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Health Promotion Planning: Learning from the Accounts of Public Health Practitioners
by Jean Marie Place Jonel Thaller Scott S. HallHEALTH PROMOTION PLANNING “I find this book to be an invaluable resource, offering a comprehensive guide for assessing and addressing public health issues. Its unique blend of theoretical insights and real-world narratives provides a nuanced understanding of interventions in practical contexts. This book is an essential tool for both current and aspiring professionals in the public health sector.” —DANE MINNICK, Indiana Division of Mental Health and Addiction Real stories, real solutions—a unique textbook that embeds definitions and descriptions of program planning principles within the story of one town grappling with the opioid crisis In Health Promotion Planning: Learning from the Accounts of Public Health Practitioners, you will embark on a journey through the heart of a small midwestern city, where a community grapples with the daunting challenges of the opioid epidemic. The book uses narratives in a creative and engaging way, weaving together the real-life accounts of over 100 public health practitioners. As you follow the saga of the town, you will see program planning principles in action. Through the intricacies of substance use and opioid-related challenges, this book sheds light on the interconnected efforts of diverse programs, including needs assessment, health education curriculum, health communication campaigns, environmental change strategies, peer support initiatives, and community organizing. Students and practitioners will uncover the principles and processes of building health promotion programs. Discussion questions and activities at the end of each chapter stimulate reflection and exploration, offering a valuable resource for instructors and individual learners. Health Promotion Planning is a powerful glimpse into public health practice, inspiring future generations to take up the mantle in addressing societal challenges. Learners will witness health promotion in action as they follow the compelling stories inside—where lessons are learned, lives are changed, and hope emerges from the frontlines of a devastating epidemic.
Healthcare Delivery in Surgery: Scientific Principles and Practice
by Justin B Dimick Lesly A Dossett Amir A Ghaferi Andrew M IbrahimAn invaluable resource for surgeons, surgical leaders, and health system administrators at all levels, Healthcare Delivery in Surgery: Scientific Principles and Practice provides unique, expert coverage of common challenges in the delivery of surgical care. Editor Justin B. Dimick, MD, MPH, Chair of the University of Michigan’s Department of Surgery, leads an outstanding editorial team from the UM Center for Healthcare Outcomes and Policy who provide clear guidance on the strategy and operations of delivering optimal surgical care. Using a case-based approach, authors consider the underlying principles and existing evidence followed by real-world practical solutions.
Healthcare Industry 4.0: Computer Vision-Aided Data Analytics (Computational Intelligence Techniques)
by P. Karthikeyan Polinpapilinho F. Katina R. RajagopalThis book covers computer vision-based applications in digital healthcare industry 4.0, including different computer vision techniques, image classification, image segmentations, and object detection. Various application case studies from domains such as science, engineering, and social networking are introduced, along with their architecture and how they leverage various technologies, such as edge computing and cloud computing. It also covers applications of computer vision in tumor detection, cancer detection, combating COVID-19, and patient monitoring. Features: Provides a state-of-the-art computer vision application in the digital health care industry. Reviews advances in computer vision and data science technologies for analyzing information on human function and disability. Includes practical implementation of computer vision application using recent tools and software. Explores computer vision-enabled medical/clinical data security in the cloud. Includes case studies from the leading computer vision integrated vendors like Amazon, Microsoft, IBM, and Google. This book is aimed at researchers and graduate students in bioengineering, intelligent systems, and computer science and engineering.
Healthcare Services in the Metaverse: Game Theory, AI, IoT, and Blockchain (Emerging Trends in Biomedical Technologies and Health informatics)
by Saurav Mallik Anjan Bandyopadhyay Ruifeng Hu Pawan Kumar Singh Soumadip Ghosh Sujata SwainThis book focuses on game theory approaches utilized on various domains viz., IoT, blockchain and their applications to biomedical and healthcare services. The book bridges the gap between radiologists and Artificial Intelligence (AI)-driven automated systems by investigating various techniques such as game theoretic approach, blockchain technology basically utilized for security, and IoT applied on metaverse. Healthcare Services in the Metaverse: Game Theory, AI, IoT, and Blockchain, identifies the potential areas where game theory and block chain techniques can be harnessed in the metaverse. The book discusses the integration of virtual reality (VR) with augmented reality to identify the new emerging techniques in healthcare to metaverse, where doctors and/or patients can see any kind of operation in the VR metaverse. The authors use game theoretical and blockchain approaches to understand healthcare issues, with the aim of utilizing different technologies of metaverse platform for health informatics. This book is written to help healthcare practitioners and individuals across academia and research, as well as for those who work in biomedical, Internet of Things (IoT), Artificial Intelligence (AI), metaverse, VR, blockchain, and related technologies.
Healthy Kids, Happy Kids: An Integrative Pediatrician's Guide to Whole Child Resilience
by Elisa Song M.D.Do you want to know the key to raising resilient kids, from the inside out? In this groundbreaking, evidence-based guide to raising healthy kids in our modern world, Dr. Elisa Song bridges the gap between conventional and holistic pediatrics and delivers a clear roadmap to help kids thrive.Raising healthy, happy kids shouldn’t be so hard. Yet, despite living in what should be a golden age of medicine, our children are sicker than ever. At least 1 in 5 kids has eczema, and 1 in 10 has asthma, ADHD, or anxiety—and sometimes they have all of the above. Many parents are at a loss for who to turn to for trusted advice—advice that takes a root-cause, holistic approach to whole child resilience, but doesn’t dismiss the value of conventional pediatrics.Enter Elisa Song, MD, a Stanford-, NYU-, UCSF-trained pediatrician, one of the foremost pioneers and trusted experts in pediatric integrative and functional medicine. Drawing on extensive research and over 25 years of clinical experience, Dr. Song explains why your child’s gut microbiome holds the key to lifelong wellness. She shares her proven and practical plan for building physical and emotional resilience from the inside out. You will discover how to:Optimize your child’s microbiome with 5 simple steps.Empower your kids so they want to make healthy choices (and you don’t have to nag).Heal your child’s gut to get to the root cause of their chronic health concerns.Feel calm and confident using safe and effective natural therapies when your kids are sick, with an A-to-Z guide to the top 25 acute childhood ailments.Complete with helpful quizzes, exercises, protocols, and dozens of delicious, gut-friendly recipes, Healthy Kids, Happy Kids is a comprehensive, yet simple roadmap to raising resilient kids in our not-so-simple world. Thanks to Dr. Song, parents (and practitioners) finally have the power to revolutionize the future of children’s health so that their kids can thrive—no matter what life throws their way.
Heart: An Owner's Guide (The Body Literacy Library)
by Paddy BarrettBecome body literate with Heart: An Owner's Guide, the next book in The Body Literacy Library, a helpful series that will break down heart health for a new generation of readers.Heart: An Owner's Guide is an informative, practical, and engaging introduction to all aspects of heart health to live well and longer. Find the key to a long, healthy life and your cardiac risk.Author Dr Paddy Barrett is an engaging and media-friendly Consultant Cardiologist specializing in preventative health care. He translates medical jargon into simple, straightforward prose, answering frequently asked patient queries, such as Should I take aspirin? Are heart attacks hereditary? Is red wine healthy? And much more.In this book, you can find:-Easy-to-follow science and lifestyle advice with simple Q&As. -Illustrations with data-driven images that show how certain lifestyle choices impact your health.-Best tips to help you know how to best care for your body and heart.-Chapters that outline the vital organ and how it works, risks for heart problems, and what to do to improve heart health. From what you should eat (or not) and exercising smarter to why stress is as dangerous as smoking, this hard-working book applies science to the everyday, with simple illustrations, checklists, FAQs, and myth busters, all supported by the latest medical research. Heart: An Owner's Guide won't just help you understand your body better.
Heavy Metal Remediation: Sustainable Nexus Approach (Earth and Environmental Sciences Library)
by Nitish KumarHeavy metals, in general trace elements, are one of the major environmental problems. Nowadays, increasing environmental and global public health concerns related with environmental contamination by heavy metals are well known. Moreover, human exposure has risen dramatically because of an exponential increase of their use in several activities such as agricultural, industrial, technological and urban applications. They are presented in soils, water and atmosphere and they are a serious risk for the food chain.Approximately 10 million contaminated sites have been reported globally, occupying approximately 49.42 million acres of land, of which >50% is contaminated with toxic heavy metals. This situation warrants immediate attention to limit the introduction of heavy metals into soil systems and to remove the prevailing heavy metals from polluted soils. However, the majorities of existing heavy-metal-removal technologies are expensive, inefficient, or generate secondary pollutants. Therefore, it is of great importance to develop cheaper, environmentally friendly and sustainable approaches (including the development of new immobilizing agents) to manage and rehabilitate heavy-metal-contaminated soils. In the light of the aforementioned facts, this book sheds light on this global environmental issue, and proposes solutions to contamination through multi-disciplinary approaches and case studies from different parts of the world. It addresses sustainable heavy metal contamination remediation strategies using the potential applications of recent biological technology such as biotechnology, bioremediation, phytoremediation, biochar, absorbent, genetic engineering, and nanotechnology approaches. This book is of interest to researchers, teachers, environmental scientists, environmental engineers, environmentalists, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of environmental microbiology, biotechnology, eco-toxicology, environmental remediation, waste management, and environmental sciences as well as the general audience.
Helping Skills for Counselors and Health Professionals: Building Culturally Competent Relationships
by Stephanie S. Drcar Kathryn C. MacCluskie Dakota King-WhiteHelping Skills for Counselors and Health Professionals provides a model of foundational helping skills that is grounded in a multicultural framework. Chapters explicitly examine implicit bias and the role of culture and systems of oppression and marginalization within the lives of both individuals and communities. The text also uses ecological systems theory to assist readers in conceptualizing the ways in which culture influences communication styles, perceptions of professional helpers, and individual needs. Readers will be introduced to concepts that increase awareness of micro and macro-level influences on helping skills, communication, and the patient’s life. Within the book’s multicultural framework, readers will also find tools for increasing self-awareness for improving the communication skills and cultural humility.
Hemodynamic Monitoring and Fluid Therapy during Surgery
by Alexandre Joosten Maxime Cannesson Robert G. HahnCombining two successful texts, Clinical Fluid Therapy in the Perioperative Setting, 2nd edition and Perioperative Hemodynamic Monitoring and Goal Directed Therapy, this revised volume provides a guide to fluid management and hemodynamic therapy for the perioperative practitioner. The book begins with an up-to-date overview of the basics before then exploring most of the current and controversial topics within hemodynamic monitoring and fluid therapy. This is followed by a section on practical use which explores hemodynamic and fluid therapy in various types of surgery and patient conditions. The book closes with a discussion of the future concepts in fluid and hemodynamic therapy ranging from microcirculation, to closed-loop and mobiles technologies. With contributions from the world's leading experts, chapters guide the reader in the application of fluid and hemodynamic therapy in all aspects of perioperative patient care. A valuable resource for those involved in perioperative patient management, including anaesthesiologists, intensivists, and surgeons.
Henke's Med-Math: Dosage Calculation, Preparation & Administration
by Susan BuchholzHenke’s Med-Math: Dosage Calculation, Preparation, and Administration, 10th Edition, offers a highly visual, hands-on approach to mastering dosage calculation and the principles of drug administration. Rich with side-by-side comparisons, engaging animations, and dosage calculation problems, this dynamic new edition guides students step by step through the problem-solving process and builds clinical proficiency for confident dosage calculation and medication administration.
Her Secret Baby Confession (Hope Hospital Surgeons)
by Juliette HylandA one-week fling…with binding consequences! Dive into this irresistible secret-baby romance from Juliette Hyland, the second installment in her Hope Hospital Surgeons duet. HER SECRET. THEIR FAMILY?Let me introduce you to your daughter are not words responsible surgeon Ryann ever thought she&’d say. Yet here she is, face-to-face with the man she spent one incredible, and totally out of character, week with, confessing she&’s had his baby! Despite growing up in the foster system, nurse anesthetist Jackson is thrilled to be a dad. But can they be more than co-parents when cautious Ryann so ardently protects her carefully curated life…?From Harlequin Medical: Life and love in the world of modern medicine.Hope Hospital Surgeons
Herbal Magic: A Beginner's Guide to the Magical Power of Plants
by Lydia LevineStep into the enchanting world of herbal recipes, remedies and rituals with this spellbinding guide to the magical power of plants. Including a variety of crafts, spells and rituals, this treasury of herb profiles is the perfect introduction to harnessing the natural energies at your disposal.
Herz-Kreislauf (Springer-Lehrbuch)
by Thomas F. Lüscher Ulf LandmesserDer Blick aufs GanzeEs ist immer wieder dasselbe: Wenn im klinischen Abschnitt endlich die spannenden Krankheitsbilder kommen, sind Anatomie und Physiologie längst vergessen. Mühsam muss man alles wiederholen, um zu verstehen, worum es bei der Erkrankung geht.Lernen Sie ein Organsystem doch einfach „am Stück“: von der Anatomie über die Physiologie bis zur Diagnostik und Therapie von Erkrankungen. Dieses Buch ist ideal für das Lernen im Modul, hier verstehen Sie das Organsystem im Zusammenhang. Die Erkrankungen des Herz-Kreislauf-Systems werden systematisch abgehandelt - endlich genügt ein einziges Buch, um den ganzen Themenblock durchzuarbeiten. Und dabei helfen Ihnen: Praktische Anleitungen für Diagnostik und TherapieZahlreiche diagnostische BilderNeueste Erkenntnisse und TherapieverfahrenMerksätze, Tabellen und Übersichten mit den wichtigsten FaktenWegen seiner Praxisnähe ist dieser Band sowohl für Medizinstudenten als auch für Ärzte in der kardiologischen Aus- und Weiterbildung bestens geeignet.Für die dritte Auflage wurde das Buch sorgfältig aktualisiert und um zwei neue Kapitel zur pulmonalen Hypertonie sowie Erkrankungen des venösen Systems ergänzt. So bleiben Sie auch mit der dritten Auflage am Puls der Zeit in der Kardiologie!
High Performance Computing for Drug Discovery and Biomedicine (Methods in Molecular Biology #2716)
by Alexander HeifetzThis volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.
High Performance Computing in Biomimetics: Modeling, Architecture and Applications (Series in BioEngineering)
by Kamarul Arifin Ahmad Nor Asilah Wati Abdul Hamid Mohammad Jawaid Tabrej Khan Balbir SinghThis book gives a complete overview of current developments in the implementation of high performance computing (HPC) in various biomimetic technologies. The book presents various topics that are subdivided into the following parts: A) biomimetic models and mechanics; B) locomotion and computational methods; C) distributed computing and its evolution; D) distributed and parallel computing architecture; E) high performance computing and biomimetics; F) big data, management, and visualization; and G) future of high performance computing in biomimetics. This book presents diverse computational technologies to model and replicate biologically inspired design for the purpose of solving complex human problems. The content of this book is presented in a simple and lucid style which can also be used by professionals, non-professionals, scientists, and students who are interested in the research area of high performance computing applications in the development of biomimetics technologies.
High Society
by Daniel KallaFrom internationally bestselling author Daniel Kalla comes a twisty psychological thriller about a pioneering psychiatrist hiding dark secrets, in the vein of The Golden Couple by Hendricks and Pekkanen and Nine Perfect Strangers by Liane Moriarty.At sixteen, Holly Danvers barely survived the car accident that killed her father. While she has no memory of the crash, it took an ayahuasca treatment, a native plant-based psychedelic therapy, in the jungles of Peru for her to emotionally recover. Twenty years later, Holly is a sought-after psychiatrist determined to use her expertise with psychedelics to treat patients suffering from addictions. Ignoring the risks, she embarks upon an unproven new protocol with miraculous results. But her success in probing the traumas of her patients and the secrets they keep is short-lived. When one celebrity client goes public with his recovery and another overdoses after accusing Holly of improprieties, her world is turned upside down. With her career on the line, Holly reaches out to her mentor—and estranged husband—Dr. Aaron Laing, for advice and comfort. But he has a different agenda, and it soon becomes clear that it will be up to Holly alone to figure out why her clients are relapsing and dying. To accomplish that, she will have to risk her life and revisit her own deep-seated trauma.
Higher Powers: Alcohol and After in Uganda’s Capital City
by China Scherz George Mpanga Sarah NamirembeHigher Powers draws on four years of collaborative fieldwork carried out with Ugandans working to reconstruct their lives after attempting to leave behind problematic alcohol use. Given the relatively recent introduction of biomedical ideas of alcoholism and addiction in Uganda, most of these people have used other therapeutic resources, including herbal aversion therapies, engagements with balubaale spirits, and forms of deliverance and spiritual warfare practiced in Pentecostal churches. While these methods are at times severe, they contain within them understandings of the self and practices of sociality that point away from models of addiction as a chronic relapsing brain disease and towards the possibility of release. Higher Powers offers a reconceptualization of addiction and recovery that may prove relevant well beyond Uganda.
Histology: With Correlated Cell and Molecular Biology
by Wojciech PawlinaCombining a reader-friendly textbook and a rich, full-color atlas, Histology: A Text and Atlas: With Correlated Cell and Molecular Biology, 9th Edition, equips medical, dental, health professions, and undergraduate biology and cell biology students with a comprehensive grasp of the clinical and functional correlates of histology and a vivid understanding of the structural and functional details of cells, tissues, and organs. The 9th Edition of this bestselling resource reflects the latest advances in cellular and molecular biology and relevant imaging techniques, accompanied by large, high-resolution illustrations and full-color photomicrographs that clarify microanatomy in vibrant detail. System chapters align conveniently with curricula units and emphasize a clinical context, making this proven approach ideal for integrated curricula as well as standalone histology courses. To accommodate reviewers’ suggestions, the ninth edition integrates new information in cell biology with clinical correlates, which readers will see as new clinical information items highlighted in blue text and in clinical boxes (called “Folders”). For example, the last few years of the COVID-19 pandemic has sparked interest about the changes in normal tissue when infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Several chapters contain descriptions of these changes with underlying explanations of cellular and molecular mechanisms and clinical features presented by patients. Additional changes include the following: A new discussion on the mononuclear phagocytic system and the cell biology of resident tissue macrophage has been added. The latest research findings in immune cell activation have been incorporated. Updated cellular biology topics include beige adipose tissue, the epithelial–mesenchymal transition, conjunctiva- associated lymphatic tissue, biogenesis and function of peroxisomes, and microsomes as the newest discovered form of cell-to-cell communication. New, more detailed information about the histology of the female and male external genitalia has been included. The skin chapter has been supplemented and updated with many new additions, including of skin color and aging. With the constant improvement in microscopic methods, a new basic discussion on three-dimensional (3D) microscopy methods was incorporated in the methods chapter.
Histopathology of Bone and Joint Infections
by Mohamed Fethi Ladeb Soumaya Rammeh RommaniThis book focuses on histopathological features of bone and joint infections. Bone and joint infection is a serious health problem that has increased in the past two decades. Their diagnosis requires the collaboration of physicians, radiologists, microbiologists and pathologists. Symptoms of these lesions are nonspecific often resulting in a delayed diagnosis. Radiology is needed for the diagnosis of bone and joint infection, determining the severity and extent of disease. The radiological diagnosis of these infections is challenging because of multiple overlaps with tumor etiologies.Effective antibiotic treatment relies on the detection of the causative organisms and its their susceptibility testing. However, culture is time consuming. Besides, administering antibiotics prior to performing surgery or biopsy, the low virulent bacteria, tissues contaminations and sampling errors limit the reliability of bone culture. Histology is a key tool for the diagnosis of boneand joint infection by evaluating the tissue reaction pattern caused by the pathogen. The histopathological diagnosis is based on the evaluation of the tissue changes and the leukocyte infiltration pattern.The purpose of this book will be to report in detail the histopathological features of bone and joint infections with emphasis on key diagnostic features and differential diagnoses. It will also highlight special stain and other ancillary tests that can be used as an aid in the histological diagnosis.
A History of Discoveries on Hearing (Springer Handbook of Auditory Research #77)
by Darlene R. Ketten Allison B. Coffin Richard R. Fay Arthur N. PopperThis volume focuses on the history of research on hearing from comparative approaches. Each chapters examines the most formative studies that led to current understanding of hearing across taxa and still influence hearing research in general. Much of the early work on hearing, which goes back to Aristotle, as well as the classic work of 16th to early 20th century scientists (e.g., Spellanzani, Retzius, Ramón y Cajal, and Helmholtz) is not well known to modern investigators. Similarly, work in the first 75 years of the 20th century is also unknown or, in some cases, dismissed because it is “old.” Much of the earlier work describes research approaches and results fundamental to our understanding of hearing as well as the beauty of observation and synthesis. The pioneering work on hearing contains ideas and questions that are still germane today. Thus, the goal of this volume is to introduce, review, and put into perspective, older but exemplary, extraordinary studies by investigators that form the basis of our knowledge as well as questions being asked today.Each chapter includes the first significant observations and approaches to hearing in the taxa and/or hearing type that is the focus of the chapter with some of the most important earlier papers discussed in some detail, including the theories, formative experiments, results, and conclusions. Each chapter provides briefer notations and citations of additional important papers that are outgrowths of the founding research – or correlate and even reverse the original works. This volume is a departure from the classic approach established for the SHAR books in which the focus has been on a single topic, and on the most recent and exciting discoveries. One difference in this volume from past SHAR volumes is that we have a more coordinated approach for the chapters to ensure that this volume is, indeed, a documentation of hearing research history, not a review of the latest status of the topic. A second difference is that the focus of the volume is on the historical value of studies. In that sense, the volume maintains the tutorial value for which SHAR books are famous, but it explores the ancestry of modern research in order to help new researchers to gain perspective on important questions and on fundamental information they may not fully appreciate – to their loss. Our interest in doing this volume comes from phenomena familiar to most senior investigators - that younger investigators often have little or no sense of the history of their discipline, and they often do not know that their “hot” new idea was not only pursued, and often solved, but further that it was solved in an elegant way. We believe it is important to bring the methodologies and discoveries on hearing done before the advent of the internet to light, for the benefit and growth of new research.In deciding on the chapter divisions for this book, we considered a number of different organizational schemes, and particularly using as a focus methodological approaches (e.g., psychoacoustics, low to high frequency types, physiology, anatomy). However, we came to the conclusion that most investigators tend to be more focused on working within a particular taxonomic group, settling on particular taxa, in many cases driven by the special hearing abilities. We also concluded that that this approach is more naturally related to the evolution not only of hearing, but also to the evolution of ideas, as much of hearing science was part of the “natural philosopher” approach that was a core element of historical discoveries.
HIV, Gender and the Politics of Medicine: Embodied Democracy in the Global South
by Elizabeth MillsThis book centres on women living with HIV in South Africa who have navigated affective relationships, activist networks, government institutions and global coalitions to transform health policies that govern access to HIV medicines. Drawing on 20 years of ethnographic and policy research in South Africa, Brazil and India, it highlights the value of understanding the embodied and political dimensions of health policy and reveals the networked threads that weave women’s precarity into the governance of technologies and the technologies of governance. It illuminates the entwined histories of health policy evolution, systemic inequality and everyday life and calls for a recognition of the embodied ramifications of democratic politics and global health governance. By integrating medical anthropology with science studies and political theory, this book traces the history of the struggle to access HIV medicines in the Global South and brings it into the present by articulating the lessons learned by activists and policy makers engaged in shaping these vital health policies.
HIV Protocols (Methods in Molecular Biology #2807)
by Ganjam V. Kalpana Vinayaka R. PrasadThis fourth edition volume expands on the previous editions with discussions on the latest methodologies to study HIV, live cell imaging, HIV cure, new modifications to the viral RNA that impacts HIV biology, and new types of intracellular compartments. The chapters in this book are organized into seven parts and cover topics such as HIV latency reactivation via single molecule RNA detection; T cell responses; new and efficacious anti-HIV CAR T cells; analysis of mucosal HIV infection; analysis of 3D brain organoids to study neuro AIDS; and the transfer of antibodies across the blood brain barrier. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and authoritative, HIV Protocols, Fourth Edition is a valuable resource for all preclinical HIV-1 researchers looking to learn more about this important and advancing field.
Hodson and Geddes' Cystic Fibrosis
by Andrew Bush Amaral PHD, Margarida D. Davies MBCHB, MRCP, FRCPCH, MD, FERS, Jane C. Nicholas J. J. Simmonds Bmedsci Hons Bm Bs Taylor-Cousar, Jennifer L. Sarath RanganathanCystic Fibrosis has seen dramatic advances in treatment since the last edition, including targeted cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators for most CFTR gene abnormalities. This new fifth edition is an update and expansion of the rapid clinical and scientific advances in improving prognosis, and the impact of COVID-19, all of which has transformed conventional models of care. It covers basic science, such as how detailed understanding of the biology of the CFTR gene and protein has led to novel and beneficial therapies, as well as all aspects of clinical management in high-, middle- and low-income settings and the voices of individuals with CF from across the world. It will be a useful reference for clinicians, including all levels of trainees, across the whole multidisciplinary team, scientists and students. Key Features • Follows an appealing organization of chapters, by developing fundamental knowledge of the reader before moving on to more complex or developing topics.• Presents a comprehensive, authoritative and up-to-date text, integrating fundamental science and clinical aspects of cystic fibrosis providing an attractive read for clinicians, trainee doctors and scientists.• Draws on global expertise and reflects best evidence-based practice from experts conducting cutting-edge clinical and basic science research from around the world.
Hoffbrand's Essential Haematology (Essentials)
by A. Victor HoffbrandHOFFBRAND’S ESSENTIAL HAEMATOLOGY The Essentials is an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details. The definitive introductory textbook on haematology, covering basic science, diagnostic testing, clinical features, and patient management Hoffbrand’s Essential Haematology has helped medical students and trainee physicians understand the core principles of clinical and laboratory haematology for more than four decades. Original contributions by leading experts provide authoritative coverage of clinical and laboratory features and management within haematology, including the haematological aspects of systemic diseases, pregnancy, and the neonate. Hundreds of high-quality colour images illustrate various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, bleeding and thrombotic disorders, and other blood diseases. Now in its ninth edition, this classic textbook incorporates current knowledge of the pathogenesis of blood diseases, the 5th WHO (2022) classification of haematological neoplasms, the detection of minimal residual disease, advances in the treatment of benign and neoplastic blood diseases. New sections focus on the haematological consequences of COVID-19 infection and vaccine -induced immune thrombotic thrombocy-topenia (VITT). Additional and expanded chapters describe non-Hodgkin lymphomas, amyloid, and haemophilia. Supported by a companion website with hundreds of MCQs and PowerPoint slides, Hoffbrand’s Essential Haematology, Ninth Edition, remains an indispensable resource for trainee haematologists and physicians.
A Holistic Approach to Organic Synthesis
by Philip GarnerSynthesis is one of the distinguishing features of chemistry as a science. It is the synthetic chemist who uses their intimate understanding of molecular structure and properties to produce materials of great value to society. Thus, it is important for students of chemistry to study synthesis and acquire a working knowledge that enables them to address the following question: given a specific molecular target, how does one formulate a plan for its synthesis? This synthesis primer provides students who have taken introductory organic chemistry with a set of tools that can be used to plan a synthesis. It may be used in conjunction with a synthetic methods course, or it can stand alone.Features: Provides students who have taken introductory organic chemistry with a set of tools that can be used to plan a synthesis Serves to help organic chemists at all levels to better understand published syntheses Focuses on natural products, their complexity, and diverse structures which challenge and inspire the chemists preparing them Succinct, readable treatment of important concepts and applications geared towards advanced undergraduates and graduate students Each synthesis covered begins with a brief discussion of the target molecule and challenges they present, followed by retrosynthetic considerations