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Doodlebug & Dandelion: Bandits
by Charnan SimonDoodlebug’s stuff has been disappearing. He thinks his cousins, Rudyard and Dandelion, are the thieves! They decide to investigate the thefts to prove their innocence. Together, they find the real culprits. Will Rudyard and Dandelion be able to convince Doodlebug they didn't do it?
Doppler-Effekt und Rotverschiebung: Klassische Theorie und Einsteinsche Effekte (essentials)
by Helmut Günther Volker MüllerDer Doppler-Effekt ist die Frequenzänderung von Wellen bei einer Relativgeschwindigkeit von Sender und Empfänger. So wird die Sirene einer Feuerwehr bei einer Vorbeifahrt deutlich tiefer. Der klassische Doppler-Effekt erlaubt es, den Bewegungszustand des Trägermediums der Wellen zu bestimmen. Für Licht im Vakuum ist die relativistische Gangverzögerung einer bewegten Uhr zu berücksichtigen. Die Frequenzverschiebung hängt dann nur von der Relativgeschwindigkeit ab. Es gibt keinen Bewegungszustand des Vakuums. Der Leser wird in die Lichtausbreitung in Gravitationsfeldern eingeführt. Die Autoren demonstrieren, dass Licht von kompakten Quellen eine gravitative Rotverschiebung erfährt und dass um Schwarze Löcher eine unendliche Rotverschiebung zu beobachten ist. Der Leser erfährt, warum im Kosmos zusätzlich eine kosmologische Rotverschiebung auftritt.
Dorothy Vaughan: NASA's Leading Human Computer (Movers, Shakers, and History Makers)
by Deirdre R. HeadIn 1949, Dorothy Vaughan became the first African American woman to lead a team at NASA's Langley Research Center. Her work as a mathematician was an important part of helping the United States explore space. Learn more about Vaughan's life as a famous mathematician!
Dosage Calculations Made Easy: Solving Problems Using Dimensional Analysis
by Gloria P. CraigStraightforward, approachable, and rich with practice opportunities, Dosage Calculations Made Easy: Solving Problems Using Dimensional Analysis, 8th Edition, trains students to confidently calculate accurate medication dosages and fosters the critical-thinking capabilities essential to their clinical success. From basic math functions and measurement systems to complex problem-solving methods, this up-to-date, simple-to-use skill-building guide provides a proven framework for understanding and makes it easier than ever to master effective dosage calculation and drug administration processes.
Dose Finding and Beyond in Biopharmaceutical Development (ICSA Book Series in Statistics)
by Ding-Geng Chen Joseph C. Cappelleri Wen Zhou Jingjing Ye Qiqi DengThis book covers topics in 2 parts: 1) Review of FDA Guidance, 2) Novel Designs and Analyses. While covering basic principles of dose finding, this book details advancements made in drug development. Finding the right dose(s) is one of the most important objectives in new drug development. In Phase I clinical development, one of the objectives is to escalate test doses from low to high. The low doses should be safe, then escalate up to the maximally tolerable dose (MTD). Phase Ⅱ clinical trials then lower test doses to the minimal efficacious dose (MinED). Dose range of a study drug can be thought of as the doses between MinED and MTD. From this dose range, one or a few doses are selected for Phase Ⅲ confirmation. In practice, dose finding is a very difficult in every phase of clinical development for new drugs. The editors brought distinguished researchers and practitioners in biopharmaceuticals and universities, to discuss the statistical procedures, useful methods, and their novel applications in dose finding. The chapters in the book present emerging topics in dose-finding and related interdisciplinary areas. This timely book is a valuable resource to stimulate the development of this growing and exciting field in drug development.
Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice (SpringerBriefs in Statistics)
by Shigeyuki Matsui Akihiro Hirakawa Takashi DaimonThis book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
Dose-Response Analysis Using R (Chapman & Hall/CRC The R Series)
by Christian Ritz Signe Marie Jensen Daniel Gerhard Jens Carl StreibigNowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology.In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development.Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the book’s GitHub: https://github.com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.
Double Puppy Trouble (McKellar Math)
by Danica McKellarThe newest math-focused picture book from New York Times bestselling author Danica McKellar is full of puppy-fueled chaos and a message of gratitude, with a double helping of fun!Moxie Jo always wanted MORE. But soon she'd get MORE than she bargained for!Spunky and energetic, Moxie is just like any other girl--aside from the fact that she has to have the MOST of everything! If she doesn't have the most toys, the most A's on tests, or the most time on the swing, then she makes the MOST noise! So when Moxie finds a magic stick that can double anything, she doesn't hesitate to use it--but when the button gets stuck, she may start to realize that less really is more! Teach the power of doubling through this playful puppy romp!
Double Sequence Spaces and Four-Dimensional Matrices (Chapman & Hall/CRC Monographs and Research Notes in Mathematics)
by Feyzi Başar Medine Yeşilkayagil SavaşcıDouble Sequence Spaces and Four-Dimensional Matrices provides readers with a clear introduction to the spaces of double sequences and series, as well as their properties. The book then goes beyond this to investigate paranormed double sequence spaces and their algebraic and topological properties, triangle matrices and their domains in certain spaces of double sequences, dual spaces of double sequence spaces, and matrix transformations between double sequence spaces and related topics. Each chapter contains a conclusion section highlighting the importance of results and pointing out possible new ideas that can be studied further. Features Suitable for students at graduate or post-graduate level and researchers Investigates different types of summable spaces and computes their duals Characterizes several four-dimensional matrix classes transforming one summable space into other Discusses several algebraic and topological properties of new sequence spaces generated by the domain of triangles.
Doubled Up: Shared Households and the Precarious Lives of Families
by Hope HarveyHow sharing a home with extended family or friends serves as a crucial, but imperfect, private safety net for families with childrenMore than fifteen percent of US children—over eleven million—live in doubled-up households, sharing space with extended family or friends. These households are even more common among low-income families, families of color, and single-parent families, functioning as a private safety net for many in a country with extremely limited public support for families. Yet despite their prevalence, we know little about how shared households form and how they shape family life. Doubled Up is an in-depth look at the experiences of families with children living in doubled-up households.Drawing on extensive interviews with sixty parents living in doubled-up households, Hope Harvey examines what circumstances and motivations lead families to form doubled-up households, how living in shared households affects daily routines, and how families fare after these arrangements dissolve.Harvey shows that although families rely on doubling up to get by in the face of rapidly rising housing costs, precarious labor markets, and unaffordable childcare, these private arrangements are rarely sufficient to overcome such structural barriers. And doubling up incurs its own costs for both host and guest families. For doubled-up families, negotiating household relationships and navigating shared space reshapes family life. Understanding the dynamics of doubled-up households extends scholarship on family life beyond the nuclear family and points the way toward better policies that will serve all families.
Down on the Korner: Ralph Kiner and Kiner's Korner
by Mark Rosenman Howie Karpin Tim McCarverOne of the staples of the long and storied history of baseball on television is the "postgame show,” and none was more beloved than Kiner’s Korner. From the early 1960s into the 1990s, Hall of Famer and iconic broadcaster Ralph Kiner hosted the show that brought players into the homes of fans across the nation.From the host, to the set, to the guests, to the stories amassed over more than thirty-two years on the air, Down on the Korner takes the reader behind the scenes. Authors Mark Rosenman and Howie Karpin gather insight from baseball greats like Ed Charles, Ron Darling, Pete Falcone, "Doc” Gooden, Keith Hernandez, Tim Harkness, Ron Hunt, Howard Johnson, Darryl Strawberry, Bobby Valentine, and many more. People who worked behind the scenes provide memorable moments of their own-like the time producer Jack Simon joined Jerry Koosman to play a practical joke on Hall of Famer and legendary Met Tom Seaver.Throughout his career as a player and broadcaster, Ralph Kiner was adored by millions of fans. His postgame show only strengthened that bond. Down on the Korner will give readers a wonderful ride down sports’ memory lane-an enjoyable journey for any baseball enthusiast.Skyhorse Publishing, as well as our Sports Publishing imprint, are proud to publish a broad range of books for readers interested in sports-books about baseball, pro football, college football, pro and college basketball, hockey, or soccer, we have a book about your sport or your team.Whether you are a New York Yankees fan or hail from Red Sox nation; whether you are a die-hard Green Bay Packers or Dallas Cowboys fan; whether you root for the Kentucky Wildcats, Louisville Cardinals, UCLA Bruins, or Kansas Jayhawks; whether you route for the Boston Bruins, Toronto Maple Leafs, Montreal Canadiens, or Los Angeles Kings; we have a book for you. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to publishing books on subjects that are sometimes overlooked by other publishers and to authors whose work might not otherwise find a home.
Dozens of Cousins, Trillions of Stars
by Charnan SimonIt's the Hill family annual stargazing party! With camping and hot cocoa, the thirteen cousins observe the night sky together.
Dr. Euler's Fabulous Formula: Cures Many Mathematical Ills (Princeton Science Library #52)
by Paul J. NahinIn the mid-eighteenth century, Swiss-born mathematician Leonhard Euler developed a formula so innovative and complex that it continues to inspire research, discussion, and even the occasional limerick. Dr. Euler's Fabulous Formula shares the fascinating story of this groundbreaking formula—long regarded as the gold standard for mathematical beauty—and shows why it still lies at the heart of complex number theory. In some ways a sequel to Nahin's An Imaginary Tale, this book examines the many applications of complex numbers alongside intriguing stories from the history of mathematics. Dr. Euler's Fabulous Formula is accessible to any reader familiar with calculus and differential equations, and promises to inspire mathematicians for years to come.
Dreaming Mobility and Buying Vulnerability: Overseas Recruitment Practices in India
by S. Irudaya Rajan V. J. Varghese M. S. JayakumarIn the alarming contemporary context of widespread corruption and fraudulence in the overseas labour recruitment system in India, this book attempts to understand the institution of emigration governance and recruitment practices in the country with a focus on the unskilled and semi-skilled sectors. It brings together the results of research in the major emigration hubs of India with the aid of quantitative and qualitative tools, drawing from all the major stakeholders —intending emigrants, recruiting agents, return emigrants, emigrant households, Protector of Emigrants, foreign employers, foreign recruiting agents, Indian missions and emigrant workers at the destination countries. The book unravels the underlying discriminatory rationality of the existing system of emigration governance, its logical and structural incoherencies and the consequent inefficacy in protecting the most vulnerable sections of workers leaving India for overseas employment, resulting in unaffordable levels of transaction and social costs. By outlining the institutional failure, the volume outlines the fundamental principles of a new institution which would facilitate orderly, safe and secure emigration, economically sustainable beneficial expatriate life and social protection after the emigrants return. The book will be of interest to students and scholars of sociology, law, economics, demography, anthropology, history, gender studies, cultural studies, Diaspora studies, migration studies and international relations, apart from policy-makers and administrators of transnational migration and NGOs working in the field of migration.
Dreisatz fur Dummies Das Pocketbuch (Für Dummies)
by Alexandra Miseles Bernd UhlandWer hat ihn nicht gelernt, den Dreisatz? Aber wie fit sind Sie in diesem Thema? Dabei ist Dreisatzrechnen sehr praktisch und einmal begriffen, erleichtert es den Umgang mit der Mathematik ungemein. Bernd Uhland und Alexandra Miseles bringen Ihnen in diesem kleinen Buch schnell bei, was Sie über den Dreisatz wissen sollten. Sie erklären Ihnen das grundlegende Rechenverfahren und zeigen Ihnen, was es mit zusammengesetzten Dreisätzen auf sich hat. Natürlich kommen auch praktische Anwendungen wie Prozentrechnung nicht zu kurz, und zum Schluss erläutern die Autoren auch noch fortgeschrittene Themen wie Durchschnitts-, Verteilungs-, Verhältnis- und Mischungsrechnung.
Dreisatz, Prozente und Zinsen: Umgang mit Formeln leicht gemacht (essentials)
by Thomas RießingerIn diesem essential erkl#65533;rt Thomas Rie#65533;inger anschaulich anhand vieler Beispiele die Rechenregeln der Prozent- und Zinsrechnung. Die Grundbegriffe der Zins- und Prozentrechnung und die dazugeh#65533;rigen Formeln werden wiederholt, sodass diese im Alltag leicht anzuwenden sind. Der Autor wendet die Prozentrechnung auf Zinsprobleme an und stellt verschiedene Arten der Dreisatzrechnung vor.
Drinfeld Moduli Schemes and Automorphic Forms
by Yuval Z FlickerDrinfeld Moduli Schemes and Automorphic Forms: The Theory of Elliptic Modules with Applications is based on the author's original work establishing the correspondence between ell-adic rank r Galois representations and automorphic representations of GL(r) over a function field, in the local case, and, in the global case, under a restriction at a single place. It develops Drinfeld's theory of elliptic modules, their moduli schemes and covering schemes, the simple trace formula, the fixed point formula, as well as the congruence relations and a "simple" converse theorem, not yet published anywhere. This version, based on a recent course taught by the author at The Ohio State University, is updated with references to research that has extended and developed the original work. The use of the theory of elliptic modules in the present work makes it accessible to graduate students, and it will serve as a valuable resource to facilitate an entrance to this fascinating area of mathematics.
Drone Data Analytics in Aerial Computing (Transactions on Computer Systems and Networks)
by P. Karthikeyan Sathish Kumar V. AnbarasuThis book discusses the latest research, theoretical, and experimental research innovations in drone data analytics in aerial computing. Drone data analytics guarantees that the right people have the correct data at their fingertips whenever they need it. The contents also discuss the challenges faced with drone data analytics, such as due to the high mobility of drones, aerial computing is significantly different from terrestrial computing. It also includes case studies from leading drone vendors. The book also focuses on the comparison of data management and security mechanisms in drone data analytics. This book is useful to those working in agriculture, mining, waste management, and defenses department.
Drop Heating and Evaporation: Analytical Solutions in Curvilinear Coordinate Systems (Mathematical Engineering)
by Simona Tonini Gianpietro Elvio CossaliThis book describes analytical methods for modelling drop evaporation, providing the mathematical tools needed in order to generalise transport and constitutive equations and to find analytical solutions in curvilinear coordinate systems. Transport phenomena in gas mixtures are treated in considerable detail, and the basics of differential geometry are introduced in order to describe interface-related transport phenomena. One chapter is solely devoted to the description of sixteen different orthogonal curvilinear coordinate systems, reporting explicitly on the forms of their differential operators (gradient, divergent, curl, Laplacian) and transformation matrices. The book is intended to guide the reader from mathematics, to physical descriptions, and ultimately to engineering applications, in order to demonstrate the effectiveness of applied mathematics when properly adapted to the real world. Though the book primarily addresses the needs of engineering researchers, it will also benefit graduate students.
Droplet Interactions and Spray Processes (Fluid Mechanics and Its Applications #121)
by Bernhard Weigand Grazia Lamanna Simona Tonini Gianpietro Elvio CossaliThis book provides a selection of contributions to the DIPSI workshop 2019 (Droplet Impact Phenomena & Spray Investigations) as well as recent progress of the Int. Research Training Group “DROPIT”.The DIPSI workshop, which is now at its thirteenth edition, represents an important opportunity to share recent knowledge on droplets and sprays in a variety of research fields and industrial applications. The research training group “DROPIT” is focused on droplet interaction technologies where microscopic effects influence strongly macroscopic behavior. This requires the inclusion of interface kinetics and/or a detailed analysis of surface microstructures. Normally, complicated technical processes cover the underlying basic mechanisms, and therefore, progress in the overall process modelling can hardly be gained. Therefore, DROPIT focuses on the underlying basic processes. This is done by investigating different spatial and/or temporal scales of the problems and by linking them through a multi-scale approach. In addition, multi-physics are required to understand e.g. problems for droplet-wall interactions, where porous structures are involved.
Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics
by Bret BernerExplore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Drug Development Supported by Informatics
by Hiroko SatohThis book describes the state-of-the-art of chemoinformatics, bioinformatics, materials informatics and measurement/metrology informatics to develop drugs with desired activity or physicochemical properties and to optimize the functionality, efficacy, safety and quality of the compounds for drugs. Recently, "AI drug discovery", drug discovery research utilizing artificial intelligence technology such as machine learning, has attracted much attention. This book provides an overview of the four applied informatics fields and their applications in drug development for a wide spectrum of readers from learners to professional scientists in academia and industry. It focuses on the basic research stage of drug development with contributions from experts at the forefront of these fields. The authors hope that this book will be of assistance to explore new opportunities for collaboration between pharmaceutical science and informatics.
Drug Development for Rare Diseases (Chapman & Hall/CRC Biostatistics Series)
by Yang BoA disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers, and other stakeholders. This book is proposed to give an overview of the common issues facing rare disease drug developers, summarize challenges specific to clinical development in small populations, discuss drug development strategies in the evolving regulatory environment, explain generation and utilization of different data and evidence inside and beyond clinical trials, and use recent examples to demonstrate these challenges and the development strategies that respond to the challenges. Key Features: • Rare disease. • Drug development. • Innovative clinical trial design. • Regulatory approval. • Real-world evidence.
Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications
by Liang Shen WuXi AppTec DmpkPractical, state-of-the-art pharmacokinetic research methods, ideas, advancements, applications, and strategies Drawing on a wealth of extensive practical experience and theoretical research, Drug Metabolism and Pharmacokinetics encapsulates the most recent advancements and illustrative applications in the field. Sixty-eight relatively independent yet interconnected articles are included, each offering a unique perspective and providing in-depth interpretation. Readers can either read systematically or select specific topics of interest from the table of contents. Basic concepts, frontier advancements, DMPK research strategies, and technical methods are covered for novel drug modalities and therapeutics in different disease areas. The book encompasses a wide range of application and validation cases for DMPK research, including studies in in vitro ADME, in vivo pharmacokinetics, metabolite profiling and identification, radiolabeled ADME, and bioanalysis. Case studies showing the application of topics covered are included throughout, along with valuable insights into problem-solving and critical thinking. Written by a team of scientists specializing in DMPK research from the DMPK Department of WuXi AppTec, Drug Metabolism and Pharmacokinetics discusses sample topics including: ADME properties, metabolite identification, and bioanalytical strategies for oligonucleotide drugsStrategies and challenges in the determination of drug-to-antibody ratio (DAR) values of antibody-drug conjugates (ADCs)Breaking barriers in CNS drug development with intrathecal and intracerebroventricular administrationApplication and detection techniques of biomarkers in drug developmentFlux dialysis method for assessing plasma protein binding of high protein-binding drugs Drug Metabolism and Pharmacokinetics is an essential forward-thinking reference on the subject for pharmacy students, pharmaceutical industry researchers, and DMPK scientists, especially those exploring novel drug modalities.
Drug Synergism and Dose-Effect Data Analysis
by Ronald J. TallaridaNot since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.