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5-HT2C Receptors in the Pathophysiology of CNS Disease: 5-ht2c Receptors In The Pathophysiology Of Cns Disease (The Receptors #22)
by Vincenzo Di Matteo Giuseppe Di Giovanni Ennio EspositoPart of Springer's "The Receptors," series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors' therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy.
44 Cats: Cats Rock! (I Can Read Level 1)
by RainbowBased on the all-new animated preschool show on Nickelodeon, this early reader is purrrr-fect for any 44 Cats fan! For the first time ever, little ones can read and rock out with The Buffycats in this level 1 early reader.In this story, Lampo, Milady, Meatball, and Pilou come together to form the greatest rock band of all time—The Buffycats!44 Cats is an animated preschool comedy starring four cats: Lampo, Milady, Meatball, and Pilou. Also known as The Buffycats, they transform the garage in their clubhouse–a place where all cats from the neighborhood get together to have fun, relax, and most of all to help each other.44 Cats: Cats Rock! is a Level One I Can Read, which means it’s perfect for children learning to sound out words and sentences.
44 Cats: Cats on a Mission (44 Cats)
by RainbowBased on the all-new animated preschool show on Nickelodeon, this all-new storybook retells a key episode from 44 Cats.When the evil neighbor tries to steal Granny Pina’s house, the cats must find the missing deed before it’s too late! They will need to use their courage, smarts, and a touch of music to save the day.44 Cats is an animated preschool comedy starring four cats: Lampo, Milady, Meatball, and Pilou. Also known as The Buffycats, they transform the garage into their clubhouse—a place where all cats from the neighborhood get together to have fun, relax, and most of all to help each other.
44 Cats: A Cat's Best Friend (I Can Read Level 1)
by RainbowBased on the all-new animated preschool show on Nickelodeon, this level 1 early reader is purrrr-fect for any 44 Cats fan! When the neighbor’s dog Terry comes over, it’s up to the cats to teach him how to be a fabulous feline!44 Cats is an animated preschool comedy starring four cats: Lampo, Milady, Meatball, and Pilou. Also known as The Buffycats, they transform the garage into their clubhouse—a place where all cats from the neighborhood get together to have fun, relax, and most of all to help each other.44 Cat: A Cat's Best Friend is a Level One I Can Read, which means it’s perfect for children learning to sound out words and sentences.
40 Years of Evolution: Darwin's Finches on Daphne Major Island
by Peter R. Grant B. Rosemary GrantAn important look at a groundbreaking forty-year study of Darwin's finchesRenowned evolutionary biologists Peter and Rosemary Grant have produced landmark studies of the Galápagos finches first made famous by Charles Darwin. In How and Why Species Multiply, they offered a complete evolutionary history of Darwin's finches since their origin almost three million years ago. Now, in their richly illustrated new book, 40 Years of Evolution, the authors turn their attention to events taking place on a contemporary scale. By continuously tracking finch populations over a period of four decades, they uncover the causes and consequences of significant events leading to evolutionary changes in species.The authors used a vast and unparalleled range of ecological, behavioral, and genetic data—including song recordings, DNA analyses, and feeding and breeding behavior—to measure changes in finch populations on the small island of Daphne Major in the Galápagos archipelago. They find that natural selection happens repeatedly, that finches hybridize and exchange genes rarely, and that they compete for scarce food in times of drought, with the remarkable result that the finch populations today differ significantly in average beak size and shape from those of forty years ago. The authors' most spectacular discovery is the initiation and establishment of a new lineage that now behaves as a new species, differing from others in size, song, and other characteristics. The authors emphasize the immeasurable value of continuous long-term studies of natural populations and of critical opportunities for detecting and understanding rare but significant events.By following the fates of finches for several generations, 40 Years of Evolution offers unparalleled insights into ecological and evolutionary changes in natural environments.
4: Koala Crazy (WILD)
by Lucy CourtenayFeaturing tiger cubs, circus bears, swimming monkeys and cute koalas - this is a must-read series for all animal lovers!Twins Tori and Taya Wild disagree about almost everything ... except for their love of animals. Which is good since their mother fosters all kinds of wild animals so their house is always full of them! And now their family has set up an 'animals on film' business their lives have become even WILDER. It was only a matter of time before Tori and Taya had their chance to be on the set of a famous music video when Taya's baby croc is selected to star on a snappy rap video ... And when the twins aren't busy with crocs, it's cute Koco the-kangeroo-loving koala bear who is grabbing their attention. When he goes missing things at Wild World get a bit koala crazy!Check out these other titles in the series: Tiger Trouble, Monkey Magic, Bear Hug
4-H Filly
by Patsey GrayDove was Sandy’s filly. More than anything else in the world, Sandy wanted Dove to win a prize at the County Fair on Labor Day. Sandy knew that if she could win the prize money, her parents might not have to sell the ranch. When her parents went to San Francisco, Sandy was left to run the ranch single-handed. Fortunately, Mr. Baxter, the 4-H Club advisor, gave Sandy some excellent tips about running the ranch profitably. The first thing Sandy did was to set up a schedule. Then, when her chores were over, she had time to groom Dove and train her for the show. One night when Rosie Kelham, Sandy’s best friend was staying over, there was a terrible crashing of glass and widening of the crack in the wall. The girls knew that the noise meant only one thing--earthquake! It took weeks before the slide that blocked the road between the ranch and civilization could be cleared. Sandy and Rosie learned a lot about themselves and their growing friendship for each other. There are some frightening moments for both teenagers, particularly for Sandy, who attempts to cross the treacherous Back Lands on foot in order to register Dove for the fair. There are sad moments, too, when it looks as if Dove and the ranch will have to be sold. With the help of the 4-H president, Alan McMillan, Sandy manages to solve her problems and win congratulations from all the 4-H members. Since she is a 4-H worker, Patsey Gray can well understand the important role the 4-H plays in the lives of young people. Mrs. Gray lives with her husband, two daughters, and son on Ten Acre Ranch in Walnut Creek, California.
30 Days to a Well-Mannered Dog: The Loved Dog Method
by Tamar Geller Jonathan GrotensteinLong known as a dog coach to the stars—her clients include Oprah Winfrey, Ben Affleck, Courteney Cox-Arquette, Owen Wilson, Natalie Portman, and Larry King—Tamar Geller changed the way Americans relate to their dogs with her bestselling book The Loved Dog. Her approach is simple and down-to-earth. Instead of utilizing the negative and often painful feedback of physical dominance, choke chains, and prong collars, Tamar recommends love, play, and mutual respect as the keys to a happy home for dog and human alike.Now, Tamar makes her Loved Dog™ Method accessible for everyone with this day-by-day guide that will lead you through the first thirty days with your new dog—or help you make a fresh start with your current dog. Drawing on her studies of wolves in the wild and basing her method on the principles of child development, Tamar uses an "instincts versus choice" approach that satisfies a dog’s Seven Basic Needs and will result in a pet with good manners.30 Days to a Well-Mannered Dog covers every question commonly asked by people embarking on the momentous journey of dog ownership: why it’s important to choose the appropriate dog for you and your lifestyle, what you can expect from a puppy versus an adult dog, how to introduce your new dog to your home, and how to respond when things don’t go according to plan. Tamar guides you every step of the way, from addressing undesired behaviors in your dog to crate and paper training him to introducing him to other dogs and helping him become relaxed with strangers. Included are important but often overlooked tips about the use of words and body language to communicate, the power of play, and the amazing value of teaching your dog some lighthearted pet tricks.Along the way, Tamar debunks myths in need of debunking: that dogs are frequently "alpha" by nature and need to be dominated; that discipline is the key to dog training, and that "success" only means getting your dog to do what you want. Instead, she shows how to align your dog's wishes with your own to create a rich and enduring relationship that works wonderfully for you both.Gentle, firm, and effective, 30 Days to a Well-Mannered Dog will build your relationship with your dog to make every new day together a day of love, joy, and discovery.
The 3 Little Dassies
by Jan BrettThe Three Little Pigs with a twist! In the tradition of her bestseller The Three Snow Bears, Jan Brett finds inspiration for her version of a familiar story in Namibia, where red rock mountains and vivid blue skies are home to appealing little dassies and hungry eagles. Mimbi, Pimbi and Timbi hope to find "a place cooler, a place less crowded, a place safe from eagles!" to build their new homes. The handsomely dressed Agama Man watches from the borders as the eagle flies down to flap and clap until he blows a house down. But in a deliciously funny twist, that pesky eagle gets a fine comeuppance! Bold African patterns and prints fill the stunning borders, but it is the dassies in their bright, colorful dresses and hats that steal the show in this irresistible tale, perfect for reading aloud.
The 3-Dimensional Atlas of the Marmoset Brain: Reconstructible In Stereotaxic Coordinates (Brain Science)
by Atsushi Iriki Hirotaka James Okano Erika Sasaki Hideyuki OkanoThis book provides accurate, comprehensive, and convenient reference for usages of the “freely rotatable three dimensional combined Nissl-stained and MRI digital data of the marmoset brain”. The key features of the original 3D digital data and of this atlas are: 1. The original digital datasets are freely rotatable in three dimensions, thus expected to be useful for any disciplines and anatomical interest, using any coordinate system, 2. Combined Nissl stained and MRI images are obtained from the same marmoset, to allow cross-modality matched references for multiple usages, 3. 86 Horizontal Series of Images with Neurosurgical Plane (based on the actual data), with more accuracy and resolution (Chapter 2) than the web-based digital images, 4. 32 Coronal Series of Images with Neurosurgical Plane (reproduced from the brain model) (Chapter 3), 5. 10 Parasagittal Series of Images with Neurosurgical Plane (reproduced from the brain model) (Chapter 4), 6. 3 Omnidirectionally Sliceable Planes (reproduced from the brain model) (Chapter 5), 7. In order to provide higher resolution structures to match systematic accuracy for supplementation of the digital data on the website, additional information are included. They are: 1) Nomenclature, 2) List of Brain Structures in Hierarchical Order, 3) Index of Abbreviations, together with 143 useful Bibliographic References list as of 2016, 8. Horsley-Clarke’s stereotaxic coordinates were adopted in the present atlas.
3: Bear Hug (WILD)
by Lucy CourtenayFeaturing tiger cubs, circus bears, swimming monkeys and cute koalas - this is a must-read series for all animal lovers!Twins Tori and Taya Wild disagree about almost everything ... except for their love of animals! That's a good thing, too, since their mother fosters all kinds of wild animals so their house is always full of them! And now their family has set up an 'animals on film' business their lives have become even WILDER. When her father has to find a cast of horses for a TV period drama Taya thinks it's finally her time to be the STAR. She's desperate to be the one in front of the camera for once. But she's in danger of being upstaged by Boris, the tiny Russian circus bear cub her mum is fostering, who could end up stealing the show ...
3-2-1 Circus!
by William WegmanA kid-friendly concept book about countingWhat could be more irresistible than puppies? Puppies at the circus! William Wegman combines his signature Weimaraner photographs with colorful drawings to create a carnival of cute pups. Of course, counting by puppy clowns, acrobats, and trapeze artists makes learning numbers in 3…2…1…Circus! a whole lot more exciting.Read this board book alongside William Wegman’s Early Rider for an entertaining and educational puppy pairing.
286 Full-Color Animal Illustrations: From Jardine's "Naturalist's Library"
by Sir William JardineA spectacular range of wildlife appears in this fine collection of painstakingly accurate 19th-century drawings. Both artists and animal lovers will treasure these splendid illustrations of mammals, birds, fish, and insects. A priceless archive of royalty-free art. Captions.
25 Stupid Mistakes Dog Owners Make
by Janine AdamsThis book identifies the most common reasons why dogs and their human counterparts don't see eye to eye. Armed with keen psychological insight and the latest training techniques, the author provides practical solutions for everyday problems.
21 Days To The Perfect Dog: The friendly boot camp for your imperfect pet
by Karen WildSimple, structured and effective, this 21-day course will prevent problem behaviour and, over subsequent days, encourage positive interaction, so that your dog continues to behave well. Exercises are given for each day in the training plan, with reinforcement of the previous day's learning scheduled in, as well as time for relaxation and play with your dog. The first section helps you to assess your key concerns so that you can tailor the programme to fit your needs, while a 'quick fix' section after the main training plan providing you with 50 speedy solutions to common problems, such as damaging furniture or unsociable behaviour towards strangers. Easy to fit in around your life, with this book you are just 21 training days away from the perfect dog.
21 Days To The Perfect Dog: The friendly boot camp for your imperfect pet
by Karen WildSimple, structured and effective, this 21-day course will prevent problem behaviour and, over subsequent days, encourage positive interaction, so that your dog continues to behave well. Exercises are given for each day in the training plan, with reinforcement of the previous day's learning scheduled in, as well as time for relaxation and play with your dog.The first section helps you to assess your key concerns so that you can tailor the programme to fit your needs, while a 'quick fix' section after the main training plan providing you with 50 speedy solutions to common problems, such as damaging furniture or unsociable behaviour towards strangers.Easy to fit in around your life, with this book you are just 21 training days away from the perfect dog.
21 Days To The Perfect Cat
by Kim HoustonSimple, structured and effective, this 21-day course will prevent problem behaviour and, over subsequent days, encourage positive interaction, so that your cat continues to behave well. Exercises are given for each day in the training plan, with reinforcement of the previous day's learning scheduled in, as well as time for relaxation and play with your cat. The first section helps you to assess your key concerns so that you can tailor the programme to fit your needs, while a 'quick fix' section after the main training plan providing you with 50 speedy solutions to common problems, such as damaging furniture or unsociable behaviour towards strangers. Easy to fit in around your life, with this book you are just 21 training days away from the perfect cat.
21 Days To The Perfect Cat: The friendly boot camp for your imperfect pet
by Kim HoustonSimple, structured and effective, this 21-day course will prevent problem behaviour and, over subsequent days, encourage positive interaction, so that your cat continues to behave well. Exercises are given for each day in the training plan, with reinforcement of the previous day's learning scheduled in, as well as time for relaxation and play with your cat.The first section helps you to assess your key concerns so that you can tailor the programme to fit your needs, while a 'quick fix' section after the main training plan providing you with 50 speedy solutions to common problems, such as damaging furniture or unsociable behaviour towards strangers.Easy to fit in around your life, with this book you are just 21 training days away from the perfect cat.
20 Years of Computational Neuroscience (Springer Series in Computational Neuroscience #9)
by James M BowerWhen funding agencies and policy organizations consider the role of modeling and simulation in modern biology, the question is often posed, what has been accomplished ? This book will be organized around a symposium on the 20 year history of the CNS meetings, to be held as part of CNS 2010 in San Antonio Texas in July 2010. The book, like the symposium is intended to summarize progress made in Computational Neuroscience over the last 20 years while also considering current challenges in the field. As described in the table of contents, the chapter's authors have been selected to provide wide coverage of the applications of computational techniques to a broad range of questions and model systems in neuroscience. The proposed book will include several features that establish the history of the field. For each article, its author will select an article originally appearing in a CNS conference proceedings from 15 - 20 years ago. These short (less than 6 page) articles will provide illustrations of the state of the field 20 years ago. The new articles will describe what has been learned about the subject in the following 20 years, and pose specific challenges for the next 20 years. The second historical mechanism will be the reproduction of the first 12 years of posters from the CNS meeting. These posters in and of themselves have become famous in the field (they hang in the halls of the NIH in Bethesda Maryland) and were constructed as allegories for the state and development of computational neuroscience. The posters were designed by the book's editor, who will, for the first time, provide a written description of each poster.
20,000 Leagues Under the Sea
by VerneDive into this beautiful edition of a time-honored classic with new illustrations!Originally published in the late 1800s, 20,000 Leagues Under the Sea has captivated readers for nearly two centuries. This edition, enhanced with lavish full-color illustrations by artist Arkady Roytman, is the premier edition of this time-honored classic. The story follows Professor Aronnax, his faithful servant, Conseil, and the Canadian harpooner, Ned Land, and dangerous mission to rid the seas of terrifying monster that lurks in the depths of the sea. However, the "monster" turns out to be a giant submarine, commanded by the mysterious Captain Nemo, by whom they are soon held captive. So begins not only one of the great adventure classics by Jules Verne, but also a truly fantastic voyage from the lost city of Atlantis to the South Pole.
2: Monkey Magic (WILD #2)
by Lucy CourtenayFeaturing tiger cubs, circus bears, swimming monkeys and cute koalas - this is a must-read series for all animal lovers!Twins Tori and Taya Wild disagree about almost everything ... except for their love of animals - which is good since their mother fosters all kinds of wild animals so their house is almost always full of them! But now their house has gone up in flames and the family's animal film business is struggling to get off its feet. And as if Taya doesn't have enough to worry about, Tori is making new friends without her. But when a request comes in for a swimming troupe of monkeys, things are looking up. They've got the monkeys - now they have to train them. If only Taya could swim ... It's lights, cameras, MONKEYS!
2, 4, 6, 8 Patas (¡Arriba la Lectura! Level C #53)
by Patricia BrennanNIMAC-sourced textbook <p><p> Las personas tienen dos piernas. Pero algunos animales tiene dos, cuatro, seis o hasta ocho patas. ¡En este libro sabrás cuáles son!
189 Canaries
by Dieter BögeIn a cozy room in northern Germany, a yellow canary sings rolling melodies to the miners and carpenters of the Harz mountains. But today a bird dealer has come, and he will take the canary far, far away from everything he knows. The journey leads onto trains and steamships, across Europe and even the Atlantic. At last the canary arrives in a room in New York where he hears a strangely familiar song…This beautiful, poignant book introduces readers to the little-known history of a beloved songbird. Lushly illustrated in rich colors, 189 Canaries is an unforgettable story about music, migration, and the search for home.
17 Kings and 42 Elephants
by Margaret MahyWhere those kings are headed is a mystery, but no travelers ever had such a jolly time. Here is a royal romp through a tongue-twisting paradise.
150 Years of Racing in Saratoga: Little-Known Stories & Fact's from America's Most Historic Racing City (Sports Ser.)
by Allan Carter Mike KaneCelebrate a century and a half of horse racing in Saratoga Springs with stories of the events, horse and people who have made its summers so special.Since the inaugural meeting of August 1863, Saratoga Springs is home to one of the oldest sports venues in the country and has been the scene of memorable races, often featuring legends of the sport. Although some of the epic moments are still familiar today, such as Upset&’s defeat of Man o&’ War in the 1919 Sanford Memorial, many of the triumphs and defeats that were once famous have been forgotten. Few remember the filly Los Angeles, who thrived at Saratoga, winning sixteen stakes races, or the influential, sometimes suspicious, reasons why the track was closed three times for a total of six years. Authors Allan Carter and Mike Kane take a look back at these and other important but neglected stories and present statistics from the pre-NYRA years and a rundown of the greatest fields assembled at America&’s oldest track.&“As the subtitle promises, the book consists of unexpected tales regarding Saratoga people, horses, and happenings--things that even certain racing historians had no previous clue about. Kane and Carter are uniquely well-equipped to guide readers down this curious road less traveled.&” —Mary Simon, Daily Racing Forum