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Acquired Mitochondropathy – A New Paradigm in Western Medicine explaining Chronic Diseases
by Enno FreyeThe book on Acquired Mitochondropathy offers a new perspective on the understanding and the treatment of chronic ailments. Addressing a new paradigm deemed necessary, since in one of every four adults in the western world chronic ailments are on the rise. Resulting from energy dysfunction of cellular organelles, the mitochondria, the most of the common symptoms the physician faces during medical consultation are presented. An increasing focus on chronic disabilities presents difficulties for the busy practitioner, since patients typically describe a complex pattern of discomfort, disability, and distress, with pain affecting physical, social, and psychological functioning, which have to be put in the proper perspective. Since clinicians must efficiently condense widely varied symptomatic descriptions into characteristic patterns to permit accurate diagnosis and implement effective treatment, this book serves as a useful educational resource for the healthcare provider.
Neuroscience, Consciousness and Spirituality
by Wayne B. Jonas Harald Walach Stefan SchmidtNeuroscience, Consciousness and Spirituality presents a variety of perspectives by leading thinkers on contemporary research into the brain, the mind and the spirit. This volumes aims at combining knowledge from neuroscience with approaches from the experiential perspective of the first person singular in order to arrive at an integrated understanding of consciousness. Individual chapters discuss new areas of research, such as near death studies and neuroscience research into spiritual experiences, and report on significant new theoretical advances. From Harald Walach's introductory essay, "Neuroscience, Consciousness, Spirituality - Questions, Problems and Potential Solutions," to the concluding chapter by Robert K. C. Foreman entitled "An Emerging New Model for Consciousness: The Consciousness Field Model," this book represents a milestone in the progress towards an integrated understanding of spirituality, neuroscience and consciousness. It is the first in a series of books that are dedicated to this topic.
Honeybee Neurobiology and Behavior
by Dorothea Eisenhardt Martin Giurfa C. Giovanni GaliziaThe book is a sequel of a similar book, edited by Randolf Menzel and Alison Mercer, "Neurobiology and Behavior of Honeybees", published in 1987. It is a "Festschrift" for the 70th birthday of Randolf Menzel, who devoted his life to the topic of the book. The book will include an open commentary for each section written by Randolf Menzel, and discussed with the authors. The written contributions take their inspiration from a symposium on the topic, with all the authors, that was held in Berlin in summer 2010
Regulation of Agricultural Biotechnology: The United States and Canada
by Chris A. Wozniak Alan MchughenAgricultural biotechnology takes many forms and applications, with the number and diversity of products ever increasing. With this rapid development, regulatory authorities have sought to keep pace through regulatory adjustments and advances to ensure the safe and beneficial use of this critical technology. The regulatory systems for the U.S. and Canada are not static and must evolve in order to maintain relevance, efficiency and applicability to the challenges encountered. The diverse authors, drawn from the biotechnology industry, academia, government research and regulatory agencies, offer their perspectives of the historical and current system and suggest where it can be improved in the future. Based upon vast experience interacting with the regulatory system, the editors and authors offer demystifying views of the US and Canadian regulatory structures and how they came to be. We know of no other effort to present the biotechnology regulatory systems of the US and Canada in an open forum which will benefit those in the regulated community as well as those charged with oversight of the products of biotechnology, and ultimately the consumer!
The Acheulian Site of Gesher Benot Ya‘aqov Volume III
by Lutz Kindler Naama Goren-Inbar Rivka Rabinovich Sabine Gaudzinski-WindheuserMultidisciplinary research on the Early-Middle Pleistocene site of Gesher Benot Ya'aqov has yielded abundant climatic, environmental, ecological and behavioral records. The 15 archaeological horizons form a sequence of Acheulian occupational episodes on the shore of the paleo-Lake Hula. These enable us to reconstruct numerous aspects of the survival and adaptation of ancient hominins, leading to a better understanding of their evolution and behavior. This book presents the faunal analyses of medium-sized and large mammals, providing taxonomic, taphonomic and actualistic data for the largest faunal assemblages. The study of modes of animal exploitation reveals valuable information on hominin behavior.
A Master of Science History: Essays in Honor of Charles Coulston Gillispie (Archimedes #30)
by Jed Z. BuchwaldNew essays in science history ranging across the entire field and related in most instance to the works of Charles Gillispie, one of the field's founders.
The Biotechnology Debate
by Bernice BovenkerkThis book grounds deliberative democratic theory in a more refined understanding of deliberative practice, in particular when dealing with intractable moral disagreement regarding novel technologies. While there is an ongoing, vibrant debate about the theoretical merits of deliberative democracy on the one hand, and more recently, empirical studies of specific deliberative exercises have been carried out, these two discussions fail to speak to one another. Debates about animal and plant biotechnology are examined as a paradigmatic case for intractable disagreement in today's pluralistic societies. This examination reveals that the disagreements in this debate are multi-faceted and multi-dimensional and can often be traced to fundamental disagreements about values or worldviews. "One of the acute insights to emerge from this examination is that deliberation can serve different purposes vis-à-vis different types of problem. In the case of deeply unstructured problems, like the modern biotechnology debate, the aim of inclusion is more appropriate than the aim of consensus. This book highlights the importance of political culture and broader institutional settings in shaping the capacity and propensity of citizens to engage in deliberation and the degree to which governments are prepared to relinquish authority to deliberative mini-publics." Robyn Eckersley, University of Melbourne, Australia
Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases
by Gal Bitan Farid RahimiAmyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to mediate various pathogenic mechanisms that lead to cellular dysfunction, cytotoxicity, and cell loss, eventuating in disease-specific degeneration and systemic morbidity. The particular pathologies thus are determined by the afflicted cell types, organs, systems, and the proteins involved. Evidence suggests that the oligomeric species may share structural features and possibly common mechanisms of action. In many cases, the structure-function interrelationships amongst the various protein assemblies described in vitro are still elusive. Deciphering these intricate structure-function correlations will help understanding a complex array of pathogenic mechanisms, some of which may be common across different diseases albeit affecting different cell types and systems.
Stem Cells and Human Diseases
by Rakesh K. Srivastava Sharmila ShankarThe main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.
The Biology of Subcellular Nitric Oxide
by Tamás RőszerThis book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.
Insect Conservation: Past, Present and Prospects
by Tim R. NewThe history of interest and practice in insect conservation is summarised and traced through contributions from many of the leaders in the discipline, to provide the first broad global account of how insects have become incorporated into considerations of conservation. The essays collectively cover the genesis and development of insect conservation, emphasising its strong foundation within the northern temperate regions and the contrasts with much of the rest of the world. Major present-day scenarios are discussed, together with possible developments and priorities in insect conservation for the future.
Evolutionary Psychology and the Propositional-attitudes
by Alex WalterThe two essays provide a critical examination of theory and research in the field of evolutionary psychology. The view advanced here is that philosophical materialism and minimalist assumptions about adaptation serve Darwinian psychology better than the more popular alternative view that relies on cognitive dualism and propositional-attitude psychology to formulate evolutionary psychology theory. A commitment to cognitive dualism is destined to undermine the physical basis of behavior upon which evolutionary theory depends. Many evolutionary psychologists do not see this but are seduced by the easy way in which hypotheses can be formulated using the 'propositional-attitude' model. The challenge is to develop a materialistic and mechanistic approach to understanding human cognition and behavior, including linguistic and social behavior.
Evolutionary Psychology and the Propositional-attitudes: Two Mechanist Manifestos (SpringerBriefs in Philosophy)
by Alex WalterThe two essays provide a critical examination of theory and research in the field of evolutionary psychology. The view advanced here is that philosophical materialism and minimalist assumptions about adaptation serve Darwinian psychology better than the more popular alternative view that relies on cognitive dualism and propositional-attitude psychology to formulate evolutionary psychology theory. A commitment to cognitive dualism is destined to undermine the physical basis of behavior upon which evolutionary theory depends. Many evolutionary psychologists do not see this but are seduced by the easy way in which hypotheses can be formulated using the ‘propositional-attitude’ model. The challenge is to develop a materialistic and mechanistic approach to understanding human cognition and behavior, including linguistic and social behavior.
Ecology of Cyanobacteria II
by Brian A. WhittonCyanobacteria have existed for 3.5 billion years, yet they are still the most important photosynthetic organisms on the planet for cycling carbon and nitrogen. The ecosystems where they have key roles range from the warmer oceans to many Antarctic sites. They also include dense nuisance growths in nutrient-rich lakes and nitrogen-fixers which aid the fertility of rice-fields and many soils, especially the biological soil crusts of arid regions. Molecular biology has in recent years provided major advances in our understanding of cyanobacterial ecology. Perhaps for more than any other group of organisms, it is possible to see how the ecology, physiology, biochemistry, ultrastructure and molecular biology interact. This all helps to deal with practical problems such as the control of nuisance blooms and the use of cyanobacterial inocula to manage semi-desert soils. Large-scale culture of several organisms, especially "Spirulina" (Arthrospira), for health food and specialist products is increasingly being expanded for a much wider range of uses. In view of their probable contribution to past oil deposits, much attention is currently focused on their potential as a source of biofuel. Please visit http://extras.springer.com/ to view Extra Materials belonging to this volume. This book complements the highly successful Ecology of Cyanobacteria and integrates the discoveries of the past twelve years with the older literature.
Arthropod-Plant Interactions: Novel Insights and Approaches for IPM (Progress in Biological Control #14)
by Guy Smagghe Isabel DiazThe book consists of multiple chapters by leading experts on the different aspects in the unique relationship between arthropods and plants, the underlying mechanisms, realized successes and failures of interactions and application for IPM, and future lines of research and perspectives. Interesting is the availability of the current genomes of different insects, mites and nematodes and different important plants and agricultural crops to bring better insights in the cross talk mechanisms and interacting players. This book will be the first one that integrates all this fascinating and newest (from the last 5 years) information from different leading research laboratories in the world and with perspectives from academia, government and industry.
Arthropod Management in Vineyards: Pests, Approaches, and Future Directions
by Charles Vincent Rufus Isaacs Noubar J. BostanianProvides a state-of-the-science overview of arthropods affecting grape production around the world. Vineyard pest management is a dynamic and evolving field, and the contributed chapters provide insights into arthropods that limit this important crop and its products. Written by international experts from the major grape-growing regions, it provides a global overview of arthropods affecting vines and the novel strategies being used to prevent economic losses, including invasive pests affecting viticulture. The book contains reviews of the theoretical basis of integrated pest management, multiple chapters on biological control, current status of chemical control, as well as in-depth and well-illustrated reviews of the major arthropod pests affecting grape production and how they are being managed worldwide. This text will serve as a primary resource for applied entomologists, students, growers, and consultants with interests at the intersection of viticulture and applied entomology.
Morphology and Evolution of Turtles
by Donald B. Brinkman James D. Gardner Patricia A. HolroydThis volume celebrates the contributions of Dr. Eugene Gaffney to the study of turtles, through a diverse and complementary collection of papers that showcases the latest research on one of the most intriguing groups of reptiles. A mix of focused and review papers deals with numerous aspects of the evolutionary history of turtles, including embryonic development, origins, early diversification, phylogenetic relationships, and biogeography. Moreover it includes reports on important but poorly understood fossil turtle assemblages, provides historical perspectives on turtle research, and documents disease and variation in turtles. With its broad scope, which includes descriptions of material and new taxa from Australia, Asia, and Europe, as well as North and South America, this work will be an essential resource for anyone interested in the morphology and evolution of turtles. "This volume's breadth of time, geography, and taxonomic coverage makes it a major contribution to the field and a 'must have' for all vertebrate paleontologists.", James F. Parham, California State University, CA, USA "A comprehensive and sweeping overview of turtle evolution by the top experts in the field that will interest everyone curious about these unique reptiles." Jason S. Anderson, University of Calgary, Canada "An invaluable addition to the literature that covers the full spectrum of approaches toward understanding the evolution of these noble creatures." Ann C. Burke, Wesleyan University, CT , USA "A truly comprehensive volume that both the student of fossil turtles, as well as the general reader interested in these enigmatic creatures, will find fascinating." Tyler Lyson, Yale University, CT, USA
Advanced Technologies for Managing Insect Pests
by Isaac Ishaaya A. Rami Horowitz Subba Reddy PalliAmong the highlights of this book is the use of novel insecticides acting on a specific site in an insect group and are compatible with natural enemies and the environment. One of such approaches is based on disrupting the activity of biochemical sites acting on transcription factors such as the Helix-Loop-Helix (bHLH) family, anti juvenile hormone (AJH) agents that target JH biosynthetic enzymes, G-protein coupled receptors (GPCR) and bursicon as a target for insect control. Another one is the biotechnology or the genetic approach such as gene silencing (RNA interference) and Bt-crops. Other sections of the book are devoted to the plant's natural products, optical manipulation and the use of nanotechnology for improving insect control methods.
Bacterial Fish Pathogens: Disease of Farmed and Wild Fish (Springer Praxis Books / Aquaculture And Fisheries Ser.)
by Dawn A. Austin Brian AustinThis completely updated fifth edition of Bacterial Fish Pathogens is a comprehensive discussion of the biological aspects of the bacteria which cause disease in farmed and wild fish. Since the 4th edition was published in 2007, there has been an upturn in the application of molecular approaches to taxonomy, diagnosis and vaccine development. New pathogens, e.g. Aeromonas schubertii, have been described. Also, there has been the emergence of diseases caused by bacteria which have not been cultured, and which have been equated with new taxa, i.e. 'Candidatus'. Consideration is given to all the bacterial fish pathogens, including primary pathogens and opportunists.
Novel Apoptotic Regulators in Carcinogenesis
by Paul B.S. Lai George G. ChenOur recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.
Transhumanism and Society
by Stephen LilleyThis book provides an introductory overview to the social debate over enhancement technologies with an overview of the transhumanists' call to bypass human nature and conservationists' argument in defense of it. The author present this controversy as it unfolds in the contest between transhumanists proponents and conservationists, who push back with an argument to conserve human nature and to ban enhancement technologies. This book provides an overview of the key contested points and present the debate in an orderly, constructive fashion. Readers are informed about the discussion over humanism, the tension between science and religion, and the interpretation of socio-technological revolutions; and are invited to make up their own mind about one of the most challenging topics concerning the social and ethical implications of technological advancements.
Management Planning for Nature Conservation: A Theoretical Basis & Practical Guide
by Mike AlexanderThe first edition of Mike Alexander's Management Planning for Nature Conservation, brought a new dimension to the modern literature on conservation management. This second edition, a significant enhancement of the original, deals with the development both, conceptual and practical, of adaptive management planning for nature conservation. It is about preparing management plans, and guides the reader through the entire process. Case-studies, including a conservation and access plan, demonstrate the planning process in action. This approach to planning can be applied to any place which is managed entirely, or in part, for wildlife. It can be applied to the management of species or habitats in any circumstance, regardless of site designation. The process is fully compatible with the Convention on Biological Diversity's 'ecosystem approach' to conservation management. Mike Alexander has long been at the forefront of developing management planning for conservation, with experience ranging from Uganda to Estonia, and from Costa Rica to Wales. He is the General Secretary of the Conservation Management System Consortium, a group of organisations with a common aim of raising standards and developing best practice in conservation management and planning. In 2012 Mike Alexander was elected a Fellow of the Society of Biology in recognition of his contribution to nature conservation and in particular management planning. This book has drawn on the experiences and expertise of the CMS consortium and other leaders in both conservation research and wildlife management from around the world. It is essential reading for professional conservation managers and any student studying management planning for conservation within a range of degree and postgraduate courses.
MicroRNAs as Tools in Biopharmaceutical Production
by Niall BarronFocused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease (Subcellular Biochemistry #65)
by J. Robin HarrisThis volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer's disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer's disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.
Late Cretaceous/Paleogene West Antarctica Terrestrial Biota and its Intercontinental Affinities
by Marcelo Reguero Francisco Goin Tania Dutra Sergio Marenssi Carolina Acosta HospitalecheOne of the most intriguing paleobiogeographical phenomena involving the origins and gradual sundering of Gondwana concerns the close similarities and, in most cases, inferred sister-group relationships of a number of terrestrial and freshwater vertebrate taxa, e.g., dinosaurs, flying birds, mammals, etc., recovered from uppermost Cretaceous/ Paleogene deposits of West Antarctica, South America, and NewZealand/Australia. For some twenty five extensive and productive investigations in the field of vertebrate paleontology has been carried out in latest Cretaceous and Paleogene deposits in the James Ross Basin, northeast of the Antarctic Peninsula (AP), West Antarctica, on the exposed sequences on James Ross, Vega, Seymour (=Marambio) and Snow Hill islands respectively. The available geological, geophysical and marine faunistic evidence indicates that the peninsular (AP) part of West Antarctica and the western part of the tip of South America (Magallanic Region, southern Chile) were positioned very close in the latest Cretaceous and early Paleogene favoring the "Overlapping" model of South America-Antarctic Peninsula paleogeographic reconstruction. Late Cretaceous deposits from Vega, James Ross, Seymour and Snow Hill islands have produced a discrete number of dinosaur taxa and a number of advanced birds together with four mosasaur and three plesiosaur taxa, and a few shark and teleostean taxa.