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Atlas of Oral Microbiology: From Healthy Microflora To Disease
by Xuedong Zhou Yuqing LiThis book is the second edition of Atlas of Oral Microbiology: From Healthy Microflora to Disease (ISBN 978-0-12-802234-4), with two new features: we add about 60 pictures of 14 newly isolated microbes from human dental plaque, at the same time, we re-organize the content of this book and provide more research progress about the oral microbiome bank of China, the invasion of oral microbiota into the gut, and the relationships between Oral Microflora and Human Diseases. This book is keeping up with the advanced edge of the international research field of oral microbiology. It innovatively gives us a complete description of the oral microbial systems according to different oral ecosystems. It collects a large number of oral microbial pictures, including cultural pictures, colonies photos, and electron microscopy photos. It is by far the most abundant oral microbiology atlas consists of the largest number of pictures. In the meantime, it also described in detail a variety of experimental techniques, including microbiological isolation, culture, and identification. It is an atlas with strong practical function. The editors and writers of this book have long been engaged in teaching and research work in oral microbiology and oral microecology. This book deserves a broad audience, and it will meet the needs of researchers, clinicians, teachers, and students major in biology, dental medicine, basic medicine, or clinical medicine. It can also be used to facilitate teaching and international academic exchanges.
Tropical Diseases in China: Schistosomiasis (Public Health in China #5)
by Xiao-Nong ZhouThis book introduces the changing patterns of schistosomiasis transmission in China at different stages. Arduous efforts have been made in the last 7 decades to control and eliminate schistosomiasis in China using various control strategies, such as snail control to reduce the intensity of the disease transmission, morbidity control to reduce disease prevalence, and integrated control strategies to block the disease transmission, supported by governments at different levels. This book also presents the scientific progresses which technically support the control and surveillance of schistosomiasis in the field. It summarizes the working mechanism and control strategies of multi-sectoral collaboration to promote the national control programme leading to schistosomiasis elimination eventually.
Statistical Methods in Diagnostic Medicine
by Xiao-Hua Zhou Nancy A. Obuchowski Donna K. McclishA new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample size calculations Correcting techniques for verification and imperfect standard biases Sample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effects Three case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS®, and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics.
Oncoplastic surgery
by Xiao Zhou Yilin Cao Wei WangThis book introduces oncoplastic surgery as an interdisciplinary branch of oncological surgery that integrates theories and technologies in oncological surgery, plastic surgery and microsurgery with characteristics of planned radical resection of tumors and one-stage repair and reconstruction of surgical defects on the basis of multidisciplinary treatment (MDT) of tumors. Consisting of 23 chapters, the book covers a range of surgical topics related to oncoplastic surgery in clinical disciplines, with a focus on oncology surgery, plastic surgery, microsurgery, vascular surgery, otolaryngology-head and neck surgery, neurosurgery, oral and maxillofacial surgery, breast surgery, urinary surgery, gynecologic oncology, bone surgery, thoracic surgery and abdominal surgery. In most of the surgical cases oncology surgery is combined with plastic surgery. The book summarizes the basic theories and clinical experiences in oncoplastic surgery, focusing on repair and aesthetic reconstruction after tumor removal, which increases patients' survival rate and significantly improves their quality of life. It is a valuable reference resource for tumor surgeons, plastic surgeons, head and neck surgeons, breast surgeons as well as surgeons in other relevant fields.
Mammalian Cell Cultures for Biologics Manufacturing
by Weichang Zhou Anne KantardjieffVolumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism
by Shufeng ZhouCytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners. This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research. Cytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.
Multimodality Imaging: For Intravascular Application
by Qifa Zhou Zhongping ChenThis book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.
Atlas of Digestive Endoscopic Resection
by Pinghong Zhou Liqing Yao Xinyu QinDigestive Endoscopic Resection provides a minimally invasive method of diagnosing and treating gastrointestinal cancer. This book contains a comprehensive and detailed introduction to this technique. It includes preoperative preparation, surgical methods, intraoperative complications and postoperative management of advanced endoscopic procedures. It mainly focuses on endoscopic submucosal dissection (ESD) and endoscopic submucosal tunneling technologies, such as peroral endoscopic myotomy (POEM) and submucosal tunneling endoscopic resection (STER). This book presents essential surgical steps and diagnostic illustrations of these fast developing techniques. It provides a theoretical basis and valuable technical guidance for experts to perform ESD and summarizes this new treatment of gastrointestinal disease not only early cancers but also other gastrointestinal disorders including esophageal achalasia, etc. The Atlas of Digestive Endoscopic Resection will serve as an ideal reference for physicians and surgeons involved in endoscopic minimally invasive surgery. Editors Pinghong Zhou, Liqing Yao and Xinyu Qin are professors at Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
Computational Peptidology (Methods in Molecular Biology #1268)
by Peng Zhou Jian HuangIn this volume expert researchers detail in silico methods widely used to study peptides. These include methods and techniques covering the database, molecular docking, dynamics simulation, data mining, de novo design and structure modeling of peptides and protein fragments. Chapters focus on integration and application of technologies to analyze, model, identify, predict, and design a wide variety of bioactive peptides, peptide analogues and peptide drugs, as well as peptide-based biomaterials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Computational Peptidology seeks to aid scientists in the further study into this newly rising subfield.
Practical Genitourinary Pathology: Frequently Asked Questions (Practical Anatomic Pathology)
by Ming Zhou Ximing J. YangThis book serves as a practical guide and provides updates in Genitourinary (GU) Pathology. By using a “Questions and Answers” format, it addresses frequently encountered diagnostic challenges in daily practice for pathologists. Emphasis is placed on diagnosis and differential diagnosis based on morphological characteristics, clinicopathologic correlation, and interpretation of immunohistochemical and other ancillary tests. Concise answers to each question are provided by experts in the field accompanied by ample high quality illustrations and updated references. This book includes common and rare benign and malignant conditions in the GU system, covering the entire genitourinary system including the prostate, kidney, bladder, testis, urethra, ureter, penis and adrenal. It also reviews current topics, controversies and diagnostic dilemmas in diagnostic GU pathology. Practical Genitourinary Pathology serves as a quick reference for busy practicing pathologists, pathologists in training, urologists, medical students, and other physicians with questions of genitourinary conditions.
Prostate Biopsy Interpretation: An Illustrated Guide
by Ming Zhou Rajal B. ShahThis book covers all the practical issues related to the interpretation of prostatic biopsies in day-to-day practice, including: biopsy sampling and processing; the diagnosis of limited cancer; differentiation of prostate cancers from benign lesions and recognition of histologic variants; the recognition and clinical significance of "atypical" diagnoses and HGPIN; the identification of recently described entities; the contemporary approach to Gleason grading; the utility of immunohistochemical markers and emerging molecular markers; and the reporting of prostate biopsies. Algorithms, flow charts, and tables are used throughout to simulate the thought and decision-making process upon encountering common clinical scenarios during sign-out of prostate biopsy. The book is richly illustrated with carefully selected, high-quality color images and will appeal especially to practicing surgical pathologists as well as pathology residents and fellows in training.
Prostate Biopsy Interpretation: An Illustrated Guide
by Ming Zhou Rajal B. ShahThis book retains the core contents of the successful first edition and covers all the practical issues related to prostate biopsy diagnosis in day-to-day practice. It uses abundant algorithms, flow charts, and tables to simulate a pathologist’s thought process and assist decision making during evaluation of prostate biopsies. Chapters address the most effective ways to evaluate a prostate biopsy and how to formulate a diagnostic approach upon encountering a specific clinical problem. Pertinent new information is incorporated in all chapters, particularly in how novel diagnostic tools such as MRI and genomic tests may affect prostate biopsy practice and diagnosis. An entirely new chapter on pattern-based approaches to prostate biopsy interpretation has been added.The second edition of Prostate Biopsy Interpretation: An Illustrated Guide is not meant to be an all-encompassing, definitive bibliography of pathology of prostate cancer. Instead, it provides practicing surgical pathologists and trainees a quick and handy reference for all the practical issues relevant to day-to-day interpretation of prostate biopsy.
Large-Scale Annotation of Biomedical Data and Expert Label Synthesis and Hardware Aware Learning for Medical Imaging and Computer Assisted Intervention: International Workshops, LABELS 2019, HAL-MICCAI 2019, and CuRIOUS 2019, Held in Conjunction with MICCAI 2019, Shenzhen, China, October 13 and 17, 2019, Proceedings (Lecture Notes in Computer Science #11851)
by Luping Zhou Nicholas Heller Yiyu Shi Yiming Xiao Raphael Sznitman Veronika Cheplygina Diana Mateus Emanuele Trucco X. Sharon Hu Danny Chen Matthieu Chabanas Hassan Rivaz Ingerid ReinertsenThis book constitutes the refereed joint proceedings of the 4th International Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis, LABELS 2019, the First International Workshop on Hardware Aware Learning for Medical Imaging and Computer Assisted Intervention, HAL-MICCAI 2019, and the Second International Workshop on Correction of Brainshift with Intra-Operative Ultrasound, CuRIOUS 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2019, in Shenzhen, China, in October 2019. The 8 papers presented at LABELS 2019, the 5 papers presented at HAL-MICCAI 2019, and the 3 papers presented at CuRIOUS 2019 were carefully reviewed and selected from numerous submissions. The LABELS papers present a variety of approaches for dealing with a limited number of labels, from semi-supervised learning to crowdsourcing. The HAL-MICCAI papers cover a wide set of hardware applications in medical problems, including medical image segmentation, electron tomography, pneumonia detection, etc. The CuRIOUS papers provide a snapshot of the current progress in the field through extended discussions and provide researchers an opportunity to characterize their image registration methods on newly released standardized datasets of iUS-guided brain tumor resection.
Knowledge Sharing in Chinese Hospitals
by Lihong Zhou José Miguel Baptista NunesThis book aims to identify, understand and qualify barriers to the patient-centred knowledge sharing (KS) in interprofessional practice of Traditional Chinese Medicine (TCM) and Western Medicine (WM) healthcare professionals in Chinese hospitals. This collaboration is particularly crucial and unique to China since, contrary to Western practice, these two types of professionals actually work together complimentary in the same hospital. This study adopted a Grounded Theory approach as the overarching methodology to guide the analysis of the data collected in a single case-study design. A public hospital in central China was selected as the case-study site, at which 49 informants were interviewed by using semi-structured and evolving interview scripts. The research findings point to five categories of KS barriers: contextual influences, hospital management, philosophical divergence, Chinese healthcare education and interprofessional training. Further conceptualising the research findings, it is identified that KS is mostly prevented by philosophical and professional tensions between the two medical communities. Therefore, to improve KS and reduce the effects of the identified barriers, efforts should be made targeted at resolving both types of tensions. The conclusion advocates the establishment of national policies and hospital management strategies aimed at maintaining equality of the two medical communities and putting in place an interprofessional common ground to encourage and facilitate communication and KS.
Ion Channels in Biophysics and Physiology (Advances in Experimental Medicine and Biology #1349)
by Lei ZhouThis book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells from the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse function including secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, researches on ion channels carry significant meaning for the understanding of basic protein biophysics and diverse physiological functions and for developing novel and effective treatment for related human diseases. This book could provide graduates and scientists in both basic and clinical levels, a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.
A Case-Based Guide to Neuromuscular Pathology
by Lan Zhou Dennis K. Burns Chunyu CaiThis book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss clinical and pathological differential diagnosis, update the individual disease management, and summarize pertinent clinical and pathology pearls for each case. A Case-Based Guide to Neuromuscular Pathology will function as an indispensable reference for neurologists and pathologists looking to understand the utility of muscle, nerve, and skin biopsies. This book will also aid neurology residents, neuromuscular fellows and neuropathology fellows in preparing for questions related to the muscle and nerve pathology in their in-service and board exams.
Radiology of Infectious and Inflammatory Diseases - Volume 5: Musculoskeletal system
by Jun Zhou Hongjun Li Shinong PanThis book offers a systematic coverage of diagnostic imaging in infectious and inflammatory diseases in musculoskeletal system. The first part is devoted to a general review of infectious diseases in musculoskeletal system, as well as pathogenic classification, imaging techniques, pathogenic and imaging characteristics. In the following parts, imaging interpretation of typical infectious and inflammatory diseases affecting bone, joint, and soft tissue is described. Each disease is clearly illustrated using cases combined with high-resolution CT, MRI and PET. The book provides a valuable reference source for radiologists and doctors working in the area of infectious and inflammatory diseases.
Microtubule Protocols
by Jun ZhouThis book presents a comprehensive collection of essential and up-to-date methods for studying both the biology of microtubules and the mechanisms of action of microtubule-interacting drugs. The book contains a straightforward presentation of readily reproducible protocols, tips for troubleshooting, and advice on avoiding common mistakes. Basic scientists and clinical researchers will benefit from this collection.
Multi-Drug Resistance in Cancer
by Jun ZhouWith the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.
Respiratory Monitoring in Mechanical Ventilation: Techniques and Applications
by Jian-Xin Zhou Guang-Qiang Chen Hong-Liang Li Linlin ZhangThis book covers the up-to-date advancement of respiratory monitoring in ventilation support as well as detecting the physiological responses to therapeutic interventions to avoid complications. Mechanical ventilation nowadays remains the cornerstone in life saving in critically ill patients with and without respiratory failure. However, conclusive evidences show that mechanical ventilation can also cause lung damage, specifically, in terms of ventilator-induced lung injury.Respiratory monitoring encloses a series of physiological and pathophysiological measurements, from basic gas exchange and ventilator wave forms to more sophisticated diaphragm function and lung volume assessments. The progress of respiratory monitoring has always been accompanied by advances in technology. However, how to properly conduct the procedures and correctly interpret the data requires clear definition.The book introduces respiratory monitoring techniques and data analysis, including gas exchange, respiratory mechanics, thoracic imaging, lung volume measurement, and extra-vascular lung water measurement in the initial part. How to interpret the acquired and derived parameters and to illustrate their clinical applications is presented thoroughly. In the following part, the applications of respiratory monitoring in specific diseases and conditions is introduced, including acute respiratory distress syndrome, obstructive pulmonary diseases, patient-ventilator asynchrony, non-invasive ventilation, brain injury with increased intracranial pressure, ventilator-induced diaphragm dysfunction, and weaning from mechanical ventilation.This book is intended primarily for ICU physicians and other practitioners including respiratory therapists, ICU nurses and trainees who come into contact with patients under mechanical ventilation. This book also provides guidance for clinical researchers who take part in respiratory and mechanical ventilation researches.
ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development
by Honghui Zhou Frank-Peter TheilWith an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs• Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines• Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan• Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
by Honghui Zhou Diane R. MouldThorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.
Urinary Bladder Pathology
by Haijun Zhou Charles C. Guo Jae Y. RoThis book focuses on bladder cancer pathology, including primary bladder malignancies and other tumor varieties, with an emphasis on diagnostic pitfalls and clinical relevance. It also describes normal bladder histology, benign abnormalities with cancer mimickers, and cancer carcinogenesis, which are important subject matter for understanding bladder cancers, correct diagnosis, and differential diagnoses. Accurate diagnosis of bladder cancer plays a central role in daily pathology practice, clinical management, and prognosis. Advances in immunohistochemistry and molecular pathology have enhanced the accuracy of cancer pathology diagnoses. In addition to covering the anatomic and histologic features of bladder tumors, this book also reviews recent molecular and immunohistochemical advances in these areas. Recently updated clinical management information is also presented in this book.Written by experts in the field, Urinary Bladder Pathology serves as a useful resource for practicing pathologists, pathology trainees, and other health professionals who treat patients with bladder cancers.
Implantable Neural Prostheses 1
by David Zhou Elias GreenbaumThis book and its companion volume describe state-of-the-art advances in techniques associated with implantable neural prosthetic devices and their applications. Researchers, engineers, clinicians, students and any specialist in this field will gain a deeper understanding of the neural prosthetic techniques currently available for a wide range of biomedical applications. In part one of this two-volume sequence, Implantable Neural Prostheses 1: Devices and Applications, the focus is on implant designs and applications. Devices covered include sensory prosthetic devices such as cochlear implants, auditory midbrain implants, visual implants, spinal cord stimulators, and motor prosthetic devices including deep brain stimulators, Bions, and cardiac electro-stimulators. Readers will also understand the regulatory approval process in the U.S. and Europe for implantable medical devices.
Applied Missing Data Analysis in the Health Sciences
by Chuan Zhou Xiao-Hua Zhou Danping Lui Xaiobo DingA modern and practical guide to the essential concepts and ideas for analyzing data with missing observations in the field of biostatisticsWith an emphasis on hands-on applications, Applied Missing Data Analysis in the Health Sciences outlines the various modern statistical methods for the analysis of missing data. The authors acknowledge the limitations of established techniques and provide newly-developed methods with concrete applications in areas such as causal inference methods and the field of diagnostic medicine.Organized by types of data, chapter coverage begins with an overall introduction to the existence and limitations of missing data and continues into traditional techniques for missing data inference, including likelihood-based, weighted GEE, multiple imputation, and Bayesian methods. The book's subsequently covers cross-sectional, longitudinal, hierarchical, survival data. In addition, Applied Missing Data Analysis in the Health Sciences features:Multiple data sets that can be replicated using the SAS®, Stata®, R, and WinBUGS software packagesNumerous examples of case studies in the field of biostatistics to illustrate real-world scenarios and demonstrate applications of discussed methodologiesDetailed appendices to guide readers through the use of the presented data in various software environmentsApplied Missing Data Analysis in the Health Sciences is an excellent textbook for upper-undergraduate and graduate-level biostatistics courses as well as an ideal resource for health science researchers and applied statisticians.