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Pharmacoresistance in Epilepsy

by Esper A. Cavalheiro Luisa Rocha

Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office."

Pharmacotherapy of Depression

by Richard Irwin Shader Domenic A. Ciraulo

Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on dosing, indications, and metabolism. Augmentation strategies are reviewed, including the use of non-traditional agents. The chapters that follow next address the use of antidepressants in special populations, such as the elderly and depressed individuals with psychosis, bipolar disorder, substance abuse, and post traumatic stress disorder. The complex issues involving the diagnosis and treatment of depression during pregnancy is thoroughly reviewed in Chapter 8 and provides a synthesis of the scientific literature in the area, one that is noted for contradictory and controversial findings, as well as guidelines for prescribing. The next chapter then provides an overview of the treatment of depression in the pediatric population, highlighting clinical concerns such as suicide risk. The book concludes with two chapters at the interface of medicine and psychiatry in the treatment of mood disorders: managing depression in primary care settings and depression associated with medical illnesses. The outstanding clinician-scientists who have contributed to this volume are all leaders in their fields and represent a broad spectrum of renowned institutions. A timely contribution to the literature, The Pharmacotherapy of Depression, Second Edition, offers busy clinicians from many disciplines a strong scientific foundation that seamlessly transitions into practical recommendations for clinical practice. The result is another gold-standard guide to the safe and effective use of the latest antidepressant medications.

Pharmacovigilance Medical Writing

by Justina Orleans-Lindsay

Pharmacovigilance Medical Writing covers the preparation of pharmacovigilance documents for all stages of the drug development process (i.e. from clinical development through to applications for marketing authorisations to the post-marketing stage). For each document, the book presents a review of the regulatory framework that governs the content of the document, followed by practical guidance (e.g. scheduling, source data, department/functions involved in document preparation/review, appropriate timelines and planning activities), ending with a generic model document compliant with the current guidelines, which can be modified to meet specific company and product requirements.

Pharmacy: An Introduction to the Profession

by L. Michael Posey

As editorial director of the APA, Posey updates his 2003 textbook introducing not the technical aspects of pharmacy, but the nature of the profession itself. It supplies core knowledge needed to put information from other courses into perspective, and is best supplements with lectures from pharmacy faculty or administrators. Revisions are based on student and instructor feedback, as well as changes in the profession and recent publications. American Pharmacists Association books are distributed by McGraw-Hill. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)

Phase Theory

by Barbara Citko

Phase Theory is the latest empirical and conceptual innovation in syntactic theory within the Chomskyan generative tradition. Adopting a cross-linguistic perspective, this book provides an introduction to Phase Theory, tracing the development of phases in minimalist syntax. It reviews both empirical and theoretical arguments in favor of phases, and examines the role phases play at the interface with semantics and phonology. Analyzing current phasehood diagnostics, it applies them in a systematic fashion to a broad range of syntactic categories, both phases and non-phases. It concludes with a discussion of some of the more contentious issues in Phase Theory, involving cross-linguistic variation with respect to phasehood and the dynamic versus static nature of phases.

Phase Transitions

by Ricard V. Sole

Phase transitions--changes between different states of organization in a complex system--have long helped to explain physics concepts, such as why water freezes into a solid or boils to become a gas. How might phase transitions shed light on important problems in biological and ecological complex systems? Exploring the origins and implications of sudden changes in nature and society, Phase Transitions examines different dynamical behaviors in a broad range of complex systems. Using a compelling set of examples, from gene networks and ant colonies to human language and the degradation of diverse ecosystems, the book illustrates the power of simple models to reveal how phase transitions occur.Introductory chapters provide the critical concepts and the simplest mathematical techniques required to study phase transitions. In a series of example-driven chapters, Ricard Solé shows how such concepts and techniques can be applied to the analysis and prediction of complex system behavior, including the origins of life, viral replication, epidemics, language evolution, and the emergence and breakdown of societies.Written at an undergraduate mathematical level, this book provides the essential theoretical tools and foundations required to develop basic models to explain collective phase transitions for a wide variety of ecosystems.

The Phaselock Code: Through Time, Death and Reality -- The Metaphysical Adventures of Man

by Roger Hart

ONE MAN'S REMARKABLE SEARCH FOR THE ULTIMATE TRUTHS OF OUR WORLD. For Professor Roger Hart, life truly began after he almost lost his -- in a horrific fall off the slopes of Mount Everest that he miraculously survived. This near-death experience sparked a desire in him to devote his studies to the very nature of human consciousness, in order to unlock the code of reality that binds our world. On an adventure of discovery that would take him around the world, Hart would experience life-altering transcendental events in Tibet, Morocco, and Tierra del Fuego -- opening the door to a true understanding of the nature of man. In this groundbreaking volume, he explores the participation of consciousness in the creation of reality, challenging the traditional scientific view of time, space, and objectivity -- and describing in detail his own metaphysical journey, which has involved synchronicity, precognition, and telekinesis. It is an exploration of the very things that make us human -- and a quest that touches upon the meaning of life itself.

Phases of Gravity

by Dan Simmons

Richard Baedecker thinks his greatest challenge was walking on the moon, but then he meets a mysterious woman who shows him his past. Join Baedecker as he comes to grips with the son and wife he lost owing to his passion for space exploration, his forgotten childhood, and the loss he experienced during the deadly flight of the Challenger. The most difficult exploration of his life is not the cold, rocky crevices of the moon, but the warm interior of his heart. Brilliant and beautifully written, Phases of Gravity is a masterpiece about love and loss that transports readers far beyond the confines of space and time.

A PhD Is Not Enough!

by Peter J. Feibelman

Despite your graduate education, brainpower, and technical prowess, your career in scientific research is far from assured. Permanent positions are scarce, science survival is rarely part of formal graduate training, and a good mentor is hard to find.In A Ph.D. Is Not Enough!, physicist Peter J. Feibelman lays out a rational path to a fulfilling long-term research career. He offers sound advice on selecting a thesis or postdoctoral adviser; choosing among research jobs in academia, government laboratories, and industry; preparing for an employment interview; and defining a research program. The guidance offered in A Ph.D. Is Not Enough! will help you make your oral presentations more effective, your journal articles more compelling, and your grant proposals more successful.A classic guide for recent and soon-to-be graduates, A Ph.D. Is Not Enough! remains required reading for anyone on the threshold of a career in science. This new edition includes two new chapters and is revised and updated throughout to reflect how the revolution in electronic communication has transformed the field.

A PhD Is Not Enough!

by Peter J. Feibelman

Despite your graduate education, brainpower, and technical prowess, your career in scientific research is far from assured. Permanent positions are scarce, science survival is rarely part of formal graduate training, and a good mentor is hard to find.In A Ph.D. Is Not Enough!, physicist Peter J. Feibelman lays out a rational path to a fulfilling long-term research career. He offers sound advice on selecting a thesis or postdoctoral adviser; choosing among research jobs in academia, government laboratories, and industry; preparing for an employment interview; and defining a research program. The guidance offered in A Ph.D. Is Not Enough! will help you make your oral presentations more effective, your journal articles more compelling, and your grant proposals more successful.A classic guide for recent and soon-to-be graduates, A Ph.D. Is Not Enough! remains required reading for anyone on the threshold of a career in science. This new edition includes two new chapters and is revised and updated throughout to reflect how the revolution in electronic communication has transformed the field.

Pheme the Gossip

by Joan Holub Suzanne Williams

Get to know Goddess Girl Pheme...the original "gossip girl"!As the goddess girl of rumor and gossip, Pheme prides herself on being "in the know" and having the most up-to-date info on anyone and everyone at Mount Olympus Academy. To make sure that people really get her VIP messages, her words tend to linger in cloud letters above her head--just in case people don't catch what she says! But not everyone is thrilled with Pheme's insider knowledge on everything MOA--including the Goddess Girls. Can Pheme ever be trusted? Or will this "gossip girl" find herself on the other end of the rumors?

Phenomenal Woman

by Maya Angelou

Maya Angelou, the bestselling author of On the Pulse of Morning, Wouldn't Take Nothing for My Journey Now, and other lavishly praised works, is considered one of America's finest poets. Here, four of her most highly acclaimed poems are assembled in a beautiful gift edition that provides a feast for the eyes as well as the heart. (Poetry)From the Hardcover edition.

Phenomenology for Therapists

by Linda Finlay

This book provides an accessible comprehensive exploration of phenomenological theory and research methods and is geared specifically to the needs of therapists and other health care professionals. An accessible exploration of an increasingly popular qualitative research methodologyExplains phenomenological concepts and how they are applied to different stages of the research process and to topics relevant to therapy practiceProvides practical examples throughout

The Phenomenology of Religious Life

by Martin Heidegger Matthias Fritsch Jennifer Anna Gosetti-Ferencei

The Phenomenology of Religious Life presents the text of Heidegger's important 1920-21 lectures on religion. The volume consists of the famous lecture course Introduction to the Phenomenology of Religion, a course on Augustine and Neoplatonism, and notes for a course on The Philosophical Foundations of Medieval Mysticism that was never delivered. Heidegger's engagements with Aristotle, St. Paul, Augustine, and Luther give readers a sense of what phenomenology would come to mean in the mature expression of his thought. Heidegger reveals an impressive display of theological knowledge, protecting Christian life experience from Greek philosophy and defending Paul against Nietzsche.

Phenomenology of the Human Person

by Robert Sokolowski

In this book, Robert Sokolowski argues that being a person means to be involved with truth. He shows that human reason is established by syntactic composition in language, pictures, and actions and that we understand things when they are presented to us through syntax. Sokolowski highlights the role of the spoken word in human reason and examines the bodily and neurological basis for human experience. Drawing on Husserl and Aristotle, as well as Aquinas and Henry James, Sokolowski here employs phenomenology in a highly original way in order to clarify what we are as human agents.

Phenomenon: Everything You Need to Know About the Paranormal

by Sylvia Browne Lindsay Harrison

In this compelling new book, bestselling author Sylvia Browne offers her most comprehensive guide to the afterlife. Phenomenon is a fascinating compendium of all things on the Other Side that influence our life here on Earth. Sylvia Browne provides evocative stories and powerful explanations to help make life on the Other Side real for all of us. In Phenomenon, she provides reassuring answers to questions such as: Atlantis - Where did it go and when will it return? Clairvoyance - How do you know if you have the gift? Deja vu - Are past lives the answer to this strange phenomenon? Ghosts - What are they? Miracles - Can they happen every day? Reincarnation - Have we lived before? Sorcery - Is there something we should fear? Zombies - Are they only in horror movies? An easy-to-use reference full of hope and guidance, Phenomenon is sure to have wide appeal among Browne's loyal fans and anyone in search of signs of the paranormal.

Phi

by Giulio Tononi

This title is printed in full color throughout.From one of the most original and influential neuroscientists at work today, here is an exploration of consciousness unlike any other--as told by Galileo, who opened the way for the objectivity of science and is now intent on making subjective experience a part of science as well. Galileo's journey has three parts, each with a different guide. In the first, accompanied by a scientist who resembles Francis Crick, he learns why certain parts of the brain are important and not others, and why consciousness fades with sleep. In the second part, when his companion seems to be named Alturi (Galileo is hard of hearing; his companion's name is actually Alan Turing), he sees how the facts assembled in the first part can be unified and understood through a scientific theory--a theory that links consciousness to the notion of integrated information (also known as phi). In the third part, accompanied by a bearded man who can only be Charles Darwin, he meditates on how consciousness is an evolving, developing, ever-deepening awareness of ourselves in history and culture--that it is everything we have and everything we are. Not since Gödel, Escher, Bach has there been a book that interweaves science, art, and the imagination with such originality. This beautiful and arresting narrative will transform the way we think of ourselves and the world.

Phil Gordon's Little Gold Book

by Phil Gordon

Since reigning poker expert Phil Gordon's Little Green Book illuminated the strategies and philosophies necessary to win at No Limit Texas Hold'em, poker has changed quickly and dramatically. Today, Pot Limit Omaha is the game of choice at nosebleed stakes. The players are aggressive, the games are volatile, the decisions are tough, and the pressure is relentless. This is Poker 2.0. In his Little Gold Book, Phil Gordon reexamines the game from the ground up. The key to competing with today's top players is finding the post-flop edge, but to really understand this new playing style, you need to get comfortable with the underlying math. Don't be intimidated. Gordon makes this challenging material as approachable and simple as possible. Beginning with the foundations of Poker 2.0, he unpacks the modern poker player's tool kit, rigorously examines the new lines of play in No Limit Hold'em, dissects the fast and furious strategies of Pot Limit Omaha, and explores the winning poker mind-set that will take your game to an entirely different level. The golden age of poker is upon us. Phil Gordon's Little Gold Book will shorten your learning curve, and if you're willing to put in the time and the work, big bankrolls await.

Phil Jackson

by Peter Richmond

With eleven championship rings to his name, Phil Jackson is internationally recognized as one of the greatest coaches in the history of the NBA. Known as a defensive disrupter and a master fouler during his early days as a New York Knick and later celebrated as the "Zen Master" for his inspirational tactics as a leader, Jackson has had a long and storied career marked by constant self-reflection and reinvention. This is the man who led Michael Jordan and the Chicago Bulls to six championships, Kobe Bryant and the Los Angeles Lakers to five; who was inducted into the Basketball Hall of Fame; and who retired in 2011, an official legend--and the most sought-after free-agent coach in history. As befits a legend, Jackson has written several candid, insightful books about his life and career, but now one of America's most respected sportswriters turns an unvarnished light on Jackson's strange and remarkable journey, from his sheltered childhood and adolescence in Montana and North Dakota, through his years playing at Madison Square Garden, to his experiences coaching Jordan, Bryant, and more of the greatest players of our time. New York Times-bestselling author Peter Richmond has written a personal, definitive, revealing biography of a veritable sports genius, and an American classic.

The Philadelphia Adventure (The Vesper Holly Adventures #5)

by Lloyd Alexander

In 1876, on the eve of the Centennial Exposition in Philadelphia, twenty-year-old Vesper Holly and her friends clash yet again with the archfiend Dr. Helvitius, whose evil schemes plunge them into danger in the wild Pennsylvania countryside.

Philadelphia Fire

by John Edgar Wideman

From "one of America's premier writers of fiction" (New York Times) comes this novel inspired by the 1985 police bombing of a West Philadelphia row house owned by the back-to-nature, Afrocentric cult known as Move. The bombing killed eleven people and started a fire that destroyed sixty other houses. At the center of the story is Cudjoe, a writer and exile who returns to his old neighborhood after spending a decade fleeing from his past, and his search for the lone survivor of the fire - a young boy who was seen running from the flames. An impassioned, brutally honest journey through the despair and horror of life in urban America, "Philadelphia Fire isn't a book you read so much as one you breathe" (San Francsisco Chronicle).

The Philadelphia Negro

by Elijah Anderson W. E. B. Du Bois

In 1897 the promising young sociologist William Edward Burghardt Du Bois (1868-1963) was given a temporary post as Assistant in Sociology at the University of Pennsylvania in order to conduct in-depth studies of the Negro community in Philadelphia. The product of those studies was the first great empirical book on the Negro in American society.More than one hundred years after its original publication by the University of Pennsylvania Press, The Philadelphia Negro remains a classic work. It is the first, and perhaps still the finest, example of engaged sociological scholarship--the kind of work that, in contemplating social reality, helps to change it.In his introduction, Elijah Anderson examines how the neighborhood studied by Du Bois has changed over the years and compares the status of blacks today with their status when the book was initially published.

Philadelphia Noir

by Carlin Romano

"It's a collection enhanced by an unerring sense of place . . . that will please the most discriminating lovers of the dark side."--Kirkus Reviews"It took long enough for Akashic's noir series to get to Philly. Now that it has, compiled under the shadowy auspices of Inquirer literary critic/West Philly native Carlin Romano, the fun begins."--Philadelphia City PaperIncludes brand-new stories by: Diane Ayres, Cordelia Frances Biddle, Keith Gilman, Cary Holladay, Solomon Jones, Gerald Kolpan, Aimee LaBrie, Halimah Marcus, Carlin Romano, Asali Solomon, Laura Spagnoli, Duane Swierczynski, Dennis Tafoya, and Jim Zervanos.Carlin Romano, critic-at-large of the Chronicle of Higher Education and literary critic of The Philadelphia Inquirer for twenty-five years, teaches philosophy and media theory at the University of Pennsylvania. In 2006 he was a finalist for the Pulitzer Prize for Criticism, cited by the Pulitzer Board for "bringing new vitality to the classic essay across a formidable array of topics." He lives in University City, Philadelphia, in the only house on his block.

Showing 155,676 through 155,700 of 206,090 results

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