory information management systems has seen development of a number of unpublished but powerful systems, which we would also include. Three groups have agreed to provide chapters in this area (USC/Norris CAFE extensible clinical trials system, St Jude Unified LIMS, Fox Chase/British Columbia flow cytometry LIMS). While there has been a great deal of development of informatics tools that can be applied to problems in cancer research, there has not been adequate dissemination of details on these tools to the community. As such, there remains low adoption of all but a few tools. This book aims to increase overall adoption of tools by providing cancer center leaders and researchers with a single volume detailing both issues that must be addressed and tools that are ready for use.
Biomedical Materials provides a comprehensive discussion of contemporary biomaterials research and development. Highlighting important topics associated with Engineering, Medicine and Surgery, this volume reaches a wide scope of professionals, researchers and graduate students involved with biomaterials. A pedagogical writing style and structure provides readers with an understanding of the fundamental concepts necessary to pursue research and industrial work on biomaterials, including characteristics of biomaterials, biological processes, biocompatibility, and applications of biomaterials in implants and medical instruments. Written by leading researchers in the field, this text book takes readers to the forefront of biomedical materials development, providing them with a taste of how the field is changing, while also serving as a useful reference to physicians and engineers.
Gareth Stevens Vital Science books are designed to help prepare students for NCLB science testing by reinforcing key concepts across the science curriculum. the six volumes in Earth Science use clear language and a variety of photographs, illustrations, and diagrams to help students understand the properties of rocks, soils, water, gases, and fossils. Weather, biomes and ecosystems, and earth's core and crust are also covered, making this a comprehensive and indispensable resource. image descriptions present
What is biometrics? Whether you're just curious about how biometrics can benefit society or you need to learn how to integrate biometrics with an existing security system in your organization, Biometrics For Dummies can help.Here's a friendly introduction to biometrics -- the science of identifying humans based on unique physical characteristics. With the government's use of biometrics -- for example, biometric passport readers -- and application of the technology for law enforcement, biometrics is growing more popular among security experts. Biometrics For Dummies explains biometric technology, explores biometrics policy and privacy issues with biometrics, and takes a look at where the science is heading. You'll discover:How pattern recognition and fingerprint recognition are usedThe many vulnerabilities of biometric systems and how to guard against themHow various countries are handling the privacy issues and what can be done to protect citizens' privacyHow a scan of the palm, veins in the hand, and sonar imagery establish identityWhat it takes to fully authenticate a signatureHow gait, speech, linguistic analysis, and other types of biometric identification come into playThe criteria for setting up an implementation planHow to use authentication, authorization, and access principlesWritten by a pair of security experts, Biometrics For Dummies gives you the basics in an easy-to-understand format that doesn't scrimp on substance. You'll get up to speed and enjoy getting there!
This profound and accessible book details how science is studying nature's best ideas to solve our toughest 21st-century problems. If chaos theory transformed our view of the universe, biomimicry is transforming our life on Earth. Biomimicry is innovation inspired by nature - taking advantage of evolution's 3.8 billion years of R&D since the first bacteria. Biomimics study nature's best ideas: photosynthesis, brain power, and shells - and adapt them for human use. They are revolutionising how we invent, compute, heal ourselves, harness energy, repair the environment, and feed the world. Science writer and lecturer Janine Benyus names and explains this phenomenon. She takes us into the lab and out in the field with cutting-edge researchers as they stir vats of proteins to unleash their computing power; analyse how electrons zipping around a leaf cell convert sunlight into fuel in trillionths of a second; discover miracle drugs by watching what chimps eat when they're sick; study the hardy prairie as a model for low-maintenance agriculture; and more.
Fossils are essential to the reconstruction of the evolution of life and episodes in Earth history. Knowledge of biomineralization - the processes associated with the formation of mineralized biological structures - is essential to properly evaluate data derived from fossils. This book emphasizes skeletal formation and fossilization in a geologic framework in order to understand evolution, relationships between fossil groups, and the use of biomineral materials as geochemical proxies for understanding ancient oceans and climates. The focus is on shells and skeletons of calcareous organisms, and the book explores the fine structures and mode of growth of the characteristic crystalline units, taking advantage of most recent physical methodological advances. The book is richly illustrated and will be of great interest to advanced students and researchers in paleontology, Earth history, evolution, sedimentology, geochemistry, and materials science.
Over the past 40 years the field of molecular simulations has evolved from picosecond studies of isolated macromolecules in vacuum to studies of complex, chemically heterogeneous biological systems consisting of millions of atoms, with the simulation time scales spanning up to milliseconds. In Biomolecular Simulations: Methods and Protocols, expert researchers illustrate many of the methods commonly used in molecular modelling of biological systems, including methods for electronic structure calculations, classical molecular dynamics simulations and coarse-grained techniques. A selection of advanced techniques and recent methodological developments, which rarely find coverage in traditional textbooks, is also introduced. Written in the highly successful Methods in Molecular Biology series format, chapters include general introductions to well-established computational methodologies, applications to real-world biological systems, as well as practical tips and general protocols on carrying out biomolecular simulations. Special emphasis is placed on simulations of proteins, lipids, nucleic acids, and carbohydrates. Authoritative and practical, Biomolecular Simulations: Methods and Protocols seeks to aid scientists in further simulation studies of biological systems.
MICHIGAN CHILLERS WINGED MONSTERS ATTACK AN ENTIRE CITY! On a dark night in Bay City, Michigan, friends gather to plan an innocent game of hide-and-seek. However, just as they begin to play, one of them sees a bat. But it's not any ordinary bat. In fact, the bat is gigantic--as big as some of the children! And there's more than one. Forced to abandon their game, five children must flee the vicious attacks of these giant creatures from the sky. Unable to take refuge in their homes, they must fight to survive. Where did these bats come from? How on earth did they grow to such enormous size? And most important: will the five children be able to defend themselves until help arrives, or will the bats have their way? It's a night of horror in Bay City . . . and for five friends, it just might be their last night alive! #14: Bionic Bats of Bay City by Johnathan Rand
An encyclopedic look at the entire BIONICLE story line, featuring new and updated entries. Want to know more about the Piraka? They're all here. And what about Nidhiki or Makuta? The Toa? The Toa Inika? The city of Metru Nui? And the watery world of Mahri Nui? It's all here: everything you ever wanted to know-and some things you may never have asked. The answers to your questions are inside this book. A must-have for fans of all ages whether they are new to the property or think they know it all.
Tim Beatley has long been a leader in advocating for the "greening" of cities. But too often, he notes, urban greening efforts focus on everything except nature, emphasizing such elements as public transit, renewable energy production, and energy efficient building systems. While these are important aspects of reimagining urban living, they are not enough, says Beatley. We must remember that human beings have an innate need to connect with the natural world- (the biophilia hypothesis). And any vision of a sustainable urban future must place its focus squarely on nature, on the presence, conservation, and celebration of the actual green features and natural life forms. A biophilic city is more than simply a biodiverse city, says Beatley. It is a place that learns from nature and emulates natural systems, incorporates natural forms and images into its buildings and cityscapes, and designs and plans in conjunction with nature. A biophilic city cherishes the natural features that already exist but also works to restore and repair what has been lost or degraded. In Biophilic Cities Beatley not only outlines the essential elements of a biophilic city, but provides examples and stories about cities that have successfully integrated biophilic elements--from the building to the regional level--around the world.
This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician. With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.
The book is structured in nine sections, each containing several chapters. The volume starts with an overview of analytical techniques and progresses through purification of proteins; protein modification and inactivation; protein size, shape, and structure; enzyme kinetics; protein-ligand interactions; industrial enzymology; and laboratory quality control. The book is targeted at all scientists interested in protein research.
"Biophysical Foundations of Human Movement, Third Edition," introduces readers to key concepts concerning the anatomical, mechanical, physiological, neural, and psychological bases of human movement. The text provides undergraduate students with a broad foundation for more detailed study of the subdisciplines of human movement and for cross-disciplinary studies. Readers will learn the multi-dimensional changes in movement and movement potential that occur throughout the life span as well as those changes that occur as adaptations to training, practice, and other lifestyle factors. This third edition includes the latest research and improved presentation to address areas of growth and change in the fields of human movement. The following are important updates to this edition: - A new chapter on historical origins of human movement science provides students with an appreciation of the development of the field as well as its future directions. - Content regarding exercise physiology has been reorganized to provide more discrete coverage of key concepts in nutrition. - A new concluding section focuses on applications in the areas of prevention and management of chronic disease, prevention and management of injury, and performance enhancement in sport and the workplace, as well as the benefits of sport and exercise science to work, sport, and everyday living. - Ancillary materials support instructors in teaching across disciplines as they assist students in understanding the breadth of content in this comprehensive text. Using a modular approach to teaching sport and exercise science, "Biophysical Foundations of Human Movement, Third Edition," offers students a structured understanding of how the subdisciplines work independently and in tandem. Following a general introduction to the field of human movement studies, readers are introduced to basic concepts, life-span changes, and adaptations arising in response to training in each of the five major biophysical subdisciplines of human movement. Each subdiscipline is given a brief introduction, including the definition and historical development of the subdiscipline, the typical issues and problems it addresses, the levels of analysis it uses, and relevant professional training and organizations. Multi-disciplinary and cross-disciplinary approaches to human movement are also discussed along with contemporary applications. By studying the integration of knowledge from a number of the biophysical subdisciplines, students will be better prepared for advanced study and careers reliant on the integration of knowledge from various disciplines and perspectives. The third edition offers tools for retaining the material, including learning objectives and summaries in each chapter, a glossary, and lists of web-based resources. Throughout the text, special "In Focus" features highlight key organizations, individuals, and studies from around the world that have contributed to the current understanding of human movement. These features help readers appreciate the evolution of the field so that they may better understand its direction. Students interested in further study will find specialized texts for each of the subdisciplines listed in the Further Reading and References section of each chapter along with updated lists of websites. The third edition of "Biophysical Foundations of Human Movement" offers a comprehensive introduction for students, scientists, and practitioners involved in the many professions grounded in or related to human movement, kinesiology, and sport and exercise science. By considering the effect of adaptations in each of the biophysical subdisciplines of human movement, "Biophysical Foundations of Human Movement" also illustrates the important role physical activity plays in the maintenance of health throughout the life span.
The fun, easy way to get up to speed on biophysics concepts, principles, and practicesOne of the most diverse of modern scientific disciplines, biophysics applies methods and technologies from physics to the study of biological systems and phenomena, from the human nervous system to soil erosion to global warming. What are the best options for satisfying the world's growing energy demands? How can we feed the world's growing population? How can we contain, or reverse, global warming? How can we vouchsafe a plentiful supply of potable water for future generations? These are among the critical questions to which biophysicists work to provide answers.Biophysics courses are increasingly taken by students of biology, physics, chemistry, biochemistry, physiology, statistics, bioengineering, neuroscience, computer science, pharmacology, agriculture,and many moreProvides a friendly, unintimidating overview of the material covered in a typical college-level biophysics courseA one-stop reference, course supplement and exam preparation tool for university students currently enrolled in an introductory biophysics coursesAn indispensable resource for those studying the natural sciences, biological sciences, and physics, as well as math, statistics,computer science, pharmacology and many other disciplinesThe current job market for people well versed in biophysics is very strong, and biophysics is currently listed as one of the fast-growing occupations in the North America
This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.
Genetic engineering and the cloning of organisms are "the ultimate expression of the commercialization of science and the commodification of nature.... Life itself is being colonized," according to renowned environmentalist Vandana Shiva. The resistance to this biopiracy, she argues, is the struggle to conserve both cultural and biological diversity. As the land, forests, oceans, and atmosphere have already been colonized, eroded, and polluted, corporations are now looking for new colonies to exploit and invade for further accumulation--in Shiva's view, the interior spaces of the bodies of women, plants, and animals. Featuring a new introduction by the author, this edition of Biopiracy is a learned, clear, and passionately stated objection to the ways in which Western businesses are being allowed to expropriate natural processes and traditional forms of knowledge. From the Trade Paperback edition.
This book presents an historical account of media and catastrophe that engages with theories of biopolitics in the work of Michel Foucault, Giorgio Agamben, Michael Hardt, Antonio Negri and others. It explains how responses to catastrophe in media and cultural criticism over the past 150 years are embedded in biological conceptions of life and death, contamination and immunity, race and species. Mediated catastrophe is often understood today in terms of collective memory and according to therapeutic or redemptive accounts of trauma. In contrast to these approaches this book emphasizes the use of media to record, archive and analyze physical appearance and movement; to capture viewer attention through shock; to monitor and control bodies in economies of production and consumption; to enmesh social relations in information networks; and situate subjects in discourses of victimhood, immunity, survival and resilience. Chapters are focused on historical case studies of early photography, Nazi propaganda, colonial stereotypes, Hiroshima, the Holocaust, the Cold War and the war on terror.
The biological features of human beings are now measured, observed, and understood in ways never before thought possible, defining norms, establishing standards, and determining average values of human life. While the notion of "biopolitics" has been linked to everything from rational decision-making and the democratic organization of social life to eugenics and racism, Thomas Lemke offers the very first systematic overview of the history of the notion of biopolitics, exploring its relevance in contemporary theoretical debates and providing a much needed primer on the topic. Lemke explains that life has become an independent, objective and measurable factor as well as a collective reality that can be separated from concrete living beings and the singularity of individual experience. He shows how our understanding of the processes of life, the organizing of populations and the need to "govern" individuals and collectives lead to practices of correction, exclusion, normalization, and disciplining. In this lucidly written book, Lemke outlines the stakes and the debates surrounding biopolitics, providing a systematic overview of the history of the notion and making clear its relevance for sociological and contemporary theoretical debates.
Bringing together original, contemporary ethnographic research on the Northeast African state of Eritrea, this book shows how biopolitics - the state-led deployment of disciplinary technologies on individuals and population groups - is assuming particular forms in the twenty-first century. Once hailed as the "African country that works," Eritrea's apparently successful post-independence development has since lapsed into economic crisis and severe human rights violations. This is due not only to the border war with Ethiopia that began in 1998, but is also the result of discernible tendencies in the "high modernist" style of social mobilization for development first adopted by the Eritrean government during the liberation struggle (1961-1991) and later carried into the post-independence era. The contributions to this volume reveal and interpret the links between development and developmentalist ideologies, intensifying militarism, and the controlling and disciplining of human lives and bodies by state institutions, policies, and discourses. Also assessed are the multiple consequences of these policies for the Eritrean people and the ways in which such policies are resisted or subverted. This insightful, comparative volume places the Eritrean case in a broader global and transnational context.
Michel Foucault's notion of "biopower" has been a highly fertile concept in recent theory, influencing thinkers worldwide across a variety of disciplines and concerns. In The History of Sexuality: An Introduction, Foucault famously employed the term to describe "a power bent on generating forces, making them grow, and ordering them, rather than one dedicated to impeding them, making them submit, or destroying them." With this volume, Vernon W. Cisney and Nicolae Morar bring together leading contemporary scholars to explore the many theoretical possibilities that the concept of biopower has enabled while at the same time pinpointing their most important shared resonances. Situating biopower as a radical alternative to traditional conceptions of power--what Foucault called "sovereign power"--the contributors examine a host of matters centered on life, the body, and the subject as a living citizen. Altogether, they pay testament to the lasting relevance of biopower in some of our most important contemporary debates on issues ranging from health care rights to immigration laws, HIV prevention discourse, genomics medicine, and many other topics.
Bill Gates recently told Wired that if he were a teenager today, he would be hacking biology. "If you want to change the world in some big way," he says, "that's where you should start-biological molecules. " The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: - A duo who started a cancer drug company in their kitchen - A team who built an open-source DNA copy machine - A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think. .
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