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Epidemiology and Biostatistics

by Bryan Kestenbaum

Concise, fast-paced, intensive introduction to clinical research design for students and clinical research professionals Readers will gain sufficient knowledge to pass the United States Medical Licensing Examination part I section in Epidemiology

Epidemiology Foundations

by Peter J. Fos

Written by Peter J. Fos-an expert in epidemiology with more than twenty years teaching experience-Epidemiology Foundations offers an ideal introduction to the theory and practice of public health epidemiology. This important text discusses both the historical perspective and future trends of epidemiology, reviews health and disease, and explains how they are measured. The book's overview of epidemiological studies shows how they are used in practice. Epidemiology Foundations takes a social and community perspective and includes information about global diseases and epidemics. Emphasis on concepts such as population health, social determinants, and global health make this book especially interesting and accessible to those new to the subject. Each chapter is supplemented with problem-solving exercises and research assignments to aid readers in understanding its epidemiology principles. Reflecting and expanding on recommendations of the Association of American Colleges and Universities, Epidemiology Foundations is the ideal text for any course introducing epidemiology in public health.

Epidemiology Kept Simple

by B. Burt Gerstman

Epidemiology Kept Simple introduces the epidemiological principles and methods that are increasingly important in the practice of medicine and public health. With minimum use of technical language it fully explains terminology, concepts, and techniques associated with traditional and modern epidemiology. Topics include disease causality, epidemiologic measures, descriptive epidemiology, study design, clinical and primary prevention trials, observational cohort studies, case-control studies, and the consideration of random and systematic error in studies of causal factors. Chapters on the infectious disease process, outbreak investigation, and screening for disease are also included. The latter chapters introduce more advanced biostatistical and epidemiologic techniques, such as survival analysis, Mantel-Haenszel techniques, and tests for interaction.This third edition addresses all the requirements of the American Schools of Public Health (ASPH) Epidemiological Competencies, and provides enhanced clarity andreadability on this difficult subject. Updated with new practical exercises, case studies and real world examples, this title helps you develop the necessary tools to interpret epidemiological data and prepare for board exams, and now also includes review questions at the end of each chapter.Epidemiology Kept Simple continues to provide an introductory guide to the use of epidemiological methods for graduate and undergraduate students studying public health, health education and nursing, and for all practicing health professionals seeking professional development.

Epigenetic Alterations in Oncogenesis

by Adam R. Karpf

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means "above" genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Epigenetic Approaches to Allergy Research

by Marién Pascual Sergio Roa

In recent years, epigenetic approaches to existing scientific problems have offered many new and exciting perspectives. This book focuses on epigenetic approaches to study asthma and allergy research. The authors briefly review cellular factors, immune signaling, and inflammatory pathways in allergy and asthma, as well as genetic influences in the pathogenesis of atopic disorders. Diseases that have been clearly linked to an epigenetic dysregulation will be discussed, as well as the role of epigenetics in the origin of complex diseases. The authors will examine the impact of environment factors in the predisposition to atopic disorders, and they will also describe the major unanswered questions and future perspectives of an exciting new field that studies allergic diseases from the epigenetic point of view.

Epigenetic Aspects of Chronic Diseases

by Felix Bronner Helmtrud I. Roach Richard O.C. Oreffo

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

Epigenetic Regulation and Epigenomics

by Robert A. Meyers

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers.Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases.Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences.

Epigenetics in the Age of Twitter

by Gerald Weissmann

Pop culture meets cutting-edge science in this one-volume introduction to the history of science and modern biology."[Weissmann] has emerged in the last three decades as America's most interesting and important essayist. He has achieved this status both epigenetically and through Twitter, word of mouth, so to speak. . . . Much like Susan Sontag, Weissmann likes being a contemporary, and does not feel shackled by tradition. . . . This book is a joy for the heart and instructive for the mind." -ERIC KANDEL, Nobel Laureate and author of In Search of Memory"Only a mind as nimble and well traveled as Gerald Weissmann's could see, never mind make and expound on, the connections between salamanders and Prohibition . . . white blood cells, Hollywood and erectile dysfunction . . . health care reform and Marie Antoinette . . . bacteria, the Equal Rights Amendment and the "Miracle on the Hudson." Better yet, Weissmann does so with wit and insight. A fascinating tour through history, science and pop culture." -MAX GOMEZ, MD, Emmy Award-winning WCBS-TV Medical Correspondent"Erudite energy leaps from this lively commingling of art, culture and science. . . . In each [essay], Weissmann finds links between research and elements of history and pop culture, which play off each other to illuminating effect. So US politician Sarah Palin pops up in a discussion of 'Marie Antoinette syndrome'. . . and the 'meltdown' of the mythical Icarus meets the nuclear version at the Fukushima Daiichi power plant in Japan." -NatureEpigenetics, which attempts to explain how our genes respond to our environment, is the latest twist on the historic nature vs. nurture debate. In addressing this and other controversies in contemporary science, Gerald Weissmann taps what he calls "the social network of Western Civilization," including the many neglected women of science: from the martyred Hypatia of Alexandria, the first woman scientist, to the Nobel laureates Marie Curie, Christiane Nüsslein-Volhard, and Elizabeth Blackburn, among other luminaries in the field. Always instructive and often hilarious, this is a one-volume introduction to modern biology, viewed through the lens of today's mass media and the longer historical tradition of the Scientific Revolution. Whether engaging in the healthcare debate or imagining the future prose styling of the scientific research paper in the age of Twitter, Weissmann proves to be one of our most incisive cultural critics and satirists.Gerald Weissmann is director of the Biotechnology Study Center at the New York University School of Medicine and editor-in-chief of the FASEB Journal. His essays and reviews have appeared in numerous publications worldwide, including the London Review of Books and New York Times Book Review.

Epigenetics of Aging

by Trygve O. Tollefsbol

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer's disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Epigenetics Protocols

by Trygve O. Tollefsbol

A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer.

Epigenetics: The Ultimate Mystery of Inheritance

by Richard C. Francis

A writer with a PhD in neurobiology explains why "identical" twins can have different risks for health problems, how the effects of famine can be inherited across generations, and the dynamics of the breeding of hybrid animals. Francis presents an interesting, accessible introduction to epigenetics, a new field that studies how the environment (prenatal, social, and chemical stressors) can have long-term physiological and behavioral effects through regulating genes. He explains how this process offers promise for understanding development and obesity, and treating cancer. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)

Epigenomics

by Krishnarao Appasani Azim Surani

Understanding mechanisms of gene regulation that are independent of the DNA sequence itself - epigenetics - has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.

Epilepsy

by David W. Mccandless

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7-9 years, and the "success" rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

Epilepsy

by John W Miller Howard P. Goodkin

Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help clinicians develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience.

The Epilepsy Prescriber's Guide to Antiepileptic Drugs

by Philip N. Patsalos Blaise F.D. Bourgeois

This practical and concise book is an essential reference guide for use by all clinicians and allied health professionals that treat or care for patients with epilepsy. In full color throughout, this volume presents the antiepileptic drugs (AEDs), 34 in total, in alphabetical order and for each AED the information is divided into eight colored sections: general therapeutics, pharmacokinetics, interaction profile, adverse effects, dosing and use, special populations, overview, and suggested reading. This second edition has been extensively revised and updated. Specific additions include: * inclusion of the new drugs perampanel and retigabine (also called ezogabine) * updated pharmacokinetic interactions * suggested pediatric dosing schedules for several drugs * discussion about bone health, and vitamin D monitoring and supplementation * information on teratogenicity in the sections on pregnancy. This handy pocket book will be an excellent companion for all clinicians that treat patients with epilepsy.

Epilepsy: The Ultimate Teen Guide

by Kathlyn Gay Sean Mcgarrahan

Epilepsy: The Ultimate Teen Guide dispels the myths, misconceptions, and misunderstandings about epilepsy and the people who have the disorder. It provides factual medical information and advice for teens on how to live a normal life. Stories from teens who have epilepsy show readers they can participate in normal activities. They also offer advice on whether and how to tell friends, dates, teachers, or an employer about the condition. This book concludes with an extensive list of publications, websites, and organizations, as well as an appendix that covers the Americans with Disabilities Act and how it applies to people who have epilepsy.

Epileptic

by David B.

The most acclaimed European graphic novel of the last ten years, Epileptic is David B.'s story of his brother's battle with epilepsy, but it turns into a penetrating and sometimes lacerating self-examination on the author's part, as he delves into his own complex emotions and his family's troubled history, as well as his own youthful fantasy life. Particularly pointed is his description of the family journey from one attempted cure to another, including acupuncture, spiritualism and macrobiotics. David B.'s drawing is utterly extraordinary, balancing literal representation and expressionist psychological distortion.

Epiphanies

by Huston Smith Ann Jauregui

In a quiet moment of therapy, a breakthrough comes -- the miracle of the new. To experience an epiphany is to have sudden insight into the essential meaning of something, unleashed sometimes in exquisitely slow motion, sometimes in a flash. In an intimate, lyrical integration of the science of psychology and transcendence of spirituality, celebrated clinician Dr. Ann Jauregui introduces us to nine individuals who have undergone astonishing transformations by exploring a world quite different from the one described by our five senses. With moments of miraculous and joyful surprise, Epiphanies exposes a reality outside of everyday existence that has momentous implications for life's ultimate questions. "Shyly we venture out with these stories," Dr. Jauregui writes, "into a world where science itself is struggling to describe a realm out of time and space and language." We are the beneficiaries of these extraordinary shifts of perspective, invited into a sparkling conversation that allows us to see the potential residing in all of us.

Epiphany

by Ferrol Sams

Three short stories: Epiphany, Harmony Ain't Easy, and Relative & Absolute, which examine how bonds are formed between people of differing personalities and experiences.

Epiphany: True Stories of Sudden Insight to Inspire, Encourage, and Transform

by Elise Ballard

"Epiphany" is a compilation of inspiring, life-changing moments from both nationally known figures like Dr. Mehmet Oz and Rabbi Shmuley Boteach and ordinary people, including a minister, an elementary school teacher, and a former street urchin in Tanzania.

Episodes: My Life as I See It

by Blaze Ginsberg

From the author's mother: When Blaze was about ten years old, he gave me a perfect description of how his mind worked. Actually, it was more of a description of the way everyone's mind worked--at least from his perspective.

Epistemology

by Robert M. Martin

Epistemology is the philosophical study of knowledge. Without knowledge, scientific enquiry is meaningless and we can't analyse the world around us. But what exactly is it and how do we obtain it? Presuming no prior experience of philosophy, this book covers everything in the topic from scepticism and induction to Kant's transcendentalism.

Epistemology

by Robert M. Martin

Epistemology is the philosophical study of knowledge. Without knowledge, scientific enquiry is meaningless and we can't analyse the world around us. But what exactly is it and how do we obtain it? Presuming no prior experience of philosophy, this book covers everything in the topic from scepticism and induction to Kant's transcendentalism.

Showing 89,251 through 89,275 of 192,360 results

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