Helicobacter pylori Research

By: Steffen Backert and Yoshio Yamaoka

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Synopsis: This book provides the currentupdated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori isa class I carcinogen and one of the most common infections in the world. Whilemost people colonized by H. pylori willremain asymptomatic, up to 20 % of them may develop serious gastroduodenaldisease such as peptic ulcers or gastric cancer. H. pylori isthe only known bacterium linked to the development of cancer and consequentlyis an important focus of research. Outstanding international experts fromdiverse scientific disciplines contribute here to give detailed insights intothe current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences aretaken into account. The chapters target microbiology, epidemiology, genetics,biochemistry, interactions with the immune system, signal transduction,pathogenic mechanisms in the gastroduodenal mucosa, gastric diseasedevelopment, and therapy including antibiotics or probiotics treatment as wellas vaccination strategies. This book is an important reference not only forclinicians but also microbiologists. It provides in a single volume anup-to-date summary of our current knowledge of this microbe and the multipleways in which it impacts upon public health in all parts of the world.