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The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.
Rosi Braidotti's nomadic theory outlines a sustainable modern subjectivity as one in flux, never opposed to a dominant hierarchy yet intrinsically other, always in the process of becoming, and perpetually engaged in dynamic power relations both creative and restrictive. Nomadic theory offers an original and powerful alternative for scholars working in cultural and social criticism and has, over the past decade, crept into continental philosophy, queer theory, and feminist, postcolonial, techno-science, media, and race studies, as well as into architecture, history, and anthropology. This collection provides a core introduction to Braidotti's nomadic theory and its innovative formulations, which playfully engage with Deleuze, Foucault, Irigaray, and a host of political and cultural issues. Arranged thematically, essays begin with such concepts as sexual difference and embodied subjectivity and follow with explorations in technoscience, feminism, postsecular citizenship, and the politics of affirmation. Braidotti develops a distinctly positive critical theory that rejuvenates the experience of political scholarship. Inspired yet not confined by Deleuzian vitalism, with its commitment to the ontology of flows, networks, and dynamic transformations, she emphasizes affects, imagination, and creativity and the politics of radical immanence. Incorporating ideas from Nietzsche and Spinoza as well, Braidotti establishes a critical-theoretical framework equal parts critique and creation. Ever mindful of the perils of defining difference in terms of denigration and the related tendency to subordinate sexualized, racialized, and naturalized others, she explores the eco-philosophical implications of nomadic theory, feminism, and the irreducibility of sexual difference and sexuality. Her dialogue with technoscience is crucial to nomadic theory, which deterritorializes the established understanding of what counts as human, along with our relationship to animals, the environment, and changing notions of materialism. Keeping her distance from the near-obsessive focus on vulnerability, trauma, and melancholia in contemporary political thought, Braidotti promotes a politics of affirmation that has the potential to become its own generative life force.
It is now 20 years since thoracoscopic surgery first entered everyday hospital practice, revolutionizing surgery and offering major benefits to patients. The intervening years have witnessed rapid progress, with the development of a variety of specialized techniques and equipment. This superbly illustrated book provides authoritative and comprehensive descriptions of the various minimally invasive techniques that are currently employed in thoracic and cardiac surgery. A wide range of thoracoscopic procedures are explained and discussed, and detailed attention is also paid to robotic and robot-assisted surgical techniques. Throughout, the emphasis is on clear description of procedures and identification of practical aspects of relevance in surgical practice. The authors are some of the world's most experienced thoracic and cardiac surgeons, and many of them have contributed greatly to the exploration and development of the field.
Author of the acclaimed work Iceberg Risk: An Adventure in Portfolio Theory, Kent Osband argues that uncertainty is central rather than marginal to finance. Markets don't trade mainly on changes in risk. They trade on changes in beliefs about risk. In the process, markets unite, stretch, and occasionally defy beliefs. Recognizing this would make a world of difference in investing. Belittling uncertainty has driven a rift between financial theory and practice and within finance theory itself. It has misguided regulation. It has stoked the greatest financial imbalances in world history. Hoping to spark a revolution in the mindset of the investment professional, Osband recasts the market as a learning machine rather than a knowledge machine. The market continually errs, corrects itself, and makes new errors. Respecting that process without idolizing it will lead to wiser investment, trading, and regulation. With uncertainty embedded at its core, Osband's rational approach points to a finance theory worthy of twenty-first-century investing.
Ischemic optic neuropathy, often referred to as a stroke of the optic nerve, is one of the major causes of visual impairment or loss of vision. Yet it is a highly controversial and confusing subject because of the general lack of in-depth scientific understanding of the subject. In this book the leading authority in the field describes in detail the current knowledge about the different forms of the often devastating disease. Insights into the underlying pathogenesis and peculiar clinical features are given, leading the reader to the most appropriate way of management. This information will help any physician dealing with patients who suffer from sudden loss of vision.
If college is supposed to be the best time of our lives, why are so many students unhappy? What causes a well-adjusted and academically successful high school graduate to suddenly flounder when he reaches college? Why might she start to skip classes, binge on alcohol, or engage in unsatisfying hook-ups? Where does the anger and self-doubt come from, and why is it directed at loving parents or the student himself? Drawing on years of experience treating college-age youth, David Leibow, M. D. provides fresh, honest, and realistic answers to these and other important questions. Instead of adventure, liberation, and a triumphant march into adulthood, many college students experience shame, regression, and social and academic failure. Yet by understanding themselves better and making reasonable changes, students can grow from these challenges and turn bad choices into wiser personal and educational decisions. Leibow focuses on issues common to college settings-anxiety and depression, drug and alcohol abuse, laziness and work avoidance, body-image problems, and unhealthy relationships-detailing coping strategies and professional resources that best respond to each crisis. His intimate knowledge of campus life and its unique challenges adds credibility and weight to his advice. Reorienting the expectations of parents and students while providing the tools for overcoming a variety of hurdles, Leibow shows how college can still become one of the best times of our lives.
Azo dyes play an important role as coloring agents in the textile, food, and pharmaceutical industry. Due to the toxicity, mutagenicity and carcinogenicity of azo dyes and their breakdown products, their removal from industrial wastewaters has been an urgent challenge. Promising and cost-effective methods are based on their biodegradation, which is treated in this volume. The topics presented by experts in the field include: the classification of azo dyes; toxicity caused by azo dyes; aerobic and anaerobic azo dye biodegradation mechanisms; the role of bacteria, fungi, algae and their enzymes in biodegradation; the impact of redox mediators on azo dye reduction; the integration of biological with physical and chemical processes; the biotransformation of aromatic amines; reactor modelling for azo dye conversion; the biodegradation of azo dyes by immobilized bacteria and fungi; and factors affecting the complete mineralization of azo dyes.
The purpose of the present volume is to illustrate the modern biological concept of basic endocrinology in one single book. It first describes general issues such as maturation of secretory granules in the cells, the roles of the chaperonic granins, and cell-specific prohormone processing. Subsequently, the specific part of the book illustrates the new endocrine biology, using as examples a broad variety of individual peptide systems: ACTH, Neurotensin and Neuromedines, Natriuretic Peptides, Glucagon and Glucagon-like peptides, Somatostatin, Ghrelin, Gastrin and VIP (Vasoactive Intestinal Polypeptide).
Joseph Margolis, known for his considerable contributions to the philosophy of art and aesthetics, pragmatism, and American philosophy, has focused primarily on the troublesome concepts of culture, history, language, agency, art, interpretation, and the human person or self. For Margolis, the signal problem has always been the same: how can we distinguish between physical nature and human culture? How do these realms relate? The Cultural Space of the Arts and the Infelicities of Reductionism identifies a conceptual tendency that can be drawn from the work of the twentieth century's best-known analytic philosophers of art: Arthur Danto, Richard Wollheim, Kendall Walton, Nelson Goodman, Monroe Beardsley, Noël Carroll, and Jerrold Levinson, among others. This trend threatens to impoverish our grasp and appreciation of the arts by failing to do justice to the culturally informed nature of the arts themselves. Through his analysis, Margolis sets out to retrieve an adequate picture of the essential differences between physical nature and human culture& mdash;particularly through language, history, meaning, significance, the emergence of the human self or person, and the essential features of human life& mdash;all to explain how such difference bears on our perception of paintings and literature. Clearly argued and provocatively engaging, Margolis's work reestablishes what is essential to a productive encounter with art.
Collaborating with community members adds a critical dimension to social work research, providing practitioners with intimate knowledge of a community's goals and needs while equipping community advocates with vital skills for social change. Sharing the inspiring story of one such partnership, Corey Shdaimah, Roland Stahl, and Sanford F. Schram recount their efforts working with an affordable housing coalition in Philadelphia, helping activists research low-income home ownership and repair. Their collaboration helped create the Philadelphia Housing Trust Fund, which funnels millions of dollars to people in need. This volume describes the origins of their partnership and its growth, including developing tensions and their diffusion in ways that contributed to the research. The authors personalize methods of research and the possibilities for advocacy, ultimately connecting their encounters to more general, critical themes. Building on the field's commitment to social justice, they effectively demonstrate the potential of change research to facilitate widespread, long-term difference and improve community outcomes.
Mutual funds form the bedrock of retirement savings in the United States, and, considering their rapid growth, are sure to be more critical in the future. Because the size of fees paid by investors to mutual fund advisers can strongly affect the return on investment, these fees have become a contentious issue in Congress and the courts, with many arguing that investment advisers grow rich at the expense of investors. This ground-breaking book not only conceptualizes a new economic model of the mutual fund industry, but also uses this model to test for price competition between investment advisers, evaluating the assertion that market forces fail to protect investors' returns from excessive fees. Highly experienced authors track the growth of the industry over the past twenty-five years and present arguments and evidence both for and against theories of adviser malfeasance. The authors review the regulatory history of mutual fund fees and summarize leading case decisions addressing excessive fees. Revealing the extent to which the governance structure of mutual funds truly impacts fund performance, this book provides the best understanding of today's mutual fund industry and is a vital tool for investors, money managers, fund directors, securities lawyers, economists, and anyone concerned with the regulation of mutual funds.
There couldn't be a more appropriate method for illustrating the dynamics of psychoanalysis than the vehicle of story. In this book, Kerry L. Malawista, Anne J. Adelman, and Catherine L. Anderson share amusing, poignant, and sometimes difficult stories from their personal and professional lives, inviting readers to explore the complex underpinnings of the psychoanalytic profession and its esoteric theories. Through their narratives, these practicing analysts show how to incorporate psychodynamic concepts and identify common truths at the root of shared experience. Their approach demystifies dense material and the emotional consequences of deep clinical work. The book covers psychodynamic theory, the development of ideas, various techniques, the challenges of treatment, and the experiences of trauma and loss. Each section begins with a brief memoir by one of the authors and leads into a discussion of related concepts. Overall the text follows a developmental trajectory, opening with stories from early childhood and concluding with present encounters. The result is a unique approach enabling the absorption of psychodynamic concepts as they unfold across the life span.
Exposing the pseudoscience, ideological agendas, and biological determinism behind a disturbing new trend in gender development.
Beginning in the sixth century C.E. and continuing for more than a thousand years, an extraordinary poetic practice was the trademark of a major literary movement in South Asia. Authors invented a special language to depict both the apparent and hidden sides of disguised or dual characters, and then used it to narrate India's major epics, the Ramayana and the Mahabharata, simultaneously. Originally produced in Sanskrit, these dual narratives eventually worked their way into regional languages, especially Telugu and Tamil, and other artistic media, such as sculpture. Scholars have long dismissed simultaneous narration as a mere curiosity, if not a sign of cultural decline in medieval India. Yet Yigal Bronner's Extreme Poetry effectively negates this position, proving that, far from being a meaningless pastime, this intricate, "bitextual" technique both transcended and reinvented Sanskrit literary expression. The poems of simultaneous narration teased and estranged existing convention and showcased the interrelations between the tradition's foundational texts. By focusing on these achievements and their reverberations through time, Bronner rewrites the history of Sanskrit literature and its aesthetic goals. He also expands on contemporary theories of intertextuality, which have been largely confined to Western texts and practices.
Public deliberation and group discussion can strengthen the foundations of civil society, even when the groups engaged in debate share a history of animosity. Scholars have begun to study the dialogue sustaining these conversations, especially its power to unite and divide groups and individuals. The twenty-four essays in this collection analyze public exchanges and the nature of sustained dialogue within the context of race relations, social justice, ethnic conflicts, public-safety issues, public management, community design, and family therapy. They particularly focus on college campuses and the networks of organizations and actors that have found success there. Open discussion may seem like an idealistic if not foolhardy gesture in such milieus, yet in fact the practice proves crucial to establishing and reinforcing civic harmony.
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.
Das Buch Work-Life Balance ist eine praxisnahe und gleichzeitig fundierte Bestandsaufnahme zum Thema Work-Life Balance. Der Fokus liegt auf dem Bereich der Extremjobber, die sich vor allem in wissensintensiven Dienstleistungsunternehmen, auf der Managementebene von Industrieunternehmen, aber auch in freiberuflichen Tätigkeiten wiederfinden. Das Buch zeigt auf, welche Maßnahmen gerade für Extremjobber als erfolgversprechend gelten, und warum es auf lange Sicht sinnvoll ist, Work-Life Balance Maßnahmen im Unternehmen zu etablieren. Es richtet sich vor allem an Praktiker, die sich täglich mit Personal- und Führungsthemen auseinandersetzen, sowie an betroffene Extremjobber. Ihnen soll das Buch die Möglichkeit geben, das Thema Work-Life Balance kritisch zu reflektieren und neuartig zu managen.
One of therapy's greatest challenges is the moment of transference, when a patient unconsciously transfers emotion or desire to a new and present object, in some cases the therapist. During the course of treatment, a patient's projections and the analyst's struggle to divert them can stress, distort, or contaminate the therapeutic relationship. It may lead to various forms of enactment, in which the therapist unconsciously colludes with the client in interpretation and treatment, or projective identification, in which the client imposes negative feelings and behaviors onto the therapist, further interfering with analysis and intervention.
The law plays a significant role in ensuring aviation security. This book addresses new and emerging threats to civil aviation; evaluates security tools now in use such as the Public Key Directory, Advance Passenger Information, Passenger Name Record and Machine Readable travel documents in the context of their legal and regulatory background; and discusses applicable security treaties while providing an insight into the process of the security audits conducted by the International Civil Aviation Organization (ICAO). The book also examines issues of legal responsibility of States and individuals for terrorist acts of third parties against civil aviation and discusses from a legal perspective the latest liability Conventions adopted at ICAO. The Conclusion of the book provides an insight into the application oflegal principles through risk management.
Since the early days of film, critics and theorists have debated the value of formula, cliché, conventional imagery, and recurring narrative patterns of reduced complexity. The high noon showdown or last-minute rescue, the lonely woman standing in the window or two lovers saying goodbye in the rain-many films rely on these scenes, and audiences have come to expect them. Outlining a comprehensive theory of film stereotype, a device as functionally important to film narrative as it is problematic, Jörg Schweinitz builds an overlooked critical history from the 1920s to today. Drawing on theories of stereotype in linguistics, literary analysis, art history, and psychology, Schweinitz identifies the major facets of film stereotype and articulates the positions of theorists in response to the challenges posed by stereotype. He reviews the writing of Susan Sontag, Roland Barthes, Theodor W. Adorno, Robert Musil, Béla Balázs, Hugo Münsterberg, and Edgar Morin, and he brings to light less prominent writers, such as René Fülöp-Miller and Gilbert Cohen-Séat, and traces the evolution of the discourse into a postmodern celebration of the device. Through detailed readings of specific films, Schweinitz also maps models for adapting and reflecting stereotype, from early ironic (Alexander Granowski) and conscious rejection (Robert Rossellini) to critical deconstruction (Robert Altman in the 1970s) and celebratory transfiguration (Sergio Leone and the Coen brothers). His history, which won the prestigious Geisteswissenschaften International award, reveals the role of film stereotype in shaping processes of communication and recognition, as well as its function in developing media competence beyond cinema.
The European Commission requires an impact assessment report for any regulation proposed. This book analyzes the quality of impact assessments and discusses deficits and possible improvements. Based on 30 case studies of impact assessments, an institutional analysis of the relevant actors is conducted, which shows that there are many shortcomings, among them an incentive problem concerning desk officers in the European Commission. The book includes various articles which address controversial problems and possible solutions. It offers a comprehensive overview of the practice of impact assessment in the EC, as well as an institutional analysis of the processes involved and of the checks and balances between politicians and their administration.
The attack on Pearl Harbor, which precipitated the Greater East Asia War and its initial triumphs, aroused pride and a host of other emotions among the Japanese people. Yet the single year in which Japanese forces occupied territory from Alaska to Indonesia was followed by three years of terrible defeat. Nevertheless, until the shattering end of the war, many Japanese continued to believe in the invincibility of their country. But in the diaries of well-known writers-including Nagai Kafu, Takami Jun, Yamada Futaru, and Hirabayashi Taiko-and the scholar Watanabe Kazuo, varying doubts were vividly, though privately, expressed. Donald Keene, renowned scholar of Japan, selects from these diaries, some written by authors he knew well. Their revelations were sometimes poignant, sometimes shocking to Keene. Ito Sei's fervent patriotism and even claims of racial superiority stand in stark contrast to the soft-spoken, kindly man Keene knew. Weaving archival materials with personal recollections and the intimate accounts themselves, Keene reproduces the passions aroused during the war and the sharply contrasting reactions in the year following Japan's surrender. Whether detailed or fragmentary, these entries communicate the reality of false victory and all-too-real defeat.
This volume is the result of a research project entitled "Evolutionary Continuity - Human Specifics - The Possibility of Objective Knowledge" that was carried out by representatives of six academic disciplines (evolutionary biology, evolutionary anthropology, brain research, cognitive neuroscience, cognitive psychology and philosophy) over a period of three and a half years. The starting point for the project was the newly emerging riddle of human uniqueness: though the uniqueness of human beings is undisputable, all explanations for this fact have successively been discarded or refuted in recent decades. There is no special factor that could explain the particularities of human existence. Rather, all human skills derive from a continuous relation to pre-human skills, that is to say, to elements that were developed earlier in the phylogeny and were later inherited. But starting from abilities that are anything but special, how could the particularity of human beings have evolved? This was the guiding question of the project. In this work we try to answer it by addressing the following problems: How strong is evolutionary continuity in human beings? How can we understand that it gave way to cultural discontinuity? Which aspect of cultural existence is really unique to humans? Can the possibility of objective knowledge be seen as a (admittedly extreme) case in point? - The answers are meant to help clarify the central issue of contemporary scientific anthropology.
Known as the New Madrid seismic zone, the Midwestern rift between two geologic plates on the continental US has led many people to believe in strong likelihood of an imminent and hugely destructive earthquake in the Midwest. After the San Francisco earthquake of 1905 the biggest and most damaging earthquake in US history was the one in New Madrid, Missouri in 1811-1812. This New Madrid story has been written about and debated for years in advanced scientific communications and in the popular media. Yet, there has never been an accurate and approachable telling of the real science and the hazard preparation policy that is warranted in light of the science. With the 200th anniversary of the New Madrid earthquake coming up in 2011 and numerous predictions of doom in the media there will be a lot of interest in this topic. After Hurricane Katrina the whole topic of disaster preparation has become a major issue in scientific media and the public eye. Seth Stein is THE author to tell this story. He is a major figure in US Geosicence and a leading seismologist. He was actively involved in doing the research on the New Madrid Rift Zone. He writes beautifully and has a knack for telling stories about how science is done - the give and take of different hypotheses and the scientific leg work to test these ideas all get a clear and engaging exposition in what the author calls a "Discover Magazine" style. How the science gets played out in a policy arena and how the media can distort sound science to create a good story are also important features of the book. Along the way this book presents a solid dose of real science - the basics of earthquake science and seismology are given a very lively treatment here all within the context of a fascinating tale that features science, history, psychology and public policy.
This practical, up-to-date, bedside-oriented radiation oncology book encompasses the essential aspects of the subject with coverage on radiation physics, radiobiology, and clinical radiation oncology. The first two sections examine concepts that are crucial in radiation physics and radiobiology. The third section describes radiation treatment regimens appropriate for the main cancer sites and tumor types.