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Current Applications of Deep Learning in Cancer Diagnostics

This book examines deep learning-based approaches in the field of cancer diagnostics, as well as pre-processing techniques, which are essential to cancer diagnostics. Topics include introduction to current applications of deep learning in cancer diagnostics, pre-processing of cancer data using deep learning, review of deep learning techniques in oncology, overview of advanced deep learning techniques in cancer diagnostics, prediction of cancer susceptibility using deep learning techniques, prediction of cancer reoccurrence using deep learning techniques, deep learning techniques to predict the grading of human cancer, different human cancer detection using deep learning techniques, prediction of cancer survival using deep learning techniques, complexity in the use of deep learning in cancer diagnostics, and challenges and future scopes of deep learning techniques in oncology.

Current Applications of Pharmaceutical Biotechnology (Advances in Biochemical Engineering/Biotechnology #171)

This book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, chronic diseases (e.g. diabetes, Crohn's disease, psoriasis and rheumatoid arthritis), neurodegenerative disorders (e.g. multiple sclerosis), and they have also been contributing to the progress of innovative therapies such as assisted reproductive medicine. Since the eighties, several biopharmaceuticals have been approved and, due to patents expiration, many biosimilars are also marketed.In this book, readers will find the most relevant updated information about the main clinical applications of pharmaceutical biotechnology. The authors provide expert analysis about the industrial challenges of recombinant proteins and the different classes of biopharmaceuticals, including monoclonal antibodies, vaccines, growth factors and stem cells. Topics such as bioprinting technologies in tissue engineering, gene therapy and personalized medicine are also covered in this book. Professionals, students and researchers interested in this field will find this work an important account.

Current Approach to Heart Failure

This book is intended to be a link between guidelines and clinical practice, a complementary tool to help physicians to be well informed regarding the important field of heart failure. It will be a useful tool for professionals from all the fields of cardiology: non-invasive cardiology, interventional cardiology, electrophysiology and cardiovascular imaging. The topic of heart failure is continuously changing, with new important information being added constantly. The pathophysiology is better understood and there is a trend for a better characterization of special groups of population, such as oncologic patients with heart failure. The new imaging techniques have become valuable tools for the diagnosis of heart failure, while pharmacological and novel cell and gene treatments have evolved enormously. The challenge for the practitioners is making the right selection of treatment strategy that best fits a patient. This book presents detailed information on the indications, selection and mechanism of action of these treatments, whether they be mechanical circulatory devices or pharmacological treatments. The contemporary pharmacological and non-pharmacological management of heart failure has the main target of early prevention of disease progression and the avoidance of heart transplant. In the era of shortage of donors, prevention is the mainstay of the therapeutic strategy, and this is the main philosophy of our book.

Current Aspects of Flavonoids: Their Role in Cancer Treatment

The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.

Current Best Practice in Interventional Cardiology

Current Best Practice in Interventional Cardiology addresses the questions which challenge clinicians involved with interventional procedures. Helpfully organized into four sections, the text addresses; coronary artery disease, non-coronary interventions, left ventricular failure and the latest advances in imaging technologies, and provides authoritative guidance on the current recommendations for best practice.Containing contributions from an international team of opinion leaders, this new book reviews the key advances in equipment, techniques and therapeutics and is an accessible reference for all hospital-based specialists.

Current Common Dilemmas in Colorectal Surgery

This text reviews the areas of colorectal surgery that are at the cutting edge of innovation, paradigm shift and controversy with regard to diagnosis, patient selection, treatment algorithm, and therapeutic approaches. From the impact of enhanced recovery protocols on traditional colorectal practices, to that of novel strategies merging endoscopic and surgical techniques, to recent paradigm shifts in the management of common colorectal disorders, this text provides readers with an update on current controversies and evolving treatment rationale in the management of common colorectal diseases. Current Common Dilemmas in Colorectal Surgery provides a guide for the current common dilemmas that caregivers encounter in their daily practice. It is of great utility to colorectal surgeons, surgical oncologists and general surgeons practicing colorectal surgery, senior residents in general surgery training or surgical oncology or colorectal fellowships, allied healthcare professionals involved in the care of patients with colorectal disease, pharma and biomedical technology industry with an interest in current care of patients with colorectal disease.

Current Concept in Cleft Surgery: Moving Toward Excellence of Outcome and Reducing the Burden of Care

This book intends to cover cleft-related topics which are mainly focused on the current concept of balancing excellence in outcome and burden of cleft care. The wide spectrum of covered topics includes the understanding challenges and needs to deliver the modern surgical cleft care worldwide and comprehending multidisciplinary-based longitudinal life-changing concept. The chapters are focused on professional-friendly technical descriptions from diagnosis to execution such as nasoalveolar molding, cleft lip repair, cleft palate repair, myringotomy tube insertion, primary and secondary rhinoplasties, oronasal fistula reconstruction, velopharyngeal insufficiency management, virtual-aided alveolar reconstruction, surgery-first approach in cleft orthognathic surgery, 3D computer-assisted orthognathic surgery, revisionary surgeries, and postoperative care. Traditional and current principle-based methods are itemized into many algorithms and protocols to aid in diagnosing, planning, and selecting the best therapeutic approach in order to balance excellence in outcome and burden of care. Many surgical-, orthodontic-, speech-, and postoperative care-related technical examples, intraoperative photos, and full-colour illustrative drawings can guide the professionals working in multidisciplinary teams through each traditional and newer hybrid operative procedure in a detailed step-by-step fashion with emphasis on how to perform each procedure, rather than on theoretical-only descriptions. This book provides time- and scientifically-tested treatment algorithms to guide multidisciplinary teams during decision making process for each clinical scenario of the longitudinal cleft care

Current Concepts and Management of Eye Injuries

This reader-friendly and well-illustrated book is a concise clinical reference on the management of severe ocular injuries. It will serve as an ideal guide for clinicians dealing with trauma and ophthalmology, assisting in the implementation of individualized treatment strategies and the performance of up-to-date surgical interventions. Easy-to-follow instructions are provided on the management of each injured tissue of the globe, with emphasis on key pearls and pitfalls that must be borne in mind in order to achieve an optimal anatomical and functional outcome. Both common and rare causes of injury are covered, including mass casualty incidents, and current concepts regarding the evaluation and classification of injury mechanisms are fully taken into consideration. In addition, each chapter pays special attention to hot topics and medicolegal issues in patient management.​

Current Concepts in Bovine Reproduction

This book provides updated information on the current concepts in bovine reproduction. It describes the complex issues associated with fertility and infertility in bovines and suggests strategies for achieving high reproductive efficiency. It discusses topics related to the fertility trend in bovines, estrus detection, controlled breeding, postpartum uterine health, uterine infections, and its therapeutic management. The essential roles of metabolic hormones on gonadal functions and fertility are also covered. Additionally, the book presents new insights in maternal recognition of pregnancy in bovines and suggest nutritional strategies to improve reproductive efficiency. The chapters on male fertility provide current information on semen cryopreservation, sperm quality assessment and measures to improve sperm fertility. A special chapter on intricacies in buffalo semen cryopreservation and measures to improve the quality of cryopreserved sperm is also included in this book. Lastly, the book introduces the immunobiological roles of anti-microbial peptides during sperm transport in reproductive tract and epigenetic bearing on fertility. This book is an invaluable resource for veterinary scientists, students and practitioners to understand the current developments in bovine reproduction for improving reproductive efficiency.

Current Concepts in Endometrial Cancer

This book comprehensively covers endometrial carcinoma, a type of gynecological cancer that is often overlooked but of great interest. Although the incidence of the disease is rapidly increasing, both per se and as part of familial cancer syndromes, there is a great deal of controversy regarding its diagnosis, evaluation and management. This book underlines the significance of endometrial carcinoma, highlights key prevention measures, charts its evaluation, and addresses the stage-by-stage management of this malignancy, with particular attention to the role of minimally invasive surgery. Further, it includes a chapter on future perspectives including robotics, targeted therapies and other developments in the offing. Overall, the book provides a comprehensive guide to endometrial cancer, which if approached properly, can have an excellent prognosis, thus saving many lives and/or achieving substantially improved quality of life. >

Current Concepts in Forensic Entomology

Twenty years ago the use of entomology in a crime scene investigation was considered bizarre, despite the solid scientific background and documented historical applications. Today, the use of insect evidence is an accepted sub-discipline in modern forensic science. Nevertheless, forensic entomology is still growing and remains a living scientific discipline with many branches. The present book highlights this diversity by collecting contributions dealing with novel aspects, for example, marine biology, chemical ecology and acarology, as well as the basic disciplines like entomotoxiciology and decomposition. It also offers keys for immature insects, discussions of important pitfalls and introductions to the statistical evaluation of data sets. Many topics are covered in depth for the first time. All the authors are leading experts in their respective fields of research. Their chapters show directions for future research for both new and veteran forensic entomologists. Undoubtedly, forensic entomology will continue to grow and attract new professionals, students, as well as interested observers. This book is written for all of them.

Current Concepts in Medical Research and Practice (Advances in Experimental Medicine and Biology #1039)

Change is an inherent feature of all aspects of clinical practice and patient management. This book seeks to contribute to presenting novel knowledge in various fields of clinical work. The articles tackle transdisciplinary topics and focus on the underlying mechanisms of clinical disorders, their prevention and management. The themes addressed include allergy and pseudoallergy in the pediatric population, influenza-related infections and their sequelae, which continues to be a scourge in the developing world, the risk of lung cancer repeats and their management, viral hepatitis that may lead to hepatocarcinoma, respiratory consequences of diaphragmatic hernias, disorders of steroid hormone metabolism, and others. The articles bring the updated strategies, research, and best practices to improve outcomes and to deliver state-of-the-art clinical care to patients. The book will be of interest to physicians, academic scientists, and researchers who are keen in sharing the latest medical practice developments.

Current Concepts in Ophthalmology

This book casts light on the most recent and significant changes and challenges in Ophthalmology over the last years. It provides essential and relevant new information and improvements on the main areas of Ophthalmology. Current Concepts of Ophthalmology elaborates on recent developments in Refractive and Cataract surgery, Cornea transplants, Neuro-Ophthalmology and many more. Based on increasing professional subject specialisation, this book offers the opportunity to stay up-to-date with areas outside of the own specific sub-specialty. Further, it traces issues and useful information to understand the trends and areas of future interest.Written by renowned experts of the respective fields, readers will discover a concise update on modern ophthalmology.

Current Concepts of Intestinal Failure

This book provides readers with a succinct but comprehensive overview of current concepts relating to intestinal failure, including its treatment, with a particular focus on recent advancements. The opening chapters address basic aspects of intestinal failure, including etiology, clinical pathophysiology, physiology of intestinal adaptation, and intestinal microbiota. The complications of intestinal failure, such as bacterial overgrowth and intestinal failure-associated liver disease, are then discussed. A series of chapters specifically address important strategies in the nutritional, pharmacological, and surgical treatment of intestinal failure as well as the concept of intestinal rehabilitation. Finally, two significant emerging developments are considered: regenerative medicine and distraction enterogenesis. The authors are internationally recognized experts from Europe and North America who are ideally placed to describe current knowledge and progress in the field.

Current Controversies in Cancer Care for the Surgeon

Over the past decade, major advances have occurred in the management of the many fields of cancer treatment encountered by the general surgeon. These developments have evolved from improved understanding of disease biology, high level clinical outcomes studies, as well as translational research with new available therapies. These advances have brought major changes to cancer care and have surfaced new dilemmas in clinical decision-making. Modern cancer management requires an understanding of the current status of a diverse array of oncologic diseases. Current Controversies in Cancer Care for the Surgeon provides a comprehensive update on the management of various cancers as interpreted by recognized experts in the field. In addition, each chapter will focus on current controversies and areas of advance. The text is designed to assist the practicing surgeon in achieving optimal management of encountered oncologic problems. Such an inclusive text will be invaluable resource for clinical surgeons, surgeons in training, students and researchers.

Current Diagnosis & Treatment Obstetrics & Gynecology

An up-to-date clinically focused text written to answer even the most difficult obstetrics and gynecology question A Doody’s Core Title for 2021! The single-source OB/GYN resource acclaimed for its currency, comprehensiveness, and strong focus on the practical aspects of clinical diagnosis and patient management Expanded and extensively updated to reflect the latest research and advances – including the concepts of precision medicine Of value to medical students, residents, and practicing physicians who will find this an outstanding guide to the management of common and uncommon conditions Ready-to-apply coverage of more than 1,000 diseases and disorders Strikes the perfect balance between brevity and clinical necessity, delivering exactly the amount of information needed for quick diagnosis, effective treatment, and improved outcomes Strong emphasis on disease prevention and evidence-based medicine Hundreds anatomic drawings, image studies, diagrams, charts, and graphs NEW CHAPTER on Benign Disorders of the Uterine Corpus; Cardiac Disorders in Pregnancy and Pulmonary Disorders in Pregnancy are now two separate chapters for more detailed, focused coverage of these important topics Quick-access design facilities use at the point of care

Current Directions in Dyslexia Research

This book covers research on biopsychological aspects of dyslexia reflects on psycholinguistic aspects of dyslexia offers reflections on dyslexia treatment research in general. It points out that in some dyslexics it is not sufficient to treat word identification difficulties alone.

Current Directions in Health Psychology

These timely, cutting-edge articles allow instructors to bring their students real-world perspective--from a reliable source--about today's most current and pressing issues in health psychology.

Current Drug Synthesis (Wiley Series on Drug Synthesis)

Current Drug Synthesis The latest entry in the widely read Drug Synthesis series In Current Drug Synthesis, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas – including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section – the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs. Each chapter includes coverage of background material on a relevant drug class or disease indication and key aspects of drug discovery, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. Readers will also find: Thorough introductions to drugs for infectious diseases, including relebactam, vaborbactam, and baloxavir marboxil In-depth treatments of cancer-treating drugs, including darolutamide, venetoclax, and osimertinib Comprehensive explorations of central nervous system drugs, including zuranolone and risdiplam Extensive discussions of computational drug discovery and peptide drugs Perfect for medicinal, organic, synthetic, and process chemists, Current Drug Synthesis will also earn a place in the libraries of research scientists working in lead optimization and process development, as well as graduate students studying organic chemistry, heterocyclic chemistry, or medicinal chemistry.

Current Hypotheses and Research Milestones in Alzheimer's Disease

Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease. Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD. These chapters grew out of "Current Hypothesis on Alzheimer's Disease", held in Viña del Mar, Chile, in November of 2007. Participants included the world's leading Alzheimer's researchers, whose work has illuminated AD investigations during the past few decades. Students, academics and medical professionals will find this text an invaluable addition to the study of this important subject.

Current Immunotherapeutic Strategies in Cancer (Recent Results in Cancer Research #214)

This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.

Current Laboratory Methods in Neuroscience Research (Springer Protocols Handbooks)

Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a "blueprint" for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.

Current Management of Melanoma (Updates in Surgery)

In the last decade, the clinical management of melanoma has become more effective: basic clinical studies, randomized clinical trials, and new drugs have greatly improved the prognosis of patients, both in the initial and in the advanced stage of the disease.This book offers a wide and up-to-date overview of the multidisciplinary treatment of melanoma. Among the topics discussed, there are the role of sentinel lymph node biopsy and the radical dissection, following the results of international randomized clinical trials, in particular MSLT-II. The last chapters are focused on new medical treatments in adjuvant, neoadjuvant, and metastatic settings. The volume has been written for all the professionals involved in melanoma treatment, such as general surgeons, surgical oncologists, medical oncologists, dermatologists, radiotherapists, and nuclear medicine physicians.

Current Management of Venous Diseases

This text provides an overview of venous diseases and focuses on clinical evaluation and management. It is intended to guide the treating physician by summarizing the evidence, giving technical tips, and outlining algorithms for common conditions. A unique feature of this book is clinical pearls given by experts in the field that are highlighted in each chapter. The first section of the book describes the essential anatomy and physiology/pathophysiology. It also includes evaluation of common presentations of venous diseases such as extremity edema and lower extremity ulceration with a summary for work up that includes conditions that can mimic venous diseases. The organization of the book follows the basic pathophysiology of venous disorders with chapters addressing special conditions of common interest such as pelvic congestion syndrome, thoracic outlet syndrome, and May-Thurner syndrome. There is emphasis on novel treatment modalities and emerging technologies through dedicated chapters to anticoagulant agents, emerging modalities to treat superficial venous reflux and venous stent technology. Finally, this book is a melting pot for physicians who have shown dedication and passion to the care of patients with venous disease regardless of specialty and location. The authors are an international panel of vascular experts who trained in vascular surgery, interventional radiology, interventional cardiology, hematology, pulmonology and critical care medicine. Therefore, the book will be of great value to the physicians and trainees in those specialties and to any person interested in developing in depth knowledge of the management of venous diseases.

Current Medical Diagnosis And Treatment 2019