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Functional Selectivity of G Protein-Coupled Receptor Ligands

by Kim Neve

Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Functions and Change: A Modeling Approach to College Algebra (3rd Edition)

by Bruce Crauder Benny Evans Alan Noell

This edition provides an alternative to a traditional college algebra course for students who either will not take another math course or may go on to a business calculus course. An informal approach offers clear explanations that leave out unnecessary technicalities so that students who are not comfortable with algebra will easily understand the concepts.

Functions Modeling Change: A Preparation for Calculus (2nd Edition)

by Eric Connally Elliot J. Marks Jerry Morris Karen Rhea Pat Shure Carl Swenson Katherine Yoshiwara Deborah Hughes-Hallett Frank Avenoso Philip Cheifetz Ann Davidian Daniel E. Flath Andrew M. Gleason Brigitte Lahme Patti Frazer Lock

This is a new edition of the precalculus text developed by the Consortium based at Harvard University and funded by a National Science Foundation Grant. The text is thought-provoking for well-prepared students while still accessible to students with weaker backgrounds. It provides numerical and graphical approaches as well as algebraic approaches to give students another way of mastering the material. This approach encourages students to persist, thereby lowering failure rates. A large number of real-world examples and problems enable students to create mathematical models that will help them understand the world in which they live. The focus is on those topics that are essential to the study of calculus and these topics are treated in depth. Linear, exponential, power, and periodic functions are introduced before polynomial and rational functions to take advantage of their use to model physical phenomena. Building on the Consortium's Rule of Four: Each function is represented symbolically, numerically, graphically, and verbally where appropriate.

Functions, Statistics, and Trigonometry (The University of Chicago School Mathematics Project, 3rd Edition)

by John W. Mcconnell Susan A. Brown Paul J. Karafiol Sara Brouwer Mary Ives Marshall Lassak Rosa Mccullagh Natalie Jakucyn Zalman Usiskin

The text has been developed by the Secondary Component of the project, and constitutes the core of the sixth year in a seven-year middle and high school mathematics curriculum. All lessons have been reviewed and examined afresh for this edition but the overall content and mathematical prerequisites are the same as in previous editions. New instructional features for this edition include: a Big Idea, Mental Math questions, Activities, Guided Examples, and Quiz Yourself (QY).

Fundamental Accounting Principles

by John J. Wild Ken W. Shaw Barbara Chiappetta

With 55 years of success in the principles of accounting market, Fundamental Accounting Principles, 21e by Wild, Shaw and Chiappetta has endured and adapted to changes in accounting, technology, and student learning styles. Its innovation is reflected in its extensive use of small business examples, the integration of new technology learning tools, superior end-of-chapter material, and a highly engaging, pedagogical design.

Fundamental Aspects of Plasma Chemical Physics

by Annarita Laricchiuta Domenico Bruno Mario Capitelli

Fundamental Aspects of Plasma Chemical Physics: Transport develops basic and advanced concepts of plasma transport to the modern treatment of the Chapman-Enskog method for the solution of the Boltzmann transport equation. The book invites the reader to consider actual problems of the transport of thermal plasmas with particular attention to the derivation of diffusion- and viscosity-type transport cross sections, stressing the role of resonant charge-exchange processes in affecting the diffusion-type collision calculation of viscosity-type collision integrals. A wide range of topics is then discussed including (1) the effect of non-equilibrium vibrational distributions on the transport of vibrational energy, (2) the role of electronically excited states in the transport properties of thermal plasmas, (3) the dependence of transport properties on the multitude of Saha equations for multi-temperature plasmas, and (4) the effect of the magnetic field on transport properties. Throughout the book, worked examples are provided to clarify concepts and mathematical approaches. This book is the second of a series of three published by the Bari group on fundamental aspects of plasma chemical physics. The first book, Fundamental Aspects of Plasma Chemical Physics: Thermodynamics, is dedicated to plasma thermodynamics; and the third, Fundamental Aspects of Plasma Chemical Physics: Kinetics, deals with plasma kinetics.

Fundamental Principles of International Relations

by J. Martin Rochester

This book distills the essential elements of world politics, both the enduring characteristics as well as the revolutionary changes that may be altering the very fabric of the centuries-old state system. Author J. Martin Rochester explores all the important topics that one would expect to find in an IR text (war, diplomacy, foreign policy, international law and organization, the international economy, and more) but injects fresh perspectives on how globalization and other contemporary trends are affecting these issues. In addition, the author does so through a highly engaging, lively writing style that will appeal to today's students. Fundamental Principles of International Relations is a tightly woven treatment of international politics past and present, drawing on the latest academic scholarship while avoiding excessive jargon and utilizing pedagogical aids while avoiding clutter. Rochester ultimately challenges the reader to think critically about the future of a post-Cold War and post-9/11 world that is arguably more complex, if not more dangerous, than some previous eras, with the potential for promise as well as peril.

Fundamental Questions in Cross-Cultural Psychology

by Seger M. Breugelmans Athanasios Chasiotis Fons J. van de Vijver

Cross-cultural psychology has come of age as a scientific discipline, but how has it developed? The field has moved from exploratory studies, in which researchers were mainly interested in finding differences in psychological functioning without any clear expectation, to detailed hypothesis tests of theories of cross-cultural differences. This book takes stock of the large number of empirical studies conducted over the last decades to evaluate the current state of the field. Specialists from various domains provide an overview of their area, linking it to the fundamental questions of cross-cultural psychology such as how individuals and their cultures are linked, how the link evolves during development, and what the methodological challenges of the field are. This book will appeal to academic researchers and post-graduates interested in cross-cultural research.

Fundamentalism and American Culture (2nd edition)

by George M. Marsden

Many Americans today are taking note of the strong political force that is the religious right. Controversial decisions by the government are met with hundreds of lobbyists, millions of dollars of advertising spending, and a grassroots response.

Fundamentalism In American Religion And Law

by David A. J. Richards

Why, from Reagan to George Bush, have fundamentalists in religion and in law (originalists) exercised such political power and influence in the United States? Why has the Republican Party forged an ideology of judicial appointments (originalism) hostile to abortion and gay rights? Why and how did Barack Obama distinguish himself among Democratic candidates not only by his opposition to the Iraq war but by his opposition to originalism? This book argues that fundamentalism in both religion and law threatens democratic values and draws its appeal from a patriarchal psychology still alive in our personal and political lives and at threat from the constitutional developments since the 1960s. The argument analyzes this psychology (based on traumatic loss in intimate life) and resistance to it (based on the love of equals). Obama's resistance to originalism arises from his developmental history as a democratic, as opposed to patriarchal, man who resists the patriarchal demands on men and women that originalism enforces - in particular, the patriarchal love laws that tell people who and how and how much they may love.

Fundamentalism: A Very Short Introduction

by Malise Ruthven

Fundamentalism is seen as the major threat to world peace today, a conclusion impossible to ignore since the events in New York on September 11, 2001. But what does "fundamentalism" really mean? Since it was coined by American Protestant evangelicals in the 1920s, the use of the term "fundamentalist" has expanded to include a diverse range of radical conservatives and ideological purists, not all religious. Fundamentalism could now mean both militant Israeli settlers as well as the Islamist radicals who oppose them, it can mean Christians, Hindus, animal liberationists, and even Buddhist nationalists. Here, Middle East expert Malise Ruthven investigates fundamentalism's historical, social, religious, political, and ideological roots, and tackles the polemic and stereotypes surrounding this complex phenomena--one that eludes simple definition, yet urgently needs to be understood.

Fundamentals and Applications of Controlled Release Drug Delivery

by Michael J. Rathbone Juergen Siepmann Ronald A. Siegel

This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.

Fundamentals of Anaesthesia

by Robert Jones Tim Smith Colin Pinnock Ted Lin

The third edition of Fundamentals of Anaesthesia is the gold standard text for the Primary FRCA, encapsulating the basic principles of modern anaesthesia in one easily accessible volume. Written and edited by a team of expert contributors with extensive FRCA examination experience, Fundamentals of Anaesthesia, Third Edition deliberately blends the expertise of invited authors in an unrivalled consistency of style more akin to that of a single author text. Deliberate use of authors with a more general anaesthesia background ties in well with the education of anaesthetists in their early years. The third edition is fully updated, with a number of completely new chapters. Presentation of information is clear and concise, with extensive use of tables, colour illustrations, summary boxes of key information and bullet lists. This Highly Commended award winning textbook is a unique revision aid for the Primary FRCA and an essential companion for all exam candidates.

Fundamentals of Anatomy and Physiology (6th Edition)

by Frederic H. Martini

This text is the central component of an integrated learning system that includes the Atlas, Applications Manual, Interactive CD and Website. Designed to work together, all components of the package are linked by cross-references. Students are given clear directions to resources in other components.

Fundamentals Of Anatomy & Physiology

by Donald C. Rizzo

Designed for allied health learners with little or no biology knowledge, this full-color book is a comprehensive introduction to anatomy & physiology. It is organized according to body systems, and focuses on the body working together to promote homeostasis. Chapters are self-contained so instructors can teach in any order preferred. Essential laboratory exercises included at the end of chapters provide hands-on lab experience. Key terms with phonetic pronunciations help build vocabulary. Free interactive CD-ROM encourages mastery of content through quizzes, games, and animations.

Fundamentals of Automotive Technology

by Cdx Automotive Staff

Brought to you by CDX Automotive, the world's leading provider of interactive automotive training programs, Fundamentals of Automotive Technology: Principles and Practice serves as the centerpiece of an integrated teaching and learning system designed to fully support students and make life easy for instructors. Fundamentals of Automotive Technology: Principles and Practice covers crucial material for career and technical education, secondary/post-secondary, and community college students and provides both rationales and step-by-step instructions for virtually every non-diagnosis NATEF task. Each section provides a comprehensive overview of a key topic area, with real-life problem scenarios that encourage students to develop connections between different skill and knowledge components. Customer service, safety, and math, science, and literary principles are demonstrated throughout the text to build student skill levels. Chapters are linked via cross-reference tools that support skill retention, critical thinking, and problem-solving. Students are regularly reminded that people skills are as important as technical skills in customer service fields. Fundamentals of Automotive Technology: Principles and Practice is filled with tools and pedagogical features designed to maximize student absorption of course materials and reinforce classroom learning. These tools include:* NATEF Tasks, Knowledge Objectives, and Skills Objectives* Case studies that provide an overview of each chapter while stimulating student discussion and building interest in key topics* New pictures and illustrations designed specifically for this text* Skill Drills with written step-by-step instructions and visual summaries of important skills and procedures* Coverage of NATEF Applied Academic skills for math, science, and communication * Tables and figures that present essential data in a format suited to visual learners* Technician Tips that offer advice and on-the-job tricks of the trade* Caring for the Customer sections that highlight essential customer-service skills* Highlighted key terms to maximize retention* Review of key concepts at the end of every chapter to reinforce major concepts * ASE-type questions to prepare students for certification testing.

Fundamentals of Biomechanics

by Margareta Nordin David Goldsheyder Dawn Leger Nihat Özkaya

Biomechanics applies the principles and rigor of engineering to the mechanical properties of living systems. This book integrates the classic fields of mechanics--statics, dynamics, and strength of materials--using examples from biology and medicine. Fundamentals of Biomechanics is excellent for teaching either undergraduates in biomedical engineering programs or health care professionals studying biomechanics at the graduate level. Extensively revised from a successful first edition, the book features a wealth of clear illustrations, numerous worked examples, and many problem sets. The book provides the quantitative perspective missing from more descriptive texts, without requiring an advanced background in mathematics. It will be welcomed for use in courses such as biomechanics and orthopedics, rehabilitation and industrial engineering, and occupational or sports medicine.

Fundamentals of Business Organizations for Paralegals (3rd Edition)

by Deborah E. Bouchoux

Fundamentals of Business Organizations for Paralegals, Third Edition, offers a concise treatment of all of the forms of business organizations in the United States. The author provides thorough, succinct treatment of all pertinent topics, making this book the ideal choice for instructors who teach a shorter course and need a text that covers critical topics with a more straightforward approach. Attentive To The fundamentals paralegal students need to know, this concise paperback provides: a basic and thorough understanding of all the various types of business organizations in a direct and concise format a discussion of each form of business organization, including the nature of the entity, advantages and disadvantages, formation of the entity, operation and management, transferability of ownership, dissolution, and tax consequences more in-depth treatment of Limited Liability Partnerships and Limited Liability Companies than other texts useful exhibits and charts that highlight important topics and sample forms that are integrated with the textual discussion throughout the book Internet resources in each chapter that direct readers to Internet sites that may provide additional information, forms, or agreements Key Terms defined in the margins for easy reference, practice tips in each chapter that provide pragmatic information for paralegals, lists of relevant websites and of tasks commonly performed by paralegals, and a complete glossary that provides an easy reference for terminology Case Illustrations -- brief summaries of cases that illustrate one of the concepts or topics addressed in the chapter Discussion Questions in each chapter that stimulate class discussion and ensure that students Understand The material a complete ancillary package, including an instructor's manual with a test bank and PowerPoint slides. The Instructor's Manual will also provide additional forms, such as tax forms, not included in the text New to Third Edition: each chapter includes all new discussion questions, Internet questions, and Case Illustrations Chapter 6 discusses Revised Uniform Limited Liability Company Act Chapter 10 discusses new trends in corporate governance, such as the move toward electing boards of directors by majority rather than plurality vote, The move toward eliminating staggered or classified boards of directors, new SEC rules and regulations, And The availability of proxy materials on the Internet coverage of the 2008 financial crisis Clear and To The point, Fundamentals of Business Organizations for Paralegals is an excellent, concise treatment of the basics of business organizations, providing students with a thorough understanding of essential topics.

Fundamentals of Business Writing

by Joseph C. Mancuso Yvonne V. Chabrier

A ground-breaking approach to writing with a greater focus on planning and revising documents. When you complete this book, you will know how to write with clarity and style, so your ideas come across clearly and quickly. You'll become a sharp-eyed critic, constantly spurring yourself to do better. Best of all, you'll learn by doing--by building and evaluating your own business letter. You'll discover how to avoid writer's block by making writing a process with a beginning, middle, and end. You will learn how to: * Sharpen your competitive edge through good, clear writing * Make sure your written words say exactly what you mean * Identify words and phrases that get in the way of clear, concise communication * Quickly analyze, organize, write, and revise any document * Use expressive words; keep sentences and paragraphs short; keep thoughts simple * Use techniques that involve the reader and create the feeling of personal communication * Format documents so they're inviting to look at and easy to read

Fundamentals of C++ and Data Structures, Advanced Course (2nd Edition)

by Kenneth Lambert Thomas Naps

Following the success of Fundamentals of Program Design and Data Structures by Lambert and Naps, C++ Advanced Course is essential for a second course in Computer Science. Completely updated, this text provides in-depth coverage to help students prepare for the AP exam, Exam AB. A full introduction to the essential features of C++ is provided and programming techniques are emphasized in the context of interesting and realistic case problems. This text is compatible with C++ compilers from Microsoft, Borland, and Metrowerks.

Fundamentals of C++: Introductory Course (2nd Edition)

by Kenneth Lambert Douglas W. Nance

Following the success of Fundamentals of C++ by Lambert and Nance, C++ Introductory course is essential for a first course in Computer Science. Completely updated, this text provides in-depth coverage to help students prepare for the AP exam, Exam A. A full introduction to the essential features of C++ is provided and programming techniques are emphasized in the context of interesting and realistic case problems. This text is compatible with C++ compilers from Microsoft, Borland, and Metrowerks.

Fundamentals of Clinical Trials

by Curt D. Furberg Lawrence M. Friedman David L. Demets

This is the fourth edition of a very successful textbook on clinical trials methodology, written by three recognized experts who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the third edition. A chapter on ethics has been added and topics such as noninferiority and adaptive designs now receive considerable discussion. There is much new material on adverse events, adherence, data monitoring, and issues in analysis. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials from a variety of medical disciplines to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology.

Showing 77,376 through 77,400 of 146,450 results


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