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So many women who do everything right to stay healthy still wind up with breast cancer, heart disease, or osteoporosis. In The Fragile Wisdom, Grazyna Jasienska provides an evolutionary perspective on the puzzle of why disease prevention among women is so frustratingly difficult. Modern women, she shows, are the unlucky victims of their own bodies' conflict of interest between reproductive fitness and life-long health. The crux of the problem is that women's physiology has evolved to facilitate reproduction, not to reduce disease risk. Any trait-no matter how detrimental to health in the post-reproductive period-is more likely to be preserved in the next generation if it increases the chance of giving birth to offspring who will themselves survive to reproductive age. To take just one example, genes that produce high levels of estrogen are a boon to fertility, even as they raise the risk of breast cancer in mothers and their daughters. Jasienska argues that a mismatch between modern lifestyles and the Stone Age physiology that evolution has bequeathed to every woman exacerbates health problems. She looks at women's mechanisms for coping with genetic inheritance and at the impact of environment on health. Warning against the false hope gene therapy inspires, Jasienska makes a compelling case that our only avenue to a healthy life is prevention programs informed by evolutionary understanding and custom-fitted to each woman's developmental and reproductive history.
From the author of stunning debut The Mourning Hours comes a powerful new novel that explores every parent's worst nightmare...The Kaufmans have always considered themselves a normal, happy family. Curtis is a physics teacher at a local high school. His wife, Kathleen, restores furniture for upscale boutiques. Daniel is away at college on a prestigious music scholarship, and twelve-year-old Olivia is a happy-go-lucky kid whose biggest concern is passing her next math test.And then comes the middle-of-the-night phone call that changes everything. Daniel has been killed in what the police are calling a "freak" road accident, and the remaining Kaufmans are left to flounder in their grief.The anguish of Daniel's death is isolating, and it's not long before this once-perfect family finds itself falling apart. As time passes and the wound refuses to heal, Curtis becomes obsessed with the idea of revenge, a growing mania that leads him to pack up his life and his anxious teenage daughter and set out on a collision course to right a wrong.An emotionally charged novel, The Fragile World is a journey through America's heartland and a family's brightest and darkest moments, exploring the devastating pain of losing a child and the beauty of finding the way back to hope.e left to flounder in their grief. The anguish of Daniel's death is isolating, and it's not long before this once-perfect family finds itself falling apart. As time passes and the wound refuses to heal, Curtis becomes obsessed with the idea of revenge, a growing mania that leads him to pack up his life and his anxious teenage daughter and set out on a collision course to right a wrong. An emotionally charged novel, The Fragile World is a journey through America's heartland and a family's brightest and darkest moments, exploring the devastating pain of losing a child and the beauty of finding healing in unexpected ways.
In Fragile X-Associated Tremor Ataxia Syndrome (FXTAS), the editors present information on all aspects of FXTAS, including clinical features and current supportive management, radiological, psychological, and pathological findings, genotype-phenotype relationships, animal models and basic molecular mechanisms. Genetic counseling issues are also discussed. The book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS and their families, as well as presenting the molecular basis for disease that may lead to the identification of new markers to predict disease risk and eventually lead to target treatments.
This book is a study of ancient views about "moral luck. " It examines the fundamental ethical problem that many of the valued constituents of a well-lived life are vulnerable to factors outside a person's control, and asks how this affects our appraisal of persons and their lives. The Greeks made a profound contribution to these questions, yet neither the problems nor the Greek views of them have received the attention they deserve. This updated edition contains a new preface.
In The Fragility of Things, eminent theorist William E. Connolly focuses on several self-organizing ecologies that help to constitute our world. These interacting geological, biological, and climate systems, some of which harbor creative capacities, are depreciated by that brand of neoliberalism that confines self-organization to economic markets and equates the latter with impersonal rationality. Neoliberal practice thus fails to address the fragilities it exacerbates. Engaging a diverse range of thinkers, from Friedrich Hayek, Michel Foucault, Hesiod, and Immanuel Kant to Voltaire, Terrence Deacon, Friedrich Nietzsche, and Alfred North Whitehead, Connolly brings the sense of fragility alive as he rethinks the idea of freedom. Urging the Left not to abandon the state but to reclaim it, he also explores scales of politics below and beyond the state. The contemporary response to fragility requires a militant pluralist assemblage composed of those sharing affinities of spirituality across differences of creed, class, gender, sexual orientation, and ethnicity.
FROM THE INTRODUCTION BY JOHN LE CARRÉ" This novel comprises some of the best work of an extremely gifted and perhaps under-regarded British crime novelist. . . . What gave John Bingham his magic was something we look for in every writer, too often in vain: an absolute command of the internal landscape of his characters, acutely observed by a humane but wonderfully corrosive eye. "On a recuperative trip in Italy after a car accident, reporter and novelist James Compton is witness to the discovery of a murder victim, a woman who had been vacationing at the same hotel. Lucy Dawson seemed like a gentle old lady, and so the motive for her death appeared to be unmeditated assault. But when he returns to England and makes a benign inquiry into her background, Compton receives a note warning him to leave the past alone -- a note clearly written on his own typewriter, though his apartment shows no sign of a break-in. Unable to resist pursuing the unfinished story, Compton's own investigation reveals a sinister side to Lucy Dawson and a cold-blooded conspiracy she may have helped to perpetrate while alive. Suddenly Compton finds a dangerous net closing in around him: threatening phone calls, terrifying invasions of privacy, and no way of proving to the police that anyone is responsible but himself. In the tradition of Agatha Christie and Patricia Highsmith, John Bingham's writing has earned him a place amongst the great suspense writers of the twentieth century. With taut, compelling prose, A Fragment of Fearis a captivating thriller by a master storyteller at the height of his powers.
From New York Times bestselling author Stephanie Tyler, the Section 8 series continues... WHEN THE RISKS ARE THIS GREAT... When Dr. Drea Timmons was kidnapped during Section 8's last mission, Jem did everything in his power to rescue the woman he'd fallen for--a woman unwillingly recruited for one of S8's most personal and dangerous covert operations. Drea survived, but at a price. The trauma of her capture has rendered her without a single memory of her ordeal--or any recollection of how violently unpredictable her ex-boyfriend, Danny, an Outlaw Angel, had become, or why she had left him. IS TRUST EVEN AN OPTION? When Danny threatens to turn Drea over to the feds, she is forced to go on the run and confront a past that is as deadly as her future. As trouble closes in on both ends, Drea has no choice but to trust Jem, the only man who can help her, the only man whose electrifying touch brings back memories--piece by piece--too stirring to forget.
The landmark Supreme Court decision in June 2015 legalizing the right to same-sex marriage marked a major victory in gay and lesbian rights in the United States. Once subject to a patchwork of laws granting legal status to same-sex couples in some states and not others, gay and lesbian Americans now enjoy full legal status for their marriages wherever they travel or reside in the country. For many, the Supreme Court's ruling means that gay and lesbian citizens are one step closer to full equality with the rest of America. In Fragmented Citizens, Stephen M. Engel contends that the present moment in gay and lesbian rights in America is indeed one of considerable advancement and change--but that there is still much to be done in shaping American institutions to recognize gays and lesbians as full citizens. With impressive scope and fascinating examples, Engel traces the relationship between gay and lesbian individuals and the government from the late nineteenth century through the present. Engel shows that gays and lesbians are more accurately described as fragmented citizens. Despite the marriage ruling, Engel argues that LGBT Americans still do not have full legal protections against workplace, housing, family, and other kinds of discrimination. There remains a continuing struggle of the state to control the sexuality of gay and lesbian citizens--they continue to be fragmented citizens. Engel argues that understanding the development of the idea of gay and lesbian individuals as 'less-than-whole' citizens can help us make sense of the government's continued resistance to full equality despite massive changes in public opinion. Furthermore, he argues that it was the state's ability to identify and control gay and lesbian citizens that allowed it to develop strong administrative capacities to manage all of its citizens in matters of immigration, labor relations, and even national security. The struggle for gay and lesbian rights, then, affected not only the lives of those seeking equality but also the very nature of American governance itself. Fragmented Citizens is a sweeping historical and political account of how our present-day policy debates around citizenship and equality came to be.
Author Dan Wells is back with the sequel to the sci-fi blockbuster Partials, which Pittacus Lore called a "thrilling sci-fi adrenaline rush, with one of the most compelling and frightening visions of Earth's future I've seen yet."After discovering the cure for RM, Kira Walker sets off on a terrifying journey into the ruins of postapocalyptic America and the darkest desires of her heart in order to uncover the means--and a reason--for humanity's survival.Dan Wells extends his richly imagined, gritty world and introduces new memorable characters in this second installment in the Partials Sequence.
Brilliant psychologists have assembled in a small college town to conduct a revolutionary experiment that challenges the very nature of identity and individuality. Their subjects are savants, mentally and emotionally challenged individuals, each of whom possesses an amazing gift. One person can calculate calendar dates backward and forward, while another can memorize an entire library or assemble jigsaw puzzles at the speed of lightning. . Each of these very special people is flawed and psychologically handicapped, but what if five such savants are cybernetically linked together to create a sixth composite personality? Can this newly created entity be more than the sum of its parts? At first the experiment yields promising results, but a terrifying secret in the past will transform the project in ways the researchers never anticipated-and infect the newborn intelligence with a catastrophic thirst for vengeance. Soon all of them are at risk to become killers or to be killed. Good intentions and care for safety are overwhelmed by escalating powers, and the struggle to contain those lethal powers and to survive. Tension begins early in the book as a man with the secret power to control others insinuates himself in to the experiment. The suspense mounts rapidly to breathtaking levels. Scientific and emotional thinkers combine efforts to stop the destructive rampage they started. The subjects of the experiments, all with one special gift superimposed on limited intellects, are sympathetically and fascinatingly examined. Each has a part to play in this gripping novel about human and superhuman nature.
In the sixth century b.c.-twenty-five hundred years before Einstein-Heraclitus of Ephesus declared that energy is the essence of matter, that everything becomes energy in flux, in relativity. His great book, On Nature, the world's first coherent philosophical treatise and touchstone for Plato, Aristotle, and Marcus Aurelius, has long been lost to history-but its surviving fragments have for thousands of years tantalized our greatest thinkers, from Montaigne to Nietzsche, Heidegger to Jung. Now, acclaimed poet Brooks Haxton presents a powerful free-verse translation of all 130 surviving fragments of the teachings of Heraclitus, with the ancient Greek originals beautifully reproduced en face.
Kira Walker has found the cure for RM, but the battle for the survival of humans and Partials is just beginning. Kira has left East Meadow in a desperate search for clues to who she is. That the Partials themselves hold the cure for RM in their blood cannot be a coincidence--it must be part of a larger plan, a plan that involves Kira, a plan that could save both races. Her companions are Afa Demoux, an unhinged drifter and former employee of ParaGen, and Samm and Heron, the Partials who betrayed her and saved her life, the only ones who know her secret. But can she trust them? Meanwhile, back on Long Island, what's left of humanity is gearing up for war with the Partials, and Marcus knows his only hope is to delay them until Kira returns. But Kira's journey will take her deep into the overgrown wasteland of postapocalyptic America, and Kira and Marcus both will discover that their greatest enemy may be one they didn't even know existed. The second installment in the pulse-pounding Partials saga is the story of the eleventh hour of humanity's time on Earth, a journey deep into places unknown to discover the means--and even more important, a reason--for our survival.
This book is the first of its kind to reflect upon the intense and rapidly growing interest in open geodesic polyaromatic molecules, specifically focusing on their synthesis and reactivity in metal binding reactions. The book broadly covers all aspects related to the fullerene fragment chemistry: current synthetic techniques, description of the available members of this new family (which has grown to more than two dozens members, with none being available commercially), molecular geometry and trends in the solid state packing, as well as extensions into physical properties and new buckybowl-based molecules and materials. It covers fundamental research related to a new class of hydrocarbons, namely open geodesic polyarenes that map onto the surfaces of fullerenes (and referred to as fullerene fragments or buckybowls.
In these conversations with a friend and contemporary the Nobel prize-winning Colombian novelist speaks movingly, revealingly and unaffectedly about his family background, his early travels and struggles as a writer, his literary antecedents and his personal artistic concerns. Guided by Mendoza, García Márquez reveals -- as transfigured in his work by the power of language -- the heat and colour of the Spanish Caribbean, the mythological world of its inhabitants, the exotic mentality of its leaders.
The "Alice Waters of American natural perfume" (indieperfume.com) celebrates our most potent sense, through five rock stars of the fragrant world. Mandy Aftel is widely acclaimed as a trailblazer in natural perfumery. Over two decades of sourcing the finest aromatic ingredients from all over the world and creating artisanal fragrances, she has been an evangelist for the transformative power of scent. In Fragrant, through five major players in the epic of aroma, she explores the profound connection between our sense of smell and the appetites that move us, give us pleasure, make us fully alive. Cinnamon, queen of the Spice Route, touches our hunger for the unknown, the exotic, the luxurious. Mint, homegrown the world over, speaks to our affinity for the familiar, the native, the authentic. Frankincense, an ancient incense ingredient, taps into our longing for transcendence, while ambergris embodies our unquenchable curiosity. And exquisite jasmine exemplifies our yearning for beauty, both evanescent and enduring. In addition to providing a riveting initiation into the history, natural history, and philosophy of scent, Fragrant imparts the essentials of scent literacy and includes recipes for easy-to-make fragrances and edible, drinkable, and useful concoctions that reveal the imaginative possibilities of creating with--and reveling in--aroma. Vintage line drawings make for a volume that will be a treasured gift as well as a great read.
The Fragrant Mind is written in an easy, accessible style for anyone who wishes to learn how essential oils can influence our minds and emotions and how to use aromatherapy to maintain a peaceful equilibrium or bring about positive change. Valerie Worwood's The Complete Book of Essential Oils and Aromatherapy (over 200,000 copies sold) has become the encyclopedia of essential oils and aromatherapy, earning itself the status of a popular household and reference classic. In this companion volume, Worwood concentrates on the emotional, psychological, and mood-changing effects of nature's oils.
'It isn't likely that this collection of journal entries will pass the censors. If it can't be published, I hope my friends will circulate it among themselves. I'll leave Vietnam tomorrow. . . ' Thus Thich Nhat Hanh begins his 11 May 1966 journal entry. Since that time, he has been unable to return to his homeland but, now based in France, he has become one of the world's most respected spiritual leaders. Fragrant Palm Leaves reveals a vulnerable and questioning young man reflecting on the many difficulties he and his fellow monks faced in Vietnam trying to make Buddhism relevant to the people's needs. We follow him, in 1964, as he helps establish the movement known as 'engaged Buddhism': starting self-help villages, a new university, a Buddhist order and many other efforts for peace. Fragrant Palm Leaves is regarded by many Vietnamese as Thich Nhat Hanh's most endearing and stimulating book. It offers readers a glimpse into the mind of a great thinker and activist and shows how to live fully, with awareness, during a time of challenge and upheaval.
In a post-zombie world, life is what you make it . . . Since a devastating, morphing plague swept through human and zombie populations, almost everyone who survived is an "ex" these days. Ex-human. Ex-zombie. Both creatures crave flesh, have the strength and speed of predators--and are seemingly immortal. Pierced skin and broken bones mend, but their all-consuming hunger never dies . . . Amy is the only purely human survivor from her town: a frail. For a girl used to going it alone, trusting anyone isn't easy, but Amy will have to. She has secrets from her past she can't afford to face by herself, and secrets in her future that will cost her just about everything--including her humanity . . .
Fram is the story of Oscar, a minor bureaucrat in the US government's Bureau of Ice Prognostication, an agency created to compete with the Soviets during the heyday of the Cold War and still operating in the present without the public's knowledge. Oscar and his partner Alexi are tasked with inventing discoveries and settlements in the Arctic, then creating the paperwork and digital records to "prove" their existence, preventing the inconvenience and expense of actual exploration. The job is the closest Oscar has come to his boyhood dream of being a polar explorer, until he and Alexi are sent on a secret mission to the actual Arctic, which brings them into a mysterious tangle of rival agencies and espionage that grows more dangerous the farther north they travel. The trip also allows Oscar to reconnect with his wife, Julia, from whom he's grown alienated by years of lying about what he does for a living (a distance compounded by Julia's own secret government job), leading both of them to discover what can be lost if we let one part of ourselves--or one part of a story--distract us from everything else the world offers.Steve Himmer is the author of the novel The Bee-Loud Glade (2011) and editor of the web journal Necessary Fiction. His stories, essays, and reviews have appeared in publications including the Millions, Ploughshares, Post Road, Hobart, 3:AM Magazine, and the Los Angeles Review. He lives with his wife and daughter near Boston, Massachusetts, where he teaches at Emerson College.
When organizations apply old methods of problem-solving to new kinds of problems, they may accomplish only temporary fixes or some ineffectual tinkering around the edges. Today's problems are a new breed -- open, complex, dynamic, and networked -- and require a radically different response. In this book, Kees Dorst describes a new, innovation-centered approach to problem-solving in organizations: frame creation. It applies "design thinking," but it goes beyond the borrowed tricks and techniques that usually characterize that term. Frame creation focuses not on the generation of solutions but on the ability to create new approaches to the problem situation itself.The strategies Dorst presents are drawn from the unique, sophisticated, multilayered practices of top designers, and from insights that have emerged from fifty years of design research. Dorst describes the nine steps of the frame creation process and illustrates their application to real-world problems with a series of varied case studies. He maps innovative solutions that include rethinking a store layout so retail spaces encourage purchasing rather than stealing, applying the frame of a music festival to understand late-night problems of crime and congestion in a club district, and creative ways to attract young employees to a temporary staffing agency. Dorst provides tools and methods for implementing frame creation, offering not so much a how-to manual as a do-it-yourself handbook -- a guide that will help practitioners develop their own approaches to problem-solving and creating innovation.
In Frame Structures, Susan Howe brings together those of her early poems she wishes to remain in print, and in the forms in which she cares to have them last. Gathered here are versions of Hinge Picture (1974), Chanting at the Crystal Sea 91975), Cabbage Gardens (1979), and Secret History of the Dividing Line (1978) that differ in some respects from their original small-press editions. In a long preface, "Frame Structures," written especially for this volume, Howe suggests the autobiographical, familial, literary, and historical motifs that suffuse these early works. Taken together, the preface and poems reflect her rediscovered sense of her own beginnings as a poet, her movement from the visual arts into the iconography of the written word.
CAN SHE TRUST A MYSTERY MAN? Stranded in a blinding snowstorm, Laurel Adams must pin her hope of survival on a handsome stranger. The single mother and her teen daughter take refuge in his remote Rocky Mountain cabin. But Laurel's anything but safe when she discovers a dead body in her trunk...and becomes the prime suspect in a murder investigation. Her rescuer, millionaire David Greene, knows what it's like to be accused. Three years ago he was arrested for a crime he didn't commit-an unsolved case that still haunts him. With the clock ticking, can they stop a cold-blooded killer with deadly ties to them both?
Strange things are going on at the police station. Shelby's friend Susan Skelton has been accused of embezzling $10,000 in bail money. But Shelby doesn't believe that sweet, middle-aged Susan would commit such a crime. She knows it has to be a frame-up. Why? And more important-who? One thing is clear: the culprit must have had access to Susan's desk and files. Could it have been Officer Jack Bridges? Perhaps this new patrolman's not as loyal as he appears. Or could it have been... Detective Hineline? It sure doesn't seem his nature, but he's been acting very secretive lately. Suddenly, everyone at the station is becoming a suspect. Shelby knows it's up to her to find out who framed Susan. But the more clues she uncovers, the more complicated this becomes!
A prince is in River Heights. A prince! This is big news.A prince from a relatively minor royal Italian family has come to River Heights to deliver a painting to Mrs. Mahoney, a friend of the royal family. Everyone excited about the royal visit--so you can imagine how shocking it is when the prince is thrown into jail. His family thinks he stole the painting! Nancy and her dad have reason to believe that the prince is innoncent. But can they prove that to everyone else?
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