Blood-Brain Barrier in Drug Discovery
By: and
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- Synopsis
- Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery.* Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects* Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies* Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes* Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)* Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
- Copyright:
- 2015
Book Details
- Book Quality:
- Publisher Quality
- ISBN-13:
- 9781118788493
- Related ISBNs:
- 9781118788356
- Publisher:
- Wiley
- Date of Addition:
- 01/28/15
- Copyrighted By:
- Wiley
- Adult content:
- No
- Language:
- English
- Has Image Descriptions:
- No
- Categories:
- Nonfiction, Science, Medicine
- Submitted By:
- N/A
- Usage Restrictions:
- This is a copyrighted book.