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Epigenetics: Development and Disease
by Tapas Kumar KunduEpigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Epigenetik des Menschen
by Carsten Carlberg Ferdinand MolnárDie Ansicht „Es liegt alles in unseren Genen und wir können es nicht ändern“ hat sich in den letzten 150 Jahren seit Gregor Mendels Experimenten mit blühenden Erbsenpflanzen entwickelt. Es gibt jedoch eine besondere Form der Genetik, die Epigenetik, bei der unsere Gene nicht verändert werden, sondern geregelt wird, wie und wann sie genutzt werden. Unsere Umwelt und Lebensstilentscheidungen beeinflussen die Epigenetik unserer Zellen und Organe, d. h. die Epigenetik verändert sich dynamisch während unseres gesamten Lebens. Wir haben also die Möglichkeit, unsere Epigenetik sowohl positiv als auch negativ zu verändern.In diesem Buch wird auf molekularer Ebene erklärt, wie unser Genom mit Umweltsignalen verbunden ist. Es zeigt auf, dass die epigenetische Programmierung ein Lernprozess ist, der zu einem epigenetischen Gedächtnis in jeder Zelle unseres Körpers führt. Die zentrale Bedeutung der Epigenetik während der Embryogenese und der zellulären Differenzierung sowie beim Alterungsprozess und dem Risiko für die Entstehung von Krebs werden erörtert. Darüber hinaus wird die Rolle des Epigenoms als molekularer Speicher für zelluläre Ereignisse nicht nur im Gehirn, sondern auch in Stoffwechselorganen und im Immunsystem beschrieben.Das Buch ist die Übersetzung des Lehrbuchs „Human Epigenetics: How Science Works“ (ISBN 978-3-030-22907-8) der Autoren. In den ersten fünf Kapiteln werden die molekularen Grundlagen der Epigenetik erläutert, während die folgenden sieben Kapitel Beispiele für die Auswirkungen der Epigenetik auf die menschliche Gesundheit und Krankheit liefern.
Epigenetik – Grundlagen und klinische Bedeutung: Aus Der Vortragsreihe Der Medizinischen Gesellschaft Mainz E. V.
by Hendrik Lehnert Henriette Kirchner Ina Kirmes Ralf DahmDas vorliegende Buch gibt einen kurzen Überblick über die neuesten Erkenntnisse auf dem spannenden Gebiet der Epigenetik. Es wird erklärt, wie die Epigenetik das Schicksal von Zellen bestimmt, unserem Genom Komplexität verleiht und wie die Epigenetik Informationen der Umwelt für das Genom übersetzt.
Epigenetische Mechanismen der Zellprogrammierung und Zellreprogrammierung
by Gang PeiDieses Buch stellt ein umfangreiches Forschungsprogramm zu epigenetischen Mechanismen der Zellprogrammierung und Reprogrammierung vor. Das Programm wurde von der National Natural Science Foundation of China während des 11. Fünfjahresplans gestartet, der im Oktober 2008 begann und Ende 2016 abgeschlossen wurde. Es fasst zunächst die epigenetischen Forschungspläne und den aktuellen Stand der epigenetischen Forschung in China und im internationalen Vergleich zusammen. Unter Anwendung interdisziplinärer Forschungsmethoden erörtert das Buch die Entwicklungstrends der epigenetischen Forschung, wie die Mechanismen der Etablierung und Aufrechterhaltung epigenetischer Informationen und die epigenetische Regulierung von Reproduktion und Entwicklung. Außerdem wird eine Vielzahl von Forschungsergebnissen vorgestellt. So werden beispielsweise die Entdeckung neuer epigenetischer Regulatoren und Chromatin-Remodulatoren sowie deren biologische Funktionen und Mechanismen hervorgehoben. Es werden verschiedene Regulierungsmechanismen der Zelldifferenzierung und Transdifferenzierung erörtert, insbesondere die Entdeckung der Schlüsselfaktoren zur Förderung der Transdifferenzierung von Körperzellen zu Hepatozyten. Darüber hinaus werden in diesem Buch einige wichtige akademische Bereiche mit zunehmender Bedeutung vorgestellt, wie Biochemie, Zellbiologie und klinische Medizin. Aufgrund seines Umfangs ist das Buch für Forscher interessant, die in den Bereichen Zellbiologie, Biochemie, Strukturbiologie, Bioinformatik, klinische Medizin und anderen verwandten Gebieten arbeiten.
Epigenome Editing: Methods And Protocols (Methods In Molecular Biology #1767)
by Albert Jeltsch Marianne G. RotsThis detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenome Editing: Methods and Protocols will be of great assistance to people new to the field but also to those already engaged, as epigenetic editing is still a relatively unexplored field with many issues to be resolved.
Epigenome-Wide Association Studies: Methods and Protocols (Methods in Molecular Biology #2432)
by Weihua GuanThis volume details features of DNA methylation data, data processing pipelines, quality control measures, data normalization, and to discussions of statistical methods for data analysis, control of confounding and batch effects, and identification of differentially methylated regions. Chapters focus on microarray-based methylation measures and sequence-based measures. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary methodologies and software packages, step-by-step, readily reproducible analysis pipelines, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Epigenome- Wide Association Studies: Methods and Protocols: aims to be a useful practical guide to researches to help further their study in this field.
Epilepsy
by David W. MccandlessThe present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7-9 years, and the "success" rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.
Epilepsy
by Vivek Mishra Krishnamoorthy Ennapadam S. Shorvon Simon D. Schachter Steven C. Mishra Vivek Steven C.This title in the acclaimed Blue Books of Neurology series highlights advances in epileptology and new ways of managing seizure disorders. Contributors from around the world-most new to this volume-lend a global perspective and provide the latest thinking on the new and controversial issues surrounding epilepsy. You ll find detailed discussions of difficulties in diagnosing and treating epilepsy, including the latest pharmacologic management strategies. This book covers the entire range of issues in epilepsy from basic science research to current clinical issues to medical and surgical therapeutics. Find all you need on critical issues in treating epilepsy and seizure disorders. Provides the expertise of new contributors and volume editors who are world-class authorities in the field for authoritative guidance. Features thoroughly updated content including new chapters-Seizure Prediction; Drug Resistance Genes; Cortical Myoclonus and Epilepsy; Sudden Unexplained Death in Epilepsy; Seizures in the Elderly; Rasmussen s Encephalitis; Epilepsies Due to Monogenic Disorders of Metabolism; Epilepsy and Sleep; Long-term Effects of Seizures on Brain Structure and Function; Brain Stimulation in Epilepsy-for the most current information for use in the decision-making process. Includes coverage of the surgical management of epilepsy to help you determine when it s best to recommend surgery and for which patients. Emphasizes pharmacologic management of seizure patients that reflects advances in biotechnology and imaging. "
Epilepsy
by John W Miller Howard P. GoodkinEpilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help clinicians develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience.
Epilepsy (The\experience Of Illness Ser.)
by Graham ScamblerIn examining the social and psychological aspects of epilepsy, the author takes not only the perspectives of individuals and their families, but also popular conceptions of the disorder. The result is an illuminating account of the social reality of epilepsy that demonstrates the distinctive contribution that the social sciences can play in understanding illness.
Epilepsy Across the Spectrum
by Committee on the Public Health Dimensions of the EpilepsiesAlthough epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2. 2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.
Epilepsy Board Review
by Mohamad Z. Koubeissi Nabil J. AzarThis concise text mirrors the content of the Epilepsy Board as distributed by the American Board of Psychiatry and Neurology. Epilepsy diagnosis, classification and treatment are thoroughly covered, along with seizure classification, epidemiology, normal and abnormal EEG, and treatment with antiepileptic medications and other modalities. Formatted with multiple choice questions and explanations, this complete resource will prepare physicians and students for the Epilepsy Board examination and provide the latest clinical approaches.
Epilepsy Case Studies
by William O. Tatum Joseph I. Sirven Gregory D. CascinoWritten by expert epilepsy clinicians from the Mayo Clinic, Epilepsy Case Studies: Pearls for Patient Care presents a wide variety of case histories drawn from "real life" experiences in people with seizures. Designed to stimulate the same deductive reasoning that is commonly used when seeing epilepsy patients in the clinic, this practical book presents the clinical scenario and then poses a range of stimulating questions to organize the reader's thoughts to address each case. Questions that revolve around each case include common ones such as "How does this test help us with the diagnosis?" and "What is the precise relationship of the patient's seizures to their overall neurological condition?" The most poignant questions include "How does this information help us to devise a treatment plan?" and "What do we know about the anticipated course and prognosis?" The questions raised in each section incorporate the clinical course and evaluation. Where possible, the discussion relies upon the latest medical evidence to support the responses and includes up-to-date techniques used for patients with and without seizure control. At the end of each case a few salient citations are referenced, as are a few of the more pertinent articles that the reader can reference to obtain an overview of the topic. Take-home messages are encapsulated in the form of clinical pearls that are designed to form the basic understanding of the case scenarios presented. A major contribution to the literature in epileptology, Epilepsy Case Studies: Pearls for Patient Care will be an invaluable reference for all clinicians who treat patients with epilepsy.
Epilepsy Case Studies: Pearls for Patient Care
by William O. Tatum Joseph I. Sirven Gregory D. CascinoThis book presents a case based approach to epilepsy management in both diagnostic challenges and treatment of complex cases. Cases reflect “real life” patient scenarios that practitioners encounter with up-to-date terminology and treatment approaches.With 51 chapters, the book presents 51 unique, nuanced cases. Beginning with an initial presentation of a case history, the book opens with a basis for drawing in multiple aspects in the treatment of patients with epilepsy. Each chapter is organized into a clinical history, physical examination results, and ancillary testing to concentrate on differential diagnosis and focus on a definitive procedural approach to the final diagnosis. Subsequent information about the condition expands on the knowledge of the clinical features to a solution of common patient clinical scenarios as it affects people with epilepsy.A comprehensive successor edition, Epilepsy Case Studies is an invaluable resource to clinicians ranging from those looking for a quick review of a topic present in the table of contents, to those crossing disciplines into medical areas where seizures are a symptom of disordered or dysfunctional brain.
Epilepsy Explained: A Book for People Who Want to Know More
by Steven C. Schachter Christian E. Elger Markus Reuber Ulrich AltrupIn the last five years, approximately 2.7 million people have been treated for epilepsy and it is estimated that as much as one in one-hundred of the world's population will develop epilepsy during their lifetime. It is further estimated that 60 million people worldwide have epilepsy and in the United States alone, between seventy to eighty thousand people are newly diagnosed each year. Despite being such a common problem, most people know little about the disorder and people with epilepsy feel stigmatized. Filled with illustrations on almost every page and boasting an attractive and stimulating layout, Epilepsy Explained offers a wealth of crystal clear information on epilepsy, intended for patients, family members, friends, and caregivers. This down-to-earth book is divided into easy-to-digest sections that address such fundamental questions as what epilepsy is, what happens in different types of epileptic seizures, how epilepsy is diagnosed, and how seizures are treated. The authors include much-needed information on numerous topics, including living successfully with seizures, patients rights, and current drugs used to treat epilepsy--all described with directness and clarity, with many real-life examples that shed light on how the topic under discussion affects people with epilepsy. The book includes information for particular groups of readers such as women, children, and teens. It has an easy-to-follow organization, is clearly structured and has a detailed index and glossary, allowing readers to easily find specific information pertaining to their condition. Written by physicians who work daily with epilepsy, this clear and engaging book provides people with the knowledge they need to make informed choices about their illness.
Epilepsy Fundamentals: A Concise Clinical Guide
by Zulfi HaneefThere is a considerable need for a concise handbook available for the student of epilepsy. Epilepsy is a rapidly evolving field and the available books are large, unwieldy and infrequently updated. This book fills this need by providing a concise review on the evolving field of epilepsy. It's aimed for the medical student or resident rotating through epilepsy and EEG, a fellow preparing for the ABPN epilepsy board, or an epilepsy specialist seeking to quickly brush up your knowledge in the field. Chapters cover the critical areas of classification, EEG, clinical features, medication management, surgical management, and other topics. This books brings the latest research and best practices together into a streamlined resource, offering a personal touch stemming from the experience of academic epileptologists.
Epilepsy Surgery and Intrinsic Brain Tumor Surgery: A Practical Atlas
by Konstantinos Fountas Eftychia Z. KapsalakiThis book provides a comprehensive and practical guide for the safe and efficient management of patients with intrinsic brain tumors and medically intractable epilepsy. It presents in an easily understandable way the preoperative evaluation of these patients, starting from the clinical interpretation of conventional anatomical MR imaging and analyses the clinical significance of newer MR based imaging techniques such as diffusion and perfusion imaging. It demonstrates with clarity the role of MR spectroscopy and fractional anisotropy and diffusion tensor imaging in the preoperative assessment of these patients and how this data can be incorporated into the surgical planning. This book is aimed at neurosurgeons, neuroradiologists, neurologists, and epileptologists, and may also be of interest to neuropsychologists, neurophysiologists, radiation oncologists, and medical physicists.
Epilepsy Surgery: A Practical Case-Based Approach
by Lawrence J. Hirsch Aline Herlopian Dennis Dee Spencer David King-StephensThis collection of epilepsy surgical cases illustrates patients with straightforward and challenging pharmacoresistant epilepsy. These cases convey the advancements, investigative strategies, past and modern surgical tools, and sophisticated state-of-the-art of epilepsy surgery and its disciplines. This textbook is organized into four major sections that parallel the contemporary FDA-approved and clinically applicable approaches: resective surgery, disconnection procedures, laser therapy, and neuromodulation. The chapters provide a case-based, interactive, and multidisciplinary integrative approach to pre-operative evaluation, data analysis, and surgical decision-making. In addition, we present alternative approaches to certain diagnostic tools, decision-making strategies, and surgical interventions.This textbook will provide trainees and clinicians with an exhaustive understanding of epilepsy surgery. Moreover, it will be an invaluable resource for preparation for the epilepsy board examination
Epilepsy Towards the Next Decade
by Pasquale StrianoA comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0. 5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy and the approval of several new antiepileptic drugs, about 30% of patients continue to experience recurrent seizures which are medically, physically, and/or socially disabling. The editor of this volume hopes that by bridging the gap between the fundamental biology of epilepsy and its clinical implications he might spur further research and treatment options.
Epilepsy and Intellectual Disabilities
by Vee P. Prasher Mike KerrThis second edition of a successful book provides updated clinical and research knowledge, including information on the licensing of new antiepileptic drugs. All chapters are updated to reflect present accepted practice. New chapters highlighting the importance of the genetic aspects of epilepsy, nonpharmacological treatments, and the impact of epilepsy on families and carers have been added. Ongoing developments in the general population, which will more likely than not become relevant to the intellectually disabled population, are discussed. The impact of epilepsy on the person themselves and their carers is acknowledged, and person-centred treatment programs with a multifaceted team approach are proposed. This book is aimed at physicians and residents in neurology and pediatrics, as well as other practitioners working with this population, such as neuropsychologists. Epilepsy and Intellectual Disabilities, Second Edition is recommended reading for all those caring for this important group of individuals.
Epilepsy and the Interictal State
by Terence J. O'Brien David M. Ficker Erik K. St LouisEpilepsy care traditionally focuses on seizures, yet for most epilepsy sufferers, other interictal factors such as mood, cognitive abilities, and treatment adverse effects most influence how they feel and function day to day.Epilepsy and the Interictal State is a practical and comprehensive text that covers quality of life issues, cognition and therapy, adverse effects of epilepsy treatments, mood state and psychiatric co-morbidity and general health aspects of epilepsy. Each chapter employs a standard structure providing background, epidemiology, pathophysiology, etiology, diagnosis, treatment, prognosis and further practical advice.From an international team of expert editors and contributors, Epilepsy and the Interictal State is a valuable resource for specialist epileptologists and neurologists, as well as for neurosurgeons, neurology nurses, psychiatrists, family physicians and general practitioners.
Epilepsy in Children and Adolescents
by Philip L. Pearl Yu-Tze Ng Amy L. Mcgregor James W. Wheless Dave F. ClarkeThis book provides the contemporary, caring guidance you need to diagnose and manage seizures in a young patient. Beginning with an overview of the classification of seizure syndromes, the authors take a practical approach to a common but complex clinical challenge. Aimed at both professionals and trainees in neurology, this book will also be a useful guide for all primary health professionals caring for pediatric patients with this condition. It is intended as a foundation for further study into pediatric epilepsy and to serve as a quick, up-to-date reference for the recognition, diagnosis, basic understanding, evaluation and management of this condition in children and adolescents.
Epilepsy in Other Brain Diseases: A Guide to Diagnosis and Management
by Johan ZelanoA substantial proportion of patients with other brain diseases like stroke, traumatic brain injury, and dementia will develop epilepsy. This book provides a clear and concise guide to the epidemiology and clinical research on epilepsy as it occurs in the context of other brain diseases.A better and more detailed understanding of the diseases related to the brain following decades of advances in neuroimaging, pathology, and neurophysiology have led to new insights into mechanisms leading to epilepsy. Advances in research on epilepsy in one brain disease are known to lead to an improved understanding of epilepsy in others. Advances in neurological care have resulted in patients with stroke, tumors, or infections surviving longer, with ensuing demands for long-term treatment, including epilepsy.A key message across the different chapters in the book is that epilepsy in other brain diseases should be managed just as ambitiously as any other epilepsy. Neurologists treating patients with brain disease will find this book accessible and practical. It will ensure a deeper understanding of acquired epilepsy among clinicians.
Epilepsy in Resource Limited Settings: Managing Quality of Life
by Rugare MugumbateFocused on the understandings and impacts of epilepsy in resource-limited settings, particularly those in the Global South, this important book provides a thorough examination of how the condition can be managed to promote better quality of life.The book is informed by global initiatives, including the Intersectoral Global Action Plan (IGAP) on epilepsy established by the World Health Organisation in 2022. The first two chapters are centred on two broad but competing perspectives on epilepsy, the spiritual and the biological, which are followed by chapters covering the determinants and prevention of epilepsy, and first aid, guidance and counselling. The book moves on to outline the disadvantages, impacts and challenges of epilepsy, as well as initiatives to address the condition at regional and global levels, spotlighting responses in Africa, Asia and the Pacific, the Caribbean, the Middle East and North Africa, and Latin America. The final section of the book focuses on social management, individual resilience and social services, with a concluding chapter outlining a new Integrative Model for Managing Epilepsy (IMME).Written by an author with extensive experience designing and leading epilepsy programmes both internationally and in sub-Saharan Africa, this book will interest Social Work, Public Health, Nursing, Medical, Counselling, Community Health scholars, students and practitioners.
Epilepsy in Women: The Scientific Basis For Clinical Management (Issn Ser. #Volume 83)
by Cynthia L. HardenEpilepsy requires careful management and monitoring through a woman’s life Epilepsy is a complex disease. The hormonal changes women experience, both day-to-day menstrual fluctuations and the longer waxes and wanings of a reproductive lifetime, make the management of epilepsy even more complicated. At some point, the well-being of a second person, a fetus, might also have to be taken into account. Epilepsy in Women provides a detailed guide to this challenge. The wide-ranging approach encompasses all aspects of a woman’s life including: Social and psychological impacts The impact in reproductive life Contraception Pregnancy Fetal health and long term developmental outcomes Lactation Menopause Each practical chapter begins and ends with a case study that demonstrates the more general challenge. The authors develop themes to provide clinical guidance based on evidence and experience. Written and edited by an international cast of experts, Epilepsy in Women provides crucial tips and recommendations for neurologists and gynecologists who need to be aware of the subtle effects of epilepsy on woman’s life.