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This is a problem solving handbook with topics from basic arithmetic to graphs and probability, wherein underlying processes and mathematical tools are infused throughout all lessons.
Kane and Harper know what they want: Beth and Adam. And they know how to get it: Break up the shiny happy couple once and for all. Miranda thinks she knows how to hit on Kane (Mr. Unattainable). But she could take a few pointers from the all-knowing Kaia, who's seducing Mr. Powell, teacher en franÇais. And Reed? Well, he just knows how to have a good time.... Know the feeling?
The Furies are back in the second book of a chilling paranormal trilogy where revenge rules the day--and "sorry" isn't going to cut it. Spring is coming, and the ice is slowly melting in Ascension...revealing the secrets buried beneath. Emily Winters knows the Furies have roots in Ascension, Maine--but she's about to discover that they're deeper than she ever imagined. With the help of her new friend Drea, she vows to dig them out. But it's hard to focus when she's desperate to make up with JD, and to figure out why Crow, a mysterious Ascension High dropout, seems to be shadowing her. Meanwhile, new girl Skylar McVoy is determined to leave her own dark past behind. So she's thrilled when popular Gabby takes her under her wing, and the stunning and sophisticated Meg offers to give her a major makeover. But everyone knows what happens to the vainest girl of all... It's tempting to be naughty. But beware: the Furies are always watching, and their power grows stronger by the day.
Explosive tale of a long-ago crime and the victim's plan for revenge. Takes place on a remote Georgia island.
The Seven Deadly Sins have sliced up the dictionary and taken what's theirs. No one vice is too greedy as each volume prides itself on having more than 500 entries. Word lovers will lust after these richly packaged volumes--and once you've collected all seven, you'll be the envy of all your friends. Envy: A Dictionary for the Jealous Everyone else will be turning green when the Envious reveal their desirable new vocabularies. From A to Z, each entry feeds the monster and makes it want that much more.
Jealous whispers. Old rivalries. New betrayals. Two months after Elizabeth Holland's dramatic homecoming, Manhattan eagerly awaits her return to the pinnacle of society. When Elizabeth refuses to rejoin her sister Diana's side, however, those watching New York's favorite family begin to suspect that all is not as it seems behind the stately doors of No. 17 Gramercy Park South. Farther uptown, Henry and Penelope Schoonmaker are the city's most celebrated couple. But despite the glittering diamond ring on Penelope's finger, the newlyweds share little more than scorn for each other. And while the newspapers call Penelope's social-climbing best friend, Carolina Broad, an heiress, her fortune-and her fame-are anything but secure, especially now that one of society's darlings is slipping tales to the eager press. In this next thrilling installment of Anna Godbersen's bestselling Luxe series, Manhattan's most envied residents appear to have everything they desire: Wealth. Beauty. Happiness. But sometimes the most practiced smiles hide the most scandalous secrets. . . .
With an eloquence and compassion reminiscent of James Baldwin's Letter to My Nephew, Ellis Cose presents a frank and realistic examination of the daunting challenges facing black men in twenty-first-century America and offers a way out of the cycle of defeatism and despair that wreaks havoc on America's black communities. Black men have never had more opportunity for success than they do today. Yet, as Ellis Cose bluntly puts it, "We are watching the largest group of black males in history stumbling through life with a ball and chain wrapped around their legs. If brought together in one incorporated region, the population of black males behind bars would instantly become the twelfth largest urban area in America." Add to that the ravages of AIDS, murder, poverty, and illiteracy, the raging anger between many black men and women, and the widening gap separating the black elite from the so-called underclass, and you have a prescription for a paralyzing pessimism. But even as he acknowledges the systemic obstacles that confront black men of all social strata, Ellis Cose refuses to accept them as reasons for giving up or giving in. In powerful and stirring prose, Cose rails against the historical worldview that has categorized academic achievement as a source of shame instead of pride in many black communities; he also outlines steps black males can take to enhance their odds for success. With insightful anecdotes about a broad range of black men -- from Franklin Raines, the first black man to run a Fortune 500 company, to unlettered ex-prisoners -- Cose documents the amazing journey the black race has made, and contemplates the challenges ahead. Both a warning of the vast social tragedy that is wasted black potential and a vital call to arms that can enable black men to reclaim their destiny, The Envy of the World is an honest and important book for anyone concerned about the future of America.
This book contains everything from Ferrari's bizarre relationship with his illegitimate son to his brilliant marketing of the famous Ferrari image; from his sordid affairs to his work with the fascists in the Second World War; from his fanatic passion for speed to his manipulative yet enormously successful management techniques. Also presents a complete inside history of high-performance cars and motor sports from the First World War to the present.
Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.
Whether the pursuit is commercially motivated or purely academic, engineering a novel biological catalyst is an enticing challenge. High-resolution protein structure analysis allows for rational alteration of enzyme function, yet many useful enzyme variants are the product of well-designed selection schemes or screening strategies. Enzyme Engineering: Methods and Protocols provides guidance to investigators wishing to create enzyme variants with desired properties. This detailed volume covers such topics as a simple method for generating site-specific mutations within bacterial chromosomes. It also highlights the engineering of two difference types of rare-cutting endonucleases that show great potential in gene therapy applications: The newest development is the emergence of TAL effector nucleases or TALENs. Chapters describe newly developed technologies in sufficient detail so that each method can be practiced in a standard molecular biology laboratory. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Enzyme Engineering: Methods and Protocols will be valuable for scientists with a budding interest in protein engineering as well as veterans looking for new approaches to apply in established discovery programs.
In the past decade, researchers have made tremendous progress in the field of enzyme stabilization, opening up new opportunities for enzymes in molecular biology and for industrial applications. In Enzyme Stabilization and Immobilization: Methods and Protocols, expert researchers explore the latest developments through detailed laboratory protocols, which address many different theories and techniques in enzyme stabilization. Chapters outline protocols for enzyme stabilization in solutions, including: liposome formation, micelle introduction, crosslinking, and additives. Secondly, the book contain protocols for enzyme stabilization via enzyme immobilization, such as sol-gel encapsulation, polymer encapsulation, and single enzyme nanoparticle formation. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, Enzyme Stabilization and Immobilization: Methods and Protocols is an essential handbook for all molecular biologists, biochemists, and biomedical and biochemical engineers.
Provides key information on a wide range of enzymes commonly used as tools in molecular biology, helping to minimize the time a scientist spends researching the literature to get reactions to work efficiently and allowing the nonenzymologist to design an experiment. Each chapter gives background information on the enzyme selected and those parameters important in its use, describes both the source and application of the enzyme, and provides details on the size and structure of the protein. Specific parameters essential for achieving an optimized reaction are discussed, along with exemplary practical procedures an protocols.
When an enormous asteroid enters the Earth's orbit, the remains of a vanished human civilization are discovered within that reveal the asteroid's futuristic origins and predict a catastrophic imminent Earth war.
Eon has been revealed as Eona, the first female Dragoneye in hundreds of years. Along with fellow rebels Ryko and Lady Dela, she is on the run from High Lord Sethon's army.
This volume provides a history of Eosinophilic Esophagitis (EoE), a basic understanding of the physiology of the eosinophil, and a current understanding of the pathophysiology and genetics of EoE. The emphasis is on clinical applications including presenting symptoms, diagnosis and treatment options for patients with EoE. Written by both pediatric and adult experts in the fields of gastroenterology, allergy and pathology, this volume includes the most up to date information. Providing practical information useful in the treatment of patients, this book will be of great value to gastroenterologists, allergists, pathologists, medical residents, fellows, internists, and general practitioners who treat patients with eosinophilic esophagitis.
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