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"A shameful fact about humanity is that some people can be so ugly that no one will be friends with them. It is shameful that humans can be so cruel, and it is shameful that humans can be so ugly." So begins the incredible story of Myron Horowitz, a disfigured thirteen-year-old just trying to fit in at his Pennsylvania school. When a fight with a bully leaves him unconscious and naked in the wreckage of the cafeteria, Myron discovers that he is an immortal lycanthrope--a were-mammal who can transform from human to animal. He also discovers that there are others like him, and many of them want Myron dead. "People will turn into animals," says the razor-witted narrator of this tour-de-force, "and here come ancient secrets and rivers of blood."
The signs are everywhere...disastrous world events. Evil rising up, unleashed upon the innocent. The prophecies were there...but no one listened. Until now. The time has come for those who can either usher in Doomsday...or prevent it. They are here. They ride. The Four Horsemen of the Apocalypse.Arik Wagner, a soldier with the U.S. Army's paranormal unit, the R-XR, kissed a girl and liked it. And then he went to hell as punishment. Where he's spent weeks being tortured...and plotting revenge.Limos, Horsewoman of the Apocalypse, isn't your average girl. She's immortal, dangerous, and her fiancé is Satan himself. In a moment of weakness, she gave in to her desire and kissed Arik, triggering her fiancé's wrath - and his claim on her. In order to save Arik, and the world, Limos must make a dangerous pact with her recently turned evil brother, Pestilence. A deal that might just cost her her soul...and her heart.
OUT OF THE GASLIGHTKane and his Cerberus rebels have defied the odds and repelled an alien infiltration by minds of far greater complexity than those of man. But with Earth undefended and ripe for the plucking, a new threat emerges...one that has been created by man himself.SOMETHING WICKEDNurtured in the secret laboratories of nineteenth-century London where they were designed as Queen Victoria's ultimate supersoldiers, five immortals break free from their most recent subterranean prison in the Gray Area. Impervious to attack, stronger and faster than ordinary humans, these surreally beautiful, self-serving five are the ultimate killing machines. And they're ready to make up for centuries of boredom, warping everyone they meet in their perverted quest to rule the world. Only Kane and his team dare to stand against their wicked art-if they can.
A bloody war is raging across the oceans, with the Pirate Federation and Nocturnals in alliance against the renegade Vampirates, led by Sidorio and Lola. Nothing will stop either one from making their presence dangerously known in battle.Connor and Grace Tempest each have important roles to play in the war - he as a pirate warrior at the heart of the fight; she as a powerful healer working with the war-wounded. As the twins face their greatest challenges to date, old allies and foes return to play their part in the ultimate battle of Pirate versus Vampirate.In this - the conclusion of this sequence of VAMPIRATES novels, the stakes are higher than ever. Relationships will change. An army of the dead will return to fight. There will be new threats and new alliances and characters will die before the ending which will see Grace and Connor poised to start momentous new journeys. In the words of Obsidian Darke, "So it ends, so it begins."
Exiled to a life of extreme loneliness because everyone she touches dies, Emily Burke has every reason to distrust Raphael Robichaux. The immortal werewolf possesses immense power and has been summoned by her pack to end her life. And yet, from the moment she lays eyes on the powerful rebel, he awakens all the longings she's kept bottled inside. . . and gives her hope. When Raphael meets Emily, he knows something enormous is at stake. For not only does he see that her blood can restore life--but she is his destined mate. Trust doesn't come easily to Emily. But somehow Raphael must convince her to put her life in his hands. Only then will an ancient prophecy be fulfilled and a terrible evil destroyed. . . .
A fascinating work of popular philosophy and history that both enlightens and entertains, Stephen Cave's Immortality investigates whether it just might be possible to live forever and whether we should want to. But it also makes a powerful argument, which is that it's our very preoccupation with defying mortality that drives civilization. Central to this book is the metaphor of a mountaintop where one can find the Immortals. Since the dawn of humanity, everyone - whether they know it or not - has been trying to climb that mountain. But there are only four paths up its treacherous slope, and there have only ever been four paths. Throughout history, people have wagered everything on their choice of the correct path, and fought wars against those who've chosen differently. While Immortality takes the reader on an eye-opening journey from the beginnings of civilization to the present day, the structure is not chronological. Rather it is path driven. As each path is revealed to us, an historical figure serves as our guide. In drawing back the curtain on what compels humans to "keep on keeping on," Cave engages the reader in a number of mind-bending thought experiments. He teases out the implications of each immortality gambit, asking, for example, how long a person would live if they did manage to acquire a perfectly disease-free body. Or what would happen if a super-being tried to round up the atomic constituents of all who've died in order to resurrect them. Or what our loved ones would really be doing in heaven if it does exist. Or what part of us actually lives in a work of art, and how long that work of art can survive. Toward the the book's end, we're confronted with a series of brain-rattling questions: What would happen if tomorrow humanity discovered that there is no life but this one? Would people continue to care about their favorite sports team, please their boss, vie for the title of Year's Best Salesman? Would three-hundred-year projects still get started? If the four paths up the Mount of the Immortals lead nowhere -- if there is no getting up to the summit -- is there still reason to live? And can civilization survive? Immortality is a deeply satisfying book, as optimistic about the human condition as it is insightful about the true arc of history.
This book takes a riveting look at how the law responds to that distinctly American dream of immortality. While American law provides virtually no protections for the interests we hold most dear--our bodies and our reputations--when it comes to property interests, the American dead have greater control than anywhere else in the world. Moreover, these rights are growing daily. From grave robbery to Elvis impersonators, Madoff shows how the law of the dead has a direct impact on how we live. Madoff examines how the rising power of the American dead enables the deceased to exert control over their wealth forever through grandiose schemes like "dynasty trusts" and perpetual private charitable foundations and to control their creative works and identities well into the unforeseeable future. Madoff explores how the law of the dead can, in essence, extend the reach of life by granting virtual immortality to individuals. All of this comes, Madoff contends, at real costs imposed on the living.
Sequel to Code Of The Lifemaker.
The astonishing case for life after death as revealed through the revolutionary science of parapsychology
A great philosopher will change the way you think about your life.For most of human history, religion provided a clear explanation of life and death. But in the late 19th and early 20th centuries new ideas -- from psychiatry to evolution to Communist -- seemed to suggest that our fate was now in our own hands. We would ourselves become God.This is the theme of a remarkable new book by one of the world's greatest lving philosophers. It is a brilliant and frightening look at the problems and opportunities of a world coming to grips with humankind's now solitary, unaided place in the universe. Gray takes two major examples: the belief that the science-backed Communism of the new USSR could reshape the planet, and the belief among a group of Edwardian intellectuals -- popularized through mediums and automatic writing -- that there was a non-religious form of life after death.Gray presents an extraordinary cast of philosophers, journalists, politicians, charlatans and mass murderers, all of whom felt driven by a specifically scientific and modern world view. He raises a host of fascinating questions about what it means to be human. The implications of Gray's book will haunt its readers for the rest of their lives.From the Hardcover edition.
Shyamji has music in his blood, for his father was the acclaimed 'heavenly singer' and guru, Ram Lal. But Shyam Lal is not his father, and knows he never will be. Mallika Sengupta's voice could have made her famous, but being the wife of a successful businessman is a full-time occupation in itself. Mallika's son, Nirmalya, believes in suffering for his art, and for him, all compromise is failure: those with talent should be true to that talent. No matter what. Written in haunting, melodic prose, The Immortalstells the story of Shyam, Mallika and Nirmalya: their relationships, their lives, their music. 'As seductive as a delicate, half-heard tune' Daily Mail 'A memorable work - capacious, multi-faceted and intimate, it is Indian to the core but universal in its implications' Independent 'A beautiful novel of music and time, hopes and regrets' Irish Times
When it comes to staying young, some people will pay any price... What if Ponce de Leon really did discover the fountain of youth? Mr. Leon is alive in the twentieth century and is the owner of a high-end cosmetics company. His handpicked salespeople are his disciples. They remain forever young and healthy, but the cost is soul-wrenching. When Cynthia Edwards realizes her husband has become part of this madness she tries in vain to make her husband understand...but Mr. Leon demands terrible sacrifices.
It is Samhain--the Blood Harvest. Nonbelievers call it Hallowe'en. The night when eight Nashville teenagers are found dead, with occult symbols carved into their naked bodies. It's a ritual the killers believe was blessed by Death himself. When children are victimized, emotions always run high, and this case has the public both outraged and terrified: a dangerous combination. Recently reinstated homicide lieutenant Taylor Jackson knows she has to act quickly, but tread carefully. Exploring the baffling culture of mysticism and witchcraft, Taylor is immersed in a darkness that threatens to unbalance the order of her world, and learns how unchecked wrath can push a killer to his limits.
This comprehensive overview of immune reactions inducing fertility disorders in both sexes first describes the nature and the function of sperm antigens which are capable to induce immune infertility as well as the methods to analyse and characterize these antigens. Secondly, the nature, the origin and induction of antisperm antibodies (ASA) in both sexes and the role of reproductive organs and their interaction with the immune system will be discussed. A large section of the book, which is most important for clinicians working in reproductive medicine, deals with the clinical impact of the immune reaction in reproductive medicine, including the methods of determination and the treatment in immune infertility. Closely related to immune infertility is the development of immune contraceptives which is also discussed.
Parham (structural biology, microbiology, immunology, Stanford U.) offers a third edition to his textbook explaining the functions of the human immune system. It is specifically intended for undergraduate students in medical, dental, and pharmacy in immunology courses. Extensively updated, the textbook includes new chapters on innate and adaptive immunity, enhanced treatment of aspects of innate immunity such as the complement system and defensins, immunotherapies, and the nature of immune response in mucosal tissues and immunological memory. It is well-illustrated and includes essay, multiple choice, and case study questions at the conclusion of each chapter. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)
"Immunity to error through misidentification is recognised as an important feature of certain kinds of first-person judgments, as well as arguably being a feature of other indexical or demonstrative judgments. In this collection of newly commissioned essays, the contributors present a variety of approaches to it, engaging with historical and empirical aspects of the subject as well as contemporary philosophical work. It is the first collection of essays devoted exclusively to the topic and will be essential reading for anyone interested in philosophical work on the self, first-person thought or indexical thought more generally"--
The National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
With current recommendations calling for infants to receive multiple doses of vaccines during their first year of life and with sudden infant death syndrome (SIDS) the most frequent cause of death during the postneonatal period, it is important to respond to concerns that vaccination might play a role in sudden unexpected infant death. The committee reviewed epidemiologic evidence focusing on three outcomes: SIDS, all SUDI (sudden unexpected death in infancy), and neonatal death (infant death, whether sudden or not, during the first 4 weeks of life). Based on this review, the committee concluded that the evidence favors rejection of a causal relationship between some vaccines and SIDS; and that the evidence is inadequate to accept or reject a causal relationship between other vaccines and SIDS, SUDI, or neonatal death. The evidence regarding biological mechanisms is essentially theoretical, reflecting in large measure the lack of knowledge concerning the pathogenesis of SIDS.
This eighth and final report of the Immunization Safety Review Committee examines the hypothesis that vaccines, specifically the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally associated with autism. The committee reviewed the extant published and unpublished epidemiological studies regarding causality and studies of potential biologic mechanisms by which these immunizations might cause autism. Immunization Safety Review: Vaccines and Autismfinds that the body of epidemiological evidence favors rejection of a causal relationship between thimerosal-containing vaccines and autism. The book further finds that potential biological mechanisms for vaccine-induced autism that have been generated to date are only theoretical. It recommends a public health response that fully supports an array of vaccine safety activities and recommends that available funding for autism research be channeled to the most promising areas. The book makes additional recommendations regarding surveillance and epidemiological research, clinical studies, and communication related to these vaccine safety concerns.
The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells. They are also the major histocompatibility barriers to transplantation, which is the clinical paradigm of the self versus non self concept. It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to be important in many aspects of clinical practice. As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, and immunogenetic laboratories specializing in these methods have developed to support transplantation and other clinical programs. Immunogenetics: Methods and Applications in Clinical Practice focuses on methods for human clinical practice. The emphasis rests on those assays which are of established or potential clinical utility and are likely to be included in the repertoire of tests provided by a routine diagnostic and service laboratory. This volume also contains several review chapters of the MHC complex, the KIR complex, the human immunoglobulin allotypes, as well as reviews of the methods for the detection of alloreactive NK cells and the detection of HLA antibodies by solid phase assays. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Immunogenetics: Methods and Applications in Clinical Practice seeks to serve both the immunogenetics community and the wider scientific community with a collection of detailed information and helpful tips attained by many years of experience in the field.
This book will be a comprehensive study of the lymphatic system and its immunological role. It will begin with lymphatic capillaries, their origin and development. It will treat lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section will address lymph nodes, subcortical circulation and the conduit system. It will discuss organs with no lymphatic system, such as the brain. Finally, it will cover lymph composition and cells in the lymph. While primarily basic research, the volume will touch upon elements of the clinical, as well, broadening its scope and appeal.
Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases. To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on "Key Points" as well as "Recommendations" where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.
This a story of young Imogene who wakes up one morning to find she has sprouted antlers.
Meet Imogene, a plucky heroine with a passion for history.As a baby, Imogene's first words were "Four score and seven years ago." In preschool, she fingerpainted a map of the Oregon Trail. So it's not surprising that when the mayor wants to tear down the long-neglected Liddleton Historical Society to make room for a shoelace factory, Imogene is desperate to convince the town how important its history is. But even though she rides through the streets in her Paul Revere costume shouting, "The bulldozers are coming, the bulldozers are coming!" the townspeople won't budge. What's a history-loving kid to do? Filled with quotes from history's biggest players--not to mention mini-bios on the endpapers--and lots of humor, here's the perfect book for budding historians.From the Hardcover edition.
Apple's video-editing program is better than ever, but it still doesn't have a printed guide to help you get started. That's where this gorgeous, full-color book comes in. You get clear explanations of iMovie's impressive new features, like instant rendering, storyboarding, and one-step special effects. Experts David Pogue and Aaron Miller also give you a complete course in film editing and DVD design. Edit video like the pros. Import raw footage, add transitions, and use iMovie's newly restored, intuitive timeline editor. Create stunning trailers. Design Hollywood-style "Coming Attractions!" previews for your movies. Share your film. Distribute your movie in a variety of places--on smartphones, Apple TV, your own site, and with one-click exports to YouTube, Facebook, Vimeo, CNN iReport, and MobileMe. Make DVDs. Design the menus, titles, and layout for your DVDs, and burn them to disc.
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