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Discover an enhanced synthetic approach to developing and screening chemical compound librariesDiversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book:Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocyclesExpands on the concept of diversity-oriented synthesis by describing chemical librariesProvides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assaysPresents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical researchThis book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications.Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Between every man and every woman there is a wilderness called the divide
A scathing portrait of an urgent new American crisis Over the last two decades, America has been falling deeper and deeper into a statistical mystery: Poverty goes up. Crime goes down. The prison population doubles. Fraud by the rich wipes out 40 percent of the world's wealth. The rich get massively richer. No one goes to jail. In search of a solution, journalist Matt Taibbi discovered the Divide, the seam in American life where our two most troubling trends--growing wealth inequality and mass incarceration--come together, driven by a dramatic shift in American citizenship: Our basic rights are now determined by our wealth or poverty. The Divide is what allows massively destructive fraud by the hyperwealthy to go unpunished, while turning poverty itself into a crime--but it's impossible to see until you look at these two alarming trends side by side. In The Divide, Matt Taibbi takes readers on a galvanizing journey through both sides of our new system of justice--the fun-house-mirror worlds of the untouchably wealthy and the criminalized poor. He uncovers the startling looting that preceded the financial collapse; a wild conspiracy of billionaire hedge fund managers to destroy a company through dirty tricks; and the story of a whistleblower who gets in the way of the largest banks in America, only to find herself in the crosshairs. On the other side of the Divide, Taibbi takes us to the front lines of the immigrant dragnet; into the newly punitive welfare system which treats its beneficiaries as thieves; and deep inside the stop-and-frisk world, where standing in front of your own home has become an arrestable offense. As he narrates these incredible stories, he draws out and analyzes their common source: a perverse new standard of justice, based on a radical, disturbing new vision of civil rights. Through astonishing--and enraging--accounts of the high-stakes capers of the wealthy and nightmare stories of regular people caught in the Divide's punishing logic, Taibbi lays bare one of the greatest challenges we face in contemporary American life: surviving a system that devours the lives of the poor, turns a blind eye to the destructive crimes of the wealthy, and implicates us all.Praise for The Divide "These are the stories that will keep you up at night. . . . The Divide is not just a report from the new America; it is advocacy journalism at its finest."--Los Angeles Times Praise for Matt Taibbi's Griftopia "A stinging new history of the financial crisis that heralds a return of Menckenesque, dirt-under-the-fingernails American journalism."--GQ "A relentlessly disturbing, penetrating exploration of the root causes of the trauma that upended economic security in millions of American homes . . . a full-scale indictment of Wall Street and Washington."--The New York Times Book Review "Matt Taibbi is [Hunter S.] Thompson's heir. . . . [Griftopia] is the most lucid, justifiably angry description of what happened and what continues to happen to our nation's economy."--Seattle Post-Intelligencer "Taibbi chronicles the corruption of the political process with indignation and dark humor. The takeaway? Be angry, but blame the right culprits."--TimeFrom the Hardcover edition.
#1 New York Times bestselling phenomenon Tom Clancy delivers an all-new, original novel, Op Center: Divide and Conquer. Shadowy elements within the State Department secretly cause tensions to flare between Iran and the former Soviet republic of Azerbaijan. They hope to start a shooting war to increase their own power and profit. At the same time, the conspirators decide to up the ante - by deposing the president of the United States. In a treacherous scheme, they convince the president that he is mentally unstable, and a silent coup d'etat is within their reach. Now, Paul Hood and the members of Op-Center must race against the clock to prevent the outbreak of war, save the honor of the president - and expose the traitors.
Two backcountry skiers find the body of a young woman embedded in the ice of a remote mountain creek. All through the night police work with arc lights and chainsaws to prise her out. Identifying her doesn't take so long. Abbie Cooper is wanted for murder and her picture is on law enforcement computers all across America. But how did she die? And what was the trail of events that led this golden child of a loving family so tragically astray?From the number one bestselling author of The Horse Whisperer, master storyteller Nicholas Evans, comes this powerful new novel, an epic thriller of the human heart. In a journey of discovery and redemption, from the streets of New York to the daunting grandeur of the Rocky Mountains, it tells the heart-rending tale of a family fractured by divorce. As both parents and children struggle in search of lost happiness, some devastating truths unravel. The Divide is the story of a great love betrayed and of the yearnings and needs, the dashed hopes and disillusionments that connect and separate all men and women.
Since 2000, approximately 440,000 Mexicans have migrated to the United States every year. Tens of thousands have left children behind in Mexico to do so. For these parents, migration is a sacrifice. What do parents expect to accomplish by dividing their families across borders? How do families manage when they are living apart? More importantly, do parents' relocations yield the intended results? Probing the experiences of migrant parents, children in Mexico, and their caregivers, Joanna Dreby offers an up-close and personal account of the lives of families divided by borders. What she finds is that the difficulties endured by transnational families make it nearly impossible for parents' sacrifices to result in the benefits they expect. Yet, paradoxically, these hardships reinforce family members' commitments to each other. A story both of adversity and the intensity of family ties, "Divided by Borders " is an engaging and insightful investigation of the ways Mexican families struggle and ultimately persevere in a global economy.
Puzzled by signs warning you to "mind the gap" in the London Underground? Wondering what will be on your plate if you order "toad in the hole" in a London café? In Divided by a Common Language, Christopher Davies explains these expressions and discusses the many differences in pronunciation, spelling, and vocabulary between British and American English. He compares the customs, manners, and practical details of daily life in the United Kingdom and the United States, and American readers will enjoy his account of American culture as seen through an Englishman's eyes. Davies tops it off with an amusing list of expressions that sound innocent enough in one country but make quite the opposite impression in the other. Two large glossaries help travelers translate from one variety of English to the other, and additional lists explain the distinctive words of Australia, New Zealand, and South Africa. Divided by a Common Language is the ideal travel companion for both British visitors to the U. S. and American visitors to the U. K. It is also the perfect book for Britons interested in American culture and Americans enjoying British novels, movies, and television at home.
The hunter becomes the hunted. . . . West Grayer is done killing. She defeated her Alternate, a twin raised by another family, and proved she's worthy of a future. She's ready to move on with her life. The Board has other plans. They want her to kill one last time, and offer her a deal worth killing for. But when West recognizes her target as a ghost from her past, she realizes she's in over her head. The Board is lying, and West will have to uncover the truth of the past to secure her future. How far will the Board go to keep their secrets safe? And how far will West go to save those she loves? With nonstop action and surprising twists, Elsie Chapman's intoxicating sequel to Dualed reveals everything.Praise for Dualed:"A gripping, thought-provoking thriller that keeps your heart racing and your palms sweaty. . . . The kind of book Katniss Everdeen and Jason Bourne would devour." --Andrew Fukuda, author of the Hunt series "Full of unexpected turns. . . . Fans of the Divergent trilogy will want to read this imaginative tale." --VOYA "A fast ride from first to final pages, Dualed combines action and heart." --Mindy McGinnis, author of Not a Drop to Drink "Intense and swift, Dualed grabbed me by the throat and kept me turning pages all the way to the end. Romance and action fans alike will love it." --Elana Johnson, author of the Possession series "Stylish, frenetic, and violent, . . . the textual equivalent of a Quentin Tarantino movie."--Publishers Weekly "A double dose of intensity and danger in this riveting tale of survival, heartache, and love."--Kasie West, author of Pivot Point "This thought-provoking survival-of-the-fittest story will leave you breathless for more." --Ellen Oh, author of Prophecy "Clever suspense--here, stalking is a two-way street." --Kirkus Reviews
From the Pulitzer Prize-winning author of William Cooper's Town comes a dramatic and illuminating portrait of white and Native American relations in the aftermath of the American Revolution. The Divided Ground tells the story of two friends, a Mohawk Indian and the son of a colonial clergyman, whose relationship helped redefine North America. As one served American expansion by promoting Indian dispossession and religious conversion, and the other struggled to defend and strengthen Indian territories, the two friends became bitter enemies. Their battle over control of the Indian borderland, that divided ground between the British Empire and the nascent United States, would come to define nationhood in North America. Taylor tells a fascinating story of the far-reaching effects of the American Revolution and the struggle of American Indians to preserve a land of their own.
What do Levittown, the 1939 World's Fair, and the Model T have in common? To what invention can the existence of suburban sprawl, toll booths, mall shopping, an oil-obsessed foreign policy, fast food, and air and noise pollution be attributed? The interstate highway. This landmark enterprise of the 1950s literally changed the face of America for eternity. In 1919, Dwight D. Eisenhower needed sixty-two days to travel from Washington, D. C. , to San Francisco. Now, eighty years and 42,500 miles of paved roads later, the trip can be made in less than seventy-two hours. Divided Highways is the fascinating history behind the efforts to make cement trails across America, told through the stories of the people who dreamed up, mapped out, paved'and even tried to stop'the interstate highways. Popular historian Tom Lewis details "man's triumph over nature" in an engaging, sweeping style. Award-winning film director Ken Burns says: "He tells the story of how we get from point A to point B in America. And just as our lives should be, Lewis makes the journey more interesting and meaningful than the destination. " * Basis of the 1997 Peabody Award-winning PBS documentary.
"She wanted him to die. A slow, withering, agonizing death. Nobody cheated on Reva Ewing." Roarke's security specialist Reve Ewing is the prime suspect in a double homicide - accused of killing her adulterous husband and his lover. But despite having every reason for wanting both of them dead, Reva protests her innocence and Lieutenant Eve Dallas believes her. At the time of the murders, Reva's husband's computer system was also sabotaged. To Roarke, it's the computer attack that poses the real threat. Roarke Industries have been working on a top secret government contract to develop a program that would shield against a new breed of hackers. The Doomsday Group are techno-terrorists who attack systems, steal data, and kill anyone who gets too close.
The book that will change the way we think about health and illness, The Divided Mind is the crowning achievement of Dr. John E. Sarno's distinguished career as a groundbreaking medical pioneer, going beyond pain to address the entire spectrum of psychosomatic (mindbody) disorders. The interaction between the generally reasonable, rational, ethical, moral conscious mind and the repressed feelings of emotional pain, hurt, sadness, and anger characteristic of the unconscious mind appears to be the basis for mindbody disorders. The Divided Mind traces the history of psychosomatic medicine, including Freud's crucial role, and describes the psychology responsible for the broad range of psychosomatic illness. The failure of medicine's practitioners to recognize and appropriately treat mindbody disorders has produced public health and economic problems of major proportions in the United States. One of the most important aspects of psychosomatic phenomena is that knowledge and awareness of the process clearly have healing powers. Thousands of people have become pain-free simply by reading Dr. Sarno's previous books. How and why this happens is a fascinating story, and is revealed in The Divided Mind.
Growing up in the 1950s, Carolyn Spiro was always in the shadow of her more intellectually dominant and socially outgoing twin, Pamela. But as the twins approached adolescence, Pamela began to succumb to schizophrenia, hearing disembodied voices and eventually suffering many breakdowns and hospitalizations. Divided Minds is a dual memoir of identical twins, now in their fifties, one of whom faces a life sentence of schizophrenia, and the other who becomes a psychiatrist, after entering the spotlight that had for so long been focused on her sister. Told in the alternating voices of Carolyn and Pamela, Divided Minds is a heartbreaking account of the far reaches of madness, as well as the depths of ambivalence and love between twins. It is a true and unusually frank story of identical twins with very different identities and wildly different experiences of the world around them.
Dr. Laing's first purpose is to make madness and the process of going mad comprehensible.
In this intimate biography of the Prince of Soul, David Ritz provides a candid look at a star and a friend. Ritz had been working on Gaye's story for several years before the singer's tragic death, and had conducted a series of extraordinary interviews in which Gaye discussed his deepest secrets. Drawing from these interviews, Gaye's life is recounted in his own words and the words of those who knew him best: his family, friends, and colleagues. What emerges is a full-scale portrait of a charming but tortured artist, a brilliant singer with a divided soul. Here is Marvin's story, from his early years as an abused child in the slums of Washington, D. C. , through his rise to the top of the Motown industry, his fall from grace, and his comeback, to his death at the hands of his own father. But it is also the story of his music, and the music of Black America over the past four decades-from gospel to doo-wop to soul to funk. The result is an epic tale whose cast of characters includes Diana Ross, Berry Gordy, Smokey Robinson, and Stevie Wonder, among others. The definitive biography of an enormously gifted and sensitive man, Divided Soul takes us deep into the life and music of one of America's most soulful-and most troubled-singers.
In this wrenching sequel to DIVIDED WE FALL, Danny and friends fight to defend Idaho against a Federal takeover and the ravages of a BURNING NATION. At the end of DIVIDED WE FALL, Danny Wright's beloved Idaho had been invaded by the federal government, their electricity shut off, their rights suspended. Danny goes into hiding with his friends in order to remain free. But after the state declares itself a Republic, Idaho rises to fight in a second American Civil War, and Danny is right in the center of the action, running guerrilla missions with his fellow soldiers to break the Federal occupation. Yet what at first seems like a straightforward battle against governmental repression quickly grows more complicated, as more states secede, more people die, and Danny discovers the true nature of some of his new allies. Chilling, powerful, and all too plausible,, BURNING NATION confirms Trent Reedy's place as a provocative new voice in YA fiction.
Danny Wright never thought he'd be the man to bring down the United States of America. In fact, he enlisted in the Idaho National Guard because he wanted to serve his country the way his father did. When the Guard is called up on the governor's orders to police a protest in Boise, it seems like a routine crowd-control mission ... but then Danny's gun misfires, spooking the other soldiers and the already fractious crowd, and by the time the smoke clears, twelve people are dead.
When the World Trade Towers in New York City were erected at the Hudson's edge, they led the way to a real estate boom that was truly astonishing. Divided We Standreveals the coming together and eruption of four volatile elements: super-tall buildings, financial speculation, globalization, and terrorism. The Trade Center serves as a potent symbol of the disastrous consequences of undemocratic planning and development. This book is a history of that skyscraping ambition and the impact it had on New York and international life. It is a portrait of a building complex that lives at the convergence point of social and economic realities central not only to New York City but to all industrial cities and suburbs. A meticulously researched historical account based on primary documents,Divided We Standis a contemporary indictment of the prevailing urban order in the spirit of Jane Jacobs's mid-century classicThe Death and Life of Great American Cities.
You see someone smoking a cigarette and say,"Smoking is bad for your health," when what you mean is, "You are a bad person because you smoke. " You encounter someone whose body size you deem excessive, and say, "Obesity is bad for your health," when what you mean is, "You are lazy, unsightly, or weak of will. " You see a woman bottle-feeding an infant and say,"Breastfeeding is better for that child's health," when what you mean is that the woman must be a bad parent. You see the smokers, the overeaters, the bottle-feeders, and affirm your own health in the process. In these and countless other instances, the perception of your own health depends in part on your value judgments about others, and appealing to health allows for a set of moral assumptions to fly stealthily under the radar. Against Health argues that health is a concept, a norm, and a set of bodily practices whose ideological work is often rendered invisible by the assumption that it is a monolithic, universal good. And, that disparities in the incidence and prevalence of disease are closely linked to disparities in income and social support. To be clear, the book's stand against health is not a stand against the authenticity of people's attempts to ward off suffering. Against Health instead claims that individual strivings for health are, in some instances, rendered more difficult by the ways in which health is culturally configured and socially sustained. The book intervenes into current political debates about health in two ways. First, Against Health compellingly unpacks the divergent cultural meanings of health and explores the ideologies involved in its construction. Second, the authors present strategies for moving forward. They ask, what new possibilities and alliances arise? What new forms of activism or coalition can we create? What are our prospects for well-being? In short, what have we got if we ain't got health? Against Health ultimately argues that the conversations doctors, patients, politicians, activists, consumers, and policymakers have about health are enriched by recognizing that, when talking about health, they are not all talking about the same thing. And, that articulating the disparate valences of "health" can lead to deeper, more productive, and indeed more healthy interactions about our bodies.
Dividends And Dividend Policy As part of the Robert W. Kolb Series in Finance, Dividends and Dividend Policy aims to be the essential guide to dividends and their impact on shareholder value. Issues concerning dividends and dividend policy have always posed challenges to both academics and professionals. While all the pieces to the dividend puzzle may not be in place yet, the information found here can help you gain a firm understanding of this dynamic discipline. Comprising twenty-eight chapters-contributed by both top academics and financial experts in the field-this well-rounded resource discusses everything from corporate dividend decisions to the role behavioral finance plays in dividend policy. Along the way, you'll gain valuable insights into the history, trends, and determinants of dividends and dividend policy, and discover the different approaches firms are taking when it comes to dividends. Whether you're a seasoned financial professional or just beginning your journey in the world of finance, having a firm understanding of the issues surrounding dividends and dividend policy is now more important than ever. With this book as your guide, you'll be prepared to make the most informed dividend-related decisions possible-even in the most challenging economic conditions. The Robert W. Kolb Series in Finance is an unparalleled source of information dedicated to the most important issues in modern finance. Each book focuses on a specific topic in the field of finance and contains contributed chapters from both respected academics and experienced financial professionals.
A timely follow-up to the bestselling classic Dividends Don't LieIn 1988 Geraldine Weiss wrote the classic Dividends Don't Lie, which focused on the Dividend-Yield Theory as a method of producing consistent gains in the stock market. Today, the approach of using the dividend yield to identify values in blue chip stocks still outperforms most investment methods on a risk-adjusted basis.Written by Kelley Wright, Managing Editor of Investment Quality Trends, with a new Foreword by Geraldine Weiss, this book teaches a value-based strategy to investing, one that uses a stock's dividend yield as the primary measure of value. Rather than emphasize the price cycles of a stock, the company's products, market strategy or other factors, this guide stresses dividend-yield patterns.Details a straightforward system of investing in stick-to-quality blue-chip stocks with reliable dividend historiesDiscusses how to buy and sell when dividend yields instruct you to do soInvestors looking for safety and transparency will quickly discover how dividends offer the yields they desireWith Dividends Still Don't Lie, you'll gain the confidence to make sophisticated stock market decisions and obtain solid value for your investment dollars.
Mary Madison was a child of unspeakable horrors, a young woman society wanted to forget. Now a divine power has set Mary free to bring life-changing hope and love to battered and abused women living in the shadow of the nation's capital. Mary is educated and redeemed, a powerful voice in Washington D.C. - both to the politically elite and to other women like her. But she also has a past that shamed polite society. Her experiences created in her paralyzing fear, faithlessness, addiction, and promiscuity. At the crossroads of her life, only one power set Mary free and gave her a lifetime of love and hope. A power that could only be divine.
Divine Art, Infernal Machine: The Reception of Printing in the West from First Impressions to the Sense of an Endingby Elizabeth L. Eisenstein
The author has written a magisterial and highly readable account of five centuries of ambivalent attitudes toward printing and printers. Once again, she makes a compelling case for the ways in which technological developments and cultural shifts are intimately related.
The Divine Art of Dying looks at the unique moment when a person turns toward death and examines what the dying person and their caregivers can expect. Based on the author's own current experience, it's about how we might die well and live well up to the very end of our physical existence. Combining personal stories with solid research on palliative and hospice care, this book identifies the decisions the dying one and his or her loved ones and friends must make. Unlike other books on dying, The Divine Art of Dying takes a broader approach than just a medical one. It is not a "case book" but rather a well integrated look at the divine art of living and dying to the fullest, that includes spiritual insights from many sources along with references from literature, movies, and current culture. Karen Speerstra is an award-winning author. Her previous Divine Arts title Sophia: The Feminine Face of God (ISBN: 978-1611250046) won the 2013 Nautilus gold award. Written in a very readable style, The Divine Art Of Dying addresses real and common fears and the challenges of letting go and handing over a life. The book introduces new concepts to the body of writing on death and dying. It explains the medical complexities of end-of-life choices and gives helpful advice to caregivers to the dying in every chapter. and authentically chronicles the author's own dying process. Foreword by author and internationally recognized authority on hospice and palliative care Dr. Ira Byock.
Go back in time, fifty years before the events of New York Times bestselling author P. C. Cast's Partholon books. . . Something isn't right at Guardian Castle, and Aine can't figure out what. As Healer, she's supposed to be making things better, but there's a darkness that can't be brightened. And then Aine finds an injured Fomorian--winged, dark, blood-thirsty and inherently evil. Or is he? Because there's something about Tegan that Aine can't resist. . . and once they've shared blood, Aine realizes that everything she's always believed is going to be cast aside. . . .
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