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Evolving technologies starting with tracer studies, and more recently with genomics and proteomics, have provided novel information about the molecular properties of cerebral endothelium and astrocytes; however, further studies must be done in animal models of neurological diseases and in humans to get a clearer understanding of the pathogenesis of blood-brain barrier (BBB) breakdown in nervous system diseases. In The Blood-Brain and Other Neural Barriers: Reviews and Protocols, experts in the field present a series of cutting-edge protocols which can be used to study the barriers. Opening with detailed information on components of the neurovascular unit as well as the blood-cerebrospinal, blood-retinal, and blood-nerve barriers, the book continues with meticulous techniques to image the barriers in humans and experimental animals, followed by cutting-edge molecular techniques to study the BBB and novel models to study the barriers, and it concludes with techniques for the delivery of therapeutic agents across the BBB. Written in the highly successful Methods in Molecular BiologyTM series format, protocol chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, The Blood-Brain and Other Neural Barriers: Reviews and Protocols will aid the research efforts of not only graduate students but also more experienced investigators and support future studies of these vital systems.
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery.* Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects* Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies* Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes* Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)* Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
That Adrienne Rich is a not only a major American poet but an incisive, compelling prose writer is made clear once again by this collection, in which she continues to explore the social and political context of her life and art. Examining the connections between history and the imagination, ethics and action, she explores the possible meanings of being white, female, lesbian, Jewish, and a United States citizen, both at this particular time and through the lens of the past.
What happens if, after being given up for adoption in childhood, you reestablish contact with your biological family -- only to discover that your newfound brother is a killer? Anne Bird, the sister of Scott Peterson, knows firsthand. Soon after her birth in 1965, Anne was given up for adoption by her mother, Jackie Latham. Welcomed into the well-adjusted Grady family, she lived a happy life. Then, in the late 1990s, she came back into contact with her mother, now Jackie Peterson, and her family -- including Jackie's son Scott Peterson and his wife, Laci. Anne was welcomed into the family, and over the next several years she grew close to Scott and especially Laci. Together they shared holidays, family reunions, and even a trip to Disneyland. Anne and Laci became pregnant at roughly the same time, and the two became confidantes. Then, on Christmas Eve 2002, Laci Peterson went missing -- and the happy façade of the Peterson family slowly began to crumble. Anne rushed to the family's aid, helping in the search for Laci, even allowing Scott to stay in her home while police tried to find his wife. Yet Scott's behavior grew increasingly bizarre during the search, and Anne grew suspicious that her brother knew more than he was telling. Finally she began keeping a list of his disturbing behavior. And by the time Laci's body -- and that of her unborn son, Conner -- were found, Anne was becoming convinced: Her brother Scott Peterson had murdered his wife and unborn child in cold blood. Filled with news-making revelations and intimate glimpses of Scott and Laci, the Peterson family, and the investigation that followed the murder, Blood Brother is a provocative account of how long-dormant family ties dragged one woman into one of the most notorious crimes of our time.
On December 1, 1950, during the heart of the Korean War, Lieutenant Everett Donovan awakens in a mortar crater behind enemy lines. During the Battle of Chosin Reservoir, a mine explosion has killed his entire platoon of U. S. Marines. Shaken and shivering from the subzero temps, the lieutenant struggles to his feet and stands among the bodies of his fellow Devil Dogs. Suddenly, a shot rings out! Donovan falls to his knees and when he looks up, he's face to face with his Korean counterpart. Both men know the standoff will end in brotherhood or blood -- and neither choice will come easy.
Old church meets new with a vengeance when a monk is brutally murdered at St. Botolph's. Murder wasn't on the agenda for the symposium on the role of the Anglican Church today--until a brother is found dead in his cell. Suddenly the diverse guest list falls under suspicion. Could it be the bishop famous for his television appearances or his exotic counterpart from Africa; one of the three vicars who run the gamut from trendy to traditional; the nondenominational American with a passion for fundraising; or perhaps one of the two Norwegian lady divines? Or is it one of the brothers themselves, taking advantage of the camouflage provided by outside visitors? Surely the tensions between the cloistered clergy and their more worldly visitors can't have led to such an unthinkable occurrence. But why is Father Anselm, the austere head of the Anglican Community, so reluctant to allow an investigation? Is he concerned simply about unfavourable publicity? Or is there a darker secret hidden behind the inscrutable walls of St. Botolph's?
MAFIA. CAMORRA. 'NDRANGHETA. The Sicilian mafia, known as Cosa Nostra, is far from being Italy's only dangerous criminal fraternity. The country hosts two other major mafias: the camorra from Naples; and, from the poor and isolated region of Calabria, the mysterious 'ndrangheta, which has now risen to become the most powerful mob group active today. Since they emerged, the mafias have all corrupted Italy's institutions, drastically curtailed the life-chances of its citizens, evaded justice, and set up their own self-interested meddling as an alternative to the courts. Yet each of these brotherhoods has its own methods, its own dark rituals, its own style of ferocity. Each is uniquely adapted to corrupt and exploit its own specific environment, as it collaborates with, learns from, and goes to war with the other mafias. Today, the shadow of organized crime hangs over a country racked by debt, political paralysis, and widespread corruption. The 'ndrangheta controls much of Europe's wholesale cocaine trade and, by some estimates, 3 percent of Italy's total GDP. Blood Brotherhoods traces the origins of this national malaise back to Italy's roots as a united country in the nineteenth century, and shows how political violence incubated underworld sects among the lemon groves of Palermo, the fetid slums of Naples, and the harsh mountain villages of Calabria. Blood Brotherhoods is a book of breathtaking ambition, tracing for the first time the interlocking story of all three mafias from their origins to the present day. John Dickie is recognized in Italy as one of the foremost historians of organized crime. In these pages, he blends archival detective work, passionate narrative, and shrewd analysis to bring a unique criminal ecosystem#151;and the three terrifying criminal brotherhoods that have evolved within it#151;to life on the page.
MAFIA. CAMORRA. 'NDRANGHETA.The Sicilian mafia, known as Cosa Nostra, is far from being Italy's only dangerous criminal fraternity. The country hosts two other major mafias: the camorra from Naples; and, from the poor and isolated region of Calabria, the mysterious 'ndrangheta, which has now risen to become the most powerful mob group active today.Since they emerged, the mafias have all corrupted Italy's institutions, drastically curtailed the life-chances of its citizens, evaded justice, and set up their own self-interested meddling as an alternative to the courts. Yet each of these brotherhoods has its own methods, its own dark rituals, its own style of ferocity. Each is uniquely adapted to corrupt and exploit its own specific environment, as it collaborates with, learns from, and goes to war with the other mafias.Today, the shadow of organized crime hangs over a country racked by debt, political paralysis, and widespread corruption. The 'ndrangheta controls much of Europe's wholesale cocaine trade and, by some estimates, 3 percent of Italy's total GDP. Blood Brotherhoods traces the origins of this national malaise back to Italy's roots as a united country in the nineteenth century, and shows how political violence incubated underworld sects among the lemon groves of Palermo, the fetid slums of Naples, and the harsh mountain villages of Calabria.Blood Brotherhoods is a book of breathtaking ambition, tracing for the first time the interlocking story of all three mafias from their origins to the present day. John Dickie is recognized in Italy as one of the foremost historians of organized crime. In these pages, he blends archival detective work, passionate narrative, and shrewd analysis to bring a unique criminal ecosystem-and the three terrifying criminal brotherhoods that have evolved within it-to life on the page.e terrifying criminal brotherhoods that have evolved within it, to life on the page.
Originally published in 1932 and banned by the Nazis one year later, Blood Brothers follows a gang of young boys bound together by unwritten rules and mutual loyalty.Blood Brothers is the only known novel by German social worker and journalist Ernst Haffner, of whom nearly all traces were lost during the course of World War II. Told in stark, unsparing detail, Haffner's story delves into the illicit underworld of Berlin on the eve of Hitler's rise to power, describing how these blood brothers move from one petty crime to the next, spending their nights in underground bars and makeshift hostels, struggling together to survive the harsh realities of gang life, and finding in one another the legitimacy denied them by society.
From New York Times bestselling authors James Rollins and Rebecca Cantrell comes a dark story of murder, mystery, and a brotherhood steeped in a bloody past.As a young reporter, Arthur Crane exposed the secrets behind the Orchid Killer, a cult murderer from the late '60s whose crimes blackened the end of the Summer of Love. Half a century later, Arthur wakes to find an orchid resting on his pillow, a symbol of death from a killer connected to his estranged younger brother, Christian. To discover the horrifying truth, Arthur will risk all-even his very soul-for Christian may not be the brother that Arthur remembers...Included with this chilling story is a sneak peek at Innocent Blood, the second book in the Order of the Sanguines Series.
Although he has a great job at the hospital and dreams of becoming a doctor, Clay can't afford to go to college. Clay wishes his life could be more like his best friend Joeys. But Joeys golden future shatters when he overdoses at a party. Now hes clinging to life at the hospital where Clay works.
Harry Keogh spent his life defending mankind from deadly alien vampires but Harry was corrupted by the very evil he battled. He sacrificed himself to save mankind, but now they're back...
Though they were raised by the same decent and well-respected parents, two brothers could not be more different than Frank and Joe Arnold. The pair have nothing in common but blood . . . and Alice Jacobs. Joe has fallen hard for the shy, kindhearted young woman. But it is Frank, a devious schemer, who is determined to have her. He sees Alice as the key to his fortune, and will do everything, including hide his brutal nature, to succeed. When Frank and Alice announce their engagement, Joe leaves home, determined to put distance between himself and temptation. Despite his best efforts, the inevitable happens when Joe returns for the wedding. And though Alice is drawn to Joe too, she ultimately chooses duty and Frank-a decision that will have dark and violent repercussions for them all. From number one Times of London bestselling author Josephine Cox comes a powerful and dramatic story of a love triangle gone terribly wrong.
DOUBLE TROUBLE That was what you got when cousins Gabe McBride, a Montana cowboy, and Randall Stanton, a British lord, traded places! What Gabe and Randall got was the challenge of their lives! Anything Randall could do, Gabe could do better-- but tackling centuries of tradition proved tougher than he thought. Almost as tough as convincing a beautiful widowed mother, Frederica Crossman, that he was a risk worth taking. Meanwhile, back at the ranch, Randall knew anything Gabe could do, he could do, too. He was resourceful, competent, clever. He could handle everything-- except gorgeous, feisty Claire Stevens. When Randall and Gabe took on a challenge, they never quit. But to win Claire and Freddie, they' d need all their lordly pluck and cowboy try!
Lucy knows there must be something, somewhere, that can tell her why she was chosen to see the terrible visions; why she feels the shadowy presence all around her. But what? Could the explanation lie with the mysterious stranger claiming to be Byron's brother? As Lucy searches desperately for answers, she knows time is running out. Too many people have disappeared--or worse--and the constant feeling of being surrounded by something truly evil grows stronger each night.
Eighteen-year-old Stony De Coco is trapped in a working-class world that offers him only one way of proving his loyalty, and no way out.
Though they were raised by the same decent and well-respected parents, two brothers could not be more different than Frank and Joe Arnold. The pair have nothing in common but blood . . . and Alice Jacobs. Joe has fallen hard for the shy, kindhearted young woman. But it is Frank, a devious schemer, who is determined to have her. He sees Alice as the key to his fortune, and will do everything, including hide his brutal nature, to succeed.When Frank and Alice announce their engagement, Joe leaves home, determined to put distance between himself and temptation. Despite his best efforts, the inevitable happens when Joe returns for the wedding. And though Alice is drawn to Joe too, she ultimately chooses duty and Frank--a decision that will have dark and violent repercussions for them all.From number one Times of London bestselling author Josephine Cox comes a powerful and dramatic story of a love triangle gone terribly wrong.
As a child, Elias Chacour lived in a small Palestinian village in Galilee. The townspeople were proud of their ancient Christian heritage and lived at peace with their Jewish neighbors. But early in 1947, their idyllic lifestyle was swept away as tens of thousands of Palestinians were killed and nearly one million forced into refugee camps. An exile in his native land, Elias began a years-long struggle with his love for the Jewish people and the world's misunderstanding of his own people, the Palestinians. How was he to respond? He found his answer in the simple, haunting words of the Man of Galilee: "Blessed are the peacemakers." <P> In Blood Brothers, Chacour blends his riveting life story with historical research to reveal a little-known side of the Arab-Israeli conflict and the birth of modern Israel. He touches on controversial questions such as "What behind-the-scenes politics touched off the turmoil in the Middle East? ", "What does Bible prophecy really have to say? ", and "Can bitter enemies ever be reconciled? " <P> Originally published by Chosen Books in 1984 and now expanded with a new introduction by the author, a new foreword by former Secretary of State James A. Baker III, and a "Since Then" epilogue by writer David Hazard, this compelling book offers readers hope-filled insight into living at peace in the most volatile region of the world.
In 1962, boxing writers and fans considered Cassius Clay an obnoxious self-promoter, and few believed that he would become the heavyweight champion of the world. But Malcolm X, the most famous minister in the Nation of Islam--a sect many white Americans deemed a hate cult--saw the potential in Clay, not just for boxing greatness, but as a means of spreading the Nation's message. The two became fast friends, keeping their interactions secret from the press for fear of jeopardizing Clay's career. Clay began living a double life--a patriotic "good Negro" in public, and a radical reformer behind the scenes. Soon, however, their friendship would sour, with disastrous and far-reaching consequences. Based on previously untapped sources, from Malcolm's personal papers to FBI records, Blood Brothers is the first book to offer an in-depth portrait of this complex bond. Acclaimed historians Randy Roberts and Johnny Smith reconstruct the worlds that shaped Malcolm and Clay, from the boxing arenas and mosques, to postwar New York and civil rights-era Miami. In an impressively detailed account, they reveal how Malcolm molded Cassius Clay into Muhammad Ali, helping him become an international symbol of black pride and black independence. Yet when Malcolm was barred from the Nation for criticizing the philandering of its leader, Elijah Muhammad, Ali turned his back on Malcolm--a choice that tragically contributed to the latter's assassination in February 1965. Malcolm's death marked the end of a critical phase of the civil rights movement, but the legacy of his friendship with Ali has endured. We inhabit a new era where the roles of entertainer and activist, of sports and politics, are more entwined than ever before. Blood Brothers is the story of how Ali redefined what it means to be a black athlete in America--after Malcolm first enlightened him. An extraordinary narrative of love and deep affection, as well as deceit, betrayal, and violence, this story is a window into the public and private lives of two of our greatest national icons, and the tumultuous period in American history that they helped to shape.
Half-Ear, or Zarendargar, a Kur general fallen from favor in the Steel Worlds, now sought by a death squad of his savage compeers, has determined to lure his pursuers into the Barrens, the vast prairies to the east of known Gor, populated by warring tribes known to Goreans as the Red Savages. He has arranged matters in such a way that he will be abetted in his stand against the death squad and its human allies by a human ally of his own, his former foe, Tarl Cabot. The ancestors of the Red Savages, like those of many other Goreans, were brought to Gor long ago in Voyages of Acquisition by the Priest-Kings. The Red Savages were settled in an area not unlike that of their former home, a sweeping, almost endless grassland, where they tend to continue their former ways of life--and war. Rediscover this brilliantly imagined world where men are masters and women live to serve their every desire.
Every seven years, on the seventh day of the seventh month, strange things happen. It began when three young boys - Caleb, Fox, and Gage - went on a camping trip to the Pagan Stone. And twenty-one years later, it will end in a showdown between evil and the boys who have become men - and the women who love them. This modern-day legend draws reporter and author Quinn Black to Hawkins Hollow with the hope of making the eerie happening the subject of her new book. It is only February, but Caleb Hawkins, descendent of the town founders, has already seen and felt the stirrings of evil. Though he can never forget the beginning of the terror in the woods twenty-one years ago, the signs have never been this strong before. Cal will need the help of his best friends, Fox and Gage, but surprisingly he must rely on Quinn as well. She, too, can see the evil that the locals cannot, somehow connecting her to the town and to Cal. As winter turns to spring, Cal and Quinn will shed their inhibitions, surrendering to a growing desire. They will form the cornerstone of a group of men and women bound by fate, passion, and the fight against what is to come from out of the darkness. . .
Marshal Matt Dillon keeps Dodge City safe from rustlers, gamblers, and desperados-and rejoins Doc Adams, Kitty Russell, and all the cherished characters from the classic TV series.
Just in time for the scariest season of all, three popular paranormal authors come together to tell original tales of romance where Anything can happen under a Halloween moon . . . Tempers flare and passions rise in Jocelynn Drake's Of Monsters and Men as the local werewolf pack clashes with the Winter Court's Wild Hunt . . . In Terri Garey's The Ghoul Next Door, a witch and a warlock battle it out for possession of a haunted house, but the ghost may have her own agenda . . . And, in Trick or Treathen by Caris Roane, a master vampire struggles to stay away from the mortal woman who enflames his very soul.
THE SCENT OF BLOOD LURED HIM. . . ;But for vampire Diego Rivera, Ramona Escobar's sensuality proved even more potent. He had to resist-for there could be no such thing as love for him. Five centuries ago Diego had vowed never to turn another with the bite of the undead. And though Diego knew the dark underworld of New York was no place for a human, his unslaked desire commanded that Ramona be his for one night. . . ;. But when the artist's life was threatened by a reclusive millionaire who had used Ramona's skills to build a forgery ring, Diego needed to unleash his inner demon to save her. Then he was faced with a choice-lose the woman he loved. . . ;or turn her with a vampire's kiss.
Following the recent film of QUEEN OF THE DAMNED (starring the late cult singer Aaliyah and Stuart Townsend) and the success of her latest novel, BLACKWOOD FARM, there's been a resurgence of interest in Lestat, the ultimate vampire creation, and his creator-Lestat has returned, and, moving through the worlds of BLACKWOOD FARM and the Mayfair family, he finds himself ensnared by love and loyalty. Here are all of the brilliantly conceived Anne Rice characters that make up these two worlds of vampires and witches: Mona Mayfair, who's come to Blackwood Farm to die and is brought into the realm of the undead-her uncle, Julian Mayfair, guardian of the family, determined to forever torment Lestat because of what he has done to Mona-Rowan Mayfair, brilliant neurosurgeon, a true witch, a woman who attracts spirits to herself, casts spells on others and finds herself dangerously drawn to the undead and all-powerful Lestat-her husband, Michael Curry, hero of the Mayfair Chronicles, who seeks Lestat's help with the temporary madness of his wife-Ash Templeton, a 5,000 year old Taltos, whose genes live on in the Mayfairs, who has taken Mona's child- Patsy, a country-western singer, killed by Quinn Blackwood and dumped in a swamp, who returns as a ghost to avenge her own death-and at the book's centre - the Vampire Lestat, once the epitome of evil, now following the transformation set in motion with MEMNOCH THE DEVIL, struggling with his vampiredom, yearning for goodness and purity and love as he saves Patsy's ghost from the dark realm of the Earthbound, uncovers the mystery of the Taltos, and unselfishly decides the fate of his beloved Rowan Mayfair. This latest vampire novel will delight all Anne Rice fans.
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