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A comprehensive collection of optimized methods for dissecting the mechanisms that control epidermal growth factors (EGF) and their regulators in both normal and pathological states. These readily reproducible techniques range from the study of purified EGF receptor to complex signaling and processing networks in intact cells, including a chapter on the clinical and pharmacological considerations of their use in cancer therapy. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer's disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Prescriber's Guide to Antiepileptic Drugs provides a practical and concise reference guide for use by all those clinicians and allied health professionals that treat or care for patients with epilepsy. In full colour throughout, this volume presents the antiepileptic drugs (AEDs) in alphabetical order and for each AED the information is divided into eight coloured sections: general therapeutics, pharmacokinetics, interaction profile, adverse effects, dosing and use, special populations, and suggested reading. This handy pocket guide will be an excellent companion for all clinicians that treat patients with epilepsy.
Epilepsy: The Ultimate Teen Guide dispels the myths, misconceptions, and misunderstandings about epilepsy and the people who have the disorder. It provides factual medical information and advice for teens on how to live a normal life. Stories from teens who have epilepsy show readers they can participate in normal activities. They also offer advice on whether and how to tell friends, dates, teachers, or an employer about the condition. This book concludes with an extensive list of publications, websites, and organizations, as well as an appendix that covers the Americans with Disabilities Act and how it applies to people who have epilepsy.
The most acclaimed European graphic novel of the last ten years, Epileptic is David B.'s story of his brother's battle with epilepsy, but it turns into a penetrating and sometimes lacerating self-examination on the author's part, as he delves into his own complex emotions and his family's troubled history, as well as his own youthful fantasy life. Particularly pointed is his description of the family journey from one attempted cure to another, including acupuncture, spiritualism and macrobiotics. David B.'s drawing is utterly extraordinary, balancing literal representation and expressionist psychological distortion.
If you read and loved the #1 "New York Times "bestseller "Hidden Order," enjoy this free bonus chapter.
Epinets presents a new way to think about social networks, which focuses on the knowledge that underlies our social interactions. Guiding readers through the web of beliefs that networked individuals have about each other and probing into what others think, this book illuminates the deeper character and influence of relationships among social network participants. Drawing on artificial intelligence, the philosophy of language, and epistemic game theory, Moldoveanu and Baum formulate a lexicon and array of conceptual tools that enable readers to explain, predict, and shape the fabric and behavior of social networks. With an innovative and strategically-minded look at the assumptions that enable and clog our networks, this book lays the groundwork for a leap forward in our understanding of human relations.
Atlanta Police Department BulletinAll police officers should be aware that the recent increase in crime activity that is running rampant through the city of Atlanta, Georgia, is quickly destroying the holiday spirit of our citizens. As sworn officers of the law, we must do everything we can to save Christmas.Ã¿Detective: Max MaloneAssignment: Protect former flame Angelica North and her nephew, an eyewitness to his mother's murder, from the madman who wants them both dead.
Focusing on the way bishops in the eleventh century used the ecclesiastical tithe - church taxes - to develop or re-order ties of loyalty and dependence within their dioceses, this book offers a new perspective on episcopacy in medieval Germany and Italy. Using three broad case studies from the dioceses of Mainz, Salzburg and Lucca in Tuscany, John Eldevik places the social dynamics of collecting the church tithe within current debates about religious reform, social change and the so-called 'feudal revolution' in the eleventh century, and analyses a key economic institution, the medieval tithe, as a social and political phenomenon. By examining episcopal churches and their possessions not in institutional terms, but as social networks which bishops were obliged to negotiate and construct over time using legal, historiographical and interpersonal means, this comparative study casts fresh light on the history of early medieval society.
Though best known for The Red Badge of Courage, his classic novel of men at war, in his tragically brief life and career Stephen Crane produced a wealth of stories-among them "The Monster," "The Upturned Face," "The Open Boat," and the title story-that stand among the most acclaimed and enduring in the history of American fiction. This superb volume collects stories of unique power and variety in which impressionistic, hallucinatory, and realistic situations alike are brilliantly conveyed through the cold, sometimes brutal irony of Crane's narrative voice.
From the author's mother: When Blaze was about ten years old, he gave me a perfect description of how his mind worked. Actually, it was more of a description of the way everyone's mind worked--at least from his perspective.
The book offers an exploration of the relationships between epistemology and probability in the work of Niels Bohr, Werner Heisenberg, and Erwin Schrödinger; in quantum mechanics; and in modern physics as a whole. It also considers the implications of these relationships and of quantum theory itself for our understanding of the nature of thinking and knowledge in general. These implications are radical and controversial. While they have been seen as scientifically productive and intellectually liberating to some, Bohr and Heisenberg among them, they have been troublesome to many others, beginning with Schrödinger and, most famously, Einstein, who refused to believe that God would resort to playing dice, as quantum theory appeared to demand. The situation led to an intense debate, in particular the great confrontation between Einstein and Bohr, which began around the time of the discovery of quantum mechanics by Heisenberg and Schrödinger in 1920s and has overshadowed the history of the debate concerning quantum mechanics ever since. The controversy itself surrounding quantum theory and the intensity of the debate concerning it have remained undiminished. No end appears to be in sight. At the same time, in spite of the enormous and ever proliferating amount of commentaries in all genres (technical, philosophical, and popular), some of the deeper philosophical aspects of quantum mechanics and of the philosophical thought of the figures considered in this study often remain explored. The main aim of this book is to contribute to a better understanding of the nature of quantum-theoretical thinking and of the reasons for this extraordinary impact and controversy. Philosophically, the book pursues this task by bringing together in a new way the relationships between epistemology and probability in quantum theory and beyond. Historically, it does so by engaging comprehensively and in a mutually illuminating way with the work of all three key figures responsible for the birth of quantum mechanics - Heisenberg, Schrödinger, and, as concerns quantum epistemology, Bohr - which has not be previously done in literature on quantum mechanics. Among other key contributions of the book is an analysis of the role of mathematics in quantum theory and in the thinking of Bohr, Heisenberg, and Schrödinger; a new treatment of the famous experiment of Einstein, Podolsky, and Rosen (EPR) and of the Bohr-Einstein exchange concerning it; and an exploration of the implications of the epistemological problematics considered by the book for new developments of quantum mechanics itself, such as quantum information theory, on the one hand, and, on the other, for higher-level physical theories, from quantum field theory to string/brane theories and new cosmological theories.
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Epitaph, Arizona. Nice place. Beer's cold, at least. But Win and Joe barely get two drops to their lips before the shootin' starts. When the smoke clears, a marshal and two lowlifes are dead, and the Coulter brothers are hip deep in a war. On one side's the ranchers. Other side's the miners. Who's good and who's bad ain't the issue. Who's gonna survive is. And with the Coulters in town, every two-bit gunslinger's chances just dropped to zero. Violence. 6th novel in the
Following a string of clues, William Riskin investigates the mysterious disappearance of numerous people. As he uncovers his partner's part in these crimes, he comes face to face with the ultimate evil.
Through Abbey's own writings and personal papers, as well as interviews with friends and acquaintances, Bishop gives us a penetrating, compelling, no-holds-barred view of the life and accomplishments of this controversial figure.
In 2097--30 years after a powerful virus wiped out 97 percent of the male population--a new world order has emerged. With women at the helm of every leadership role, Earth has entered a virtual utopia. But when a rumored outbreak of the virus threatens his community, 14-year-old Kellen must warn his father of the coming danger.
The scope of this book was preempted and precipitated by the pioneering studies of Ussing and co-workers. The first phase of the phenomenological description of the cell as a black box has been followed by studies of cellular mechanisms, the interplay of the different transport components, and the mechanisms of regulation which will be covered in the individual chapters. For the individual epithelia transport schemes that have been proposed, I think it is appropriate to take pause and search for elements common to several epithelia. This aspect triggered the common theme idea for this book, and in fact the various chapters emphasize that the functional transporter components, expressed in the various epithelia, are not infinite in number, but they occur in epithelia which are separated in evolution by several hundred million years.
Preparing for the end of the world isn't new to fourteen-year-old Vincent and his religious family. But he can hardly believe it when he starts seeing elves and pixies--who tell him the world is ending in two days. Can he get his family off Earth before demons wipe out everything? Combining fantasy, sci/fi, and satire, this novel is the missing link between The Hitchhiker's Guide to the Galaxy and The Left Behind.
Tom and Elenna must journey on to face the last of the Beasts enslaved by the evil wizard Malvel: the Winged Flame, a phoenix of terrible power. It has been been slowly awakening a long-dead volcano.
<div><div><font class="Apple-style-span" face="Helvetica, sans-serif"><span class="Apple-style-span" style="font-size: 14px;">She's back, but this time she's a mother...intent on protecting her young.</span></font></div><div><font class="Apple-style-span" face="Helvetica, sans-serif"><span class="Apple-style-span" style="font-size: 14px;"><br></span></font></div><div><font class="Apple-style-span" face="Helvetica, sans-serif"><span class="Apple-style-span" style="font-size: 14px;">Two years after her husband's death, Kate Marshall returns home seeking security and stability for her three-year-old daughter. But when her path crosses with 'the one who got away'...her husband's best friend, she has to fight the desire to be with him for the sake of further heartbreak for her and her daughter.</span></font></div><div><font class="Apple-style-span" face="Helvetica, sans-serif"><span class="Apple-style-span" style="font-size: 14px;"><br></span></font></div><div><font class="Apple-style-span" face="Helvetica, sans-serif"><span class="Apple-style-span" style="font-size: 14px;">A tough, straight talking theatrical agent, Mark Johnston is dangerously handsome, exceedingly rich, irresistibly charming - and branded by the tabloids as one of the UK's most eligible bachelors. So even though Mark lost the girl of his dreams to his best friend, he finds no hardship in being single. Or so he thought.Determined not to lose her a second time, Mark has to find a way to convince her they can work. But can Kate cope with the media interest and ruthless, money-hungry clients surrounding him, being anywhere near her daughter? Or accept that Mark Johnston is really the family man he claims to be?</span></font></div></div>
The author of the international Suitable Boy returns with a passionate and deeply romantic tale of two gifted musicians. When an EngLish quartet, the Maggiore, undertakes a challmging Work of Beethoven's, violinist Michael Hohne is overwhelmcd by memories of mastering the piece as a student re'Vienna. That where he also met Julia McNicholl, a pianist whose beauty was as mesmerizing as her musical genius, and whom Michael loved with an intensity he never found again. Years later, Michael is living a life" devoted to music, until one day he is riding a London bus, and there, on another bus, separated only by glass, sits Julia McNicholl. Though the mutual passion flares anew, the love they shared in their younger days is now complicated by the secrets and silences that have Been generated by the passing of years. Unable to resist the }ower of their shared history,#12;Julia agrees to tour Vienna and Venice with Michael and the Maggiore Quartet. Against the magical backdrop of concert halls and canals, Michael and Julia must confront the truth about their love for one another, their love for the music that brought them together, and the true consequences for their tangled hearts. An Equal Music shows Seth to be at the top of his form: It is a tour de force of" poetic, impassioned writing, conjuring brilliantly the worlds of Beethoven and Bach, of Vienna,Venice, and London, of individual heartache and the familial bonds that tie a quartet. Interweaving themes loss, longing, and the power of music, An Equal Music is a deeply affecting story about the strands of passion that run through all our lives, masterfully confirming Vikram Seth as one of the. world's finest most daring novelists
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