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Epic Measures

by Jeremy N. Smith

Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time and the visionary mastermind behind it.Medical doctor and economist Christopher Murray began the Global Burden of Disease study to gain a truer understanding of how we live and how we die. While it is one of the largest scientific projects ever attempted--as breathtaking as the first moon landing or the Human Genome Project--the questions it answers are meaningful for every one of us: What are the world's health problems? Who do they hurt? How much? Where? Why?Murray argues that the ideal existence isn't simply the longest, but the one lived well and with the least illness. Until we can accurately measure global health issues, we cannot understand what makes us sick or do much to improve it. Challenging the accepted wisdom of the WHO and the UN, the charismatic and controversial health maverick has made enemies--as well as some influential friends, including Bill Gates who gave Murray a $100 million grant.Told with novelistic verve by acclaimed journalist Jeremy N. Smith, the story of Murray's lifelong determination to understand how we live and die encompasses wars and famines, presidents and activists, billionaires and billions of people worldwide living in poverty. It shows the human side of scientific revolutions and of revolutionary scientists--their breakthroughs and setbacks, their genius and their flaws, their champions and their critics--as they strive to bring the news of their findings to the world. This transformational effort is far from over, but the story of its genesis and impact is already an epic tale.

The Epic of New York City

by Edward Robb Ellis

In swift, witty chapters that flawlessly capture the pace and character of New York City, acclaimed diarist Edward Robb Ellis presents his masterpiece: a thorough, and thoroughly readable, history of America's largest metropolis. Ellis narrates some of the most significant events of the past three hundred years and more--the Revolutionary and Civil Wars, Alexander Hamilton and Aaron Burr's fatal duel, the formation of the League of Nations, the Great Depression--from the perspective of the city that experienced, and influenced, them all. Throughout, he infuses his account with the strange and delightful anecdotes that a less charming tour guide might omit, from the story of the city's first, block-long subway to that of the blizzard of 1888 that turned Macy's into one big slumber party. Playful yet authoritative, comprehensive yet intimate, The Epic of New York City confirms the words of its own epigraph, spoken by Oswald Spengler: "World history is city history," particularly when that city is the Big Apple.

The Epic of New York City

by Edward Robb Ellis

In swift, witty chapters that flawlessly capture the pace and character of New York City, acclaimed diarist Edward Robb Ellis presents his masterpiece: a thorough, and thoroughly readable, history of America's largest metropolis. Ellis narrates some of the most significant events of the past three hundred years and more-the Revolutionary and Civil Wars, Alexander Hamilton and Aaron Burr's fatal duel, the formation of the League of Nations, the Great Depression-from the perspective of the city that experienced, and influenced, them all. Throughout, he infuses his account with the strange and delightful anecdotes that a less charming tour guide might omit, from the story of the city's first, block-long subway to that of the blizzard of 1888 that turned Macy's into one big slumber party. Playful yet authoritative, comprehensive yet intimate, The Epic of New York City confirms the words of its own epigraph, spoken by Oswald Spengler: "World history is city history," particularly when that city is the Big Apple.

Epic Rivalry: The Inside Story of the Soviet and American Space Race

by Gene Eisman Von Hardesty

When Neil Armstrong and Buzz Aldrin walked on the moon in 1969, they personified an almost unimaginable feat-the incredibly complex task of sending humans safely to another celestial body. This extraordinary odyssey, which grew from the rivalry between the United States and the Soviet Union during the Cold War, was galvanized by the Sputnik launch in 1957. To mark the fiftieth anniversary of Sputnik, National Geographic recaptures this gripping moment in the human experience with a lively and compelling new account. Written by Smithsonian curator Von Hardesty and researcher Gene Eisman, Epic Rivalry tells the story from both the American and the Russian points of view, and shows how each space-faring nation played a vital role in stimulating the work of the other. Scores of rare, unpublished, and powerful photographs recall the urgency and technical creativity of both nations' efforts. The authors recreate in vivid detail the "parallel universes" of the two space exploration programs, with visionaries Wernher von Braun and Sergei Korolev and political leaders John F. Kennedy and Nikita Khrushchev at the epicenters. The conflict between countries, and the tense drama of their independent progress, unfolds in vivid prose. Approaching its subject from a uniquely balanced perspective, this important new narrative chronicles the epic race to the moon and back as it has never been told before-and captures the interest of casual browsers and science, space, and history enthusiasts alike.

Epic Survival

by Josh Young Matt Graham

Matt Graham, star of the Discovery Channel's Dual Survival and Dude, You're Screwed, details the physical, mental, and emotional joys and harrowing struggles of his life as a modern-day hunter-gatherer.Early on in his life, Matt craved a return to nature. When he became an adult, he set aside his comfortable urban life and lived entirely off the land to learn from the smallest and grandest of all things. In this riveting narrative that brings together epic adventure and spiritual quest, he shows us what extraordinary things the human body is capable of when pushed to its limits. In Epic Survival, written with Josh Young, coauthor of five New York Times bestsellers, Matt relays captivating stories from his life to show just how terrifying--and gratifying--living off the grid can be. He learns the secrets of the Tarahumara Indians that helped him run the 1,600-mile Pacific Crest Trail in just fifty-eight days and endure temperature swings of 100 degrees. He takes us with him as he treks into the wilderness to live alone for half a year, armed with nothing but a loincloth, a pair of sandals, a stone knife, and chia seeds. He recounts near-death experiences of hiking alone through the snowdrifts at the bottom of the Grand Canyon, and tells us about the time he entered a three-day Arabian horse race on foot--and finished third. Above all, Epic Survival is a book about growing closer to the land that nurtures us. No matter how far our modern society takes us from the wilderness, the call remains. Whether you're an armchair survivalist or have taken the plunge yourself, Matt's story is both inspiration and invigoration, teaching even the most urbane among us important and breathtaking lessons.

An Epic Swindle

by Brian Reade

AN EPIC SWINDLE is the inside story of how Liverpool FC came within hours of being re-possessed by the banks after the shambolic 44-month reign of American owners Tom Hicks and George Gillett. It is the tale of a civil war that dragged Britain's most successful football club to its knees, through the High Court and almost into administration. Players Steven Gerrard and Jamie Carragher tell of their anger at the broken promises, as well as their pain at watching loyal fans in open revolt. Manager, chief executive, board members, leading fans and journalists reveal the turmoil at a revered sporting institution run by two men at war with each other, who trampled Liverpool's cherished traditions into the gutter. No story sums up the naked greed at the heart of modern football quite like Hicks' and Gillett's attempt to turn a buck at Liverpool. No-one has had as much access to the truth, or tells it with as much passion, wit and insight as Brian Reade. bAN EPIC SWINDLE is the riveting story of how close one of the great football clubs came to financial implosion. b

Epic Tales from Adventure Time: the Lonesome Outlaw

by T. T. Macdangereuse

The #1 hit show heads out West! The third novel in the Epic Tales from Adventure Time series takes the adventure to the Wild West and stars Marceline as a notorious outlaw on the run. <P><P>The series, based on an idea from Adventure Time creator Pendleton Ward, features the show's beloved characters in stories inspired by classic pulp novels (with a touch of romance) in a fan-fiction version of Ooo.

Epicenter 2. 0: Why the Current Rumblings in the Middle East Will Change Your Future

by Joel C. Rosenberg

What does the future hold for Israel and the world? Joel Rosenberg novelist and commentator looks at the future through three lenses: current events, history, and scripture. Joel Rosenberg writes "My intent with Epicenter is not to persuade anyone of what is coming. Rather it is to explain how I came to write The Last Jihad, The Last Days, The Ezekiel Option, and The Copper Scroll and to answer the questions that have flowed from the novels and the prophecies upon which they were based. it is the premise of this book that the earthshaking events that lie ahead can actually be forecast with a surprising degree of accuracy. In writing Epicenter, I have pored over previously classified intelligence documents, internal White House and State Department memos, thousands of U.S. and foreign news articles, scores of books and research studies and the sacred writings of Christians, Jews, and Muslims in the ancient Middle East. I have traveled to Israel, Egypt, Jordan, Turkey, Morocco, and Russia. I have also interviewed political, military, intelligence, business, and religious leaders who live and work in the epicenter and are helping shape its future." Epicenter is a wide-ranging discussion of an end times prophesy by an author whose fiction tends to fall uncomfortably close to what actually happens. Is there oil in Israel? Will Russia attack Israel as predicted in the book of Ezekiel? The only subject in End Times Prophesy Mr. Rosenberg doesn't speculate much on is Anti-Christ. Much of what he talks about is going to happen first. The book is clear, concise, and more than a little frightening.

The Epicure's Lament

by Kate Christensen

For ten years, Hugo Whittier, upper-class scion, former gigolo, failed belle-lettrist has been living a hermit's existence at Waverly, his family's crumbling mansion overlooking the Hudson. He passes the time reading Montaigne and M. F. K. Fisher, cooking himself delicious meals, smoking an endless number of cigarettes, and nursing a grudge against the world. But his older brother, Dennis, has returned, in retreat from an unhappy marriage, and so has his estranged wife, Sonia, and their (she claims) daughter, Bellatrix, shattering Hugo's cherished solitude. He's also been told by a doctor that he has the rare Buerger's disease, which means that unless he stops smoking he will die--all the more reason for Hugo to light up, because his quarrel with life is bitter and an early death is a most attractive prospect. As Hugo smokes and cooks and sexually schemes and pokes his perverse nose into other people's marriages and business, he records these events as well as his mordant, funny, gorgeously articulated personal history and his thoughts on life and mortality in a series of notebooks. His is one of the most perversely compelling literary personalities to inhabit a novel since John Lanchester'sThe Debt to Pleasure, and his ancestors include the divinely cracked and eloquent narrators of the works of Nabokov. As snobbish and dislikable as Hugo is, his worldview is so enticingly conveyed that even the most resistant reader will be put under his spell. His insinuating voice gets into your head and under your skin in the most seductive way. And as he prepares what may be his final Christmas feast for family and friends, readers will have to ask, "Is this the end of Hugo?" The Epicure's Lamentis a wry and witty novel about love and death and family, a major contribution to a vein of literature that the author Kate Christensen has dubbed "loser lit. " It more than fulfills the bright promise of her lavishly praised previous two novels, and gives us an antihero for our time--hard to like, impossible to resist.

The Epicurious Cookbook: More Than 250 of Our Best-Loved Four-Fork Recipes for Weeknights, Weekends & Special Occasions

by The Editors of Epicurious.com Tanya Steel

For home cooks hungry for make-again recipes, here is an impeccably curated collection from Epicurious with more than 250 of their "4-fork" recipes, conveniently compiled in a book with new photography, new headnotes, and informative user tips. Epicurious is, undisputedly, the most respected website for people who like to cook. In their first-ever cookbook, the Epicurious editors have culled their extraordinary database of 180,000 recipes and selected their most popular recipes. Organized seasonally and by meal type, The Epicurious Cookbook offers everything from 30-minute weeknight dinners to weekend warrior show-stoppers. Also included are comfort food favorites, small dishes perfect for parties and plenty of repertoire-building mains and sides, plus breakfasts, breads, and desserts. All new stunning four-color photography shows Epicurious at its most irresistible. Throughout are Epicurious member suggestions for tweaking recipes, ideas for menu planning, smart substitutions, and homespun recipes from dozens of Epicurious members newly tested for this cookbook. Recipes include:

Epicurus and the Epicurean Tradition

by Kirk R. Sanders Jeffrey Fish

Epicureanism after the generation of its founders has been characterised as dogmatic, uncreative and static. But this volume brings together work from leading classicists and philosophers that demonstrates the persistent interplay in the school between historical and contemporary influences from outside the school and a commitment to the founders' authority. The interplay begins with Epicurus himself, who made arresting claims of intellectual independence, yet also admitted to taking over important ideas from predecessors, and displayed more receptivity than is usually thought to those of his contemporaries. The same principles of autonomy and openness figure importantly in the three major areas of focus in these essays: theology, politics and the emotions.

The Epicurus Reader: Selected Writings and Testimonia

by Brad Inwood D. S. Hutchinson Epicurus L. P. Gerson

TABLE OF CONTENTS: Introduction The ancient biography of Epicurus The extant letters Ancient collections of maxims Doxographical reports The testimony of Cicero The testimony of Lucretius The polemic of Plutarch Short fragments and testimonia from known works: * From On Nature * From the Puzzles * From On the Goal * From the Symposium * From Against Theophrastus * Fragments of Epicurus' letters Short fragments and testimonia from uncertain works: * Logic and epistemology * Physics and theology * Ethics Index

The Epicurus Reader: Selected Writings and Testimonia

by Brad Inwood Epicurus Lloyd P. Gerson

TABLE OF CONTENTS:Introduction The ancient biography of Epicurus The extant letters Ancient collections of maxims Doxographical reports The testimony of Cicero The testimony of Lucretius The polemic of PlutarchShort fragments and testimonia from known works: * From On Nature * From the Puzzles * From On the Goal * From the Symposium * From Against Theophrastus * Fragments of Epicurus' lettersShort fragments and testimonia from uncertain works: * Logic and epistemology * Physics and theology * EthicsIndex

The Epidemic

by Suzanne Young

Can one girl help others find closure by slipping into the identities of their loved ones? Find out in this riveting sequel to The Remedy and companion to the New York Times bestselling The Treatment and The Program.In a world before The Program... Quinlan McKee has spent her life acting as other people. She was a closer--a person hired to play the role of the recently deceased in order to give their families closure. Through this process, Quinn learned to read people and situations, even losing a bit of herself to do so. But she couldn't have guessed how her last case would bring down her entire world. The only person Quinn trusts is Deacon, her best friend and the love of her life. Except Deacon's been keeping secrets of his own, so Quinn must set out alone to find Arthur Pritchard, the doctor who's been trying to control her life. The journey brings Quinn to Arthur's daughter, Virginia, who tells Quinn the truth about Pritchard's motives. The former closer will start to see that she is the first step in fighting an epidemic. But Quinlan doesn't want to be a cure. And with all the lies surrounding her, she realizes she has no one left to rely on but herself--even if she doesn't know who that is anymore.

The Epidemic

by Suzanne Young

Can one girl help others find closure by slipping into the identities of their loved ones? Find out in this riveting sequel to The Remedy and companion to the New York Times bestselling The Treatment and The Program.In a world before The Program... Quinlan McKee has spent her life acting as other people. She was a closer--a person hired to play the role of the recently deceased in order to give their families closure. Through this process, Quinn learned to read people and situations, even losing a bit of herself to do so. But she couldn't have guessed how her last case would bring down her entire world. The only person Quinn trusts is Deacon, her best friend and the love of her life. Except Deacon's been keeping secrets of his own, so Quinn must set out alone to find Arthur Pritchard, the doctor who's been trying to control her life. The journey brings Quinn to Arthur's daughter, Virginia, who tells Quinn the truth about Pritchard's motives. The former closer will start to see that she is the first step in fighting an epidemic. But Quinlan doesn't want to be a cure. And with all the lies surrounding her, she realizes she has no one left to rely on but herself--even if she doesn't know who that is anymore.

The Epidemic: A History of Aids

by Jonathan Engel

From the Castro bathhouses to AZT and the denial of AIDS in South Africa, this sweeping look at AIDS covers the epidemic from all angles and across the world. Engel seamlessly weaves together science, politics, and culture, writing with an even hand--noting the excesses of the more radical edges of the ACT UP movement as well as the conservative religious leaders who thought AIDS victims deserved what they got.<P><P> The story of AIDS is one of the most compelling human dramas of our time, both in its profound tragedy and in the extraordinary scientific efforts impelled on its behalf. For gay Americans, it has been the story of the past generation, redefining the community and the community's sexuality. For the Third World, AIDS has created endless devastation, toppling economies, social structures, and whole villages and regions. And the worst may yet be to come: AIDS is expanding quickly into India, Russia, China, and elsewhere, while still raging in sub-Saharan Africa.The Epidemic: A History of Aids<P> A distinguished medical historian, Engel lets his characters speak for themselves. Whether gay activists, government officials, public health professionals, scientists, or frightened parents of schoolchildren, they responded as best they could to tragic happenstance that emerged seemingly from nowhere. There is much drama here, and human weakness and heroism too. Writing with vivid immediacy, Engel allows us to relive the short but tumultuous history of a modern scourge.

An Epidemic of Absence

by Moises Velasquez-Manoff

A brilliant, cutting-edge exploration of the dramatic rise of allergic and autoimmune diseases and the controversial, potentially groundbreaking therapies that scientists are developing to correct these disorders Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn's disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that's because it has--to levels never before seen in human history. These days no fewer than one in five--and likely more--Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works. In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global "epidemic of absence," they must restore the human ecosystem. This groundbreaking book explores the promising but controversial "worm therapy"--deliberate infection with parasitic worms--in development to treat autoimmune disease. It explains why farmers' children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease--that a mother's inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment--something as simple as a probiotic--will necessarily begin before birth. An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results. An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You'll discover that you're not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.

An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases

by Moises Velasquez-Manoff

A brilliant, cutting-edge exploration of the dramatic rise of allergic and autoimmune diseases and the controversial, potentially groundbreaking therapies that scientists are developing to correct these disorders Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn's disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that's because it has--to levels never before seen in human history. These days no fewer than one in five--and likely more--Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works. In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global "epidemic of absence," they must restore the human ecosystem. This groundbreaking book explores the promising but controversial "worm therapy"--deliberate infection with parasitic worms--in development to treat autoimmune disease. It explains why farmers' children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease--that a mother's inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment--something as simple as a probiotic--will necessarily begin before birth. An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results. An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You'll discover that you're not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.

Epidemic of Care: A Call for Safer, Better, and More Accountable Health Care

by George C. Halvorson George J. Isham

Recognizing a crisis in American health care, but rejecting any solutions that are not "market-based," Halvorson (chair and CEO, Kaiser Permanente) and Isham (chief health officer, HealthPartners) explore some of the reasons for rising health care costs (absolving the HMOs for any responsibility) and make suggestions for improving the situation. Their proposed system rests largely on promoting evidence- based care for physicians and transferring greater costs to patients to improve "efficiency."

Epidemiological Criminology

by Timothy A. Akers Roberto H. Potter Carl V. Hill

Epidemiological Criminology: A Public Health Approach to Crime and Violence Epidemiological Criminology offers an introduction to the sources and methods of epidemiological criminology and shows how to apply these methods to some of the most vexing problems now confronting researchers and practitioners in public health epidemiology, criminology, and criminal justice. The book describes, explains, and applies the newly formulated practice of epidemiological criminology, an emerging discipline that finds the intersection across theories, methods, and statistical models of public health with their corresponding tools of criminal justice and criminology. The authors show how to apply epidemiological criminology as a practical tool to address population issues of violence and crime nationally and globally. In addition, they look at future directions and the application of this emerging field in corrections, public health and law, gangs and gang violence, victimology, mental health and substance abuse, environmental justice, international human rights, and global terrorism. For students, the book presents an exciting approach to understanding epidemiology as a means with which to tackle some of the worst problems for vulnerable populations. For researchers and policymakers, the book offers a new methodological perspective that recognizes the significance of social disparities and the built environment as factors in the formulation of public health policy, and provides a tool with which to produce more effective interventions, preventive measures, and policy formulations.

Epidemiology and Biostatistics

by Bryan Kestenbaum

Concise, fast-paced, intensive introduction to clinical research design for students and clinical research professionals Readers will gain sufficient knowledge to pass the United States Medical Licensing Examination part I section in Epidemiology

Epidemiology Kept Simple

by B. Burt Gerstman

Epidemiology Kept Simple introduces the epidemiological principles and methods that are increasingly important in the practice of medicine and public health. With minimum use of technical language it fully explains terminology, concepts, and techniques associated with traditional and modern epidemiology. Topics include disease causality, epidemiologic measures, descriptive epidemiology, study design, clinical and primary prevention trials, observational cohort studies, case-control studies, and the consideration of random and systematic error in studies of causal factors. Chapters on the infectious disease process, outbreak investigation, and screening for disease are also included. The latter chapters introduce more advanced biostatistical and epidemiologic techniques, such as survival analysis, Mantel-Haenszel techniques, and tests for interaction.This third edition addresses all the requirements of the American Schools of Public Health (ASPH) Epidemiological Competencies, and provides enhanced clarity andreadability on this difficult subject. Updated with new practical exercises, case studies and real world examples, this title helps you develop the necessary tools to interpret epidemiological data and prepare for board exams, and now also includes review questions at the end of each chapter.Epidemiology Kept Simple continues to provide an introductory guide to the use of epidemiological methods for graduate and undergraduate students studying public health, health education and nursing, and for all practicing health professionals seeking professional development.

Epigenetic Alterations in Oncogenesis

by Adam R. Karpf

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means "above" genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Epigenetic Approaches to Allergy Research

by Marién Pascual Sergio Roa

In recent years, epigenetic approaches to existing scientific problems have offered many new and exciting perspectives. This book focuses on epigenetic approaches to study asthma and allergy research. The authors briefly review cellular factors, immune signaling, and inflammatory pathways in allergy and asthma, as well as genetic influences in the pathogenesis of atopic disorders. Diseases that have been clearly linked to an epigenetic dysregulation will be discussed, as well as the role of epigenetics in the origin of complex diseases. The authors will examine the impact of environment factors in the predisposition to atopic disorders, and they will also describe the major unanswered questions and future perspectives of an exciting new field that studies allergic diseases from the epigenetic point of view.

Epigenetic Aspects of Chronic Diseases

by Felix Bronner Helmtrud I. Roach Richard O.C. Oreffo

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

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