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Brain and Heart Crosstalk (Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks)
by Hemanshu Prabhakar Indu KapoorThis book discusses the underlying mechanisms connecting the brain and heart. The physiology of the brain is such that it is easily affected by any altered physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together, the brain and heart control our body systems, allowing them to function automatically. This interaction between the brain and other systems makes it important for us to understand how any kind of injury to the brain can produce complications in remote organs or systems, such as the heart. The central nervous system is responsible for vegetative function and is central to homeostasis. Further, central nervous system responses are linked to the ongoing function of other organ systems e.g. feeding, thermoregulation, reproduction and muscle activity. It is therefore logical that neural control of the cardiovascular system must also interact with the neural control of other organ systems. This book explains in detail stressed cardiac conditions, discussing the pathophysiology and proposed treatment, and also describing lesser-known crosstalks between the acutely or chronically affected brain and heart.
Brain and Lung Crosstalk (Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks)
by Hemanshu Prabhakar Charu MahajanThe central nervous system, which includes the brain and spinal cord, has a high metabolic demand. The physiology of the brain is such that it is easily affected by alterations in other systems, which in turn can compromise cerebral blood flow and oxygenation. Together the brain and spinal cord control the automatic function of our body systems. While other systems of body controls individual functions, central nervous system at the same time does many different functions, especially, controlling the function of other systems. This interaction between the brain and other systems is important when it comes to understanding how injuries to the brain can, at times, produce complications in remote organs or systems of the body, such as the lungs. This book explains the lesser-known crosstalks between acutely or chronically affected brain and lung, describing the pathophysiology of the lung following brain injury and discussing in detail the conflicts between the brain and lungs in relation to the tidal volumes, positive end-expiratory pressures, arterial carbon dioxide and oxygen levels, recruitment maneuvers and positioning, as well as potential therapeutic targets.
Brain-Computer Interface Technologies: Accelerating Neuro-Technology for Human Benefit
by Claude ClémentThis book is about the field of brain-computer interfaces (BCI) and the unique and special environment of active implants that electrically interface with the brain, spinal cord, peripheral nerves, and organs. At the heart of the book is the matter of repairing and rehabilitating patients suffering from severe neurologic impairments, from paralysis to movement disorders and epilepsy, that often requires an invasive solution based on an implanted device. Past achievements, current work, and future perspectives of BCI and other interactions between medical devices and the human nervous system are described in detail from a pragmatic point of view.Reviews the Active Implantable Medical Devices (AIMDs) industry and how it is moving from cardiac to neuro applicationsClear, easy to read, presentation of the field of neuro-technologies for human benefitProvides easy to understand explanations about the technical limitations, the physics of implants in the human body, and realistic long terms perspectives
Brain-Computer Interfaces: Revolutionizing Human-Computer Interaction (The Frontiers Collection #6)
by Gert Pfurtscheller Bernhard Graimann Brendan Z. AllisonA brain-computer interface (BCI) establishes a direct output channel between the human brain and external devices. BCIs infer user intent via direct measures of brain activity and thus enable communication and control without movement. This book, authored by experts in the field, provides an accessible introduction to the neurophysiological and signal-processing background required for BCI, presents state-of-the-art non-invasive and invasive approaches, gives an overview of current hardware and software solutions, and reviews the most interesting as well as new, emerging BCI applications. The book is intended not only for students and young researchers, but also for newcomers and other readers from diverse backgrounds keen to learn about this vital scientific endeavour.
Brain Development: Methods and Protocols (Methods in Molecular Biology #2047)
by Simon G. SprecherThis book provides a thorough introduction to widely used techniques for the study of the intersection between developmental biology and neuroscience, an exceptional area to address and investigate impacting biological questions. The fully updated volume examines cutting-edge techniques on a representative range of animals, including widely used genetic model systems, such as the fruit fly, zebra fish, chicken, and mouse, as well as non-canonical experimental systems opened up through the advent of genome editing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Brain Development: Methods and Protocols, Second Edition is an ideal guide for researchers interested in utilizing recent technical advances in molecular genetics for the study of the brain.
Brain Development of Medaka Fish: A New Concept of Brain Morphogenesis in Vertebrates
by Yuji Ishikawa Naoyuki Yamamoto Hanako HagioThis book describes the developmental process of the brain of the medaka fish. It aims to understand the brain structure of vertebrates, including humans, by taking the brain of the medaka fish as an example and showing its actual developmental process. From developmental and evolutionary viewpoints, the understanding of the brain proceeds from simple to complex structures. Fish retain the basic form of vertebrates, and their brain morphology is relatively simple. Therefore, the fish brain is useful in understanding the brain structure. This book is unique for describing the entire process of the brain development in a specific fish. In addition, the book introduces the readers to a new concept of “Hourglass of Brain Morphogenesis”, concerning the general rule of brain morphogenesis in vertebrates. The authors propose that the brain morphology is highly conserved at the middle developmental stage but diverges more extensively at earlier and later stages. The new concept challenges the accepted theory that has been widely shared for about 200 years since K. von Baer (1828, 1837) and K. von Kupffer (1906) who proposed that three primary brain vesicles at earlier developmental stages develop into five secondary brain vesicles at later developmental stages in all vertebrates. The book provides a basic understanding of the vertebrate brain and is useful for all readers who wish to understand the complex structure of the brain.
Brain Hypoxia and Ischemia: With Special Emphasis On Development (Contemporary Clinical Neuroscience)
by Gabriel G. Haddad Shan Ping YuBrain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.
Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections (Advances in Neurobiology #6)
by Armen A. GaloyanProline-rich polypeptides - in particular (PRP-1) galarmin and its structural analogues - are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory compounds. In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides. It investigates the mechanism of galarmin's action during different infectious processes, where it targets such dangerous pathogens as Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus. This research is important from both a theoretical and a clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences. Dr. Galoyan is a pioneer of the specialized field of neuroimmunology. During his 45-year long career, he has discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins.
Bramble and the Treasure Hunt: Book 8 (Railway Rabbits #8)
by Georgie AdamsMeet the Railway Rabbits! Join the irrepressible Longears family as they get in and out of scrapes, meet new friends, and perform daring rescues. But Burdock the buzzard and the terrifying Red Dragon, are always on the lookout for naughty rabbits who stray too far from home...It's wintertime and Bramble is on a very special treasure hunt.Heartwarming, hilarious, with Anna Currey's charming illustrations, this is a brilliant new animal adventure series from a bestselling children's author.
Bramblestar's Storm: Bramblestar's Storm (Warriors Super Edition #7)
by Erin Hunter Dan Jolley James L. BarryWarriors Super Edition: Bramblestar's Storm is an epic stand-alone adventure in Erin Hunter's #1 nationally bestselling Warriors series! What happened to the warrior Clans after the events of the fourth Warriors arc, Omen of the Stars? In this never-before-told story, readers will dive into ThunderClan's continuing adventures under the leadership of Bramblestar.The Dark Forest has been defeated, and Bramblestar is now leader of ThunderClan. But the warrior cats must now weather a new kind of storm--or all four Clans will be swept away. Join the legion of fans who have discovered the epic adventures, fierce warrior cats, and thrilling fantasy world of the mega-bestselling Warriors series. This stand-alone entry is perfect for new readers and dedicated fans alike.Bramblestar's Storm also includes an exclusive ten-page Warriors manga adventure!
Branded (The Aspen Valley Series)
by Colette AuclairThe third lighthearted romance in Colette Auclair's award-winning Aspen Valley series, Branded takes us on a wild and dreamy ride through the beautiful valleys and mountains of Colorado.Professional, polite, and pearl-wearing, dressage rider and resort consultant Cordy Sims is the last person anyone would expect to initiate a weekend of debauchery. And yet, that's exactly what she does after meeting a handsome stranger at an Aspen resort. Agreeing that they'll leave personal details at the door, they indulge in a memorable weekend of carnal recreation. On Sunday night, Cordy doesn't want to leave this charming, seductive man, but she must play by her own rules. On Monday, Cordy sits in a meeting at the ad agency that's hired her as a freelancer, and her professional and personal worlds collide. Turns out agency owner Jack Cormier looks just as good in the boardroom as he did in the bedroom. Forced to work together, Cordy and Jack can't ignore the chemistry that crackles between them, or the deeper feelings that have developed. But secrets and scars from their pasts may prove too formidable, even for a love that's as powerful as it is unexpected.
The Brassica napus Genome (Compendium of Plant Genomes)
by Shengyi Liu Rod Snowdon Boulos ChalhoubThis book describes how the genome sequence contributes to our understanding of allopolyploidisation and the genome evolution, genetic diversity, complex trait regulation and knowledge-based breeding of this important crop. Numerous examples demonstrate how widespread homoeologous genome rearrangements and exchanges have moulded structural genome diversity following a severe polyploidy bottleneck. The allopolyploid crop species Brassica napus has the most highly duplicated plant genome to be assembled to date, with the largest number of annotated genes.Examples are provided for use of the genome sequence to identify and capture diversity for important agronomic traits, including seed quality and disease resistance. The increased potential for detailed gene discovery using high-density genetic mapping, quantitative genetics and transcriptomic analyses is described in the context of genome availability and illustrated with recent examples. Intimate knowledge of the highly-duplicated gene space, on the one hand, and the repeat landscape on the other, particularly in comparison to the two diploid progenitor genomes, provide a fundamental basis for new insights into the regulatory mechanisms that are coupled with selection for polyploid success and crop evolution.
BRAT: A Ghost Story
by Gabriel Smith&“Gabriel Smith has written a truly unique and surprising book. He is the rarest thing: a distinctive stylist on the line and structure level. Brat is so strange and so funny. I laughed a lot while reading.&” Rachel Connolly, author of Lazy City 'Iconic', Radio 1 'i've never heard of you. good luck with your book tho !' Charli XCX on X, formerly TwitterI was in the waiting room. Then I was in the examination room. Gabriel&’s skin is falling off. His dad is dead. He owes his editor a novel. His girlfriend won&’t answer his calls. Tasked by his horribly well-adjusted brother with clearing out the family home for sale, Gabriel&’s sanity quickly begins to unravel. His parents&’ old manuscripts appear to change each time he reads them. A bizarre home video hints at long-buried secrets. And there&’s a hideous man in the garden. Disquieting and hilarious, taut yet lyrical, blisteringly-paced but formally inventive, Brat is a mediation on grief, art and love that will leave you altered, breathless and desperate for more. From a stunningly original new talent, this is a debut novel unlike anything you have read before. &“Messy with glitched realities and body horror, Brat breathes the same thrillingly claustrophobic air as Inland Empire and Ubik. It&’s a skin-shedding ouroboros of grief and laughter, and the most brain-melting British debut I&’ve read in ages.&” Ed Park, author of Same Bed Different Dreams &“Gabriel Smith&’s prose is like if Joan Didion and Shirley Jackson took Xanax and used the internet. Brat is a sharp, eerie, confident debut about grief, memory, art, and so much more. Smith is a major new talent.&” Jordan Castro, author of The Novelist &“Gabriel Smith&’s jauntily creepy and hilarious tale of a grief-stalked scapegrace&’s sloughing-off and regeneration of selves in the filial murk of a moldering homestead is a Portrait of the Artist as a Young Man for a new, quaking generation. Brat will unnerve and seduce you.&” Garielle Lutz, author of Worsted
Brave (American Dog)
by Jennifer ShotzFrom the #1 New York Times best-selling author of Max comes a heartwarming, middle grade adventure story about a rescue dog, Brave, who befriends a troubled boy in the heart of Texas. Brave is a dog without a home. After surviving a hurricane in San Antonio, Texas, stray dog Brave is hungry and afraid. When twelve-year-old Dylan finds Brave, he&’s feeling lost himself. Dylan can&’t help but think they were brought together for a reason. But Dylan knows it&’ll take hard work and training in order to convince his parents that he can keep this skittish pup. As Dylan and Brave&’s friendship grows, they learn to rescue each other in more ways than one. Can Dylan give Brave a forever home?
Brave and Loyal: An Illustrated Celebration of Livestock Guardian Dogs
by Cat UrbigkitLearn about the brave dogs who help guard livestock around the world!Wolf populations in the Rocky Mountains have reached recovery goals due in large part to an environmentally friendly method of predator control now in use on western ranches: livestock protection dogs (also called livestock guardian dogs). Although these dogs have been used around the world for thousands of years in primitive systems of livestock production, it's only in the past four decades that they have been put to work in America in a systematic manner. Guardian dogs were imported to the United States, and their use has allowed the expansion of predator populations into areas where the animals were previously subject to lethal control. The use of guardian dogs is typical wherever livestock may encounter predators-from fox and coyotes, to wolves and grizzly bears.In Brave and Loyal, Cat Urbigkit tracks her journeys from a Wyoming sheep ranch to learn about working livestock protection dogs around the globe. Using historic accounts, published research, personal interviews on four continents, and her own experience on western rangelands, she provides the reader an intimate look into the everyday lives of working livestock protection dogs. Brave and Loyal includes details on raising successful guardians, their behaviors, a discussion of breeds and historic use, an assessment of numbers for various predator challenges, the adoption and spread of programs to place guardians on American farms and ranches, problems and benefits associated with guardian dogs, predator ploys, and matching the dog to the predator challenge. Urbigkit's work provides the best information on working livestock guardian dogs around the globe, accompanied by more than one hundred beautiful color photos.
Brave as a Mouse
by Nicolo CarozziThe friendship of a goldfish and a mouse is in jeopardy when three not-so-friendly felines want to play too. This gorgeously illustrated picture book reminds us of the importance of bravery and friendship.A goldfish and a mouse become fast friends as they play in and around the goldfish's bowl. But when three cats crash the party and terrify the poor goldfish, the brave little mouse gets an idea. She leads the three black cats on a wild and epic chase up and down and over and around until they find themselves surrounded by absolutely irresistible food in the pantry. The cats gorge themselves so much that they fall into a deep sleep, but the mouse knows they won't sleep forever. So the brave little mouse gets another idea to keep the goldfish out of harm's way for good! This is a heartwarming story with a simple text and gorgeous illustrations about the lengths one brave mouse will go to in order to save her friend.
Brave Bear
by Kathy MallatA T-shirt-clad teddy bear sees a bird drop out of its nest and manages to climb a towering tree to return it. As the tree is very tall, the bird is pessimistic on its venture. Lending his helping hand, the brave bear takes the bird on his back and successfully reaches the bird's nest.
Brave Buzzy Bee
by Rima Fakih Slaiby Theresa AlHayekBuzzy was a busy bee, a friendly, little honey bee. From Miss USA 2010, Rima Fakih Slaiby, and debut author Theresa AlHayek comes a story about a brave little bee who never gives up.Buzzy Bee is excited to participate in the Colony's upcoming race. There's just one problem: he isn't very fast! But Buzzy is not a quitter, so he practices tirelessly to get better and better. But on the day of the race, things don't exactly go as expected. Can Buzzy save the day and win the race?Told in beautiful bouncing rhyme with gorgeous illustrations by Angela Li, Brave Buzzy Bee provides a lesson for young readers about the true meaning of bravery, featuring a character that audiences can't help but fall in love with.
A Brave Cat
by Marianna CoppoThis feline-focused picture book is about imagination, courage, and seeing the world differently: as a place of possibility and endless opportunity for everyday adventures!Olivia is an indoor cat—a brave adventurer, a tireless traveler, and a fearless explorer who is never afraid. From hunting fierce shoelaces to climbing all the way to the top of the bookcase, Olivia has always been able to count on her bravery. But will it be enough to help her face the big, uncertain world outside her home?From Marianna Coppo, the critically acclaimed author of Petra and Such a Good Boy, comes a charming picture book about the life of a cat: its ups and downs and sometimes-surprising in-betweens. At once relatable and illuminating, this story takes the youngest of readers straight into the mind of a cat! What may seem quiet and subdued from the outside is in fact an emotionally rich existence filled with likes and dislikes, adventures and misadventures, challenges and fears. Featuring whimsical, color-drenched art and warm, thoughtful prose, this uplifting book proves that courage is not the absence of fear—courage is believing in yourself, no matter what.PURR-FECT GIFT FOR ANY OCCASION: From its stand-out cover to its expressive spreads, this book will make an exceptional year-round gift for lovers of cats and whimsical art—at every age!SMALL ACTS OF COURAGE DESERVE CELEBRATION: At some point, we've all felt the impulse to venture out and be brave, knowing that taking that leap requires faith in oneself and heaps of imagination. This book teaches young readers that it's okay to have feelings, to react to the world around them, and to take steps beyond the familiar—even if those steps are sometimes small.PROMOTES VISUAL STORYTELLING: Coppo's whimsical, color-drenched spreads bring Olivia's story to life. Young readers will delight in her escapades, and marvel at her profound realization by the book's end.Perfect for:• Cat lovers (and cat owners) of all ages• Parents, grandparents, and caregivers of cat-loving children• Gift-givers seeking beautiful, distinctive offerings for young readers• Lovers of animals, nature, and everyday adventures• Teachers and educators looking for books about bravery
Brave Chicken Little
by Robert ByrdWhack!What’s that? Could it be? A piece of the sky! Oh my!Chicken Little and his friends run, run, run to tell the king. Nothing stands in the way except...the sly Foxy Loxy. Surely they have time to stop for lunch with Foxy and his kits. But what happens when Chicken Little and company find themselves on the menu?What this classic story needs is a new ending and a brave hero. And maybe this time, it’s Chicken Little!Cleverly retold and exquisitely illustrated by Robert Byrd, Brave Chicken Little transforms a cautionary fable into a tale of triumph.
Brave Dave
by Giles AndreaeFrom the creators of the internationally bestselling Giraffes Can't Dance comes a life-affirming new story about a little bear who learns what it really means to find your inner brave and have the confidence to be yourself . . .Dave, the grizzly bear, is in awe of his big brother Clarence - he's big, brave and strong, all the things that Dave thinks a grizzly bear should be. How Dave wishes he could be more like Clarence until, one day, Dave discovers that bravery comes in different guises and that this grizzly bear doesn't need to be more Clarence, he needs to be more Dave! A celebration of individuality, self-acceptance and having the courage to stand out - the perfect book for encouraging all little ones to take pride in being themselves and showing them that they don't have to be like anyone else, not even their older brothers or sisters.GIRAFFES CAN'T DANCE is a beloved favourite that has found its way into the hearts, and onto the bookshelves, of a whole generation of children. With positive messages about self-esteem, the multi-million bestseller is a contemporary classic.
Brave Dave
by Giles AndreaeFrom the bestselling team behind Giraffes Can't Dance comes another rhythmic and joyful picture about the importance of being brave!Dave the bear lives in the shadow of his brother, Clarence. Clarence is tall, handsome, bold, and brave. Dave… isn't. Dave wonders if he’ll ever live up to his brother's example, until he finds a special talent that's all his own.“To know that you’re different, but be who you are...Have the courage to say it out loud,To go out and find what can make your heart sing...Oh Dave, nothing could make me more proud!”Brave Dave is the empowering story of bear named Dave, who discovers the importance of simply being himself!From the creators of the international bestseller and much-loved classic Giraffes Can't Dance, Brave Dave will have young readers jumping with joy as they discover the courage to embrace who they are, with lots of laughs and smiles along the way.
Brave Dog
by Marilyn HelmerWhen Mattie brings a stray dog home, her family is not very happy. No matter what they do, he won’t leave. When Mattie goes missing on a snowy day, will Stray Dog be able to show the family his worth?
Brave Like That
by Lindsey StoddardFind yourself. Find your place. Find your brave. This uplifting tale, which award-winning author Leslie Connor dubbed “a perfectly paced journey of the heart” is perfect for fans of Lisa Graff and Lynda Mullaly Hunt. <P><P>Cyrus Olson’s dad is a hero—Northfield’s former football star and now one of their finest firefighters. Everyone expects Cyrus to follow in his dad’s record-breaking footsteps, and he wishes they were right—except he’s never been brave like that. But this year, with the help of a stray dog, a few new friends, a little bit of rhythm, and a lot of nerve, he may just discover that actually…he is. <P><P>Lauded as “remarkable” by the New York Times Book Review, Lindsey Stoddard’s heartfelt stories continue to garner critical acclaim, and her latest novel will have fans new and old rooting for Cyrus and Parker’s special bond and the courage it helps them both to find.