Personalized Treatment of Breast Cancer

By: John Benson and Masakazu Toi and Eric Winer and Suzanne Klimberg

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Synopsis: Thisbook deals with the essential factors in the personalization of treatment forprimary breast cancer. These include host issues, lymph node surgery, radiationtherapy, and preoperative systemic treatment requiring specialized knowledge,multidisciplinary care experience, techniques, and research. Locoregionaltreatment in conjunction with systemic treatments is another important factor,with options for local therapy significantly affected by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent primary breastcancer care, and these are highlighted in the book's presentation oftechnological advances in lymph node mapping and diagnosis, axillary clearancein patients with nodal metastasis, and the role of axillary surgery. Attentionis also given to locoregional treatment after preoperative systemic therapy. Becausetherapeutic impact differs depending upon biological characteristics such astumor subtype, local therapy should be based both on tumor biology and on therapeuticresponse in parallel. Associated translational research and mathematicalprediction tools such as nomograms also are introduced. This book provides theessence of primary breast cancer care, particularly its individualization withnovel therapeutic concepts and strategies, and will greatly benefit physiciansand clinical investigators in breast cancer institutions.