- Table View
- List View
Over the last decade Life Science has undergone an accelerated evolution, culminating in the -omics era characterized by the development of a multitude of high throughput methods that are becoming more routinely applied in biochemistry labs. In Functional Genomics: Methods and Protocols, Second Edition expert researchers in the field detail many of the methods which are now commonly used for studies in the life sciences focusing on the dynamic aspects of the transcriptome, proteome and metabolome, respectively.Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Functional Genomics: Methods and Protocols, Second Edition seeks to aid scientists in establishing or extending technologies and techniques in their laboratories.
Regular physical exercise is associated with substantial health benefits. Recent evidence not only holds for cardiovascular effects promoting "physical health", but also for the central nervous system believed to promote "brain health". Moderate physical exercise has been found to improve learning, memory, and attentional processing, with recent research indicating that neuroprotective mechanisms and associated plasticity in brain structure and function also benefit. Physical exercise is also known to induce a range of acute or sustained psychophysiological effects, among these mood elevation, stress reduction, anxiolysis, and hypoalgesia. Today, modern functional neuroimaging techniques afford direct measurement of the acute and chronic relation of physical exercise on the human brain, as well as the correlation of the derived physiological in vivo signals with behavioral outcomes recorded during and after exercise. A wide range of imaging techniques have been applied to human exercise research, ranging from electroencephalography (EEG), magnetoencephalography (MEG), near infrared spectroscopy (NIRS), magnetic resonance imaging (MRI) to positron emission tomography (PET). All of these imaging methods provide distinct information, and they differ considerably in terms of spatial and temporal resolution, availability, cost, and associated risks. However, from a "multimodal imaging" perspective, neuroimaging provides an unprecedented potential to unravel the neurobiology of human exercise, covering a wide spectrum ranging from structural plasticity in gray and white matter, network dynamics, global and regional perfusion, evoked neuronal responses to the quantification of neurotransmitter release. The aim of this book is to provide the current state of the human neuroimaging literature in the emerging field of the neurobiological exercise sciences and to outline future applications and directions of research.
Today, functional programming is emerging from the shadows. It turns out that when you program imperatively (viewing variables as slots in memory with changeable values), you create programs that are difficult for you to reason about when concurrency is introduced. Furthermore, thread-based concurrency techniques have not proven to be effective in enabling developers to write scalable applications. Functional languages help solve these problems by discouraging you from changing the values of variables and by providing alternate concurrency mechanics, such as actors (message-passing objects). We have created a collection of books in this bibliography on the languages and libraries of modern industrial-strength functional programming. There are books on Scala, Haskell, Erlang, Clojure, F# and R. We've even listed books on applying functional techniques to work in normally-imperative languages, like C# and Java, and books to get you started if you don't know anything about functional programming. Finally, we've listed a few books on the libraries and frameworks that we think are most helpful in writing enterprise-grade applications in functional languages.
Software development today is embracing functional programming (FP), whether it's for writing concurrent programs or for managing Big Data. Where does that leave Java developers? This concise book offers a pragmatic, approachable introduction to FP for Java developers or anyone who uses an object-oriented language. Dean Wampler, Java expert and author of Programming Scala (O'Reilly), shows you how to apply FP principles such as immutability, avoidance of side-effects, and higher-order functions to your Java code. Each chapter provides exercises to help you practice what you've learned. Once you grasp the benefits of functional programming, you'll discover that it improves all of the code you write. Learn basic FP principles and apply them to object-oriented programming Discover how FP is more concise and modular than OOP Get useful FP lessons for your Java type design--such as avoiding nulls Design data structures and algorithms using functional programming principles Write concurrent programs using the Actor model and software transactional memory Use functional libraries and frameworks for Java--and learn where to go next to deepen your functional programming skills
This comprehensive introduction to the principles of functional programming using F# shows how to apply basic theoretical concepts to produce succinct and elegant programs. It demonstrates the role of functional programming in a wide spectrum of applications including databases and systems. Coverage also includes advanced features in the . NET library, the imperative features of F# and topics such as text processing, sequences, computation expressions and asynchronous computation. With a broad spectrum of examples and exercises, the book is perfect for courses in functional programming and for self-study. Enhancing its use as a text is an accompanying website with downloadable programs, lecture slides, a mini-projects and links to further F# sources.
Many patients with pulmonary complaints fail to improve despite physicians' best efforts. Sometimes, we ascribe this failure to lack of adherence with therapy, or to the severity of the condition. What we often fail to appreciate, however, is that sometimes the lack of improvement can be explained by the patients' psychological states. The first section of Functional Respiratory Disorders: When Respiratory Symptoms Do Not Respond to Pulmonary Treatment will help clinicians recognize functional respiratory symptoms that can arise as a result of both organic and psychological causes. The second section of this book provides detailed discussions of such disorders, links to video examples of laryngoscopic evaluation of patients with vocal cord issues, case studies and quizzes. Examples and exercises that should strengthen the clinician's confidence in identifying and treating these functional conditions are also provided. Finally, the third section of the book will help the clinician differentiate the patients for whom referral to a mental health provider is mandatory from those for whom other approaches may be useful. For the latter group, the book teaches clinicians to empower themselves by learning how to incorporate various therapies for functional disorders into their practice, including biofeedback, breathing techniques, basic cognitive behavioral therapy techniques, and hypnosis. Links are provided to instructive video examples of biofeedback, hypnosis, and speech therapy. Practical strategies for obtaining training in these modalities are provided in the appendix. Functional Respiratory Disorders: When Respiratory Symptoms Do Not Respond to Pulmonary Treatment is an important new book that will help clinicians consider the possible impact of functional contributions to the clinical presentation of every patient with respiratory symptoms and identified respiratory disease.
Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.
This edition provides an alternative to a traditional college algebra course for students who either will not take another math course or may go on to a business calculus course. An informal approach offers clear explanations that leave out unnecessary technicalities so that students who are not comfortable with algebra will easily understand the concepts.
This is a new edition of the precalculus text developed by the Consortium based at Harvard University and funded by a National Science Foundation Grant. The text is thought-provoking for well-prepared students while still accessible to students with weaker backgrounds. It provides numerical and graphical approaches as well as algebraic approaches to give students another way of mastering the material. This approach encourages students to persist, thereby lowering failure rates. A large number of real-world examples and problems enable students to create mathematical models that will help them understand the world in which they live. The focus is on those topics that are essential to the study of calculus and these topics are treated in depth. Linear, exponential, power, and periodic functions are introduced before polynomial and rational functions to take advantage of their use to model physical phenomena. Building on the Consortium's Rule of Four: Each function is represented symbolically, numerically, graphically, and verbally where appropriate.
Functions, Statistics, and Trigonometry (The University of Chicago School Mathematics Project, 3rd Edition)by John W. Mcconnell Susan A. Brown Paul J. Karafiol Sara Brouwer Mary Ives Marshall Lassak Rosa Mccullagh Natalie Jakucyn Zalman Usiskin
The text has been developed by the Secondary Component of the project, and constitutes the core of the sixth year in a seven-year middle and high school mathematics curriculum. All lessons have been reviewed and examined afresh for this edition but the overall content and mathematical prerequisites are the same as in previous editions. New instructional features for this edition include: a Big Idea, Mental Math questions, Activities, Guided Examples, and Quiz Yourself (QY).
With 55 years of success in the principles of accounting market, Fundamental Accounting Principles, 21e by Wild, Shaw and Chiappetta has endured and adapted to changes in accounting, technology, and student learning styles. Its innovation is reflected in its extensive use of small business examples, the integration of new technology learning tools, superior end-of-chapter material, and a highly engaging, pedagogical design.
Fundamental Aspects of Plasma Chemical Physics: Transport develops basic and advanced concepts of plasma transport to the modern treatment of the Chapman-Enskog method for the solution of the Boltzmann transport equation. The book invites the reader to consider actual problems of the transport of thermal plasmas with particular attention to the derivation of diffusion- and viscosity-type transport cross sections, stressing the role of resonant charge-exchange processes in affecting the diffusion-type collision calculation of viscosity-type collision integrals. A wide range of topics is then discussed including (1) the effect of non-equilibrium vibrational distributions on the transport of vibrational energy, (2) the role of electronically excited states in the transport properties of thermal plasmas, (3) the dependence of transport properties on the multitude of Saha equations for multi-temperature plasmas, and (4) the effect of the magnetic field on transport properties. Throughout the book, worked examples are provided to clarify concepts and mathematical approaches. This book is the second of a series of three published by the Bari group on fundamental aspects of plasma chemical physics. The first book, Fundamental Aspects of Plasma Chemical Physics: Thermodynamics, is dedicated to plasma thermodynamics; and the third, Fundamental Aspects of Plasma Chemical Physics: Kinetics, deals with plasma kinetics.
A definitive text in neuroscience.
This book distills the essential elements of world politics, both the enduring characteristics as well as the revolutionary changes that may be altering the very fabric of the centuries-old state system. Author J. Martin Rochester explores all the important topics that one would expect to find in an IR text (war, diplomacy, foreign policy, international law and organization, the international economy, and more) but injects fresh perspectives on how globalization and other contemporary trends are affecting these issues. In addition, the author does so through a highly engaging, lively writing style that will appeal to today's students. Fundamental Principles of International Relations is a tightly woven treatment of international politics past and present, drawing on the latest academic scholarship while avoiding excessive jargon and utilizing pedagogical aids while avoiding clutter. Rochester ultimately challenges the reader to think critically about the future of a post-Cold War and post-9/11 world that is arguably more complex, if not more dangerous, than some previous eras, with the potential for promise as well as peril.
Cross-cultural psychology has come of age as a scientific discipline, but how has it developed? The field has moved from exploratory studies, in which researchers were mainly interested in finding differences in psychological functioning without any clear expectation, to detailed hypothesis tests of theories of cross-cultural differences. This book takes stock of the large number of empirical studies conducted over the last decades to evaluate the current state of the field. Specialists from various domains provide an overview of their area, linking it to the fundamental questions of cross-cultural psychology such as how individuals and their cultures are linked, how the link evolves during development, and what the methodological challenges of the field are. This book will appeal to academic researchers and post-graduates interested in cross-cultural research.
Many Americans today are taking note of the strong political force that is the religious right. Controversial decisions by the government are met with hundreds of lobbyists, millions of dollars of advertising spending, and a grassroots response.
Why, from Reagan to George Bush, have fundamentalists in religion and in law (originalists) exercised such political power and influence in the United States? Why has the Republican Party forged an ideology of judicial appointments (originalism) hostile to abortion and gay rights? Why and how did Barack Obama distinguish himself among Democratic candidates not only by his opposition to the Iraq war but by his opposition to originalism? This book argues that fundamentalism in both religion and law threatens democratic values and draws its appeal from a patriarchal psychology still alive in our personal and political lives and at threat from the constitutional developments since the 1960s. The argument analyzes this psychology (based on traumatic loss in intimate life) and resistance to it (based on the love of equals). Obama's resistance to originalism arises from his developmental history as a democratic, as opposed to patriarchal, man who resists the patriarchal demands on men and women that originalism enforces - in particular, the patriarchal love laws that tell people who and how and how much they may love.
Fundamentalism is seen as the major threat to world peace today, a conclusion impossible to ignore since the events in New York on September 11, 2001. But what does "fundamentalism" really mean? Since it was coined by American Protestant evangelicals in the 1920s, the use of the term "fundamentalist" has expanded to include a diverse range of radical conservatives and ideological purists, not all religious. Fundamentalism could now mean both militant Israeli settlers as well as the Islamist radicals who oppose them, it can mean Christians, Hindus, animal liberationists, and even Buddhist nationalists. Here, Middle East expert Malise Ruthven investigates fundamentalism's historical, social, religious, political, and ideological roots, and tackles the polemic and stereotypes surrounding this complex phenomena--one that eludes simple definition, yet urgently needs to be understood.
This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.
The third edition of Fundamentals of Anaesthesia is the gold standard text for the Primary FRCA, encapsulating the basic principles of modern anaesthesia in one easily accessible volume. Written and edited by a team of expert contributors with extensive FRCA examination experience, Fundamentals of Anaesthesia, Third Edition deliberately blends the expertise of invited authors in an unrivalled consistency of style more akin to that of a single author text. Deliberate use of authors with a more general anaesthesia background ties in well with the education of anaesthetists in their early years. The third edition is fully updated, with a number of completely new chapters. Presentation of information is clear and concise, with extensive use of tables, colour illustrations, summary boxes of key information and bullet lists. This Highly Commended award winning textbook is a unique revision aid for the Primary FRCA and an essential companion for all exam candidates.
This text is the central component of an integrated learning system that includes the Atlas, Applications Manual, Interactive CD and Website. Designed to work together, all components of the package are linked by cross-references. Students are given clear directions to resources in other components.
Designed for allied health learners with little or no biology knowledge, this full-color book is a comprehensive introduction to anatomy & physiology. It is organized according to body systems, and focuses on the body working together to promote homeostasis. Chapters are self-contained so instructors can teach in any order preferred. Essential laboratory exercises included at the end of chapters provide hands-on lab experience. Key terms with phonetic pronunciations help build vocabulary. Free interactive CD-ROM encourages mastery of content through quizzes, games, and animations.
- Embossed Braille - Use Bookshare’s DAISY Text or BRF formats to generate embossed braille.