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Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine
by Mudasir Bashir GugjooThis book reviews the potential therapeutic and reproductive applications of mesenchymal stem cells in veterinary regenerative and reproductive medicine. The systemic approach focuses on musculoskeletal structures like cartilage, bone, muscle, tendon, ligaments and nervous tissues. It also focuses on other body systems like gastrointestinal, cardiovascular, urogenital, respiratory and integumentary system. Besides, the special glands or organs like endocrine glands and eye and its adnexa are also focused. The book chapters discusses the problems and the need for regenerative medicine employing MSCs. It provides an ex vivo basis of MSCs therapeutics and reproductive potential followed by their in vivo applications. The book further provides an understanding on the behavior and mechanisms of action of mesenchymal stem cells. The book also abridges challenges and provides future prospects of mesenchymal stem cells in clinical and reproductive applications. As such, the book offers a valuable resource for students, veterinarians, and scientists working in the regenerative and reproductive sciences in human and veterinary medicine.
Textbook of Microbiology and Immunology
by Subhash Chandra ParijaThe fourth edition of “Textbook of Microbiology and Immunology” is an extensively revised edition , a healthy mixture of the old and the new contents. Many of the old traditional chapters have been retained with addition of new information along with the inclusion of new chapters more in line with the on-going changes in the syllabus and concepts in Medical Microbiology .While doing so, this book has blended the traditional organism-based learning and a syndrome based approach to infectious disease, together with the introduction of new and modified chapters incorporating the latest information in this field.The book provides an extensive coverage of fundamental topics in general and medical microbiology. The book also lays due emphasis on clinical microbiology with special focus on syndrome based approach to infectious diseases. It includes the basic concepts of microbiology as well as the recent updates and developments in the field of medical microbiology. All the topics have been incorporated in seven major sections: General microbiology, Immunology, Bacteriology, Virology, Mycology, and Applied and Clinical Microbiology.The dynamic nature of medical sciences with new guidelines and new diagnostic methods coming into the arena necessitates the incorporation of new information in each new edition of a book. This facet has been addressed with the inclusion of recent information on the various aspects of microbiology, infectious diseases and immunology, in the fourth edition of the Textbook of Microbiology and Immunology ,which makes it one of the most authoritative and informative textbooks in medical microbiology.The book is an effort to inform and engage a wide spectrum of readers including medical students , both undergraduates and postgraduates, and residents, and faculty. It aims to be a must-have companion book for graduate and advanced undergraduate as well as postgraduate students of medical microbiology, general and allied microbiology, and of immunology.
Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer: Examining the Macroscopic Images of Small and Large Intestine
by Toshiyuki Matsui Akinori Iwashita Takayuki Matsumoto Takashi Hisabe Kitaro Futami Hiroshi TanabeThis book is structured in three major parts and the first part is a comprehensive overview of IBD-related intestinal cancer. The second and third parts provide rare and important cases on ulcerative colitis (UD) and Crohn’s disease (CD) presenting the macroscopic image of the resected specimen and analyzing the endoscopic and the pathological image to explain how to find the IBD cancer. It also delivers a detailed analysis of the histological structure of cancers. This book tries to clarify the critical but yet to be answered questions such as “Why is it so difficult to find out?”, “Why so flat?” and “How to name superficial lesion with invisible margin?” and so on.Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer is designed to serve all endoscopists and gastroenterologists managing IBD patients. It also is valuable reading for pathologists who are diagnosing gastrointestinal lesions. This book is designed to assist these medical professionals to find cancers in the early stage and stay up-to-date on image-enhanced endoscopy techniques. This book is a translation of an original Japanese edition. This has been facilitated using machine translation (by the service DeepL.com) followed by editors and authors revising, editing and verifying the translated manuscript.
Towards Newborn Survival: Challenges and Priorities
by Sandhya R. MahapatroThis book offers a comprehensive study of the complexities of newborn survival in resource-poor regions, using the state of Bihar (India) as a case study. It provides important lessons for other low-performing countries, in similar socioeconomic contexts, where newborn survival is a major challenge.The volume opens with a brief account of the trends and regional variations in neonatal mortality. The empirical verification of socio-cultural, economic and health system barriers and the state interventions that affect newborn survival are subsequently explored. Innovative strategies are then proposed to scale up maternal newborn and child health (MNCH) services and improve neonatal health outcomes. Addressing this issue through appropriate policy action is essential to achieving Sustainable Development Goal-3, "Good Health and Well-being". This book will therefore appeal to public health scholars, professionals and policymakers interested in improving outcomes in low-income regions.
Maternal Mortality - Lessons Learnt from Autopsy
by Kusum D. JashnaniThe book discusses about 45 cases of maternal autopsies. These maternal mortalities are related to pregnancy-related diseases, pre-existing diseases that worsen or manifest during pregnancy and diseases for which pregnant patient has increased risk. As the study of maternal mortality is a healthcare quality indicator and plays an important role in the improvement of obstetric care, the book aims at discussing autopsy findings, which is the gold standard for establishing not only the causes of death, but also to uncover the various pathological lesions produced by the physiologic phenomenon of pregnancy. This helps in identifying the direct and indirect causes, which can be reviewed at multidisciplinary review meetings.The chapters are arranged according to direct and indirect causes of maternal death, involving varied target organ systems i.e. central nervous system, cardiovascular system, respiratory system, gastro-intestinal tract, hepato-biliary system and pancreas, urinary system, female genital tract and others. However, it does not include diseases coincidental in pregnancy.Each case begins with the complete case history (age, duration of pregnancy, clinical presentation, investigations, clinical diagnosis, therapy, and course during ward stay, if any), autopsy findings, followed by a clinico-pathological discussion and includes appropriate gross organ and microscopic images. The book caters to the specialists in pathology, obstetrics, general medicine, critical care, surgery, pulmonologists, cardiology and all those involved in the care of pregnant women.
Wilms’ Tumor
by Yogesh Kumar SarinThis book covers all aspects of Wilms’ tumor, the second most typical solid tumor in children. Its potential for complete cure underscores correct management of this tumor. To achieve this goal, the book aims to provide all necessary details for practicing Pediatric surgeons, Oncologists, Pediatricians, Urologists, and Medical students. Topics ranging from epidemiology, etiology, pathology, clinical features, diagnostic methods, surgery, chemotherapy, radiotherapy to cutting-edge inventions are described in great detail.Detailed descriptions of surgical techniques and their nuances will greatly benefit surgeons and surgical residents. Importantly, all the chapters are written by authors who have first-hand experience with clinical management. Thus the text ensures the practical application of theoretical details.
Innovation in Medicine and Healthcare: Proceedings of 10th KES-InMed 2022 (Smart Innovation, Systems and Technologies #308)
by Yen-Wei Chen Satoshi Tanaka Robert J. Howlett Lakhmi C. JainThis book presents the proceedings of the KES International Conferences on Innovation in Medicine and Healthcare (KES-InMed-22), held in Rhodes, Greece, on June 20–22, 2022. Covering a number of key areas, including digital IT architecture in health care; advanced ICT for medicine and health care; biomedical engineering, trends, research, and technologies; and healthcare support systems, this book is a valuable resource for researchers, managers, industrialists, and anyone wishing to gain an overview of the latest research in these fields.
Biophotonics: Concepts to Applications (Graduate Texts in Physics)
by Gerd KeiserThis book introduces senior-level and postgraduate students to the principles and applications of biophotonics. It also serves as a valuable reference resource or as a short-course textbook for practicing physicians, clinicians, biomedical researchers, healthcare professionals, and biomedical engineers and technicians dealing with the design, development, and application of photonics components and instrumentation to biophotonics issues. The topics include the fundamentals of optics and photonics, the optical properties of biological tissues, light-tissue interactions, microscopy for visualizing tissue components, spectroscopy for optically analyzing the properties of tissue, and optical biomedical imaging. It also describes tools and techniques such as laser and LED optical sources, photodetectors, optical fibers, bioluminescent probes for labeling cells, optical-based biosensors, surface plasmon resonance, and lab-on-a-chip technologies. Among the applications are optical coherence tomography (OCT), optical imaging modalities, photodynamic therapy (PDT), photobiostimulation or low-level light therapy (LLLT), diverse microscopic and spectroscopic techniques, tissue characterization, laser tissue ablation, optical trapping, and optogenetics. Worked examples further explain the material and how it can be applied to practical designs, and the homework problems help test readers’ understanding of the text.This second edition provides updates as follows:1) Updated references in each chapter with recent review papers, tutorials, and generic research results.2) New sections in Chap. 3 addressing tapered fibers for sensors, biocompatibility issues of optical fibers, and concepts of implantable fibers.3) Updates in Chaps. 4 and 5 on optical sources and photodetectors discussing fiber-based sources, silicon photomultipliers, and high-speed cameras for biosensing.4): Sections on improvements in microscopy, imaging, spectroscopy, and sensing in Chapters 7–10. 5) New biophotonic application techniques in Chap. 11 will include optogenetic advances, smart phones for imaging, wearable biophotonic sensors, and robotic surgery and light therapy.
Principles of Primary Total Hip Arthroplasty
by Yixin Zhou Jing Tang Hongyi ShaoThis book covers pertinent principles and practical surgical techniques related to primary total hip arthroplasty (THA) including complex cases. Written by experienced hip and knee surgeons, this book introduces the basic concepts of THA, helping the reader understand the basic science and history of THA. More chapters cover the preoperative planning and preparation, exposure using the various approaches, together with tips and tricks to position implants properly. Navigation-guided and robotic THA techniques are also included. Complications related to surgery, such as leg-length discrepancy, periprosthetic infections and fractures, hip instability, and deep vein thrombosis, are further discussed. Complex situations in specific diseases and pathology, such as rheumatoid hip arthritis, ankylosis spondylitis, and post-traumatic arthritic hip diseases are demonstrated.
When Was Arts in Health?: A History of the Present
by Frances WilliamsThis book critically appraises the field of Arts in Health in the light of the recent public health crisis and so-called culture wars. A new term was coined in Britain in 2017 for this area of work by an All-Party Parliamentary Group: “creative health”. Williams sets this hopeful assertion against a darker backdrop of austerity, rising inequality and “Covid-nationalism”. Understandings of the field as a (multi)national phenomenon are examined through contested narratives that surround its origin. Using genealogical methods, Williams shows how at supra, national and local policy levels, Arts in Health is presented as an idea that transcends place and time. Arguing against this premise, post-war decades are examined to reveal hidden, mutable arts-health expressions. Examples of practice, and their recognition as such, are context dependent it is concluded – produced by political economies as well as oppositional social movements.
UV-B Radiation and Crop Growth (Plant Life and Environment Dynamics)
by Sunita Kataria Vijay Pratap SinghThis book is an inclusive collection of topics on research on UVB for its impact on plants with a focus on its use as an emerging technology for crop growth and protection. This book covers role of UV-B on biological systems, and its transformation from generic stressor to specific regulator. It also explores the past research in UVB studies and the changing mind-sets regarding UV-B in recent time with respect to the plant growth. It also explores the discovery of specific UV-B photoreceptor, UVR8 and UVR8 mediated plants responses. This book is of interest to teachers, researchers, agriculture scientists and plant physiologists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences
Tropical Cardiovascular Pathology: Autopsy-Based Clinicopathological Cases
by Pradeep VaideeswarThe book covers 75 autopsy-based cases (about 75) of common and uncommon presentations of various cardiovascular diseases (CVDs). It emphasizes the importance of the autopsies, which have played a pivotal role in the understanding of the pathology and hence the clinical manifestations of several CVDs. The book attempts to present the material from the perspective of the autopsy table. It uses the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition with final clinico-pathological correlation. Each case covers a complete journey of the deceased patient concisely under the following headings—title, clinical history, autopsy findings and discussion, which includes a brief review of the literature. The text is accompanied by relevant high-quality macroscopic and microscopic images. The book is relevant for specialists in pathology, cardiology, cardiac surgery, internal medicine, critical care and pediatrics
The Art of Intramedullary Nailing for Femoral Fracture
by Kyu Hyun YangThis book offers precise points in intramedullary nailing for the treatment of the femoral fracture. The author's aim is to explain how to find a correct entry point, especially in the case of subtrochanteric fracture with excessive external rotation of the proximal fragment, method of reduction in a severely comminuted fracture which is challenging in the restoration of rotational alignment as well as angulation, and mode of interlocking. This book is based on the author’s personal experiences of 30 years in trauma, who dedicates himself to developing intramedullary nailing for femoral shaft fracture. It also covers cephalomedullary nailing for reverse obliquity trochanteric fracture because the incidence of hip fractures increases due to prolonged life expectancy. This book will be an ideal resource with many fluoroscopic and radiographic pictures to descript the real situations that the surgeons encounter in the operating room and techniques to solve those problems.
Mastering Endo-Laparoscopic and Thoracoscopic Surgery: ELSA Manual
by Alembert Lee-Ong Emily Rose Nery Michael Lawenko Eva Lourdes Sta. Clara Marilou Blancos Fuentes Siau Wei Tang Narendra Agarwal Asim Shabbir Jaideep Rao Rajat Goel Le Quan Anh Tuan Henry Chua Rakesh Gupta Kiyotaka Imamura Enrico Lauro Hrisikesh Salgaonkar William Tzu-Liang Chen Sajid MalikThis is an open access book.The book focuses mainly on the surgical technique, OR setup, equipments and devices necessary in minimally invasive surgery (MIS). It serves as a compendium of endolaparoscopic surgical procedures. It is an official publication of the Endoscopic and Laparoscopic Surgeons of Asia (ELSA).The book includes various sections covering basic skills set, devices, equipments, OR setup, procedures by area. Each chapter cover introduction, indications and contraindications, pre-operative patient’s assessment and preparation, OT setup (instrumentation required, patient’s position, etc.), step by step description of surgical procedures, management of complications, post-operative care. It includes original illustrations for better understanding and visualization of specific procedures.The book serves as a practical guide for surgical residents, surgical trainees, surgical fellows, junior surgeons, surgical consultants and anyone interested in MIS. It covers most of the basic and advanced laparoscopic and thoracoscopic surgery procedures meeting the curriculum and examination requirements of the residents.
Handbook of Animal Models and its Uses in Cancer Research
by Surajit Pathak Antara Banerjee Atil BisginThis reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.
Head and Neck Surgery : Surgical Landmark and Dissection Guide
by Norhafiza Mat Lazim Zul Izhar Mohd Ismail Baharudin AbdullahThis book provides concise critical points used during most types of head and neck surgeries combined with captivating figures and labeled photographs as well as live surgery photographs. Important head and neck surgery such as thyroid surgery, salivary glands surgery, sinonasal surgery, laryngeal surgery, and neck dissection are incorporated in this book. Each chapter starts with the anatomical description of the surgical structures with labelled photographs, in order to facilitate the reader's understanding the anatomic region of the surgical structures, the diseases related to the highlighted structures and its surgery. The specific type of surgeries indicated for specific diseases are provided and discussed in a concise manner. Surgical procedures have also been presented in a clear and easily comprehensible manner using both important anatomical and surgical landmarks. Attractive labels and arrows are inserted alongside the figures. This book will be an excellent guide book especially for both undergraduate and postgraduate students, junior surgeons, clinicians, anatomy dissectors, scientists, as well as general academia. It will also be a valuable reference source for the junior head and neck surgeons and trainees in the head and neck surgical oncology specialty.
Deep Convolutional Neural Network for The Prognosis of Diabetic Retinopathy (Series in BioEngineering)
by A. Shanthini Gunasekaran Manogaran G. VadivuThis book discusses a detailed overview of diabetic retinopathy, symptoms, causes, and screening methodologies. Using a deep convolution neural network and visualizations techniques, this work develops a prognosis system used to automatically detect the diabetic retinopathy disease from captured retina images and help improve the prediction rate of diagnosis. This book gives the readers an understanding of the diabetic retinopathy disease and recognition process that helps to improve the clinical analysis efficiency. It caters to general ophthalmologists and optometrists, diabetologists, and internists who encounter diabetic patients and most prevalent retinal diseases daily.
The Formation of the Swiss Hospital System (1840–1960): An Analysis of Surgeon-Modernisers in the Canton of Vaud
by Pierre-Yves DonzéThis book offers an analysis of the formation of contemporary hospital systems between the mid-19th century and the mid-20th century. Based on extensive archival material and a broad international literature review, it focuses on the case of the canton of Vaud, Switzerland, and uses a triple approach that discusses technological innovations, hospital management, and health policy. This research is a major contribution to the history of medicine which gives a unique overview of the formation of contemporary hospital systems.
Minimally Invasive Functional Reconstruction of the Knee
by Jinzhong ZhaoThe book provides essential surgical techniques to restore knee function, in addition to the anatomical reconstruction. It introduces 44 techniques in separated chapters, which are composized with the same text structure and high-resolution photos. The authors are good at managing and teaching these techniques. The step-by-step descriptions and illustrations are very helpful for the readers of orthopaedic and sports medicine surgeons.
Microbial Engineering for Therapeutics
by Mrutyunjay Suar Namrata Misra Chandravanu DashThis book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.
Pulmonary Tuberculosis and Its Prevention (Respiratory Disease Series: Diagnostic Tools and Disease Managements)
by Takefumi Saito Masahiro Narita Charles L. DaleyEvery year, 10 million people fall ill with tuberculosis (TB) in the world, and of those, 1.5 million people die even though it is a preventable and curable disease. As a result, TB remains the world’s leading infectious cause of death. On the other hand, in industrialized countries, the TB incidence has fallen to a historic low, and clinicians’ experience with TB diminished significantly in recent years. Additional challenges for clinicians include atypical presentation of TB in the immunocompromised, especially among the elderly, and an increasing number of patients with drug-resistant TB. Delayed diagnosis of TB leads to the spread of TB including nosocomial transmission because TB is an air-borne infectious disease, and suboptimal treatment can result in development of drug resistance. Furthermore, treatment of latent TB infection (LTBI) can prevent future TB cases but it has been under-utilized despite recent innovations in diagnosis and treatment regimens of LTBI. This book focuses on advances in diagnostic tools and treatment for both TB disease and latent TB infection. Each chapter/topic is written by one of the top TB experts in the field and the authors are from Japan and the US. Pulmonary Tuberculosis and its Prevention offers up-to-date information that can be incorporated into a busy practice of clinicians while they can appreciate broad international perspectives and gain in-depth knowledge on TB.
Ocular Trauma in Armed Conflicts
by Shrikant WaikarThe book comprehensively covers the complete spectrum of ocular trauma in war and peace, while most of the books on ocular trauma cover only civil trauma. It explains the care to be taken by the injured himself from the time of injury to the most specialized tertiary care management step-by-step. It covers the various modes of trauma, the evaluation, and the management from emergency care and evacuation to secondary and tertiary care. The initial chapters cover the step by step care of wounds and the application of dressings or tourniquets available in the battlefield to be taken by the individual himself and the initial medical care by forward medical officer and surgeon before evacuating to the ophthalmologist The book also covers the management of polytrauma involving the head and neck or other parts of the body based on real-life experience since most of the battlefield ocular trauma presents with it. It incorporates chapters on ocular trauma due to chemical, biological, radiological or nuclear (CBRN) hazards and the important aspect of imaging in ocular trauma. It covers the classification systems of ocular trauma. The book presents the step-by-step approach to primary repair of open globe injuries and lid lacerations by the first contact ophthalmologist. It covers the subspeciality wise tertiary care management of ocular trauma, encompassing an approach to the management of corneal scars, lenticular injuries, uveitis, traumatic glaucoma, intraocular foreign body and other posterior segment manifestations of injury like retinal detachment, vitreous and choroidal hemorrhage, etc., orbit and optic nerve trauma and other neuroophthalmological manifestations of trauma. It also includes a chapter on chemical injuries and techniques of stem cell transplantation for ocular surface reconstruction. Additionally, it covers the management of unsalvageable eyes and cosmetic rehabilitation. The book is a complete and helpful resource on ocular trauma and assists ophthalmologists, trauma care workers, and medical officers with security forces in the easy management of ocular trauma.
Terahertz Devices, Circuits and Systems: Materials, Methods and Applications
by Sudipta Das Anveshkumar Nella Shobhit K. PatelThis book is aimed to bring the emerging application aspects of THz technology and various modules used for its successful realization. It gathers scientific technological novelties and advancements already developed or under development in the academic and research communities. This book focuses on recent advances, different research issues in terahertz technology and would also seek out theoretical, methodological, well-established and validated empirical work dealing with these different topics. In particular, this textbook covers design considerations and current trends of THz antennas and antenna arrays to deal with the transmission and reception of THz EM waves. It also presents a discussion on metamaterial structures, meta-surfaces, and absorbers to be used for some kind of sensing and detection applications. Furthermore, it reports on THz wireless communication aspects, 6G network issues and challenges, advantages and disadvantages, generation and detection of THz waves, Signal and Communication Processing for THz communication, reconfigurable low-noise amplifier (LNA) design, III-Nitride HEMTs for THz Applications, photonic crystal fiber for sensing applications, THz Design Variable Estimation by Deep Optimization, and THz Imaging issues. Once the readers finish studying this book then they will learn about the importance of THz technology, advancement in the field, applications, THz modules like antennas, MIMO and DRAs, communication aspects, LNAs, generation of THz waves, etc and future scope. It also leads to enhancement in their knowledge in THz technology, gives a platform to future technology and novel applications realization.
Textbook of Nutritional Biochemistry
by Darshan Malik Nandita Narayanasamy V A Pratyusha Jayita Thakur Nimisha SinhaThis textbook for undergraduate students aims at providing an in-depth understanding of the relationship between diet, nutrients, health, diseases, and drug treatment. The book presents a comprehensive but detailed view of the field of Nutritional Biochemistry; balancing the historical with contemporary findings, the descriptive with the experimental, structure with function as well as the mechanistic and the clinical aspects of any particular nutrient. Though the major emphasis of the book is on Nutritional Biochemistry, the book also attempts to provide an insight into other related and relevant areas. Amongst the topics that are covered are: nutraceuticals, food, and nutrient interactions; the newly emerging field of the human microbiome, its interdependence on diet and human health as well as the public health concerns which is a looming burden of non-communicable diseases. Each chapter begins with an insight into the history of discovery and structure of the nutrient, its absorption, and metabolism, physiological functions, ending with diseases associated with nutrient deficiency/toxicity along with a clinical perspective. Apart from this, the book emphasizes the biochemical basis of physiological responses and correlates the same with symptoms identifying the pathophysiology. This textbook caters to students of undergraduate courses like Biochemistry, Biomedical Sciences, Biological Sciences, Life Sciences, Home Science; Nutrition and Dietetics, Clinical Nutrition and Dietetics, and Nursing.
Exploring Susceptible-Infectious-Recovered (SpringerBriefs in Applied Sciences and Technology)
by Rahul Saxena Mahipal Jadeja Vikrant BhatejaThe book focuses on mathematical modelling of COVID-19 pandemic using the Susceptible, Infectious, and Recovered (SIR) model. The predictive modelling of the disease, with the exact facts and figures, provides a ground to reason about growing trends and its future trajectory. The book emphasizes on how the pandemic actually spreads out, lockdown impact analysis, and future course of actions based on mathematical calculations. Moreover, since COVID-19 spread outburst has been twice, the intensity studies and comparative analysis of the two waves of COVID-19 are another interesting feature of the book content. The book is a knowledge base for various researchers and academicians to dive into the detailing of the COVID spread (mathematical) model and understand how it could be explored to draw outcomes. To represent the factual information and analytical results effectively, graphical and diagrammatic representations have been appended at appropriate places. To keep the explanation simple and yet concrete, mathematical concepts have also been introduced; to carry out analysis to generate results for understanding the viral dynamics.