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Training Your Shih Tzu (Training Your Dog Series)
by Joan Hustace WalkerFirst-time owners and dog lovers will rejoice at this veterinarian-approved dog training book! Training Your Shih Tzu provides advice on physical and behavioral characteristics you should look for when choosing a puppy, along with recommended training.Affectionate and confident, Shih Tzus make wonderful pet companions. As part of the Training Your Dog series, Training Your Shih Tzu focuses on this unique breed, describing its physical traits, history, and behavior. Best of all, Training Your Shih Tzu provides essential training methods for owners! Important topics covered include:What to look for when choosing a puppyLiving with a dog and understanding breed-specific traitsEveryday care, grooming, and exerciseNutrition, health maintenance, and potential breed-specific health problemsTraining and play activitiesAll books in this dog training series are spiral bound and contain full-color photos. Informative sidebars are full of breed facts, helpful hints, and quick tips on training. Plus, every book comes with an instructional DVD with a dog training course for new owners!Want to learn about even more dog breeds?The Training Your Dog series is a wonderful collection of titles focused on pairing owners with the best breed for their family, and training each breed in accordance with their characteristics. Other books in the series include, Boxers, Great Danes, Pugs, Golden Retrievers, Labrador Retrievers, Australian Shepherds, Pit Bulls, and more!
A Traitor Among the Boys
by Phyllis Reynolds NaylorThe Hatford boys' New Year's resolution is "the girls can stay . . . but only if they play by our rules." Their mother insists that they "treat those girls as though they were your sisters." Okay, but somehow the boys' interpretation owes more to sibling rivalry than to brotherly love. The one weak link is young Peter, who doesn't understand the rivalry, openly likes the girls, and sees nothing wrong with sitting in their kitchen eating homemade cookies and answering questions about his brothers' plans. Readers will find themselves laughing out loud at the pranks, the conversations, and one unforgettably embarrassing moment. The high-flying humor is juxtaposed with the budding affection between Josh and Beth and the way all the children pull together during a blizzard. The fifth entry in Naylor's refreshing series chronicling the feud between the Hatfords and the Malloys.From the Hardcover edition.
A Traitor Among the Boys (Boys Against Girls #5)
by Phyllis Reynolds NaylorAfter all the trouble at Christmas, the Hatford boys make a New Year's resolution to treat the Malloy girls like sisters. But who says you can't play tricks on sisters? The girls will need to stay one step ahead of the boys, and they are willing to pay big-time for advance information. But which boy has loose lips? For ages 9-12.
Traitor's Son: The Raven Duet Book #2 (The Raven Duet #No. 2)
by Hilari BellIn Trickster's Girl, when Kesla's journey comes to an end, she passes the pouch and the quest on to someone else. She picks Jason, a native boy she thinks will be able to finish the job. But in fact, a family feud has cut Jason off from his traditional roots, and he is even more doubtful and resistant than Kesla was. But Raven, now a beautiful girl, is quite persuasive and manages to convince Jason this is something not only that he can do, but that he must if he wants to heal his family and the earth.
Transboundary Animal Diseases in Sahelian Africa and Connected Regions
by Moustafa Kardjadj Adama Diallo Renaud LancelotThis book primarily focuses on the African Sahel region, shedding new light on the epidemiology, socio-economics, clinical manifestations and control approaches of transboundary animal diseases (TADs) in this specific region. In addition to the description of TADs in Sahelian Africa and connected regions, several issues regarding the burden of TADs, the role of national/regional/international veterinary organizations in the surveillance process, animal mobility, one health and TADs in the dromedary are discussed. The book contains 22 chapters and is structured in three parts, i- general features and commonalities, ii- viral diseases, iii- bacterial diseases. Each chapter was written by a group of experts specialized in the topic. This work will be of general interest to researchers, veterinarians, veterinary public health officers, and students engaged in the surveillance and control of animal infectious diseases, included those of zoonotic nature and that are prevalent in the Sahel.
Transcriptomics in Entomological Research
by May R Berenbaum Bernarda Calla Joanna C. Chiu Jürgen Ehlting Melanie Gee Aman Gill Martin Hasselmann Matthew Huff Brian R Johnson Juan Luis Jurat-Fuentes William E Klingeman Kyle M. Lewald Shanlin Liu Antonino Malacrinò Guanliang Meng Yoonseong Park Amber Rose Paulson Steven J Perlman Ratnasri Pothula Sampurna Sattar Margaret E Staton James P Tauber Gary A Thompson Patrick Von Aderkas Will Kipling Chengran ZhouBridging the gap between genome and phenotype, the transcriptome is a molecular-level snapshot of the act of living. Transcriptomics shows which genes are expressed into proteins in a specific tissue of a specific organism at a specific time and condition. This book gives an account of the extraordinary diversity of ways transcriptomics has been and can be utilised in basic and applied entomological research. It encompasses a vast range of disciplines within entomology, applying transcriptomics to the study of over one million described species of insects. It covers a vast range of disciplines from phylogenomics to pest management, from ecology to physiology, and from behavior to evolutionary biology. The book covers the breadth and depth of transcriptomics use in research to showcase the utility of this technology in all disciplines. Research examples in the book are relevant to fish, birds, plants, and fungi, as well as insects and other arthropods, helping scientists in any field, using any system, to understand what transcriptomics can do for them. The book: Introduces transcriptomics theory and practice for researchers of all levels wishing to gain an insight into how to apply these techniques to their own fields. Showcases the myriad ways transcriptomics can be used to answer biological questions. Is written by a team of international experts describing their own experiences, giving guidance for applying it to the reader's own work. Reviews how transcriptomics research has helped entomologists push their fields further and make new discoveries.
Transfarmation: The Movement to Free Us from Factory Farming
by Leah GarcésThe story of factory farmers, rescued farm animals, and rural communities standing up to big corporations and constructing their own new world that will change the way we eatIn Transfarmation, president and CEO of Mercy For Animals Leah Garcés explains how food and farming policies have failed over decades and offers insights into the wave of change coming from a new crop of farmers and communities who are constructing a humane and sustainable farming system. Factory animal farming faces an abundance of issues—from environmental concerns and animal cruelty, to exploited farmers and poor working conditions—and more and more farmers are searching for a way out and for a new start.Using insights from interviews and fieldwork, Garcés shares the perspectives of three groups:—Farmers—such as the Halley farm, where a family crushed by chicken factory farming builds a new way by transitioning their farm to growing hemp and rescuing dogs.—Animals—like Norma, an industrial dairy cow who was sentenced to death after injuring a worker in an effort to protect her calf.—Farm communities—including stories like how the hog industry in North Carolina preys on historically Black communities by contaminating the air and water for decades with hog pollution.Garcés demonstrates the reasons why we must end factory farming and calls on readers to imagine a future world where Transfarmation is complete and we have transitioned to a just food and farming system.
Transforme a su perro en un ángel: Cómo hablar para que su perro le escuche. Para todas las razas
by Angel Meadows¡DESCUBRA CÓMO PUEDE TRANSFORMAR A SU PERRO EN UN ÁNGEL HOY MISMO! Muchas personas traen a casa un perro recién salido del refugio o del criador pensando que es una bendición. Piensan que tienen un pequeño paquete de alegría que parece un osito de peluche. Pero la vida rara vez se queda en una fase de felicidad sin obstáculos. Aunque ame a su cachorro más que a nada, se encuentra con problemas, se frustra, se agobia y empieza a cuestionarse si tomó la mejor decisión al traerlo. Todos los días hay personas que luchan por no saber qué hacer con sus perros. Esto puede deberse a problemas de comportamiento comunes, como la agresividad o la hiperactividad, puede deberse a la falta de voluntad para cumplir órdenes importantes, o puede ser que el cuidador del perro no sepa por dónde empezar con el adiestramiento. No es de extrañar que tanta gente esté perdida,. Durante décadas, se han difundido información errónea y teorías falsas sobre el adiestramiento de perros. Algunos de estos métodos de adiestramiento son tan perjudiciales que han provocado tendencias agresivas en los perros. Esto no es culpa de nadie, ya que los dueños del perro sólo seguían consejos malintencionados con la esperanza de ayudar a su perro. Pero tampoco es culpa del perro, ya que está asustado y es vulnerable, y siente que no tiene otra opción que actuar para protegerse. Afortunadamente, se puede evitar este triste desenlace al que han llegado muchas personas. Gracias a los investigadores que han dedicado su carrera a los perros, ahora entendemos qué métodos de adiestramiento causan daño y cuáles tienen éxito para ayudar tanto a los humanos como a los caninos. Ahora sabemos que las manadas de lobos son grupos viciosos que se pelean constantemente y atacan ante cualquier signo de debilidad. Los lobos son familias que se cuidan y se ayudan mutuamente. De la misma manera, usted y su perro pueden ayudarse mutuamente en su día a día, estrechando con
Transgenesis Techniques
by Elizabeth J. CartwrightOne of the major challenges currently facing the scientific community is to understand the function of the multitude of protein-coding genes that were revealed when the human genome was fully sequenced. In Transgenesis Techniques: Principles and Protocols, Third Edition, experts in the field fully update and expand upon the previous edition in order to detail the transgenic techniques currently used to modify the genome. The volume explores classic procedures to genetically modify mice and other model organisms, as well as cutting-edge practices involving microinjection, site-specific recombination systems, cryopreservation, and many other topics. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Transgenesis Techniques: Principles and Protocols, Third Edition is a comprehensive practical guide to the generation of transgenic animals and an invaluable source of information in any lab currently involved in transgenic techniques.
Transgenic and Mutant Tools to Model Brain Disorders
by Allan V. Kalueff Carisa L. BergnerAs the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In "Transgenic and Mutant Tools to Model Brain Disorders", leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful NeuromethodsTM series, the chapters provide authoritative reviews covering the most commonly used approaches in the field. Cutting-edge and concise, "Transgenic and Mutant Tools to Model Brain Disorders" offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.
Transgenic Animals
by Louis-Marie HoudebineDuring the past 20 years, transgenesis has become a popular technique and a crucial tool for molecular geneticists and biologists. Transgene expression is now better-controlled and even specifically inducible by exogenous factors. While these techniques have quite significantly transformed the experimental approaches taken by biologists, the applications are more limited than expected and concerns have arisen regarding biosafety as well as physiological, social, and philosophical issues. Transgenic Animals: Generation and Use contains articles on the techniques used to generate transgenic animals and a section on the preparation of vectors for the optimally controlled expression of transgenes. It also examines the use of transgenic animals in the study of gene function and human diseases, the preparation of recombinant proteins and organs for pharmaceutical and medical use, and the improvement of genetic characteristics of farm animals. Finally, it discusses more recent problems generated by transgenic animals including conservation of transgenic lines, specific database patenting, biosafety, and bioethics.Drawn from both academia and industry, the contributors to this monograph present in one concise volume all the relevant information on the different aspects of transgenesis. This book can be used as both a reference book and a textbook for specialized university courses and will be of interest to everyone involved in basic research in animal biology, molecular genetics, animal biotechnology, pharmaceutical science, and medicine.
Transgenic Ascidians (Advances In Experimental Medicine And Biology #1029)
by Yasunori SasakuraThis book comprehensively describes the transgenesis techniques and applied experimental methods in ascidians including enthusiastically developed original devices in addition to concrete examples of developmental biology studies. Ascidians have been one of the most important model animals in developmental biology for studying molecular and cellular processes underlying formation of the chordate body plan. Transgenic techniques such as microinjection, electropolation, cis-element analysis and application, and TALENs and CRISPR/Cas9 have been developed in ascidians for more than 20 years, and now many applied methods, some of which are unique in ascidians, have been accumulated. Those extensive technological innovations, such as cell isolation, cell labeling, germ-line transformation, marker transgenic lines, and the experimental systems for studying notochord formation and nervous system, are exceptional particularly in marine invertebrates. This book is useful for ascidian researchers to quickly access the techniques in which they are interested as well as to compare each technology to become familiar with specialized tips, and for biologists of other organisms to learn the unique techniques and ingenious attempts specific to ascidians. Providing detailed and easily understandable descriptions of techniques, the book will inspire ascidian specialists to improve their techniques, encourage anyone wanting to begin studying ascidians, and enable readers to immediately apply the techniques to the organisms they research.
Transgenic Cotton: Methods And Protocols (Methods in Molecular Biology #958)
by Baohong ZhangThis second edition provides a comprehensive collection of the cutting-edge methods for creating and monitoring transgenic cotton and its application on agricultural and basic research. Chapters detail current status and perspectives of transgenic cotton, principle and methods for making transgenic cotton, creating gene knockout lines, foreign gene copy and expression in transgenic plants, improvements to cotton using transgenic technology, and monitoring the potential impact of transgenic cotton on environment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfallsAuthoritative and cutting-edge, Transgenic Cotton: Methods and Protocols 2nd aims to be a resource for scientists as well as graduate students who work on transgenic plants, plant genetics, molecular biology, and agricultural sciences.
Transgenic Insects: Techniques and Applications (CABI Biotechnology Series #3)
by Hassan M. Ahmed Omar S. Akbar Serap Aksoy Yehonatan Alcalay Luke Alphey Yael Arien Rotem Daniel Avraham Camilla Beech Nicholas J. Bongio Vanessa Bottino-Rojas L. Roman Carrasco Lucy Carter Jackson Champer Isabelle Coche Carolina Concha Rocco D’Amato Brinda Dass Jason A. Delborne Ellen M. Dotson Ravi V. Durvasula Matthew P. Edgington Claudia Emerson Guido Favia Adam P. Forshaw Alexander W.E. Franz Marisa L. Guido Monika Gulia-Nuss Daniella An Haber Andrew Hammond Alfred M. Handler Keith R. Hayes Ivy Hurwitz Anthony A. James Thomas P. Kelly Nicole Klein Ana Kormos Lee Benjamin Lamdan David J. Lampe Rosemary S. Lees Maria Vittoria Mancini Aditi Mankad John Mumford Tony Nolan Andrew Nuss David A. O’Brochta Riccardo Papa Philippos Aris Papathanos Michael Pham Ricardo Pereira Megan Quinlan Robyn Raban Jason L. Rasgon Aaron Roberts Yasha Rohwer Nathan Rose Marc F. Schetelig Kristof De Schutter Hideki Sezutsu Arvind Sharma Gregory S. Simmons Guy Smagghe Toshiki Tamura Delphine Thizy Lea Pare Toe Brian L. Weiss Ernst A. Wimmer Liu YangTechnology for modifying the genotypes and phenotypes of insects and other arthropods has steadily progressed with the development of more precise and powerful methods, most prominently transgenic modification. For many insect pests, there is now almost unlimited ability to modify phenotypes to benefit human health and agriculture. Precise DNA modifications and gene drive have the power to make wild-type populations less harmful in ways that could never have been performed with previous transgenic approaches. This transition from primarily laboratory science to greater application for field use has also necessitated greater development of modeling, ethical considerations and regulatory oversight. The 2nd Edition of Transgenic Insects contains chapters contributed by experts in the field that cover technologies and applications that are now possible. This edition includes increased attention to associated challenges of risk assessment, regulation, and public engagement. Featuring: Up-to-date analysis of molecular techniques, such as gene editing. Consideration of public attitudes and regulatory aspects associated with transgenic insects. Many examples of the wide range of applications of transgenic insects. This book will be very valuable to students and researchers in entomology, molecular biology, genetics, public health and agriculture, and will also appeal to practitioners who are implementing the technology, and to regulators, stakeholders and ethicists.
Transgenic Maize
by M. Paul ScottAs increasing global population and continuing economic development ensure the need for further production and cultivation of maize, the necessity of the application of transgenic technology to this model species and crop plant grows steadily. In Transgenic Maize: Methods and Protocols, experts in the various disciplines of the field contribute readily reproducible protocols covering such topics as transformation methods, transgenic maize in research, the analysis of transgenic plants, and breeding with transgenes. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters present brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, Transgenic Maize: Methods and Protocols will greatly aid researchers wishing to use these procedures in their own laboratories, and will provide readers with a better understanding of the experiments being performed by cooperators or fee-for-service labs.
Transgenic Mouse: Methods and Protocols (Methods in Molecular Biology #2066)
by Melissa A. LarsonThis volume provides readers with a historical foundation in standard techniques and a comprehensive update on the latest methods used in making gene-modified mice. The chapters in this book cover topics such as pronuclear microinjection in one-cell embryos; embryo transfer surgery; nuclear transfer and cloning; blastocyst microinjection; and cryobanking and recovery of genetically modified mice. Importantly, there are chapters devoted to the latest application of CRISPR technology, as well as the establishment of induced pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and authoritative, Transgenic Mouse: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Transgenic Mouse Methods and Protocols
by Marten H. Hofker Jan Van DeursenMarten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
Transgenic Mouse Methods and Protocols, 2nd Edition
by Jan Van Deursen Marten H. HofkerMarten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.<P><P> Fully updated from the first edition to offer cutting-edge methods for generation of transgenic mouse models
Transgenic Plants
by Leandro PeñaA collection of readily reproducible techniques for the genetic transformation and regeneration of plants. The authors cover the most commonly used transformation systems for the regeneration of whole transgenic plants. Among the techniques discussed for the detection of transgenes are quantitative real-time PCR, RT-PCR, in situ hybridization, FISH, and TAIL-PCR. Risk assessment methods offer the opportunity to study Agrobacterium persistence in plant tissues and to investigate the possibility of transgene dispersal. The protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Transgenic Plants
by Andy C Wetten Jim M. DunwellIn 2010 the global area of transgenic crops reached 148 million hectares, an 87-fold increase since 1996, making it the most rapidly adopted technology in the history of modern agriculture. In Transgenic Plants: Methods and Protocols, Second Edition expert researchers in the field provide key techniques to investigate production and analysis of transgenic plants. Focusing on selection and detection methods, transformation technology, gene targeting, silencing and directed mutation, metabolic engineering and pharming, the book encompasses protocols relating to major crops and model plants being used for genomic analysis. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Transgenic Plants: Methods and Protocols, Second Edition aids scientists in the continuous improvements being made for the production and analysis of transgenic plants.
Transgenic Wheat, Barley and Oats
by Huw D. Jones Peter R. ShewryThe understanding of the physical and genetic structure of plant genomes and the determination of phenotypes via interactions of coding and non-coding regions with the environment has quickly become the key to the future of plant breeding and agriculture. In Transgenic Wheat, Barley and Oats: Production and Characterization Protocols, expert investigators contribute the latest protocols for the transformation, regeneration and selection of these three species, using both biolistics and Agrobacterium tumefaciens, in order to fill the need for techniques and resources in this vital area of research. Covering such topics as in vitro Agrobacterium co-cultivation, the manipulation of gene expression, and GM risk assessment, this versatile collection focuses on the study of temperate small grain cereals while many of its readily reproducible procedures could be easily adapted to accommodate other cereals and plants. The in-depth chapters adhere to the highly successful Methods in Molecular BiologyTM series format, featuring brief introductions to the subject, lists of the necessary materials and reagents, step-by-step laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Transgenic Wheat, Barley and Oats: Production and Characterization Protocols is an ideal guide for scientists pursuing this powerful, forward-thinking genetic strategy.
Transhumanism and Society
by Stephen LilleyThis book provides an introductory overview to the social debate over enhancement technologies with an overview of the transhumanists' call to bypass human nature and conservationists' argument in defense of it. The author present this controversy as it unfolds in the contest between transhumanists proponents and conservationists, who push back with an argument to conserve human nature and to ban enhancement technologies. This book provides an overview of the key contested points and present the debate in an orderly, constructive fashion. Readers are informed about the discussion over humanism, the tension between science and religion, and the interpretation of socio-technological revolutions; and are invited to make up their own mind about one of the most challenging topics concerning the social and ethical implications of technological advancements.
Transitions Between Sexual Systems: Understanding the Mechanisms of, and Pathways Between, Dioecy, Hermaphroditism and Other Sexual Systems
by Janet L. LeonardThis book focuses on explaining the distribution of sexual systems (simultaneous hermaphroditism, sequential hermaphroditism, environmental sex determination,dioecy, androdioecy, etc.) among taxa, which remains a major challenge in evolutionary biology. Although significant advances have been made for angiosperms, there is not yet a theory that predicts the sexual system for the majority of animal taxa, and other taxa of plants also remain poorly understood. The problem, particularly for animals, is that sexual systems can be very conservative, with whole phyla and classes being characterized by a single sexual system; for example essentially the whole phylum Platyhelminthes is simultaneously hermaphroditic, whereas the Insecta (Hexapoda) and the Tetrapoda among the vertebrates, are exclusively dioecious. Sex allocation theory on the other hand, suggests that sexual systems should be highly responsive to evolution, changing with population density, life span, patterns of resource availability, etc. The book provides an overview of the topic and then presents a series of chapters, each dealing with a taxon with substantial lability in sexual system in order to identify the factors associated with changes in sexual system in each case. By doing so, the authors reveal factors that have not been considered in formal theory but seem to have a major impact on transitions between sexual systems.This book appeals to a wide readership in fields from zoology and evolutionary biology to botany.
Translational Stroke Research
by Paul A. Lapchak John H. ZhangThis volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.
The Transmogrification of Roscoe Wizzle
by David Elliott"The wacky plot and quirky details ... will appeal to young and reluctant readers who like their fiction light and offbeat."-- School Library Journal. Roscoe Wizzle used to be a normal ten-year-old kid. But that was before a sign reading Coming soon! GUSSY'S! sprang up in a vacant lot. A sign showing Gussy Gorilla eating a Jungle Drum--just about the biggest hamburger in the world. Roscoe Wizzle, hamburger fan, was a normal kid all right until he started turning into a bug! David Elliott's debut novel takes a hilarious and surreal look at what can happen when you get too much of a good thing.