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This book contains everything from Ferrari's bizarre relationship with his illegitimate son to his brilliant marketing of the famous Ferrari image; from his sordid affairs to his work with the fascists in the Second World War; from his fanatic passion for speed to his manipulative yet enormously successful management techniques. Also presents a complete inside history of high-performance cars and motor sports from the First World War to the present.
Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.
Whether the pursuit is commercially motivated or purely academic, engineering a novel biological catalyst is an enticing challenge. High-resolution protein structure analysis allows for rational alteration of enzyme function, yet many useful enzyme variants are the product of well-designed selection schemes or screening strategies. Enzyme Engineering: Methods and Protocols provides guidance to investigators wishing to create enzyme variants with desired properties. This detailed volume covers such topics as a simple method for generating site-specific mutations within bacterial chromosomes. It also highlights the engineering of two difference types of rare-cutting endonucleases that show great potential in gene therapy applications: The newest development is the emergence of TAL effector nucleases or TALENs. Chapters describe newly developed technologies in sufficient detail so that each method can be practiced in a standard molecular biology laboratory. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Enzyme Engineering: Methods and Protocols will be valuable for scientists with a budding interest in protein engineering as well as veterans looking for new approaches to apply in established discovery programs.
In the past decade, researchers have made tremendous progress in the field of enzyme stabilization, opening up new opportunities for enzymes in molecular biology and for industrial applications. In Enzyme Stabilization and Immobilization: Methods and Protocols, expert researchers explore the latest developments through detailed laboratory protocols, which address many different theories and techniques in enzyme stabilization. Chapters outline protocols for enzyme stabilization in solutions, including: liposome formation, micelle introduction, crosslinking, and additives. Secondly, the book contain protocols for enzyme stabilization via enzyme immobilization, such as sol-gel encapsulation, polymer encapsulation, and single enzyme nanoparticle formation. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, Enzyme Stabilization and Immobilization: Methods and Protocols is an essential handbook for all molecular biologists, biochemists, and biomedical and biochemical engineers.
Provides key information on a wide range of enzymes commonly used as tools in molecular biology, helping to minimize the time a scientist spends researching the literature to get reactions to work efficiently and allowing the nonenzymologist to design an experiment. Each chapter gives background information on the enzyme selected and those parameters important in its use, describes both the source and application of the enzyme, and provides details on the size and structure of the protein. Specific parameters essential for achieving an optimized reaction are discussed, along with exemplary practical procedures an protocols.
When an enormous asteroid enters the Earth's orbit, the remains of a vanished human civilization are discovered within that reveal the asteroid's futuristic origins and predict a catastrophic imminent Earth war.
Eon has been revealed as Eona, the first female Dragoneye in hundreds of years. Along with fellow rebels Ryko and Lady Dela, she is on the run from High Lord Sethon's army.
This volume provides a history of Eosinophilic Esophagitis (EoE), a basic understanding of the physiology of the eosinophil, and a current understanding of the pathophysiology and genetics of EoE. The emphasis is on clinical applications including presenting symptoms, diagnosis and treatment options for patients with EoE. Written by both pediatric and adult experts in the fields of gastroenterology, allergy and pathology, this volume includes the most up to date information. Providing practical information useful in the treatment of patients, this book will be of great value to gastroenterologists, allergists, pathologists, medical residents, fellows, internists, and general practitioners who treat patients with eosinophilic esophagitis.
God's Design for Living in Unity and LoveIn a world divided by political, social, economic, and religious hostility, Paul writes a letter about unity. Jew and Gentile, slave and free--all are to live as family members. Here Paul tells us how to conduct ourselves in our roles as husbands or wives, brothers or sisters, parents or children. He call us to be knit together--with every part and member working properly--by the power of the Holy Spirit. Let his practical message of order and wholeness empower you. From the Trade Paperback edition.
On New Earth, a world based on a video role-playing game, fourteen-year-old Erik persuades his friends to aid him in some unusual gambits in order to save Erik's father from exile and safeguard the futures of each of their families.
The 'Sundara Kanda'--the seed-book or bija-kanda as it has been called, of the Ramayana of Valmiki--is here presented as an autonomous epic by itself, arranged under Seven Books. The verse form used is a 4-line unit in lieu of the Sanskrit anushtup sloka. I have attempted, however, neither a word-for-word translation, nor always a sloka-stanza correspondence. The span of thought often overflows the quatrain mould, thereby softening the metrical monotony.
Will Elise's love life be an epic win or an epic fail? At Coral Tree Prep in Los Angeles, who your parents are can make or break you. Case in point: As the son of Hollywood royalty, Derek Edwards is pretty much prince of the school-not that he deigns to acknowledge many of his loyal subjects. As the daughter of the new principal, Elise Benton isn't exactly on everyone's must-sit-next-to-at-lunch list. When Elise's beautiful sister catches the eye of the prince's best friend, Elise gets to spend a lot of time with Derek, making her the envy of every girl on campus. Except she refuses to fall for any of his rare smiles and instead warms up to his enemy, the surprisingly charming social outcast Webster Grant. But in this hilarious tale of fitting in and flirting, not all snubs are undeserved, not all celebrity brats are bratty, and pride and prejudice can get in the way of true love for only so long.
First memory. First kiss. First love. First fight. First heartbreak. There's a first time for everything. Discover five first-time authors with sneak peeks of their debut novels-Don't Turn Around by Michelle Gagnon, Breathe by Sarah Crossan, What's Left of Me by Kat Zhang, Through to You by Emily Hainsworth, and Defiance by C. J. Redwine.
Cassandra Pybus adds greatly to the work of [previous] scholars by insisting that slaves stand at the center of their own history . . . Her 'biographies' of flight expose the dangers that escape entailed and the courage it took to risk all for freedom. Only by measuring those dangers can the exhilaration of success be comprehended and the unspeakable misery of failure be appreciated.--Ira Berlin, from the ForewordDuring the American Revolution, thousands of slaves fled their masters to find freedom with the British. Epic Journeys of Freedom is the astounding story of these runaways and the lives they made on four continents. Having emancipated themselves, with the rhetoric about the inalienable rights of free men ringing in their ears, these men and women struggled tenaciously to make liberty a reality in their own lives.This alternative narrative of freedom fought for and won is uniquely compelling; historian Cassandra Pybus's groundbreaking research has uncovered individual stories of runaways who left America to forge difficult new lives in far-flung corners of the British Empire. Harry, for example, one of George Washington's slaves, escaped from Mount Vernon in 1776, was evacuated to Nova Scotia in 1783, and eventually relocated to Sierra Leone in West Africa with his wife and three children. Ralph Henry, who ran away from the Virginia firebrand Patrick Henry in 1776, took a similar path to precarious freedom in Sierra Leone, while others, such as John Moseley and John Randall, were evacuated with the British forces to England. Stranded in England without skills or patronage during a period of high unemployment, they were among thousands of newly freed poor blacks who struggled just to survive. While some were relocated to Sierra Leone, others, like Moseley and Randall, found themselves transported to the distant penal colony of Botany Bay, in Australia. Epic Journeys of Freedom, written in the best tradition of history from the bottom up, is a fascinating insight into the meaning of liberty; it will change forever the way we think about the American Revolution.From the Hardcover edition.
This is the first book to focus on Latin epic verse saints' lives in their medieval historical contexts. Anna Taylor examines how these works promoted bonds of friendship and expressed rivalries among writers, monasteries, saints, earthly patrons, teachers and students in Western Europe in the central Middle Ages. Using philological, codicological and microhistorical approaches, Professor Taylor reveals new insights that will reshape our understanding of monasticism, patronage and education. These texts give historians an unprecedented glimpse inside the early medieval classroom, provide a nuanced view of the complicated synthesis of the Christian and Classical heritages, and show the cultural importance and varied functions of poetic composition in the ninth, tenth and eleventh centuries.
A great king Enkidu is created by the gods to challenge the arrogant King Gilgamesh. But both become friends to slay the evil monster Humbaba. When Enkidu is killed, his death haunts and breaks the mighty Gilgamesh who resolves to find the secret of eternal life.
In swift, witty chapters that flawlessly capture the pace and character of New York City, acclaimed diarist Edward Robb Ellis presents his masterpiece: a thorough, and thoroughly readable, history of America's largest metropolis. Ellis narrates some of the most significant events of the past three hundred years and more-the Revolutionary and Civil Wars, Alexander Hamilton and Aaron Burr's fatal duel, the formation of the League of Nations, the Great Depression-from the perspective of the city that experienced, and influenced, them all. Throughout, he infuses his account with the strange and delightful anecdotes that a less charming tour guide might omit, from the story of the city's first, block-long subway to that of the blizzard of 1888 that turned Macy's into one big slumber party. Playful yet authoritative, comprehensive yet intimate, The Epic of New York City confirms the words of its own epigraph, spoken by Oswald Spengler: "World history is city history," particularly when that city is the Big Apple.
When Neil Armstrong and Buzz Aldrin walked on the moon in 1969, they personified an almost unimaginable feat-the incredibly complex task of sending humans safely to another celestial body. This extraordinary odyssey, which grew from the rivalry between the United States and the Soviet Union during the Cold War, was galvanized by the Sputnik launch in 1957. To mark the fiftieth anniversary of Sputnik, National Geographic recaptures this gripping moment in the human experience with a lively and compelling new account. Written by Smithsonian curator Von Hardesty and researcher Gene Eisman, Epic Rivalry tells the story from both the American and the Russian points of view, and shows how each space-faring nation played a vital role in stimulating the work of the other. Scores of rare, unpublished, and powerful photographs recall the urgency and technical creativity of both nations' efforts. The authors recreate in vivid detail the "parallel universes" of the two space exploration programs, with visionaries Wernher von Braun and Sergei Korolev and political leaders John F. Kennedy and Nikita Khrushchev at the epicenters. The conflict between countries, and the tense drama of their independent progress, unfolds in vivid prose. Approaching its subject from a uniquely balanced perspective, this important new narrative chronicles the epic race to the moon and back as it has never been told before-and captures the interest of casual browsers and science, space, and history enthusiasts alike.
The Epicenter of Crisis argues that six contiguous states epitomize the security challenges of a post-9/11, globalized world: Saudi Arabia, Syria, Iraq, Iran, Afghanistan, and Pakistan.
For ten years, Hugo Whittier, upper-class scion, former gigolo, failed belle-lettrist has been living a hermit's existence at Waverly, his family's crumbling mansion overlooking the Hudson. He passes the time reading Montaigne and M. F. K. Fisher, cooking himself delicious meals, smoking an endless number of cigarettes, and nursing a grudge against the world. But his older brother, Dennis, has returned, in retreat from an unhappy marriage, and so has his estranged wife, Sonia, and their (she claims) daughter, Bellatrix, shattering Hugo's cherished solitude. He's also been told by a doctor that he has the rare Buerger's disease, which means that unless he stops smoking he will die--all the more reason for Hugo to light up, because his quarrel with life is bitter and an early death is a most attractive prospect. As Hugo smokes and cooks and sexually schemes and pokes his perverse nose into other people's marriages and business, he records these events as well as his mordant, funny, gorgeously articulated personal history and his thoughts on life and mortality in a series of notebooks. His is one of the most perversely compelling literary personalities to inhabit a novel since John Lanchester'sThe Debt to Pleasure, and his ancestors include the divinely cracked and eloquent narrators of the works of Nabokov. As snobbish and dislikable as Hugo is, his worldview is so enticingly conveyed that even the most resistant reader will be put under his spell. His insinuating voice gets into your head and under your skin in the most seductive way. And as he prepares what may be his final Christmas feast for family and friends, readers will have to ask, "Is this the end of Hugo?" The Epicure's Lamentis a wry and witty novel about love and death and family, a major contribution to a vein of literature that the author Kate Christensen has dubbed "loser lit. " It more than fulfills the bright promise of her lavishly praised previous two novels, and gives us an antihero for our time--hard to like, impossible to resist.
For Epicurious's enormous and devoted community -- 7.5 million unique visitors a month -- and home cooks seeking a perfectly curated roster of diverse recipes, here are the top-rated recipes from Epi, compiled conveniently in a book with brand-new stunning colour photography. Epicurious.com is, undisputedly, the website for people who like to cook. Launched in the dark ages of 1995, Epi was one of the first on the block and is the go-to respected food site among home cooks. Now, The Epicurious Cookbook provides a completely new experience for Epi's fans with a perfectly curated roster of Epi's 300 best recipes organized seasonally for breakfasts, starters, mains, sides, breads, and desserts. The book includes new headnotes and 100 new photographs, plus dozens of member recipes that have been tested in Epi's kitchens. Throughout, readers will find clever substitutions, special holiday menus, and make-ahead tips, from Epi's editors and community alike.
Epicureanism after the generation of its founders has been characterised as dogmatic, uncreative and static. But this volume brings together work from leading classicists and philosophers that demonstrates the persistent interplay in the school between historical and contemporary influences from outside the school and a commitment to the founders' authority. The interplay begins with Epicurus himself, who made arresting claims of intellectual independence, yet also admitted to taking over important ideas from predecessors, and displayed more receptivity than is usually thought to those of his contemporaries. The same principles of autonomy and openness figure importantly in the three major areas of focus in these essays: theology, politics and the emotions.
From an esteemed child psychiatrist: a bold, fresh, and controversial look at the faddish child-rearing practices that have created a nation of children who are depressed, alienated, often amoral, and all too often violent. The shock of the Columbine shootings and other school violence has generated a national debate, and there's a dawning realization that something incomprehensible is happening: our privileged, pampered children are turning into monsters at an alarming rate. With years of study and first-hand experience, Dr. Robert Shaw exposes the roots of what he calls The Epidemic: the violence and the more subtle behaviour problems that are jeopardizing a generation. In this eye-opening book, Dr. Shaw explains that the "advanced" parenting methods experts have promoted for the last thirty years have helped to create a nation of children who are detached loners, unable to form meaningful relationships. From infancy through the teen years, Dr. Shaw provides a map back to sanity that tracks specific misguided parenting techniques and shows parents how to get and keep their children on track and create the environment necessary for a healthy psychological future. Some of the important ground Dr. Shaw covers includes: The myths and realities of bonding and attachment How to recognize when day care is working - and when it isn't Landmarks to look for in your children's moral and ethical development Self-centeredness versus self-esteem Keeping the media from mugging your child What can be done with a child who is out of control Dr. Shaw challenges us to confront a very real problem, then helps us take steps forward using common sense and humanity. The Epidemic calls us to become better parents--and feel better about the choices we make for our children.
A call for parents to take responsibility for their children and give them what they truly need in order to grow, thrive, and love. Take a good look around you: you can't go into stores or restaurants without seeing joyless children screaming and sulking while their parents ignore them. According to esteemed child psychiatrist Robert Shaw, this epidemic has become so much the norm that we often don't recognize its warning signs. This bold and timely book tells you how to save your child and your family--with a commonsense approach that cuts to the core of the problem and shows us the cure. The Epidemic covers: Developing your child's ability to love Managing child care and minimizing the damage Raising cooperative, joyful, and creative children Promoting self-esteem and confidence rather than self-centeredness Avoiding the harmful effects of electronic media Healing angry, contemptuous, withdrawn, and out-of-control children
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