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Evidence-Based Dermatology

by Berthold Rzany Hywel Williams Michael Bigby Masutaka Furue Luigi Naldi Robert Dellavalle Andrew Herxheimer Yuping Ran

Be sure your skin-care treatments have strong evidential support Evidence-based Dermatology, Third Edition takes a unique approach to clinical dermatology by emphasising use of only the highest quality available evidence when treating people with skin diseases.Beginning with a toolbox introduction to the practice of evidence-based dermatology, it then covers the application of evidence for dermatological treatments across a wide range of ailments, including:* Common inflammatory skin diseases* Skin cancer, moles and actinic keratoses* Infective skin disease, exanthems and infestations* Disorders of pigmentationIn addition, many of the rarer skin disorders are also included so as to provide comprehensive coverage of the topic.World-leading experts in dermatology follow a clinical approach for each disease, and as well as providing their expert guidance on the description and diagnosis of dermatologic disorders, they also discuss common dilemmas that clinicians face when considering the best approach to patient management. 'Key Points' accompany each chapter to provide a quick review of the most important points.Clinically oriented and practically focused, Evidence-based Dermatology ensures that your treatments are entirely patient-focused and fully supported by the very latest medical evidence.

Drug Delivery Applications of Noninvasive Imaging

by Mei Tian Chun Li

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditionsIn vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:In vivo imaging techniques and quantitative analysisImaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticlesApplications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral deliveryTranslational research leading to clinical applicationsImaging drug delivery in large animal modelsClinical applications of imaging techniques to guide drug development and drug deliveryChapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems.Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

Creative Execution

by Eric Beaudan

The ultimate game-changer for reinventing strategy and igniting peopleWhether it was Alexander the Great or Lord Horatio Nelson, the management team at Toyota or Google, the indisputable alchemy of strategy, execution, and leadership led to each's phenomenal success. With years of experience assessing and developing executive talent, author Eric Beaudan examines the essence of such a dynamic mix, summed up as "Creative Execution," showing how organizations and individuals can attain, or reach for, unheralded levels of success.Profiling extraordinary leaders and the uncommon leadership tactics that are their hallmark, the book also includes proprietary research and firsthand experiences with clients across the globe, illustrating the principles of Creative Execution in action.Details the five elements of Creative Execution, including fostering candid dialogue across the organization, spelling out clear roles and responsibilities, and taking bold actionIncludes proprietary research, assessments, and case studiesWith tactics, strategies, and calls to action to help any organization shape and apply the dynamics of Creative Execution, this powerful one-volume manifesto will help any leader get in the trenches, learn firsthand the impact of their decisions, and restore ingenuity, cooperation, and a sense of collective commitment to the workplace.

Weight Loss Surgery For Dummies

by Al Roker Brian K. Davidson Barbara Thompson Marina S. Kurian

Your trusted guide to surgical weight-lossSixty percent of individuals over the age of 20--or 58 million people in the U.S.--are overweight. As the obesity epidemic continues to grow, many Americans are researching the benefits and complications of weight-loss surgeries. Weight Loss Surgery For Dummies, 2nd edition is the most up-to-date and authoritative guide to understanding the impact of surgical weight-loss before, during, and after surgery.Weight-loss surgery is often an overweight person's last resort, and it comes with many risks, questions, and fears. So how do you know if it's right for you? Weight Loss Surgery For Dummies gives you expert guidance on knowing whether you qualify for the procedures, advice on choosing the best center and doctor, and trusted information on evaluating the risks involved. Plus, it helps you plan to finance the procedure, prepare for surgery, and achieve the best results as you adjust to a new diet and lifestyle post-surgery. Trusted information on choosing a weight loss surgery that's best for youAdvice on what to expect before, during, and after surgerySample recipes and information to ensure you're getting proper nutrition post-surgeryIf you or a loved one is considering gastric bypass surgery, Weight Loss Surgery For Dummies gives you everything you need to decide if it's the right course of action, what to expect during recovery, and how to ensure the best results through healthy eating behaviors and regular physical activity.

Molecular Basis of Oxidative Stress

by Frederick A. Villamena

Sets the stage for the development of better diagnostic techniques and therapeuticsFeaturing contributions from an international team of leading clinicians and biomedical researchers, Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease.Molecular Basis of Oxidative Stress is logically organized, beginning with a comprehensive discussion of the fundamental chemistry of reactive species. Next, the book:Presents new mechanistic insights into how oxidative damage of biomolecules occursExamines how these oxidative events effect cellular metabolismInvestigates the role of oxidative stress in the pathogenesis of cancer, neurodegenerative disease, cardiovascular disease, and cystic fibrosisExplores opportunities to improve the diagnosis of disease and the design of new therapeutic agentsReaders will find much novel information, including new radical chemistries and the latest discoveries of how free radicals react with biomolecules. The contributors also present recent findings that help us better understand the initiation of oxidative stress and the mechanisms leading to the pathogenesis of various diseases.Throughout the book, the use of molecular structures helps readers better understand redox chemistry. In addition, plenty of detailed figures illustrate the mechanisms of oxidative stress and disease pathogenesis.Examining everything from the basic chemistry of oxidative stress to the pathogenesis of disease, Molecular Basis of Oxidative Stress will help readers continue to explore the nature of oxidative stress and then use that knowledge to develop new approaches to prevent, detect, and treat a broad range of disease conditions.

Wireless Communications

by Andreas F. Molisch

"Professor Andreas F. Molisch, renowned researcher and educator, has put together the comprehensive book, Wireless Communications. The second edition, which includes a wealth of new material on important topics, ensures the role of the text as the key resource for every student, researcher, and practitioner in the field."--Professor Moe Win, MIT, USAWireless communications has grown rapidly over the past decade from a niche market into one of the most important, fast moving industries. Fully updated to incorporate the latest research and developments, Wireless Communications, Second Edition provides an authoritative overview of the principles and applications of mobile communication technology.The author provides an in-depth analysis of current treatment of the area, addressing both the traditional elements, such as Rayleigh fading, BER in flat fading channels, and equalisation, and more recently emerging topics such as multi-user detection in CDMA systems, MIMO systems, and cognitive radio. The dominant wireless standards; including cellular, cordless and wireless LANs; are discussed.Topics featured include: wireless propagation channels, transceivers and signal processing, multiple access and advanced transceiver schemes, and standardised wireless systems.Combines mathematical descriptions with intuitive explanations of the physical facts, enabling readers to acquire a deep understanding of the subject.Includes new chapters on cognitive radio, cooperative communications and relaying, video coding, 3GPP Long Term Evolution, and WiMax; plus significant new sections on multi-user MIMO, 802.11n, and information theory.Companion website featuring: supplementary material on 'DECT', solutions manual and presentation slides for instructors, appendices, list of abbreviations and other useful resources.

Inflammatory Diseases of Blood Vessels

by Carol A. Langford Jorg J. Goronzy Gary S. Hoffman Cornelia M. Weyand

In recent years, considerable progress has been made in understanding the vasculitic diseases, largely due to the introduction of effective treatments for diseases that were once uniformly fatal, the conduct of structured clinical studies, and advances in immunology and molecular biology. Despite these achievements, the vasculitic diseases continue to be associated with morbidity and mortality from chronic organ damage, relapses, and the side effects of treatment. Investigations into the mechanisms of vascular inflammation may lead to a better comprehension of the pathogenesis of vasculitic diseases and to treatment that is more effective and less toxic. These areas of promising research, together with current knowledge about the vasculitic diseases, are extensively examined in this new edition, which is designed to provide a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.

The Science of Intimate Relationships

by Lorne Campbell Jeffry A. Simpson Garth Fletcher Nickola Overall

The Science of Intimate Relationships represents the first interdisciplinary approach to the latest scientific findings relating to human sexual relationships.Offers an unusual degree of integration across topics, which include intimate relationships in terms of both mind and body; bonding from infancy to adulthood; selecting mates; love; communication and interaction; sex; passion; relationship dissolution; and moreSummarizes the links among human nature, culture, and intimate relationshipsPresents and integrates the latest findings in the fields of social psychology, evolutionary psychology, human sexuality, neuroscience and biology, developmental psychology, anthropology, and clinical psychology.Authored by four leading experts in the fieldInstructor materials are available at

Freelance Fashion Designer's Handbook

by Paula Keech

Do you have the passion and the creativity for fashion? Why not earn a living from it?The Freelance Fashion Designer's Handbook is your essential guide on how to go it alone, covering what to expect, making sure you get paid, planning your time, keeping up with your accounts, compiling technical packages for garments. It is your portable mentor, equipping you to work independently.Part 1 covers all the information to becoming a freelance designer such as creating a basic freelance contract, invoicing, how to find work, tax returns and much more. All supported with case studies.Part 2 contains the technical aspects of being a designer - including how to compile full technical packages for garments to be manufactured abroad.

Electron Flow in Organic Chemistry

by Paul H. Scudder

Sets forth the analytical tools needed to solve key problems in organic chemistryWith its acclaimed decision-based approach, Electron Flow in Organic Chemistry enables readers to develop the essential critical thinking skills needed to analyze and solve problems in organic chemistry, from the simple to complex. The author breaks down common mechanistic organic processes into their basic units to explain the core electron flow pathways that underlie these processes. Moreover, the text stresses the use of analytical tools such as flow charts, correlation matrices, and energy surfaces to enable readers new to organic chemistry to grasp the fundamentals at a much deeper level.This Second Edition of Electron Flow in Organic Chemistry has been thoroughly revised, reorganized, and streamlined in response to feedback from both students and instructors. Readers will find more flowcharts, correlation matrices, and algorithms that illustrate key decision-making processes step by step. There are new examples from the field of biochemistry, making the text more relevant to a broader range of readers in chemistry, biology, and medicine. This edition also offers three new chapters:Proton transfer and the principles of stabilityImportant reaction archetypesQualitative molecular orbital theory and pericyclic reactionsThe text's appendix features a variety of helpful tools, including a general bibliography, quick-reference charts and tables, pathway summaries, and a major decisions guide.With its emphasis on logical processes rather than memorization to solve mechanistic problems, this text gives readers a solid foundation to approach and solve any problem in organic chemistry.

Polymer Processing

by Dimitris I. Collias Donald G. Baird

Fundamental concepts coupled with practical, step-by-step guidanceWith its emphasis on core principles, this text equips readers with the skills and knowledge to design the many processes needed to safely and successfully manufacture thermoplastic parts. The first half of the text sets forth the general theory and concepts underlying polymer processing, such as the viscoelastic response of polymeric fluids and diffusion and mass transfer. Next, the text explores specific practical aspects of polymer processing, including mixing, extrusion dies, and post-die processing. By addressing a broad range of design issues and methods, the authors demonstrate how to solve most common processing problems.This Second Edition of the highly acclaimed Polymer Processing has been thoroughly updated to reflect current polymer processing issues and practices. New areas of coverage include:Micro-injection molding to produce objects weighing a fraction of a gram, such as miniature gears and biomedical devicesNew chapter dedicated to the recycling of thermoplastics and the processing of renewable polymersLife-cycle assessment, a systematic method for determining whether recycling is appropriate and which form of recycling is optimalRheology of polymers containing fibersChapters feature problem sets, enabling readers to assess and reinforce their knowledge as they progress through the text. There are also special design problems throughout the text that reflect real-world polymer processing issues. A companion website features numerical subroutines as well as guidance for using MATLAB®, IMSL®, and Excel to solve the sample problems from the text. By providing both underlying theory and practical step-by-step guidance, Polymer Processing is recommended for students in chemical, mechanical, materials, and polymer engineering.

Biophysical Methods for Biotherapeutics

by Tapan K. Das

With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.* Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods * Chapters organized according to the sequential nature of the drug development process * Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods * Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity * With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

Heterocyclic Chemistry in Drug Discovery

by Jie Jack Li

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compoundsIntegrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls.Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features:Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discoveryStep-by-step descriptions of synthetic methods and practical techniquesExamination of the physical properties for each heterocycle, including NMR data and quantum calculationsDetailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocyclesHeterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Flavonoid Pharmacokinetics

by Jaime A. Yáñez Neal M. Davies Basil Roufogalis

SETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDSMore and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions.With contributions from a multidisciplinary team of leading researchers, Flavonoids Pharmacokinetics reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers:Methods of analysis of achiral flavonoidsPreclinical pharmacokinetic of flavonoidsToxicology and safety of flavonoidsMethods of analysis for chiral flavonoidsClinical pharmacokinetics of flavonoidsFlavonoids and drug interactionsThroughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process.Flavonoid Pharmacokinetics is written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.

Biopharmaceutics Modeling and Simulations

by Kiyohiko Sugano

A comprehensive introduction to using modeling and simulation programs in drug discovery and developmentBiopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs.A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses:The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS)The concept of drug concentrationHow to simulate key drug absorption processesThe physiological and drug property data used for biopharmaceutical modelingReliable practices for reporting resultsWith over 200 figures and illustrations and a peerless examination of all the key aspects of drug research--including running and interpreting models, validation, and compound and formulation selection--this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.

Publish / Subscribe Systems

by Sasu Tarkoma

This book offers an unified treatment of the problems solved by publish/subscribe, how to design and implement the solutionsIn this book, the author provides an insight into the publish/subscribe technology including the design, implementation, and evaluation of new systems based on the technology. The book also addresses the basic design patterns and solutions, and discusses their application in practical application scenarios. Furthermore, the author examines current standards and industry best practices as well as recent research proposals in the area. Finally, necessary content matching, filtering, and aggregation algorithms and data structures are extensively covered as well as the mechanisms needed for realizing distributed publish/subscribe across the Internet.Key Features:Addresses the basic design patterns and solutionsCovers applications and example cases including; combining Publish/Subscribe with cloud, Twitter, Facebook, mobile push (app store), Service Oriented Architecture (SOA), Internet of Things and multiplayer gamesExamines current standards and industry best practices as well as recent research proposals in the areaCovers content matching, filtering, and aggregation algorithms and data structures as well as the mechanisms needed for realizing distributed publish/subscribe across the InternetPublish/Subscribe Systems will be an invaluable guide for graduate/postgraduate students and specialists in the IT industry, distributed systems and enterprise computing, software engineers and programmers working in social computing and mobile computing, researchers. Undergraduate students will also find this book of interest.

Chemical Sensors and Biosensors

by Florinel-Gabriel Banica

Key features include:Self-assessment questions and exercisesChapters start with essential principles, then go on to address more advanced topics More than 1300 references to direct the reader to key literature and further readingHighly illustrated with 450 figures, including chemical structures and reactions, functioning principles, constructive details and response characteristicsChemical sensors are self-contained analytical devices that provide real-time information on chemical composition. A chemical sensor integrates two distinct functions: recognition and transduction. Such devices are widely used for a variety of applications, including clinical analysis, environment monitoring and monitoring of industrial processes. This text provides an up-to-date survey of chemical sensor science and technology, with a good balance between classical aspects and contemporary trends. Topics covered include: Structure and properties of recognition materials and reagents, including synthetic, biological and biomimetic materials, microorganisms and whole-cellsPhysicochemical basis of various transduction methods (electrical, thermal, electrochemical, optical, mechanical and acoustic wave-based)Auxiliary materials used e.g. synthetic and natural polymers, inorganic materials, semiconductors, carbon and metallic materialsproperties and applications of advanced materials (particularly nanomaterials) in the production of chemical sensors and biosensorsAdvanced manufacturing methodsSensors obtained by combining particular transduction and recognition methodsMathematical modeling of chemical sensor processesSuitable as a textbook for graduate and final year undergraduate students, and also for researchers in chemistry, biology, physics, physiology, pharmacology and electronic engineering, this bookis valuable to anyone interested in the field of chemical sensors and biosensors.

Novel Ecosystems

by Eric S. Higgs Carol Hall Richard J. Hobbs

Land conversion, climate change and species invasions are contributing to the widespread emergence of novel ecosystems, which demand a shift in how we think about traditional approaches to conservation, restoration and environmental management. They are novel because they exist without historical precedents and are self-sustaining. Traditional approaches emphasizing native species and historical continuity are challenged by novel ecosystems that deliver critical ecosystems services or are simply immune to practical restorative efforts. Some fear that, by raising the issue of novel ecosystems, we are simply paving the way for a more laissez-faire attitude to conservation and restoration. Regardless of the range of views and perceptions about novel ecosystems, their existence is becoming ever more obvious and prevalent in today's rapidly changing world. In this first comprehensive volume to look at the ecological, social, cultural, ethical and policy dimensions of novel ecosystems, the authors argue these altered systems are overdue for careful analysis and that we need to figure out how to intervene in them responsibly. This book brings together researchers from a range of disciplines together with practitioners and policy makers to explore the questions surrounding novel ecosystems. It includes chapters on key concepts and methodologies for deciding when and how to intervene in systems, as well as a rich collection of case studies and perspective pieces. It will be a valuable resource for researchers, managers and policy makers interested in the question of how humanity manages and restores ecosystems in a rapidly changing world.A companion website with additional resources is available at

The Visualisation of Spatial Social Structure

by Danny Dorling

How do you draw a map of 100,000 places, of more than a million flows of people, of changes over time and space, of different kinds of spaces, surfaces and volumes, from human travel time to landscapes of hopes, fears, migration, manufacturing and mortality? How do you turn the millions of numbers concerning some of the most important moments of our lives into images that allow us to appreciate the aggregate while still remembering the detail?The visualization of spatial social structure means, literally, making visible the geographical patterns to the way our lives have come to be socially organised, seeing the geography in society. To a statistical readership visualization implies using data. More widely defined it implies freeing our imaginations.The Visualization of Spatial Social Structure introduces the reader to new ways of thinking about how to look at social statistics, particularly those about people in places. The author presents a unique combination of statistical focus and understanding of social structures and innovations in visualization, describing the rationale for, and development of, a new way of visualizing information in geographical research. These methods are illustrated through extensive full colour graphics; revealing mistakes, techniques and discoveries which present a picture of a changing political and social geography. More complex aspects on the surface of social landscapes are revealed with sculptured symbols allowing us to see the relationships between the wood and the trees of social structure. Today's software can be so flexible that these techniques can now be emulated without coding.This book centres on a particular place and time; 1980s Britain, and a particular set of records; routine social statistics. A great deal of information about the 80s' social geography of Britain is contained within databases such as the population censuses, surveys and administrative data. Following the release of the 2011 census, now is a good time to look back at the past to introduce many new visualization techniques that could be used by future researchers.

The Toxicology of Methanol

by John J. Clary

The Toxicology of Methanol presents a single source of information and an understanding of the toxicity of methanol from animal data, potential environmental effects as well as human effects. The animal data, which goes to making up the majority of the data on the toxicity of methanol and the mechanism of action, is reviewed as it relates to the potential toxicity in humans.

The Syntax Workbook

by Andrew Carnie

The Syntax Workbook was written as a response to the students and instructors who, over the years, have requested more problem sets that give greater experience in analyzing syntactic structure. Aligned chapter-by-chapter with Carnie's bestselling textbook, this workbook provides over 120 new exercises on all of the major topics in generative syntax.An all-new workbook to accompany the bestselling syntax textbook, Syntax: A Generative Introduction, which answers the need for a practical text in this fieldFeatures over 120 problem sets with answers, designed to give students greater experience of analyzing syntactic structureExercises and topics covered includes phrase structure, the lexicon, Case theory, ellipsis, auxiliaries, movement, covert movement, locality conditions, VP shells, and controlSupported by expanded online student and instructor resources, including extra chapters on HPSG, LFG and time-saving materials for lecturers, including problem sets, PowerPoint slides, and an instructors' manual Structured to reflect the style and chapter-by-chapter coverage of the textbook, but its practical, reader-friendly layout also makes it suitable for use as a stand-alone Workbook

Aircraft Design

by Mohammad H. Sadraey

A comprehensive approach to the air vehicle design process using the principles of systems engineeringDue to the high cost and the risks associated with development, complex aircraft systems have become a prime candidate for the adoption of systems engineering methodologies. This book presents the entire process of aircraft design based on a systems engineering approach from conceptual design phase, through to preliminary design phase and to detail design phase.Presenting in one volume the methodologies behind aircraft design, this book covers the components and the issues affected by design procedures. The basic topics that are essential to the process, such as aerodynamics, flight stability and control, aero-structure, and aircraft performance are reviewed in various chapters where required. Based on these fundamentals and design requirements, the author explains the design process in a holistic manner to emphasise the integration of the individual components into the overall design. Throughout the book the various design options are considered and weighed against each other, to give readers a practical understanding of the process overall. Readers with knowledge of the fundamental concepts of aerodynamics, propulsion, aero-structure, and flight dynamics will find this book ideal to progress towards the next stage in their understanding of the topic. Furthermore, the broad variety of design techniques covered ensures that readers have the freedom and flexibility to satisfy the design requirements when approaching real-world projects.Key features:* Provides full coverage of the design aspects of an air vehicle including: aeronautical concepts, design techniques and design flowcharts* Features end of chapter problems to reinforce the learning process as well as fully solved design examples at component level* Includes fundamental explanations for aeronautical engineering students and practicing engineers* Features a solutions manual to sample questions on the book's companion websiteCompanion website -

Publishing E-Books For Dummies

by Ali Luke

Publish, market, and sell your own e-book Although creating an e-book seems fairly straightforward, it is not. You need to select and create a variety of formats that will be read on a variety of e-reader devices--and market and sell your book in a variety of ways. Before you take the plunge, get this practical guide. With clear instruction and sensible advice, it will help you navigate the often confusing, time-consuming, and costly world of self-publishing an e-book. The book gives you solid marketing tips for selling your e-book, including using blogging and social media and how to build an online platform. It also discusses key technologies you'll encounter, including Smashwords, iBooks Author, Amazon, Microsoft Word, Open Office, Calibre, WordPress, E-junkie, and others.Helps readers navigate the confusing, time-consuming, and often costly world of self-publishing an e-book Provides both technical how-tos as well solid marketing advice on how to sell your e-book using Facebook, Twitter, Goodreads, and other social media sites Covers essential technologies, such as Smashwords, iBooks Author, Amazon, Microsoft Word, Open Office, Calibre, WordPress, and E-junkie Explores e-book devices, including Kindle, Kobo, Sony Reader, Nook, iPad, and other tablets Delves into the nitty-gritty of e-book formats Before you self-publish your e-book, start first with Publishing eBooks For Dummies.

Using the Weibull Distribution

by John I. Mccool

Understand and utilize the latest developments in Weibull inferential methods While the Weibull distribution is widely used in science and engineering, most engineers do not have the necessary statistical training to implement the methodology effectively. Using the Weibull Distribution: Reliability, Modeling, and Inference fills a gap in the current literature on the topic, introducing a self-contained presentation of the probabilistic basis for the methodology while providing powerful techniques for extracting information from data. The author explains the use of the Weibull distribution and its statistical and probabilistic basis, providing a wealth of material that is not available in the current literature. The book begins by outlining the fundamental probability and statistical concepts that serve as a foundation for subsequent topics of coverage, including: * Optimum burn-in, age and block replacement, warranties and renewal theory * Exact inference in Weibull regression * Goodness of fit testing and distinguishing the Weibull from the lognormal * Inference for the Three Parameter Weibull Throughout the book, a wealth of real-world examples showcases the discussed topics and each chapter concludes with a set of exercises, allowing readers to test their understanding of the presented material. In addition, a related website features the author's own software for implementing the discussed analyses along with a set of modules written in Mathcad®, and additional graphical interface software for performing simulations. With its numerous hands-on examples, exercises, and software applications, Using the Weibull Distribution is an excellent book for courses on quality control and reliability engineering at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for engineers, scientists, and business analysts who gather and interpret data that follows the Weibull distribution

Comparative Pathophysiology and Toxicology of Cyclooxygenases

by Zaher A. Radi

The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.

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