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A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis has challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the inherent ability to form tumors and metastasize. This book discusses the emerging field of cancer stem cell research, with contributions from leading experts on the basic biology, genetic pathways, and potentials for therapeutic targeting of cancer stem cells. It also covers clinical challenges for these new discoveries, namely, that cancer stem cells might be resistant to conventional chemotherapeutic and radiological treatments and may be at the biological core of relapse and therapeutic resistance. This book is an essential concise guide to the latest discoveries and therapies in cancer research.
Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.
A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.
Cancer Talk: Voices of Hope and Endurance from "The Group Room," the World's Largest Cancer Support Groupby Barry Fox Selma R. Schimmel
For the first time,Cancer Talkprovides a support group in a book. Research shows that cancer patients who attend support groups can survive longer and lead fuller lives than patients receiving medical treatment alone. Cancer Talk, based on "The Group Room®," the nation's only talk-radio cancer support show, brings hope, information, and inspiration to everyone affected by cancer. Show host Selma Schimmel, a cancer advocate and longtime survivor, has gathered the voices of cancer patients and survivors, family and friends, physicians, therapists, and other healthcare professionals to create an invaluable guide to help you: Deal with the wide range of emotions a cancer diagnosis provokes Cope with relationships, intimacy, and physical changes Optimize the doctor-patient relationship and navigate treatment options Handle the side effects of treatment Understand legal, workplace, and insurance issues Live with and beyond cancer Anyone whose life has been touched by cancer will find new support from the intimate and empowering voices of the only real experts out there--the people who live with cancer.
"Cancer Ward" examines the relationship of a group of people in the cancer ward of a provincial Soviet hospital in 1955, two years after Stalin's death. We see them under normal circumstances, and also reexamined at the eleventh hour of illness. Together they represent a remarkable cross-section of contemporary Russian characters and attitudes. The experiences of the central character, Oleg Kostoglotov, closely reflect the author's own: Solzhenitsyn himself became a patient in a cancer ward in the mid-1950s, on his release from a labor camp, and later recovered. Translated by Nicholas Bethell and David Burg.
Whether you are a cancer patient undergoing treatment, a caregiver, or a survivor, you'll find this cookbook and nutritional guide essential--it includes the latest scientific research on improving the lives of people living with cancer. Created by Seattle's Cancer Lifeline, The Cancer Wellness Cookbook features nutritional plans and 100 recipes focusing on the foods that have been shown to prevent and forestall the spread of cancer. With super healthy and delicious ingredients like berries, mushrooms, beans, tomatoes, and fish, these dishes taste great and are filled with the nutrients that aid a person undergoing chemotherapy and other cancer treatments.
Everybody wants their home's main living space to meet the needs of the whole family--and look great doing it. HGTV star Candice Olson is an expert in showing clients how a room can have many functions while still looking pulled-together and polished, and this book showcases a collection of her family room redos that is sure to inspire. Chock full of tips and ideas, Candice Olson Family Spaces features hundreds of full-color, before-and-after photos of Candice's stunning family room makeovers. Plus, you'll get access to her artful room sketches and design boards and insight into how each design took shape, giving you unprecedented guidance for planning your own family room renovation. Explains how good design accommodates all members of the family and their daily activities. Designs offer functionality, durability, and comfort without sacrificing style. As a busy mother of two, Candice brings valuable insight to what a family really needs from the spaces they share. Redecorating--or even just dreaming about decorating--can transform one's outlook on life, and Candice Olson Family Spaces is the catalyst to get readers off the couch and down to the upholstery store.
Popular TV star Candice Olson shares her favorite design challenges. Candice Olson Favorite Design Challenges focuses on the tricky situations that Candice expertly handles for her clients--the same challenges that many homeowners face. From working around architectural limitations like sloped ceilings or a lack of wall space, merging styles to ensure that a room's decor pleases all of a home's occupants, to accommodating the changes that come about when a family grows or shrinks, this book highlights those ingenious solutions that make Candice's designs both beautiful and functional.Featuring 25-30 of Candice's stunning room makeovers--described in her approachable and authoritative voice--Candice Olson Favorite Design Challenges provides gorgeous sketches and design boards that show you how each design took shape, while more than 200 full-color before-and-after photos offer a wealth of visual inspiration.Includes Candice's tips and insight into what makes each space workCandice shares how she overcame the predominant challenge in each caseProvides invaluable guidance on planning your own room redosRedecorating--or even just dreaming about decorating--can transform one's outlook on life, and Candice Olson Favorite Design Challenges is just what you need to dream, plan, and execute up a redo in your own home.
The seminal work for patients on causes, prevention, and cures for candida, yeast, and fungal infections. The author discusses the immune system, lifestyle, mercury fillings, major illnesses, self-help, antibiotics, medications, vaginal thrush, yeasts, alcohol, and much more. Matching treatments and tips abound throughout this encompassing, informative, and easy-to-read patient's book.
FEEL BETTER FAST!Follow the powerful detox in this book and you'll be rejuvenated in no time. By quickly killing the excessive candida inside your body, this cleanse ends the pain, tiredness, bloating and other health problems caused by the fungus. The 21-day program completely avoids the foods that allow candida to grow inside you, starving the fungus without starving you! After three short weeks, you'll experience a revolutionary transformation in how you feel and look. With the Candida Cleanse, you will: Lose weight Increase energy revitalize your skin Improve digestion
The Candidate is a beginning word processing simulation that is designed to develop word processing skills while completing tasks such as formatting letters, memorandums, tables, press releases, and reports.
A suspense novel set in the world of politics. With her father running for governor of Texas, Cary is determined to find out why she appears to be in danger. "Nixon is back doing the kind of book she does best... an inviting read." --Booklist
Kate Goodspeed was the perfect wife and mother, paving the way for her husband Luke's political career, burying secrets before they could erupt into scandal. At the first sign of trouble, she and Luke and their team of advisors would pull together to protect his carefully controlled image. Now Luke's running for the highest office in the nation, and Kate has a secret more devastating than anyone could ever know. For the first time, she cannot turn to her husband or his aides for help. With growing anxiety, she realizes if the explosive truth ever gets out, it will destroy not just Luke's candidacy, but everything she's ever loved, including her marriage and the family she cherishes. Alone and scared in the heat of crisis, Kate must find the courage to make the toughest decision of her life.
Candide, ou l'Optimisme (1759) is a French satire by the Enlightenment philosopher Voltaire, English translations of which have been titled Candide: Or, All for the Best (1759); Candide: Or, The Optimist (1762); and Candide: Or, Optimism (1947). The novella begins with a young man, Candide, who is living a sheltered life in an Edenic paradise and being indoctrinated with Leibnizian optimism (or simply optimism) by his tutor, Pangloss. The work describes the abrupt cessation of this existence, followed by Candide's slow, painful disillusionment as he witnesses and experiences great hardships in the world. Voltaire concludes with Candide, if not outright rejecting optimism, advocating an enigmatic precept, "we must cultivate our garden", in lieu of the Leibnizian mantra of Pangloss, "all is for the best in the best of all possible worlds". Candide is known for its sarcastic tone and its erratic, fantastical, and fast-moving plot. With a story similar to that of a more serious bildungsroman or picaresque novel, it parodies many adventure and romance clichés, the struggles of which are caricatured in a tone that is mordantly matter-of-fact. Still, the events discussed are often based on historical happenings, such as the Seven Years' War and the 1755 Lisbon earthquake. As philosophers of Voltaire's day contended with the problem of evil, so too does Candide in this short novel, albeit more directly and humourously. Voltaire ridicules religion, theologians, governments, armies, philosophies, and philosophers through allegory; most conspicuously, he assaults Leibniz and his optimism. Excerpted from Wikipedia, the free encyclopedia. [This text is listed as an example that meets Common Core Standards in English language arts in grades 9-10 at http://www.corestandards.org.]
Candide, Voltaire's biting portrayal of eighteenth-century European society, is a central text of the Enlightenment and essential reading for history students today. Preserving the text's provocative nature, Daniel Gordon's new translation enhances Candide's read-ability and highlights the text's wit and satire for twentieth-century readers. The introduction places the work and its author in historical context, showing students how the complexities of Voltaire's life relate to the events, philosophy, and characters of Candide. A related documents section -- with personal correspondence to and from Voltaire -- gives students another lens through which to view this influential thinker. Helpful editorial features include explanatory notes throughout the text and a chronology of Voltaire's life.
Voltaire's brilliant satire, in the original French, with a new and exacting English translation on the opposing page. Through the adventures of Candide, we experience life's most crushing misfortunes, see the redeeming wisdom those misfortunes can bring -- all the while enjoying Voltaire's witty burlesque of human excess.
David Wootton's scalpel-sharp translation of Candide features a brilliant Introduction, a map of Candide's travels, and a selection of those writings of Voltaire, Leibniz, Pope and Rousseau crucial for fully appreciating this eighteenth-century satiric masterpiece that even today retains its celebrated bite.
Evergreen in its appeal, Candide makes us laugh at human folly and marvel at our reluctance to face reality and the truth. Voltaire's brilliant satire, first published in Paris in 1759, is relentless and unsparing. Virtue and vice, religion and romance, philosophy and science -- all are fair game. Through the adventures of young Candide, his love Cunégonde, and his mentor Dr. Pangloss, we experience life's most crushing misfortunes. And we see the redeeming wisdom those misfortunes can bring -- all the while enjoying Voltaire's witty burlesque of human excess. In this unique volume, readers who wish to follow every nuance of Voltaire's classic tale in the original French can do so with the aid of a new and exacting English translation on facing pages. Shane Weller's critical introduction illuminates the satire of Candide and the reasons for its enduring appeal.
This book presents an annotated edition of the story of a simple, optimistic man whose travels take him from one disaster to another; and includes backgrounds, a selection of critical essays, and a summary of the debate surrounding Voltaire's works. [This text is listed as an example that meets Common Core Standards in English language arts in grades 9-10 at http://www.corestandards.org.]
This essential collection from the genius Voltaire includes his masterpiece and best-known work Candide, as well as his novel Zadig and fourteen short stories: "Micromegas," "The World as It Is," "Memnon," "Bababec and the Fakirs," "History of Scarmentado's Travels," "Plato's Dream," "Account of the Sickness, Confession, Death, and Apparition of the Jesuit Berthier," "Story of a Good Brahman," "Jeannot and Colin," "An Indian Adventure," "Ingenuous," "The One-Eyed Porter," "Memory's Adventure," "Count Chesterfield's Ears," and "Chaplain Goudman." Translated by Donald M. Frame, with notes and introduction by John Iverson.
In the wake of the Meme Wars that swept the world two generations before, fifty-five-year-old Currie Curran, his wife, and almost everyone on Earth have in their minds a copy of Resuna, biological ' software that grants its users limited telepathy and enforces f a kind of universal cooperativeness within the global collective of "One True." In his younger days, Currie hunted "cowboys"--people who had unplugged from the global net in order to evade One True. Now Currie is called back from retirement and charged with the task of capturing Lobo, the last cowboy still at large. Thoroughly equipped, comprehensively connected to the global net, Currie set out to bring Lobo in. Instead, Lobo captures Currie and manages to deprogram him. Thrown back on his own natural intelligence and courage for the first time in twenty-five years, Currie finds himself in a battle of minds with his captor...with results that will change the lives of everyone on Earth.
Continually rated as one of the best vegan restaurants in the country, Candle 79 is at the forefront of a movement to bring elegance and sophistication to vegetarian cuisine. Not only is its fare local, seasonal, organic, and sustainable, but also so flavorful and satisfying that customers--vegan and omnivore alike--are constantly asking for recipes to cook at home. This collection answers that call, with simple yet impressive recipes for Chickpea Crepes, Ginger-Seitan Dumplings, Live Lasagna, Chocolate Mousse Towers, Cucumber-Basil Martinis, and more. Expanding the horizons of vegan fare with appetizers, soups, salads, mains, brunches, desserts, cocktails, and wine pairings, Candle 79 Cookbook invites every home cook to make truly green cuisine.
An intriguing medieval mystery featuring Brother Athelstan February, 1381. London lies frozen in the grip of one of the bitterest winters on record. The ever-rising taxes demanded by the Regent, John of Gaunt, are causing increasing resentment among the city's poor. When the seething unrest boils over into a bloody massacre at a splendid Southwark tavern, The Candle Flame, in which nine people, including Gaunt's tax collectors, their military escort and the prostitutes entertaining them, are brutally murdered, the furious Regent orders Brother Athelstan to get to the bottom of the matter. For not only has Gaunt's treasure trove been stolen, he has reason to believe a French spy is active along the Thames, carefully recording for his masters in the Louvre the state of English war cogs. And a professional assassin, Beowulf, who has sworn vengeance against Gaunt and his minions, also stalks the shadows. Once again, Athelstan must enter the murky world of murder, where the darkness constantly shifts and no one is who or what they seem.
Nurse Roberta, with whom he is staying, suggests that they trim a Christmas tree at his house. Shortly after they begin, Nurse Roberta is called away on an emergency. A sweet story for the holiday.
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