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Genome Editing in Neurosciences
by Rudolf Jaenisch Feng Zhang Fred GageThis book is open access under a CC BY 4. 0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
The Genome Factor: What the Social Genomics Revolution Reveals about Ourselves, Our History, and the Future
by Jason Fletcher Dalton ConleyFor a century, social scientists have avoided genetics like the plague. But the nature-nurture wars are over. In the past decade, a small but intrepid group of economists, political scientists, and sociologists have harnessed the genomics revolution to paint a more complete picture of human social life than ever before. The Genome Factor describes the latest astonishing discoveries being made at the scientific frontier where genomics and the social sciences intersect.The Genome Factor reveals that there are real genetic differences by racial ancestry—but ones that don't conform to what we call black, white, or Latino. Genes explain a significant share of who gets ahead in society and who does not, but instead of giving rise to a genotocracy, genes often act as engines of mobility that counter social disadvantage. An increasing number of us are marrying partners with similar education levels as ourselves, but genetically speaking, humans are mixing it up more than ever before with respect to mating and reproduction. These are just a few of the many findings presented in this illuminating and entertaining book, which also tackles controversial topics such as genetically personalized education and the future of reproduction in a world where more and more of us are taking advantage of cheap genotyping services like 23andMe to find out what our genes may hold in store for ourselves and our children.The Genome Factor shows how genomics is transforming the social sciences—and how social scientists are integrating both nature and nurture into a unified, comprehensive understanding of human behavior at both the individual and society-wide levels.
Genomics in the Cloud: Using Docker, GATK, and WDL in Terra
by Brian O'Connor Geraldine A. Van der AuweraData in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytes—or over 50 million gigabytes—of genomic data, and they’re turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud?With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian O’Connor of the UC Santa Cruz Genomics Institute, guide you through the process. You’ll learn by working with real data and genomics algorithms from the field. <p><p>This book covers: <li>Essential genomics and computing technology background <li>Basic cloud computing operations <li>Getting started with GATK, plus three major GATK Best Practices pipelines <li>Automating analysis with scripted workflows using WDL and Cromwell <li>Scaling up workflow execution in the cloud, including parallelization and cost optimization <li>Interactive analysis in the cloud using Jupyter notebooks <li>Secure collaboration and computational reproducibility using Terra
Geopolitics in Health: Confronting Obesity, AIDS, and Tuberculosis in the Emerging BRICS Economies
by Eduardo J. GómezAn in-depth analysis of why leaders from the BRICS respond to public health emergencies the way they do.In recent years, political leaders in Brazil, Russia, India, China, and South Africa, collectively known as the BRICS, have worked to reformulate international discussions and policies on issues ranging from fair and free trade to human rights. When it comes to health epidemics, however, the BRICS have differed greatly in terms of how—and when—they respond, highlighting important differences in their political commitment to meeting healthcare needs.In Geopolitics in Health, Eduardo J. Gómez takes a critical look at how the emerging BRICS economies dealt with the obesity, AIDS, and tuberculosis epidemics. Despite the countries having similar international political and economic ambitions, Gómez finds that domestic policy responses were driven mainly by international, as opposed to domestic, pressures and interests. Using a theoretical framework called geopolitical positioning, Gómez explores how nations respond to international pressures and policy criticisms, as well as offers of financial and technical assistance; countries then utilize domestic policy innovations and ultimately engage in global health diplomacy in order to bolster their international reputation.Gómez draws on extensive data and case studies and argues that leaders aspiring to build their reputations among elite nations have a ready way to demonstrate their status through quick and effective public health responses; those who scorn the international community tend to react slowly and ineffectively to the same type of crises. The first book of its kind to conduct an in-depth comparative historical analysis of how the BRICS deal with public health threats, this pathbreaking text demonstrates the value of positive geopolitical positioning and strong partnerships with other governments, nongovernmental organizations, and social health movements.
Geriatric Emergency Medicine
by Christian Nickel Abdelouahab Bellou Simon ConroyThis book discusses all important aspects of emergency medicine in the elderly, identifying the particular care needs of this population, which all too often remain unmet. The up-to-date and in-depth coverage will assist emergency physicians in identifying patients at risk for adverse outcomes, in conducting appropriate assessment, and in providing timely and adequate care. Particular attention is paid to the common pitfalls in emergency management and means of avoiding them. Between 1980 and 2013, the number of elderly patients in emergency departments worldwide doubled. Compared with younger patients, the elderly suffer from more comorbidities and higher mortality, require more complex work-up and diagnostic testing, and tend to stay longer in the emergency department. This book, written by internationally recognized experts in emergency medicine and geriatrics, not only presents the state of the art in the care of this population but also underlines the increasing need for adequate training and development in the field.
Geriatric Rehabilitation: From Bedside to Curbside (Rehabilitation Science in Practice Series)
by K. Rao PoduriGeriatric Rehabilitation addresses the fact that this is an age in which individuals have increasing longevity, better health care, education and expectations of health care which present new, increasing and even radical challenges to health care providers. The care of our older patients in rehabilitation settings demands the broad understanding of the key differences in strategies to care for older adults. The combined skills embraced in rehabilitation and geriatrics are presenting unprecedented opportunities for both fields to make substantive and even ground-breaking improvements in the lives of millions of older adults who entrust their lives to us. Rarely in one’s medical career are such opportunities so evident and achievable. Geriatric Rehabilitation edited by Dr. K. Rao Poduri, MD. FAAPMR draws on a distinguished group of authors who are the front-line providers of care to the older adults. This book presents the full spectrum of the unique care needs of older patients who need the combined skills of physical medicine and geriatrics. It provides an easily accessible means of acquiring and improving these new skills for all those involved in geriatric care.
Geriatric Telepsychiatry
by James G. Bouknight Juliet Glover Shilpa SrinivasanThis book provides a basic introduction to geriatric telepsychiatry, including potential benefits and drawbacks of utilizing this treatment modality. The text discusses applications in academic, public, federal, and educational settings and suggests practical guidelines for implementing and maintaining a telepsychiatry program. As the elder population continues to grow over the next several decades, digital tools, including videoconferencing, will play a large role in meeting the needs of the elderly. Written by the leaders in geriatric telepsychiatry, this text is the first to focus on the psychiatric application of these digital tools, lay out the policies and guidelines for treating patients who can benefit from this service, and outline the most cutting-edge research on the topic. Geriatric Telepsychiatry is the ultimate guide for psychiatrists, geriatricians, social workers, geriatric nurses, students, long-term care facilitators, and all medical professionals who work with the elderly psychiatric patient.
Geriatric Trauma and Critical Care
by Jay A. Yelon Fred A. LuchetteWith the expertise of an author panel of leading clinicians in the field of surgery, trauma, critical care and geriatrics the new edition of this text addresses the explosion in knowledge on the impact aging has on injury, acute illness and critical care management. The text covers the physiologic changes associated with aging, as well as the clinical assessment, stratification, and management of acute illness and injury. Furthermore, the new edition discusses the full spectrum of critical care management of the elderly. Part I explores the impact of aging on health and the healthcare system. There will be detailed discussion on the physiologic effects of aging and the impact on clinical management. The management of common surgical emergencies in the elderly is addressed in Part II. Part III addresses the evaluation and management of trauma and injury. Finally, Part IV explores the specific challenges of critical care management, including end-of-life and ethics, in the geriatric population. Updated information, reflective of the expansive literature, is addressed in all sections. New to the second edition are chapters on prehospital care, burns, nursing concerns, and abdominal solid organ injury. Appropriate chapters will include case vignettes and clinical algorithms. All chapters include a bullet-point summary. Geriatric Trauma and Critical Care, 2nd Edition will be of great value to trauma surgeons, acute care surgeons, critical care specialists, emergency medicine physicians, geriatricians, general surgeons, and trainees in surgery, critical care, and emergency medicine. Advanced practice nurses, critical care nurses, and physician assistants will also find this a useful and practical resource.
Geriatrics for Specialists
by John R. Burton Andrew G. Lee Jane F. PotterThis book focuses on the circumstances that lead to the marked increasedvulnerability of seniors and are most challenging to clinicians including thepresence of multiple chronic medical conditions, variable losses ofphysiological function, and heterogeneity among individuals. Written bythe experts who lead the initiative to deliver high quality surgical andmedical care to the elderly, Geriatricsfor Specialists is the first book of its kind to provide the comprehensive knowledgespecialists and associated generalists need to deliver quality health care toseniors. With topics on important cross cutting issues like frailty,delirium and polypharmacy and specialty chapters on emergency medicine,anesthesia, many surgical and medical disciplines and rehabilitation, this book provides clinicians the knowledge and tools needed to evaluate,treat and manage the unique needs of seniors. Geriatrics for Specialists was created as a resource for specialist, generalists and allied healthprofessionals and their students and trainees who care for elderly patients.
Germline Stem Cells
by Michael BuszczakThis second edition provides updated and new chapters on selected genetic, molecular, biochemical, and cell biological techniques. Chapter's guide readers through methods and principles on primordial germ cells and germline stem cells, however many of these principles can be applied to different types of adult stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Germline Stem Cells: Second Edition aims to present the new findings and techniques that have developed since the first edition.
Gerontorheumatology
by Jozef RovenskýThis book covers all aspects of the specialized field of gerontorheumatology, providing a complete overview of rheumatic and musculoskeletal diseases and related conditions in the elderly. The emphasis is particularly on pathogenesis, diagnosis, prevention, and treatment, including the latest advances in biological and pharmacological therapy and potential treatment side effects. The book will provide the reader with a keen awareness of the characteristic features, distinctive etiologies, and different courses of the various disorders of the musculoskeletal system in the geriatric population. Diagnostic and treatment considerations of special relevance in daily practice are highlighted, and the importance of comorbidities and their rheumatic consequences is also emphasized. The book will be of value for gerontologists, rheumatologists, internists, and rehabilitation physicians and will offer excellent guidance for general practitioners, who are typically the first to deal with disorders of the musculoskeletal system in elderly patients.
Gesetzlich nicht normierte ärztliche Auskunfts- und Offenbarungspflichten
by Nikolaus Von BarDieses Buch zeigt auf, wann Ärzte entgegen ihrer Schweigepflicht zur Mitteilung von Patientengeheimnissen verpflichtet sind. Nach derzeit geltender Rechtslage dürfen Ärzte in Einzelfällen ihre Schweigepflicht zum Schutz eines höherwertigen Rechtsgutes brechen. Das zu schützende Rechtsgut muss in der konkreten Situation gegenüber dem allgemeinen Persönlichkeitsrecht des Patienten überwiegen und dem zu schützenden Rechtsgut muss eine Gefahr drohen. Es obliegt grundsätzlich dem einzelnen Arzt darüber zu entscheiden, ob er den drohenden Schaden für das höherwertige Rechtsgut abwendet. Nicht zuletzt nach dem Absturz der Germanwingsmaschine im März 2015 kam die Diskussion darüber auf, ob Ärzte nicht viel häufiger dazu verpflichtet sein sollten, ihre Schweigepflicht zu brechen, um Dritte vor Schäden zu schützen.Der Verfasser dieses Werkes legt verschiedene zivilrechtliche Grundsätze dar, aufgrund derer Ärzten nicht nur das Recht, sondern die Pflicht zukommt, Patientengeheimnisse zu offenbaren. Diese allgemeinen Grundsätze werden an verschiedenen Fallgruppen angewendet. Wann ist ein Arzt beispielsweise dazu verpflichtet, einem Dritten die AIDS-Erkrankung eines Patienten mitzuteilen? War der Arzt des Piloten der abgestürzten Germanwingsmaschine dazu verpflichtet, die Depressionserkrankung des Piloten Dritten mitzuteilen? Haben Eltern ein Recht darauf, von einem Arzt zu erfahren, ob ihre minderjährige Tochter schwanger ist? Können Ärzte dazu verpflichtet sein, Prädispositionen für letale Erbkrankheiten an ihre Patienten zu offenbaren und haben diese ein Recht darauf, einer solchen Mitteilung aus dem Weg zu gehen? Und in welchen Fällen müssen Ärzte Kindern anonymer Samenspender die Identität ihrer biologischen Väter mitteilen? Diese Fragen werden in dem vorliegenden Buch – auch für Mediziner verständlich - beantwortet.
Get Ahead! Basic Sciences: 100 EMQs (Get ahead!)
by Anna Kowalewski Priya JeevananthanIdeal for medical students studying basic sciences, Get ahead! Basic Sciences: 100 EMQs covers anatomy, physiology, pharmacology and biochemistry, including clinical-based themes. Questions are accompanied by explanations to guide further review, making this, along with the companion SBA volume, an essential resource for your basic sciences exams.
Get Ahead! Basic Sciences: 500 SBAs (Get ahead!)
by Priya Jeevananthan Anna KowalewskiIdeal for medical students studying basic sciences, Get ahead! Basic Sciences: 500 SBAs covers anatomy, physiology, pharmacology and biochemistry, including clinical-based themes. Questions are accompanied by explanations to guide further review, making this, along with the companion EMQ volume, an essential resource for your basic sciences exams.
Get Through Final FRCR 2A: SBAs (Get Through)
by Teck Yew Chin Akash Ganguly Chinedum AnosikeThis is the first revision guide to map directly to the new structure of the FRCR Final Part A examination (CR2A). Spanning a broad range of topics, the book follows the core clinical radiology curriculum, covering all modalities. It is divided into 7 test papers, consisting of 120 mixed SBA-type questions with detailed answers in sequential order. Every answer is followed by a short explanation and relevant discussion around the topic with appropriate references. Each paper should take three hours to complete. Delivering over 20 hours of focused exam practice, this guide is a sound investment for trainee radiologists preparing for their Final Part A exam.
Get Through MRCPsych CASC: Mock Examination Papers (Get Through)
by Melvyn W. Zhang Cyrus S. Ho Roger C. Ho Basant K. PuriThis book is intended for psychiatric trainees sitting the CASC component of the MRCPsych exam. Written by authors with recent exam experience and long-term expertise in the field, the text provides 175 stations closely matched to the subjects that appear in the actual exam, along with concise synopses and guidelines for how to target your revision to enable recall of the most relevant information.
Get Your Life Back: The Most Effective Therapies For A Better You
by Dr. Fiona Kennedy David PearsonHIGHLY COMMENDED for the British Medical Awards book prize for Popular MedicineMost of us have some behaviours which are not fully under our control but when those start interfering with our lives and with who we want to be, we need this book. When we turn away from opportunity and excitement in case it makes us anxious, we lose the joy in our lives and can experience misery and depression as well as, oddly, even more anxiety. Get Your Life Back helps you to identify what is really important to you and to notice the ways in which you behave which interfere with reaching your goals and following valued directions. It shows how to understand your own behaviour with compassion, without judgement, and how to both accept and change unhelpful or damaging ways of acting. You will learn new skills to manage emotion and endure discomfort as you journey towards mindful self-control.Uniquely, this book presents a blend of evidence-based treatments (CBT, ACT, DBT, compassion and mindfulness) giving you the best and most effective therapies for a better you.
Getting Ahead of ADHD: What Next-Generation Science Says about Treatments That Work—and How You Can Make Them Work for Your Child
by Joel T. NiggDoes toxic pollution cause attention-deficit/hyperactivity disorder (ADHD)? What about screen use? Are alternative treatments worth exploring? Can dietary changes help? From leading ADHD researcher Joel T. Nigg, this book presents exciting treatment advances grounded in the new science of epigenetics--how genes and the environment interact. Distinguishing unsupported, even dangerous, approaches from bona fide breakthroughs, Dr. Nigg describes specific lifestyle changes that have been proven to support the developing brain. Vivid stories illustrate ways to maximize the positive effects of healthy nutrition, exercise, and sleep, and minimize the damage from stress and other known risk factors. The book helps you figure out which options hold the most promise for improving your child's symptoms and overall well-being--and gives you step-by-step suggestions for integrating them into daily life.
Getting Risk Right: Understanding the Science of Elusive Health Risks
by Geoffrey C KabatDo cell phones cause brain cancer? Does BPA threaten our health? How safe are certain dietary supplements, especially those containing exotic herbs or small amounts of toxic substances? What role does HPV play in the development of cervical cancer, and is the HPV vaccine safe? In four detailed case studies, Geoffrey C. Kabat shows how science works or sometimes doesn't and what distinguishes these two very different outcomes. We depend on science and medicine like never before, yet there is widespread misinformation and confusion, amplified by the media, regarding what influences our health.Getting Risk Right helps general readers distinguish between claims that are supported by solid science and those that are the result of poorly designed or misinterpreted studies. In doing so, he shows us why certain risks are worth worrying about while others are not. Attempts to explain antiscience attitudes often focus on irrational fears and beliefs and the powerful role of business interests. These factors matter, but Kabat also emphasizes the variable quality of research in contested areas of health risks and the professional, political, and methodological factors that can distort the research process. Drawing on recent work in the "meta-analysis" of biomedical research and on insights from leading thinkers, including John Ioannides, Daniel Kahneman, and Cass Sunstein, this groundbreaking book examines factors both internal and external to the science that influence what results get attention and how questionable results can be used to support a particular narrative concerning an alleged public health threat. Kabat, a leading public health thinker, provides a much-needed antidote to what has been called "an epidemic of false claims."
Getting Risk Right: Understanding the Science of Elusive Health Risks
by Geoffrey KabatDo cell phones cause brain cancer? Does BPA threaten our health? How safe are certain dietary supplements, especially those containing exotic herbs or small amounts of toxic substances? Is the HPV vaccine safe? We depend on science and medicine as never before, yet there is widespread misinformation and confusion, amplified by the media, regarding what influences our health. In Getting Risk Right, Geoffrey C. Kabat shows how science works—and sometimes doesn't—and what separates these two very different outcomes.Kabat seeks to help us distinguish between claims that are supported by solid science and those that are the result of poorly designed or misinterpreted studies. By exploring different examples, he explains why certain risks are worth worrying about, while others are not. He emphasizes the variable quality of research in contested areas of health risks, as well as the professional, political, and methodological factors that can distort the research process. Drawing on recent systematic critiques of biomedical research and on insights from behavioral psychology, Getting Risk Right examines factors both internal and external to the science that can influence what results get attention and how questionable results can be used to support a particular narrative concerning an alleged public health threat. In this book, Kabat provides a much-needed antidote to what has been called "an epidemic of false claims."
GI Surgery Annual
by Peush Sahni Sujoy PalThe twenty-second volume of GI Surgery Annual covers a gamut of topics from oesophageal adenocarcinoma, to motility disorders of the colon and rectum, mesenteric tumours as well as the contemporary technique of ALPPS, acute portal vein thrombosis and small for size syndrome in live donor liver transplant. The chapter on advances in gastrointestinal surgery as every year reviews the important new information in the field in an easy to understand manner.
GI Surgery Annual
by Peush Sahni Sujoy PalThe 23rd volume of this highly successful series includes new contemporary topics such as PET in HPB diseases, short gut syndrome, current status of extended lymphadenectomy in esophageal cancer, splenectomy for haematological disorders, postoperative liver failure, HIPEC, and current issues in surgery of pancreatic cancer. Finally, the chapter on advances in GI surgery, like in each volume in the past, reviews the important new developments in the field. The GI Surgery Annual 23rd Volume provides an overall round up of selected topics that are considered relevant and contemporary by the editors of the series.
GI Surgery Annual: Volume 23 (GI Surgery Annual #23)
by Sujoy Pal Peush SahniThe 24th volume of this highly successful series includes new contemporary topics such as corrosive injuries of the oesophagus, post-gastrectomy complications, advances in imaging of inflammatory bowel disease, unusual presentations of gallstones, gall bladder cancer with jaundice, minimally invasive pancreatic surgery, and enhanced recovery after surgery. Finally, the chapter on advances in GI surgery, like in each past volume, reviews important new developments in the field. The GI Surgery Annual 24th Volume provides an overall roundup of selected topics that were deemed particularly relevant and topical by the series editors.
Giant Intracranial Aneurysms
by Naci KocerThis atlas focuses on the imaging and treatment options available for giant intracranial aneurysms since 1990s in the beginning of the so-called modern endovascular era. During this period, there were significant advances made in the therapy of small intracranial aneurysms though the treatment of giant aneurysms continued to pose an insurmountable challenge. At the turn of this century, this grim scenario gradually improved with better understanding of the pathophysiology of giant intracranial aneurysms. This changed scenario in giant intracranial aneurysm therapy has been illustrated with the aid of informative clinical case studies. The clinical presentation of giant aneurysms in adults and children is described as are the merits of different imaging modalities explained and illustrated. Extensive consideration has been given to modern fusion imaging that has improved our insight into the nature of the disease. Endovascular treatment approaches (including illustrative open surgical approaches) and reconstructive and deconstructive strategies are fully documented, with careful attention given to factors that influence management strategies, treatment choice and complications. The atlas will be a valuable reference and practical aid for neuroradiologists, neurosurgeons, neurologists, fellowship trainees, postgraduate & graduate students.
Global Health: An Introduction to Current and Future Trends
by David R. Phillips Kevin MccrackenGlobal Health continues to provide readers with a comprehensive, up-to-date and thought-provoking outline and understanding of the constantly evolving global health landscape. In this new edition the authors have maintained the successful structure and organisation of the previous edition to examine and explain recent health changes and consider likely future patterns. New or expanded topics covered include: emerging and re-emerging infectious disease threats increasing awareness of, and interest in, antimicrobial resistance and superbugs terrorism, global conflict and health the new UN 2030 Agenda for Sustainable Development the drive for Universal Health Coverage (UHC) the use of information technology in global health substance abuse palliative and end-of-life-care ethical issues in global health. Using clear and original explanations of complex issues, this text makes extensive use of boxed case studies and international examples, with discussion questions posed for readers at the end of each chapter. Readers will also be able to take advantage of the new website that was designed to complement this book. Global Health is essential reading for students and researchers of global health, public health and development studies.