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Systems Medicine: Physiological Circuits and the Dynamics of Disease (Chapman & Hall/CRC Computational Biology Series)
by Uri AlonWhy do we get certain diseases, whereas other diseases do not exist? In this book, Alon, one of the founders of systems biology, builds a foundation for systems medicine. Starting from basic laws, the book derives why physiological circuits are built the way they are. The circuits have fragilities that explain specific diseases and offer new strategies to treat them. By the end, the reader will be able to use simple and powerful mathematical models to describe physiological circuits. The book explores, in three parts, hormone circuits, immune circuits, and aging and age-related disease. It culminates in a periodic table of diseases. Alon writes in a style accessible to a broad range of readers - undergraduates, graduates, or researchers from computational or biological backgrounds. The level of math is friendly and the math can even be bypassed altogether. For instructors and readers who want to go deeper, the book includes dozens of exercises that have been rigorously tested in the classroom
Systems Medicine
by Ulf Schmitz Olaf WolkenhauerThis volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action. Ultimately it introduces tools, resources and methodologies from bioinformatics and systems biology, and how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human health and well-being.
Systems Metabolic Engineering
by Christoph Wittmann Sang Yup LeeSystems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story - from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.
Systems Modeling
by Mukhtar AhmedAchieving food security and economic developmental objectives in the face of climate change and rapid population growth requires systems modelling approaches, for example in the design of sustainable agriculture farming systems. Such approaches increase our understanding of system responses to different soil and climatic conditions, and provide insights into the effects of various variable climate change scenarios, providing valuable information for decision-makers. Further, in the agricultural sector, systems modelling can help optimise crop management and adaptation measures to boost productivity under variable climatic conditions. Presenting key outcomes from crop models used in agricultural systems this book is a valuable resource for professionals interested in using modelling approaches to manage the growth and improve the quality of various crops.
Systems Modeling: Methodologies and Tools (EAI/Springer Innovations in Communication and Computing)
by Antonio Puliafito Kishor S. TrivediThis book covers ideas, methods, algorithms, and tools for the in-depth study of the performance and reliability of dependable fault-tolerant systems. The chapters identify the current challenges that designers and practitioners must confront to ensure the reliability, availability, and performance of systems, with special focus on their dynamic behaviors and dependencies. Topics include network calculus, workload and scheduling; simulation, sensitivity analysis and applications; queuing networks analysis; clouds, federations and big data; and tools. This collection of recent research exposes system researchers, performance analysts, and practitioners to a spectrum of issues so that they can address these challenges in their work.
Systems Modelling and Management: First International Conference, ICSMM 2020, Bergen, Norway, June 25–26, 2020, Proceedings (Communications in Computer and Information Science #1262)
by Önder Babur Joachim Denil Birgit Vogel-HeuserThis book constitutes the refereed proceedings of the First International Conference on Systems Modelling and Management, ICSMM 2020, planned to be held in Bergen, Norway, in June 2020. Due to the COVID-19 pandemic the conference did not take place physically or virtually. The 10 full papers and 3 short papers were thoroughly reviewed and selected from 19 qualified submissions. The papers are organized according to the following topical sections: verification and validation; applications; methods, techniques and tools.
Systems Modelling and Simulation: First International Symposium, SMS 2024, Johor Bahru, Malaysia, December 16–17, 2024, Proceedings (Communications in Computer and Information Science #2483)
by Gary Tan Zaharuddin Mohamed Fazilah Hassan Anita Ahmad Leow Pei Ling Salinda BuyaminThis book CCIS 2483 constitutes the proceedings of the First International Symposium on Systems Modelling and Simulation, SMS 2024, held in Johor Bahru, Malaysia, during December 16–17, 2024. The 27 full papers were carefully reviewed and selected from 65 submissions. The proceedings focus on the applications of modelling and simulation to advanced systems such as robotics, smart manufacturing, intelligent systems and machine learning are of interest.
Systems Orthodontics: From Clinical Reasoning to Computation, and Back (Understanding Complex Systems)
by Pietro Auconi Guido Caldarelli Antonella PolimeniThis book marks one of the first applications of the Medicine Network discipline to an everyday scenario. It explores situations where patients, often in adolescence, grapple with the decision of whether to commence a treatment, seeking insights into the more plausible future scenarios. Additionally, the specific feedback from biological systems in the human body serves as a potent metaphor for addressing various challenges in the field of Complex Systems. In recent times, systems thinking and complexity theory have yielded substantial conceptual advancements across various research domains. In the context of orthodontics, these approaches offer a more comprehensive understanding in contrast to the traditional mechanistic approach, which primarily focuses on the analysis of applied forces. Systems thinking directs attention to the interaction among dentoskeletal components, where the behavior of one element can influence others. The amalgamation of multiple elements leads to entities with properties distinct from those of individual components. The increasing complexity of orthodontic reality beyond clinical or radiological observations necessitates the development of new theories. Complexity theory has demonstrated that emergent properties in biological systems can be discerned through appropriate computational models, as opposed to the analytical study of individual components. The central metaphor for the interactive craniofacial system during growth is portrayed by the facial topology revealed through network analysis, facilitating a systemic reevaluation of traditional orthodontic theories. This book delineates the novel insights derived from the clinical-computational approach, applicable for a prognostic and early interception perspective in managing dentofacial dysmorphoses. Its objective is to captivate practitioners and persuade them of the practical utility of these innovative approaches.
Systems Practice: How to Act in a Climate Change World
by Ray IsonIt is now accepted that humans are changing the climate of the Earth and this is the most compelling amongst a long litany of reasons as to why, collectively, we have to change our ways of thinking and acting. Most people now recognise that we have to be capable of adapting quickly as new and uncertain circumstances emerge: this capability will need to exist at personal, group, community, regional, national and international levels, all at the same time. Systems Practice is structured into four parts. Part I introduces the societal need to move towards a more systemic and adaptive governance against the backdrop of human-induced climate change. Part II unpacks what is involved in systems practice by means of a juggler metaphor; examining situations where systems thinking offers useful understanding and opportunities for change. Part III identifies the main factors that constrain the uptake of systems practice and makes the case for innovation in practice by means of systemic inquiry, systemic action research and systemic intervention. The book concludes with Part IV, which critically examines how systems practice is, or might be, utilised at different levels from the personal to the societal. The development of our capabilities to think and act systemically is an urgent priority and Systems Practice aims to show how to do systems thinking and translate that thinking into praxis (theory informed practical action) which will be welcomed by those managing in situations of complexity and uncertainty across all domains of professional and personal concern.
Systems Programming in Unix/Linux
by K. C. WangCovering all the essential components of Unix/Linux, including process management, concurrent programming, timer and time service, file systems and network programming, this textbook emphasizes programming practice in the Unix/Linux environment. Systems Programming in Unix/Linux is intended as a textbook for systems programming courses in technically-oriented Computer Science/Engineering curricula that emphasize both theory and programming practice. The book contains many detailed working example programs with complete source code. It is also suitable for self-study by advanced programmers and computer enthusiasts.Systems programming is an indispensable part of Computer Science/Engineering education. After taking an introductory programming course, this book is meant to further knowledge by detailing how dynamic data structures are used in practice, using programming exercises and programming projects on such topics as C structures, pointers, link lists and trees.This book provides a wide range of knowledge about computer systemsoftware and advanced programming skills, allowing readers to interface with operatingsystem kernel, make efficient use of system resources and develop application software.It also prepares readers with the needed background to pursue advanced studies inComputer Science/Engineering, such as operating systems, embedded systems, databasesystems, data mining, artificial intelligence, computer networks, network security,distributed and parallel computing.
Systems Science: Methodological Approaches (Advances in Systems Science and Engineering (ASSE))
by Yi Lin Xiaojun Duan Chengli Zhao Li Da XuBy making use of the principles of systems science, the scientific community can explain many complicated matters of the world and shed new light on unsettled problems. Each real science has its own particular methodology for not only qualitative but also quantitative analyses, so it is important to understand the organic whole of systems research
Systems Science for Engineers and Scholars
by Avner EngelSystems Science for Engineers and Scholars Brings a powerful toolkit to bear on engineering and scientific endeavors. This book describes the fundamental principles of systems science so engineers and other scholars can put them into practical use at work and in their personal lives. Systems science aims to determine systemic similarities among different disciplines and to develop applicable solutions in many fields of inquiry. Systems Science for Engineers and Scholars readers will discover: Ten systems science principles that open engineers’ and scholars’ horizons to practical insights related to their areas of interest A methodology for designing holistic systems that exhibit resilient behavior to overcome systems’ context uncertainties The most critical current dilemma of humankind—the global environment and energy crises, as well as a systemic, no-nonsense action plan to deal with these issues Independent articles describing how engineers and scholars can utilize systems science creatively in (1) engineering and systemic psychology; (2) delivering value and resolving conflicts; (3) multi-objective, multi-agent decision-making; (4) systems engineering using category theory; (5) holistic risk management using systems of systems failures methodology; and (6) systemic accident and mishap analysis Systems Science for Engineers and Scholars contains a broad spectrum of insights as well as an extensive set of examples and graphics that make it ideal for professionals and students interested in a holistic, systems-oriented approach.
Systems, Signals and Image Processing: 28th International Conference, IWSSIP 2021, Bratislava, Slovakia, June 2–4, 2021, Revised Selected Papers (Communications in Computer and Information Science #1527)
by Gregor Rozinaj Radoslav VargicThis volume constitutes selected papers presented at the 28th International Conference on Systems, Signals and Image Processing, IWSSIP 2021, held in Bratislava, Slovakia, in June 2021. Due to the COVID-19 pandemic the conference was held online. The presented 14 full and 5 short papers were thorougly reviewed and selected from the 76 submissions. The papers focus on various aspects of advanced signal processing in different scientific areas, including filter design, Fourier and other transforms, feature extraction, machine learning and system adaptation to user-oriented products like 5G networks, IoT, virtual teleport or tele-surgery operations.
Systems, Smart Technologies, and Innovation for Society: Proceedings of CITIS 2024 (Lecture Notes in Networks and Systems #1331)
by Esteban Mauricio Inga Ortega Nuria García Herranz Vladimir Espartaco Robles-Bykbaev Eduardo Gallego DiazThis open access book compiles the proceedings of the tenth edition of the International Congress on Science, Technology and Innovation for Society, a key event that addresses in a practical and multidisciplinary way smart technologies and their impact on crucial sectors such as sustainability, environment, information and telecommunications, industry and mobility. Through studies with diverse methodologies, basically applied research, it explores how emerging technologies such as artificial intelligence, machine learning, the Internet of Things and big data are transforming these fields, solving global problems and improving the quality of life. It should be noted that the novelty of the book lies in presenting research that integrates the perspectives of experts from different sectors, combining the technical vision with the analysis of the social, economic and environmental impacts of technological innovation. In this sense, it has a broad scope, as it is aimed at professionals, researchers and students of technology, engineering, data science, sustainability, etc., as well as entrepreneurs and public policy makers. It is also a valuable resource for those interested in understanding how emerging technologies can transform key sectors and contribute to a more sustainable future, from informed decision making in the fields of scientific research, technological innovation; as well as being a source of inspiration for entrepreneurs and project leaders seeking cutting-edge technological solutions. In short, a key work for those who wish to explore the future of smart technologies and their impact on society.
Systems, Smart Technologies and Innovation for Society: Proceedings of CITIS’2023, Volume 2 (Lecture Notes in Networks and Systems #871)
by Juan Pablo Salgado-Guerrero Hector Rene Vega-Carrillo Gonzalo García-Fernández Vladimir Robles-BykbaevThis book is dedicated to exploring the practical applications and future perspectives of intelligent technologies. It delves into various domains, including industry, mobility, telecommunications, and environmental considerations. The innovative nature of this text enables us to draw connections between technical advancements and experiences aimed at enhancing the integration of emerging technologies on local, national, and regional scales. It showcases the strides made in diverse engineering domains, underlining the book’s multidisciplinary appeal. This book is intended for a wide readership, catering to master's and doctoral students, professors, and researchers in the field of cutting-edge technologies. It also extends its relevance to businesses engaged in engineering development. The contents offer insights into novel methodologies, real-world case studies, and innovative techniques designed to optimize systems, ultimately contributing to societal progress.
Systems, Smart Technologies and Innovation for Society: Proceedings of CITIS´2023, Volume 1 (Lecture Notes in Networks and Systems #870)
by Juan Pablo Salgado-Guerrero Hector Rene Vega-Carrillo Gonzalo García-Fernández Vladimir Robles-BykbaevThis book is dedicated to exploring the practical applications and future perspectives of intelligent technologies. It delves into various domains, including industry, mobility, telecommunications, and environmental considerations.The innovative nature of this text enables us to draw connections between technical advancements and experiences aimed at enhancing the integration of emerging technologies on local, national, and regional scales. It showcases the strides made in diverse engineering domains, underlining the book’s multidisciplinary appeal. This book is intended for a wide readership, catering to master's and doctoral students, professors, and researchers in the field of cutting-edge technologies. It also extends its relevance to businesses engaged in engineering development. The contents offer insights into novel methodologies, real-world case studies, and innovative techniques designed to optimize systems, ultimately contributing to societal progress.
Systems, Software and Services Process Improvement: 31st European Conference, EuroSPI 2024, Munich, Germany, September 4–6, 2024, Proceedings, Part II (Communications in Computer and Information Science #2180)
by Paul Clarke Murat Yilmaz Christian Greiner Richard Messnarz Andreas Riel Thomas PeislThe two-volume set CCIS 2179 + 2180 constitutes the refereed proceedings of the 31st European Conference on Systems, Software and Services Process Improvement, EuroSPI 2024, held in Munich, Germany, during September 2024. The 55 papers included in these proceedings were carefully reviewed and selected from 100 submissions. They were organized in topical sections as follows: Part I: SPI and Emerging and Multidisciplinary Approaches to Software Engineering; SPI and Functional Safety and Cybersecurity; SPI and Standards and Safety and Security Norms; Part II: Sustainability and Life Cycle Challenges; SPI and Recent Innovations; Digitalisation of Industry, Infrastructure and E-Mobility; SPI and Agile; SPI and Good/Bad SPI Practices in Improvement.
Systems, Software and Services Process Improvement: 31st European Conference, EuroSPI 2024, Munich, Germany, September 4–6, 2024, Proceedings, Part I (Communications in Computer and Information Science #2179)
by Paul Clarke Murat Yilmaz Christian Greiner Richard Messnarz Andreas Riel Thomas PeislThe two-volume set CCIS 2179 + 2180 constitutes the refereed proceedings of the 31st European Conference on Systems, Software and Services Process Improvement, EuroSPI 2024, held in Munich, Germany, during September 2024. The 55 papers included in these proceedings were carefully reviewed and selected from 100 submissions. They were organized in topical sections as follows: Part I: SPI and Emerging and Multidisciplinary Approaches to Software Engineering; SPI and Functional Safety and Cybersecurity; SPI and Standards and Safety and Security Norms; Part II: Sustainability and Life Cycle Challenges; SPI and Recent Innovations; Digitalisation of Industry, Infrastructure and E-Mobility; SPI and Agile; SPI and Good/Bad SPI Practices in Improvement.
Systems, Software and Services Process Improvement: 27th European Conference, EuroSPI 2020, Düsseldorf, Germany, September 9–11, 2020, Proceedings (Communications in Computer and Information Science #1251)
by Paul Clarke Murat Yilmaz Richard Messnarz Jörg NiemannThis volume constitutes the refereed proceedings of the 27th European Conference on Systems, Software and Services Process Improvement, EuroSPI conference, held in Düsseldorf, Germany, in September 2020*. The 50 full papers and 13 short papers presented were carefully reviewed and selected from 100 submissions. They are organized in topical sections on visionary papers, SPI manifesto and improvement strategies, SPI and emerging software and systems engineering paradigms, SPI and standards and safety and security norms, SPI and team performance & agile & innovation, SPI and agile, emerging software engineering paradigms, digitalisation of industry, infrastructure and e-mobility, good and bad practices in improvement, functional safety and cybersecurity, experiences with agile and lean, standards and assessment models, recent innovations, virtual reality. *The conference was partially held virtually due to the COVID-19 pandemic.
Systems, Software and Services Process Improvement
by Christian Kreiner Rory V. O'Connor Alexander Poth Richard MessnarzThis volume constitutes the refereed proceedings of the 21st EuroSPI conference, held in Luxembourg, in June 2014. The 18 revised papers presented together with 11 invited papers in this volume were carefully reviewed and selected. They are organized in topical sections on SPI and very small entities; process improvement frameworks; testing and improvement issues; SPI and people issues; SPI and quality issues; software processes in various contexts. The volume also contains selected keynote papers from EuroSPI workshops and invited papers covering the topic of creating environments supporting innovation and improvement.
Systems, Software and Services Process Improvement: 25th European Conference, EuroSPI 2018, Bilbao, Spain, September 5-7, 2018, Proceedings (Communications in Computer and Information Science #896)
by Xabier Larrucea Izaskun Santamaria Rory V. O'Connor Richard MessnarzThis volume constitutes the refereed proceedings of the 25th European Conference on Systems, Software and Services Process Improvement, EuroSPI conference, held in Bilbao, Spain, in September 2018.The 56 revised full papers presented were carefully reviewed and selected from 95 submissions. They are organized in topical sections on SPI context and agility, SPI and safety testing, SPI and management issues, SPI and assessment, SPI and safety critical, gamifySPI, SPI in industry 4.0, best practices in implementing traceability, good and bad practices in improvement, safety and security, experiences with agile and lean, standards and assessment models,team skills and diversity strategies, SPI in medical device industry, empowering the future infrastructure.
Systems, Software and Services Process Improvement
by Jakub Stolfa Svatopluk Stolfa Rory V. O'Connor Richard MessnarzThis volume constitutes the refereed proceedings of the 21st EuroSPI conference, held in Luxembourg, in June 2014. The 18 revised papers presented together with 11 invited papers in this volume were carefully reviewed and selected. They are organized in topical sections on SPI and very small entities; process improvement frameworks; testing and improvement issues; SPI and people issues; SPI and quality issues; software processes in various contexts. The volume also contains selected keynote papers from EuroSPI workshops and invited papers covering the topic of creating environments supporting innovation and improvement.
Systems, Software and Services Process Improvement: 26th European Conference, EuroSPI 2019, Edinburgh, UK, September 18–20, 2019, Proceedings (Communications in Computer and Information Science #1060)
by Alastair Walker Rory V. O’Connor Richard MessnarzThis volume constitutes the refereed proceedings of the 26th European Conference on Systems, Software and Services Process Improvement, EuroSPI conference, held in Edinburgh, Scotland, in September 2019. The 18 revised full papers presented were carefully reviewed and selected from 28 submissions. They are organized in topical sections: Visionary Papers, SPI and Safety and Security, SPI and Assessments, SPI and Future Qualification & Team Performance, and SPI Manifesto and Culture. The selected workshop papers are also presented and organized in following topical sections: GamifySPI, Digitalisation of Industry, Infrastructure and E-Mobility. -Best Practices in Implementing Traceability. -Good and Bad Practices in Improvement. -Functional Safety and Cybersecurity. -Experiences with Agile and Lean. -Standards and Assessment Models. -Team Skills and Diversity Strategies. -Recent Innovations.
Systems, Software and Services Process Improvement: 29th European Conference, EuroSPI 2022, Salzburg, Austria, August 31 – September 2, 2022, Proceedings (Communications in Computer and Information Science #1646)
by Murat Yilmaz Paul Clarke Richard Messnarz Bruno WöranThis volume constitutes the refereed proceedings of the 29th European Conference on Systems, Software and Services Process Improvement, EuroSPI 2022, held in Salzburg, Austria, in August-September 2022.The 49 full papers and 8 short papers presented were carefully reviewed and selected from 110 submissions. The papers are organized according to the following topical sections: SPI and emerging and multidisciplinary approaches to software engineering; digitalisation of industry, infrastructure and e-mobility; SPI and good/bad SPI practices in improvement; SPI and functional safety and cybersecurity; SPI and agile; SPI and standards and safety and security norms; SPI and team skills and diversity; SPI and recent innovations; virtual reality and augmented reality.
Systems, Software and Services Process Improvement: 30th European Conference, EuroSPI 2023, Grenoble, France, August 30 – September 1, 2023, Proceedings, Part I (Communications in Computer and Information Science #1890)
by Murat Yilmaz Paul Clarke Andreas Riel Richard MessnarzThis two-volume set constitutes the refereed proceedings of the 30th European Conference on Systems, Software and Services Process Improvement, EuroSPI 2023, held in Grenoble, France, in August-September 2023.The 47 full papers presented were carefully reviewed and selected from 100 submissions. The papers are organized according to the following topical sections: SPI and emerging and multidisciplinary approaches to software engineering; digitalisation of industry, infrastructure and e-mobility; SPI and good/bad SPI practices in improvement; SPI and functional safety and cybersecurity; SPI and agile; SPI and standards and safety and security norms; sustainability and life cycle challenges; SPI and recent innovations; virtual reality and augmented reality.