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Innovative Pest Management Approaches for the 21st Century: Harnessing Automated Unmanned Technologies
by Akshay Kumar ChakravarthySeveral Integrated Pest Management (IPM) approaches are available for managing pests of varied kinds, including individual and integrated methods for pest suppression. Recently the focus has shifted to pest management tools that act on insect systems selectively, are compatible with the environment, and are not harmful for ecosystems. Other approaches target specific biochemical and physiological aspects of insect metabolism, and involve biotechnological and genetic manipulation. Still other approaches include the use of nanotechnology, endophytes, optical and sonic manipulation to detect and control pest insects. Unfortunately, conventional forms of pest management do not focus on technology transfer to the ground level workers and farmers. As a result, farmers are incurring huge losses of crops and revenues. This book highlights the importance of using communication tools in pest management and demonstrates some success stories of utilizing automated unmanned technologies in this context. The content is divided into three sections, the first of which, “Pest Population Monitoring: Modern Tools,” covers long and short-range pest population monitoring techniques and tools such as satellites, unmanned aerial vehicles/drones, remote sensing, digital tools like GIS, GPS for mapping, lidar, mobile apps, software systems, artificial diet designs and functional diversity of info-chemicals. The second section of the book is devoted to “Emerging Areas in Pest Management” and offers a glimpse of diversified tactics that have been developed to contain and suppress pest populations such as endophytes, insect vectors of phytoplasma, Hymenopterans parasitoids, mass production and utilization of NPV etc. In turn, the third section focuses on “Integrated Pest Management” and presents farming situations that illustrate how research in diversified aspects has helped to find solutions to specific pest problems, and how some new and evolving tactics can be practically implemented. Given its scope, the book offers a valuable asset for entomology and plant pathology researchers, students of zoology and plant protection, and readers whose work involves agriculture, horticulture, forestry and other ecosystems.
Polyembryonic Insects: An Extreme Clonal Reproductive Strategy (Entomology Monographs)
by Kikuo IwabuchiThis book provides an overview of our current understanding of polyembryony in insects. The study of polyembronic insects has advanced considerably over the last several decades.The book shows the exciting potential of polyembryonic insects and their impact on life sciences. It describes the mechanisms of polyembryogenesis; tissue-compatible invasion of the host, which is the first case of compatible cellular interaction between phylogenetically distant organisms without rejection; the sex differences in defense; and the environmental regulation of caste structure. The first book devoted to polyembryony in insects, it draws on the author’s research on polyembryonic wasps from 1990 to the present day, covering various topics such as polyembryogenesis in vitro, host-parasite interaction, sex differences in soldier function/humoral toxic factor, and the transcription analysis of polyembryogenesis.It is intended not only for researchers in the field of entomology, parasitology, ontogeny, reproductive biology, developmental biology, sociobiology, and evolutionary developmental biology (Evo-Devo), but also for postgraduate students in these fields.
Japanese Marine Life: A Practical Training Guide in Marine Biology
by Kazuo Inaba Jason M. Hall-SpencerThis book gives an overview of the diverse marine fauna and flora of Japan and includes practical guides for investigating the biology and ecology of marine organisms. Introducing marine training courses offered at a range of Japanese universities, this is the first English textbook intended for marine biology instructors and students in Japan. It provides essential information on experimental procedures for the major areas of marine biology, including cell and developmental biology, physiology, ecology and environmental sciences, and as such is a valuable resource for those in Asian countries that share a similar flora and fauna. It also appeals to visitors interested in attending Japanese marine courses from countries around the world.
Biology and Ecology of Venomous Marine Cnidarians
by Ramasamy SanthanamSeas and oceans cover 71 % of the earth’s surface and they are home to 80% of all life found on the planet . Among the different components of marine life, the phylum Cnidaria (formerly Coelenterata) has been reported to be responsible for more envenomations than any other marine phylum. It is believed that 2% of its known 11000 species are venomous to humans. Incidents caused by jellyfish are common all around the globe, with serious manifestations and occasional deaths reported in some countries. The Australian box jellyfish, Chironex fleckeri , has been reported to be very dangerous to humans, as contact with its tentacles can provoke immediate cardiovascular collapse and death within minutes. Though other volumes on venomous marine fauna are available, this is the first comprehensive book focusing on venomous marine cnidarians. It is a valuable text-cum-reference resource for researchers, teachers and students of various disciplines, including fisheries science, marine biotechnology and marine biology and for university and college libraries. It is also a useful guide for beachgoers, divers, physicians and environmentalists.
Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery
by Busi Siddhardha Madhu Dyavaiah Asad SyedThis book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Model Organisms to Study Biological Activities and Toxicity of Nanoparticles
by Busi Siddhardha Madhu Dyavaiah Kaviyarasu KasinathanThis book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
Machine Learning in Aquaculture: Hunger Classification of Lates calcarifer (SpringerBriefs in Applied Sciences and Technology)
by Zahari Taha Gian-Antonio Susto Yukinori Mukai Mohd Azraai Mohd Razman Anwar P. P. Abdul Majeed Rabiu Muazu MusaThis book highlights the fundamental association between aquaculture and engineering in classifying fish hunger behaviour by means of machine learning techniques. Understanding the underlying factors that affect fish growth is essential, since they have implications for higher productivity in fish farms. Computer vision and machine learning techniques make it possible to quantify the subjective perception of hunger behaviour and so allow food to be provided as necessary. The book analyses the conceptual framework of motion tracking, feeding schedule and prediction classifiers in order to classify the hunger state, and proposes a system comprising an automated feeder system, image-processing module, as well as machine learning classifiers. Furthermore, the system substitutes conventional, complex modelling techniques with a robust, artificial intelligence approach. The findings presented are of interest to researchers, fish farmers, and aquaculture technologist wanting to gain insights into the productivity of fish and fish behaviour.
Reproduction in Aquatic Animals: From Basic Biology to Aquaculture Technology
by Manabu Yoshida Juan F. AsturianoThis book provides an up-to-date overview of the various reproductive systems of a variety of aquatic animals, from invertebrates to fishes. While all terrestrial animals use internal fertilization, aquatic animals have diverse reproductive systems. Some are internal fertilizers with or without mating, but many perform external fertilization. Because of this diversity, the reproductive systems of aquatic animals represent excellent models for the study of adaptive evolution and the species specificity of fertilization. In addition, many aquatic animals, including fish, crustaceans, and mollusks, are important as fishery and aquaculture resources. In this book, up-and-coming researchers examine reproductive systems in representative aquatic animals, covering both the basic knowledge and late-breaking results. Reproduction in Aquatic Animals: From Basic Biology to Aquaculture Technology will be of interest to graduate and postgraduate students in biology and agricultural sciences, as well as to researchers and technicians in the fields of reproductive biology and fishery science and to non-academics.
Brain and Lung Crosstalk (Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks)
by Hemanshu Prabhakar Charu MahajanThe central nervous system, which includes the brain and spinal cord, has a high metabolic demand. The physiology of the brain is such that it is easily affected by alterations in other systems, which in turn can compromise cerebral blood flow and oxygenation. Together the brain and spinal cord control the automatic function of our body systems. While other systems of body controls individual functions, central nervous system at the same time does many different functions, especially, controlling the function of other systems. This interaction between the brain and other systems is important when it comes to understanding how injuries to the brain can, at times, produce complications in remote organs or systems of the body, such as the lungs. This book explains the lesser-known crosstalks between acutely or chronically affected brain and lung, describing the pathophysiology of the lung following brain injury and discussing in detail the conflicts between the brain and lungs in relation to the tidal volumes, positive end-expiratory pressures, arterial carbon dioxide and oxygen levels, recruitment maneuvers and positioning, as well as potential therapeutic targets.
Animal Models of Human Birth Defects (Advances in Experimental Medicine and Biology #1236)
by Aimin LiuThis book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects.
Brain and Heart Crosstalk (Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks)
by Hemanshu Prabhakar Indu KapoorThis book discusses the underlying mechanisms connecting the brain and heart. The physiology of the brain is such that it is easily affected by any altered physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together, the brain and heart control our body systems, allowing them to function automatically. This interaction between the brain and other systems makes it important for us to understand how any kind of injury to the brain can produce complications in remote organs or systems, such as the heart. The central nervous system is responsible for vegetative function and is central to homeostasis. Further, central nervous system responses are linked to the ongoing function of other organ systems e.g. feeding, thermoregulation, reproduction and muscle activity. It is therefore logical that neural control of the cardiovascular system must also interact with the neural control of other organ systems. This book explains in detail stressed cardiac conditions, discussing the pathophysiology and proposed treatment, and also describing lesser-known crosstalks between the acutely or chronically affected brain and heart.
Animal-Origin Viral Zoonoses (Livestock Diseases and Management)
by Yashpal Singh Malik Raj Kumar Singh Kuldeep DhamaThis book is the second volume in the series Livestock Diseases and Management, and reviews the importance and implications of animal origin viral zoonoses. It also highlights the specific etiology and epidemiology of these viral infections and discusses their various biological and mechanical transmission mechanisms. Further, the book reviews various measures for controlling viral zoonoses and examines novel therapeutic and prophylactic strategies.Discussing recent studies on the pathogenesis and host immune response to these infections, it underscores the importance of using vaccines against these viral diseases to reduce the risk of them being transmitted to humans.Lastly, it describes in detail the challenges posed by these viral infections and our readiness to face them.
Ketamine: From Abused Drug to Rapid-Acting Antidepressant
by Kenji Hashimoto Soichiro Ide Kazutaka IkedaThis book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants.
Insect Sex Pheromone Research and Beyond: From Molecules to Robots (Entomology Monographs)
by Yukio IshikawaThis book provides a complete overview of cutting-edge research on insect sex pheromones and pheromone communication systems. The coverage ranges from the chemistry, biosynthesis, and reception of sex pheromones to the control of odor-source searching behavior, and from molecules to the application of research findings to robotics. The book both summarizes the progress of studies conducted using Bombyx mori and several groups of moths and reviews sex pheromones of some non-lepidopteran insect groups of agricultural importance. Attention is drawn to recent findings on elaborate neural information processing in the brain in male moths and to the importance of olfactory receptors specifically tuned to sex pheromone molecules. Featuring contributions from leading experts on the topic, this book will be a unique and valuable resource for researchers and students in the fields of entomology, chemical ecology, insect physiology and biochemistry, evolution, biomimetics, and bioengineering. In addition to researchers, general insect lovers will find the book fascinating for its descriptions of the marvelous abilities of insects and the underlying mechanisms involved.
Brief Introduction to Fisheries
by Xinjun Chen Yingqi ZhouThis book offers an introduction to aquaculture sciences and fisheries, discussing the concepts and basic characteristics of fisheries, fishery resources and the related industries, as well as the status of fisheries in various countries around the globe. The book also examines aquaculture, aquatic product processing and utilization, fishery information technology, and fishery economics and management, in addition to hot topics such as blue growth in fisheries, carbon sink fisheries, and global environmental changes in the context of fisheries. Given its scope, it is a valuable resource for undergraduate students in the field as well professional requiring a basic understanding of fisheries.
The Handbook of Mummy Studies: New Frontiers in Scientific and Cultural Perspectives
by Dong Hoon Shin Raffaella BianucciOwing to their unique state of preservation, mummies provide us with significant historical and scientific knowledge of humankind’s past. This handbook, written by prominent international experts in mummy studies, offers readers a comprehensive guide to new understandings of the field’s most recent trends and developments. It provides invaluable information on the health states and pathologies of historic populations and civilizations, as well as their socio-cultural and religious characteristics. Addressing the developments in mummy studies that have taken place over the past two decades – which have been neglected for as long a time – the authors excavate the ground-breaking research that has transformed scientific and cultural knowledge of our ancient predecessors. The handbook investigates the many new biotechnological tools that are routinely applied in mummy studies, ranging from morphological inspection and endoscopy to minimally invasive radiological techniques that are used to assess states of preservation. It also looks at the paleoparasitological and pathological approaches that have been employed to reconstruct the lifestyles and pathologic conditions of ancient populations, and considers the techniques that have been applied to enhance biomedical knowledge, such as craniofacial reconstruction, chemical analysis, stable isotope analysis and ancient DNA analysis. This interdisciplinary handbook will appeal to academics in historical, anthropological, archaeological and biological sciences, and will serve as an indispensable companion to researchers and students interested in worldwide mummy studies.
Electrocardiography in Veterinary Medicine
by J.P. VarshneyThis book provides essential information on methodologies for recording electrocardiograms in various animal species, including dogs, cats, cattle, buffaloes, sheep, goats, mithun, chelonians, snakes, avians, equines, rabbits, and the Indian gray mongoose. It also reviews the electrocardiographic physiology, generation of electrocardiograms, and normal criteria for various animal species; electrocardiograms in health and disease; and the interpretation of abnormal electrocardiograms, cardiomyopathy and arrhythmias, with corresponding treatment protocols.Further, it presents several approaches to interpreting the electrocardiograms of dogs, cats, ruminants, tortoises, pigeons, and other animals, offering a valuable resource for all veterinary students, scientists, and physicians wanting to make greater use of this valuable non-invasive tool in the diagnosis of heart diseases and general health examinations.
Cryopreservation of Fish Gametes
by Judith Betsy Stephen KumarUnderstanding the reproductive physiology and endocrinology of fishes is essential for captive maturation and seed production in the field of aquaculture. Studying the spermatology of fishes is a comparatively new focus in aquaculture, which has emerged as an important area of fish research over the past two decades. In this regard, the cryopreservation of fish gametes is a crucial aspect. Moreover, energetics studies of gametes have become essential, considering the loss of vigour in the spermatozoa after cryopreservation.The latest development in this context is the cryopreservation of spermatogonial stem cell, which is also covered in the book, along with detailed information on embryo cryopreservation in fishes and crustaceans. The role of cryopreservation in conservation programmes is another important aspect, one that will especially interest biologists.This book addresses central issues in fish gamete cryopreservation and breeding, while also reviewing the history of cryopreservation. Its most unique feature is the breadth of its coverage, from basic information on reproduction in fishes, to such advanced topics as embryo cryopreservation. Chiefly intended as a handy troubleshooting guide, the book represents a valuable resource for research students in related fields.
The Origins of Language Revisited: Differentiation from Music and the Emergence of Neurodiversity and Autism
by Nobuo MasatakaThis book summarizes the latest research on the origins of language, with a focus on the process of evolution and differentiation of language. It provides an update on the earlier successful book, “The Origins of Language” edited by Nobuo Masataka and published in 2008, with new content on emerging topics.Drawing on the empirical evidence in each respective chapter, the editor presents a coherent account of how language evolved, how music differentiated from language, and how humans finally became neurodivergent as a species. Chapters on nonhuman primate communication reveal that the evolution of language required the neural rewiring of circuits that controlled vocalization. Language contributed not only to the differentiation of our conceptual ability but also to the differentiation of psychic functions of concepts, emotion, and behavior. It is noteworthy that a rudimentary form of syntax (regularity of call sequences) has emerged in nonhuman primates. The following chapters explain how music differentiated from language, whereas the pre-linguistic system, or the “prosodic protolanguage,” in nonhuman primates provided a precursor for both language and music. Readers will gain a new understanding of music as a rudimentary form of language that has been discarded in the course of evolution and its role in restoring the primordial synthesis in the human psyche. The discussion leads to an inspiring insight into autism and neurodiversity in humans. This thought-provoking and carefully presented book will appeal to a wide range of readers in linguistics, psychology, phonology, biology, anthropology and music.
Toxicology of Nanoparticles: Insights from Drosophila
by Namita Agrawal Prasanna ShahThis book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications.Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.
Mesenchymal Stem Cell in Veterinary Sciences
by Mudasir Bashir Gugjoo Amar PalThis book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.
Functional Brain Mapping: Methods and Aims (Brain Informatics and Health)
by Vassiliy Tsytsarev Vicky Yamamoto Ning ZhongThis book provides an essential overview of the broad range of functional brain imaging techniques, as well as neuroscientific methods suitable for various scientific tasks in fundamental and clinical neuroscience. It also shares information on novel methods in computational neuroscience, mathematical algorithms, image processing, and applications to neuroscience.The mammalian brain is a huge and complex network that consists of billions of neural and glial cells. Decoding how information is represented and processed by this neural network requires the ability to monitor the dynamics of large numbers of neurons at high temporal and spatial resolution over a large part of the brain. Functional brain optical imaging has seen more than thirty years of intensive development. Current light-using methods provide good sensitivity to functional changes through intrinsic contrast and are rapidly exploiting the growing availability of exogenous fluorescence probes. In addition, various types of functional brain optical imaging are now being used to reveal the brain’s microanatomy and physiology.
Sleep: Evolution and Functions
by Vibha M. Jha Sushil K. JhaThis book discusses the evolution of sleep and its possible function in the higher invertebrates and vertebrates, including humans. It describes the current concept of sleep and its functions, based on research on the mammalian system. To date, electrophysiological recordings of the brain waves, muscle activity, and eye movements are the only tools available for characterizing the sleep architecture in the majority of animals. In mammals and birds, only two distinct types of sleep are found – non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Since the discovery of REM sleep, studies have been performed to understand the purpose of the two distinct sleep states in higher vertebrates (birds and mammals), and how REM sleep was evolved. The book summarizes the role of both REM and NREM sleep in the proper functioning of the brain and body. It covers various aspects of the role of sleep in important physiological processes, including memory consolidation, induction of synaptic plasticity, energy restoration, enhancing immune response, and maturation of neuronal circuitries during early life. Lastly, the book reviews the effects of chronic/acute sleep deprivation on memory consolidation, obesity, and the immune system in animal models and humans.
Recent updates in molecular Endocrinology and Reproductive Physiology of Fish: An Imperative step in Aquaculture
by Jitendra Kumar Sundaray Mohd Ashraf Rather Sujit Kumar Deepak AgarwalThis book is dedicated to present different aspects of reproductive physiology and molecular endocrinology of commercially important as well as potential aquaculture fish species. The existing aquaculture generation is looking for species diversification for efficient utilization of available diverse water resources. The knowledge of reproductive physiology of fish will help in development of breeding strategy for use in commercial aquaculture. Reproductive system is highly coordinated and governed by means of complex network of nervous, endocrine system and environmental factor as well. This book emphasize on different key aspects of reproductive endocrine system such as basic gonadal biology in the events of climate vulnerability, sex determination, sex reversal, stimulatory hormones, inhibitory hormones and receptors, environmental and chemical factor guiding reproduction, puberty, neuroendocrine regulation of reproduction etc. This book further describes how reproduction is not just indispensable for the existence or survival of an individual, but it is important for the survival of species. Chapters also address the concerns of anthropogenic activities on fish and the aquatic environment lead main trouble on physiological and reproductive processes of aquatic animals.This book offers an attractive compilation of highly relevant aspects of current and future of aquaculture, especially in view of the growing awareness of aquaculture, to food scientists working on commercial fish, animal biologists, fish geneticists etc. This book is very timely, and relevant to the sustainable development goals. The contents would be relevant to policy makers, working towards blue revolution and blue economy.
Role of Signaling Pathways in Brain Tumorigenesis
by Mehdi Hayat ShahiThis book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.