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Immunotoxicity, Immune Dysfunction, and Chronic Disease

by Rodney R. Dietert Robert W. Luebke

Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases. To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on "Key Points" as well as "Recommendations" where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.

Imogene's Antlers

by David Small

This a story of young Imogene who wakes up one morning to find she has sprouted antlers.

Imogene's Last Stand

by Nancy Carpenter Candace Fleming

Meet Imogene, a plucky heroine with a passion for history.As a baby, Imogene's first words were "Four score and seven years ago." In preschool, she fingerpainted a map of the Oregon Trail. So it's not surprising that when the mayor wants to tear down the long-neglected Liddleton Historical Society to make room for a shoelace factory, Imogene is desperate to convince the town how important its history is. But even though she rides through the streets in her Paul Revere costume shouting, "The bulldozers are coming, the bulldozers are coming!" the townspeople won't budge. What's a history-loving kid to do? Filled with quotes from history's biggest players--not to mention mini-bios on the endpapers--and lots of humor, here's the perfect book for budding historians.From the Hardcover edition.

iMovie '11 & iDVD: The Missing Manual

by David Pogue Aaron Miller

Apple's video-editing program is better than ever, but it still doesn't have a printed guide to help you get started. That's where this gorgeous, full-color book comes in. You get clear explanations of iMovie's impressive new features, like instant rendering, storyboarding, and one-step special effects. Experts David Pogue and Aaron Miller also give you a complete course in film editing and DVD design. Edit video like the pros. Import raw footage, add transitions, and use iMovie's newly restored, intuitive timeline editor. Create stunning trailers. Design Hollywood-style "Coming Attractions!" previews for your movies. Share your film. Distribute your movie in a variety of places--on smartphones, Apple TV, your own site, and with one-click exports to YouTube, Facebook, Vimeo, CNN iReport, and MobileMe. Make DVDs. Design the menus, titles, and layout for your DVDs, and burn them to disc.

iMovie 6 & iDVD: The Missing Manual

by David Pogue

While the last version of iMovie gave moviemakers the ability to capture and edit widescreen High Definition Video (HDV) from the new generation of camcorders, iMovie 6 is all about the ease of moviemaking itself. iMovie 6 includes five professionally designed themes with backgrounds, motion graphics, titles, and effects that act as building blocks for your projects. You can preview transitions and stunning new video effects--such as time-lapse video--in real time using the full screen. Or edit audio and add sound effects with a new built-in sound studio. For presenting your movie, Magic iDVD offers easy-to-use themes, including new widescreen options. Whether you're a professional or an amateur moviemaker, this is amazing stuff. But if you want to learn the full capabilities of these applications, Apple documentation won't make the cut. Instead, iMovie 6 & iDVD: The Missing Manual is the ideal third-party authority that covers all of these changes through an objective lens. This witty and entertaining guide from celebrated author David Pogue details every step of iMovie 6 and iDVD production. The book shows you how to: *Work on multiple iMovie projects at once and drag & drop clips among them *Output your creation to a blog, its own web page, or as a video podcast with iWeb *Use "Magic iMovie" to import your video and make a movie for you *Integrate with other iLife programs to use songs, photos, and an original soundtrack And a whole lot more. From choosing and using a digital camcorder to burning the finished work onto DVDs, posting it online, or downloading it to an iPod, iMovie 6 & iDVD: The Missing Manual zooms right in on the details in a clear, concise, and understandable manner. The book also provides a firm grounding in basic film technique so that the quality of your video won't rely entirely on magic.

iMovie HD & iDVD 5: The Missing Manual

by David Pogue

The latest versions of iMovie HD and iDVD 5 are, by far, the most robust moviemaking applications available to consumers today. But whether you're a professional or an amateur moviemaker eager to take advantage of the full capabilities of these applications, don't count on Apple documentation to make the cut. You need iMovie HD & iDVD 5: The Missing Manual , the objective authority on iMovie HD and iDVD 5. Even if you own a previous version of iMovie, the new feature-rich iMovie HD may well be impossible to resist. This video editing program now enables users to capture and edit widescreen High Definition Video (HDV) from the new generation of HDV camcorders, along with standard DV and the MPEG-4 video format. iMovie HD also includes "Magic iMovie" for making finished movies automatically. The feature does everything in one step--imports video into separate clips and adds titles, transitions, and music. The finished video is then ready for iDVD 5, which now includes 15 new themes with animated drop zones that can display video clips across DVD menus, just like the latest Hollywood DVDs. This witty and entertaining guide from celebrated author David Pogue not only details every step of iMovie HD video production--from choosing and using a digital camcorder to burning the finished work onto DVDs--but provides a firm grounding in basic film technique so that the quality of a video won't rely entirely on magic. iMovie HD & iDVD 5: The Missing Manual includes expert techniques and tricks for: *Capturing quality footage (including tips on composition, lighting, and even special-event filming) *Building your movie track, incorporating transitions and special effects, and adding narration, music, and sound *Working with picture files and QuickTime movies *Reaching your intended audience by exporting to tape, transferring iMovie to QuickTime, burning QuickTime-Movie CDs, and putting movies on the Web (and even on your cell phone!) *Using iDVD 5 to stylize and burn your DVD creation. iMovie HD & iDVD 5: The Missing Manual --it's your moviemaking-made-easy guide.

Imp

by Andrew Neiderman

Mary Oaks, a religious woman, marries a man who proves to be far less than she anticipated. After their first child, a daughter, is born, Mary retreats deeper into her religion and when her husband forces her to make love and she becomes pregnant, she decides this child must be evil. After her husband is killed in an DWI accident, she gives birth to the baby in the house and keeps it in the basement. Five years later, IMP finds his way out and becomes something of a terror during his nocturnal trips. When he endangers the life of a five year old girl, the horror is exposed.

The Imp That Ate My Homework

by Laurence Yep

Showdown in Chinatown! Jim wants to be a normal American kid. The only problem: His grandfather is the meanest, ugliest man in Chinatown. Grandpop has no patience for his "native born, no brains" grandson, and Jim is not all that interested in hearing about old Chinese customs and superstitions. But then a nasty green imp shows up, determined to settle an ancient family feud. The imp is making Jim's life miserable, and Grandpop seems to be the only one who can help. Could Grandpop really be the reincarnation of an ancient Chinese warrior-- the world's only hope against one mean green imp?

IMPACT Mathematics, Course 1

by Mcgraw-Hill Staff

IMPACT Mathematicsis designed for grades 6-8 with the goal of completing Algebra 1 content by the end of the 8th grade covering Pre-Algebra and Algebra 1 over 3 years. This program has been extensively field tested and has proven to be highly successful in a large urban district with an increase in assessment scores for all students in all three grade levels. IMPACT Mathematicsmakes the big ideas of mathematics accessible to middle school students through an emphasis on investigation, problem solving, mathematical understanding, and algebra skills. This edition boasts an improved visual design, updated content, and additional NSF-funded performance assessments. The goal ofIMPACT Mathematicsremains to help students develop a deep understanding of mathematics with an emphasis on algebra.

IMPACT Mathematics, Course 2

by Mcgraw-Hill Staff

IMPACT Mathematicsis designed for grades 6-8 with the goal of completing Algebra 1 content by the end of the 8th grade covering Pre-Algebra and Algebra 1 over 3 years. This program has been extensively field tested and has proven to be highly successful in a large urban district with an increase in assessment scores for all students in all three grade levels. IMPACT Mathematicsmakes the big ideas of mathematics accessible to middle school students through an emphasis on investigation, problem solving, mathematical understanding, and algebra skills. This edition boasts an improved visual design, updated content, and additional NSF-funded performance assessments. The goal ofIMPACT Mathematicsremains to help students develop a deep understanding of mathematics with an emphasis on algebra.

IMPACT Mathematics, Course 3

by Mcgraw-Hill Staff

IMPACT Mathematicsis designed for grades 6-8 with the goal of completing Algebra 1 content by the end of the 8th grade covering Pre-Algebra and Algebra 1 over 3 years. This program has been extensively field tested and has proven to be highly successful in a large urban district with an increase in assessment scores for all students in all three grade levels. IMPACT Mathematicsmakes the big ideas of mathematics accessible to middle school students through an emphasis on investigation, problem solving, mathematical understanding, and algebra skills. This edition boasts an improved visual design, updated content, and additional NSF-funded performance assessments. The goal ofIMPACT Mathematicsremains to help students develop a deep understanding of mathematics with an emphasis on algebra.

The Impact Of Electricity

by Tanja Winther

How does everyday life change when electricity becomes available to a group of people for the first time? Why do some groups tend to embrace this icon of development while other groups actively fight against it? This book examines the effects of electricity's arrival in an African, rural community. Based on ethnographic fieldwork in Zanzibar at different points in time, the author provides a compelling account of the social implications in question. The rhythm of life changes and life is speeding up. Sexuality and marriage patterns are affected. And a range of social relations, e.g. between generations and genders, as well as relations between human beings and spirits, become modified. Despite men and women's general appreciation of the new services electricity provides, new dilemmas emerge. By using electricity as a guide through the social landscape, the particularities of social and cultural life in this region emerge. Simultaneously, the book invites readers to understand the ways that electricity affects and becomes implicated in our everyday life.

The Impact of Genetically Engineered Crops on Farm Sustainability in the United States

by National Research Council of the National Academies

Since genetically engineered (GE) crops were introduced in 1996, their use in the United States has grown rapidly, accounting for 80-90 percent of soybean, corn, and cotton acreage in 2009. To date, crops with traits that provide resistance to some herbicides and to specific insect pests have benefited adopting farmers by reducing crop losses to insect damage, by increasing flexibility in time management, and by facilitating the use of more environmentally friendly pesticides and tillage practices. However, excessive reliance on a single technology combined with a lack of diverse farming practices could undermine the economic and environmental gains from these GE crops. Other challenges could hinder the application of the technology to a broader spectrum of crops and uses. Several reports from the National Research Council have addressed the effects of GE crops on the environment and on human health. However, The Impact of Genetically Engineered Crops on Farm Sustainability in the United States is the first comprehensive assessment of the environmental, economic, and social impacts of the GE-crop revolution on U.S. farms. It addresses how GE crops have affected U.S. farmers, both adopters and nonadopters of the technology, their incomes, agronomic practices, production decisions, environmental resources, and personal well-being. The book offers several new findings and four recommendations that could be useful to farmers, industry, science organizations, policy makers, and others in government agencies.

Impact of Government Expenditure on Growth: The Case of Azerbaijan

by Junko Koeda Vitali Kramarenko

A report from the International Monetary Fund.

The Impact of MacroEconomic Policies on Poverty and Income Distribution

by François Bourguignon Maurizio Bussolo Luiz A. Pereira da Silva

A companion to the bestseller, The Impact of Economic Policies on Poverty and Income Distribution, this title deals with theoretical challenges and cutting-edge macro-micro linkage models. The authors compare the predictive and analytical power of various macro-micro linkage techniques using the traditional RHG approach as a benchmark to evaluate standard policies, such as a typical stabilization package and a typical structural reform policy.

Impact of Nonlinearities on Fiber Optic Communications

by Shiva Kumar

This book covers the recent progress in fiber-optic communication systems with a main focus on the impact of fiber nonlinearities on the system performance. Over the past few years, there has been significant progress in coherent communication systems mainly because of the advances in digital signal processing techniques. This has led to renewed interest in fiber linear and nonlinear impairments and techniques to mitigate them in electrical domain. In this book, the reader will find all the important topics of fiber optic communication systems in one place with in-depth coverage by the experts of each subtopics. Pioneers from each of the sub-topics have been invited to contribute. Each chapter will have a section on fundamentals, review of literature survey and the recent developments. The reader will benefit from this approach since many of the conference proceedings and journal articles mainly focus on the authors' research work without spending space on preliminaries.

Impact Player: Leaving a Lasting Legacy on and off the Field

by David Thomas Bobby Richardson Joe Girardi

Former Yankee Bobby Richardson played alongside Mickey Mantle, Roger Maris, Whitey Ford, Joe Pepitone, and Yogi Berra and he remains the only player from the "losing" team ever to be named World Series MVP. He shares his life story, including never-before-told tales from the clubhouse.

Impact (Wyman Ford #3)

by Douglas Preston

Wyman Ford is tapped for a secret expedition to Cambodia... to locate the source of strangely beautiful gemstones that do not appear to be of this world. A brilliant meteor lights up the Maine coast... and two young women borrow a boat and set out for a distant island to find the impact crater. A scientist at the National Propulsion Facility discovers an inexplicable source of gamma rays in the outer Solar System. He is found decapitated, the data missing. High resolution NASA images reveal an unnatural feature hidden in the depths of a crater on Mars... and it appears to have been activated. Sixty hours and counting.

Impaired Judgment

by David Compton

Book Description The new First Family plans to restore honor to the White House, and First Lady Paula Candler, to show she's just another working mom, decides to retain her position as a Virginia federal judge. The president, a devoted husband and father, supports his wife completely, and they share everything--at least until she is assigned to hear the case against reputed mobster Tony Remalli, who is accused of murdering another female judge. Representing Remalli is legendary Mob attorney Don Ross, whose law-skirting investigator hits pay dirt in his effort to dig up dirt on the supposedly pristine Paula Candler. When Ross uses the evidence to blackmail the judge, Candler is faced with the moral dilemma of letting bullies rule her courtroom or risking the safety of her family and the future of her husband's presidency. Compton fashions an exciting legal thriller that uses its high-concept premise to good advantage.

Impairing Education: Corporal Punishment of Students with Disabilities in US Public Schools

by Human Rights Watch

In this 70-page report, the ACLU and Human Rights Watch found that students with disabilities made up 18.8 percent of students who suffered corporal punishment at school during the 2006-2007 school year, although they constituted just 13.7 percent of the total nationwide student population. At least 41,972 students with disabilities were subjected to corporal punishment in US schools during that year. These numbers probably undercount the actual rate of physical discipline, since not all instances are reported or recorded.

An Impartial Witness

by Charles Todd

World War I nurse Bess Crawford, introduced in A Duty to the Dead, returns in an exciting new mystery in which a murder draws her inexorably into the sights of a cunning killer It is the early summer of 1917. Bess Crawford has returned to England from the trenches of France with a convoy of severely wounded men. One of her patients is a young pilot who has been burned beyond recognition, and who clings to life and the photo of his wife that is pinned to his tunic. While passing through a London train station, Bess notices a woman bidding an emotional farewell to an officer, her grief heart-wrenching. And then Bess realizes that she seems familiar. In fact, she's the woman in the pilot's photo, but the man she is seeing off is not her husband. Back on duty in France, Bess discovers a newspaper with a drawing of the woman's face on the front page. Accompanying the drawing is a plea from Scotland Yard seeking information from anyone who has seen her. For it appears that the woman was murdered on the very day Bess encountered her at the station. Granted leave to speak with Scotland Yard, Bess becomes entangled in the case. Though an arrest is made, she must delve into the depths of her very soul to decide if the police will hang an innocent man or a vicious killer. Exposing the truth is dangerous-and will put her own life on the line.

The Impatient Beader

by Margot Potter

Get your bead groove on withThe Impatient Beaderand you'll be a beading goddess in no time! Do you get antsy waiting for water to boil? Do you feel like it takes ages for fingernail polish to dry? If you're a creative individual who wants to make snazzy jewelry in less time than it takes to clean the kitchen and with the amount of focus required for a movie marathon, you have come to the right place. Greetings and welcome to the wonderful world of beading for the patience impaired. The Impatient Beadergives you over 40 projects plus variations that you can whip up to wear, gift or display in only an hour or two - how's that for almost instant gratification? Grab some beads, andThe Impatient Beaderwill supply the know-how you need to make saucy necklaces, bracelets and earrings that make you stand out in a crowd. Inside you'll find: An extensive step-by-step techniques guide that shows you everything you'll need to know to create all of the projects in the book A huge selection of gorgeous, one-of-a-kind jewelry pieces from sassy - like the Victorian Temptress Choker - to sweet - like the Sea Dreamer Wrap Necklace An easy-to-follow skill level guide that tells you whether a project calls for the skills of a "Beading Virgin," a "Beading Vixen," or a "Beading Goddess" Patience Booster tips and Designer Tips to help make your beading go smoothly and to encourage you to experiment with making your own designs The Impatient Beadergives you everything you need to start making stylish beaded jewelry pieces right now! What are you waiting for? Go, Bead Queen, go!

The Impatient Virgin

by Anne Weale

Her future husband?Anny was still a child when she met Giovanni-Van-Carlisle. He was nine years her senior, and Anny had soon developed a severe case of hero worship for Van. Over the years her youthful infatuation has blossomed into love.Anny dreams of becoming Van's wife, but how does he feel about her? He still treats her as if she's a little girl to be looked after-but Anny is determined to show him the woman she can be!About A MARRIAGE HAS BEEN ARRANGED:"Talented writer Anne Weale's...masterful character development and charming scenes create a rich reading experience."-Romantic Times

The Impatient Woman's Guide to Getting Pregnant

by Jean M. Twenge

Trying to get pregnant is enough to make any woman impatient. Maybe you've planned your career and are now ready to start a family with the same organized approach. Or you've been trying to get pregnant for a few months. Or perhaps you don't have time to be casual about your fertility. The Impatient Woman's Guide to Getting Pregnant is a complete guide to the medical, psychological, social, and sexual aspects of getting pregnant, told in a funny, compassionate way, like talking to a good friend who's been through it all. And in fact, Dr. Jean Twenge has been through it all--the mother of three young children, she started researching fertility when trying to conceive for the first time. A renowned sociologist and professor at San Diego State University, Dr. Twenge brought her research background to the huge amount of information--sometimes contradictory, frequently alarmist, and often discouraging--that she encountered online, from family and friends, and in books, and decided to go into the latest studies to find out the real story. The good news is: There is a lot less to worry about than you've been led to believe. Dr. Twenge gets to the heart of the emotional issues around getting pregnant, including how to prepare mentally and physically when thinking about conceiving, how to talk about it with family, friends, and your partner, and how to handle the great sadness of a miscarriage; as well as how to know when you're ovulating, when to have sex, timing your pregnancy, maximizing your chances of getting pregnant, how to tilt the odds toward having a boy or a girl, and the best prenatal diet. Trying to conceive often involves an enormous amount of emotion, from anxiety and disappointment to hope and joy. With comfort, humor, and straightforward advice, The Impatient Woman's Guide to Getting Pregnant is the bedside companion to help you through it.

Showing 88,301 through 88,325 of 146,232 results

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