Genomics in the Cloud: Using Docker, GATK, and WDL in Terra

Synopsis

Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytes—or over 50 million gigabytes—of genomic data, and they’re turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud?With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian O’Connor of the UC Santa Cruz Genomics Institute, guide you through the process. You’ll learn by working with real data and genomics algorithms from the field.

This book covers:

Essential genomics and computing technology background

Basic cloud computing operations

Getting started with GATK, plus three major GATK Best Practices pipelines

Automating analysis with scripted workflows using WDL and Cromwell

Scaling up workflow execution in the cloud, including parallelization and cost optimization

Interactive analysis in the cloud using Jupyter notebooks

Secure collaboration and computational reproducibility using Terra

Copyright:

2017

Book Details

Book Quality:

Publisher Quality

ISBN-13:

9781491975145

Related ISBNs:

9781491975152, 9781491975169, 9781491975190

Publisher:

O'Reilly Media

Date of Addition:

09/11/20

Copyrighted By:

The Broad Institute, Inc. and Brian O’Connor

Adult content:

No

Language:

English

Has Image Descriptions:

No

Categories:

Nonfiction, Science, Computers and Internet, Mathematics and Statistics, Medicine

Submitted By:

Bookshare Staff

Usage Restrictions:

This is a copyrighted book.