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Glenn Rand, longtime photographic educator and Program Director for Graduate Programs at Brooks Institute, and Tim Meyer, Portrait Division Chair at Brooks Institute, have collaborated to create a thorough and balanced textbook on the modern techniques and practice of portrait photography. They have avoided the single-style viewpoint common to so many books on portraiture and have crafted a definitive resource for professionals, as well as students and avid amateurs, wishing to advance their skills in this discipline. Topics include: Quality of light and the portrait Ambient, continuous, and strobe light sources Understanding light modifiers and enhancers Mastering lighting ratios Importance and selection of backgrounds Extensive coverage of lighting setups Understanding light meters and metering in portraiture Lighting patterns on the human face Facial analysis Composition in portraiture Eliciting the appropriate expression The fine art portrait Portraiture for the masses
Tumour survival and growth is critically dependent on an independent blood supply. As such tumour vasculature presents an ideal target for cancer therapy that is widely applicable, accessible and genetically stable rendering it less prone to resistance. Two approaches have been explored for cancer therapy; firstly the prevention of new vessel formation with inhibitors of angiogenesis, and secondly the destruction of existing tumour blood vessels with so called vascular disruptive agents (VDAs). While the first approach appears to delay tumour progression, the second has the potential to cause massive cell death and tumour regression. It si the second approach of vascular targeting that is the focus of this review. Since the tubulin binding agent combretastatin, derived from the bark of the African bush willow, was discovered by George R Pettit to have antimitotic properties over twenty years ago, the field of vascular targeting has expanded steadily. Coincident with the preclinical and clinical development of these agents, there have been advances in our understanding of their mechanism of action and in the technology required to assess their effects.
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