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Epilepsy: A Comprehensive Textbook
by Solomon L. Moshé Jerome Engel JrAuthoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.
Epilepsy: Mechanisms, Models, and Translational Perspectives
by Jong M. Rho Raman SankarEpilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo
Epilepsy: Pearls For Patient Care
by Gregory D CascinoDesigned to provide a comprehensive but accessible introduction to epilepsy and seizure disorders, Epilepsy, 2nd edition provides state-of-the-art information in a concise format useful to a wide audience, from neurology residents to epilepsy fellows and practitioners. This illustrated guide to the assessment, diagnosis, and treatment of epilepsy is a valuable resource enabling clinicians to stay on top of the latest recommendations for best practice
Epilepsy: Scientific Foundations of Clinical Practice
by Jong M. Rho Raman Sankar José E. CavazosThe most up-to-date reference on the topic, Epilepsy analyzes the most relevant research developments in parallel clinical issues impacting modern therapeutic regimens-defining the scientific basis of current clinical practices and posing a set of challenging questions and considerations that may impact the future of clinical epilepsy research and
Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics
by Ivan Osorio Hitten P. Zaveri Mark G. Frei Susan ArthursEpilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathema
Epileptic Seizure Prediction Using Electroencephalogram Signals
by Ratnaprabha Ravindra Borhade Vinayak K. Bairagi Manoj S. Nagmode Ravindra Honaji BorhadeThis book presents an innovative method of EEG-based feature extraction and classification of seizures using EEG signals. It describes the methodology required for EEG analysis, seizure detection, seizure prediction, and seizure classification. It contains a compilation of techniques described in the literature and emphasizes newly proposed techniques. The book includes a brief discussion of existing methods for epileptic seizure diagnosis and prediction and introduces new efficient methods specifically for seizure prediction. Focuses on the mathematical models and machine learning algorithms from a perspective of clinical deployment of EEG-based epileptic seizure prediction Discusses recent trends in seizure detection, prediction, and classification methodologies Provides engineering solutions to severity or risk analysis of detected seizures at remote places Presents wearable solutions to seizure prediction Includes details of the use of deep learning for epileptic seizure prediction using EEG This book acts as a reference for academicians and professionals who are working in the field of computational biomedical engineering and are interested in the domain of EEG-based disease prediction.
Epileptic Seizures and the EEG: Measurement, Models, Detection and Prediction
by Mark Cook Andrea Varsavsky Iven MareelsA study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.
Epileptische Anfälle und Epilepsien im Erwachsenenalter: Diagnostik und Therapie
by Hermann Stefan Friedhelm C. Schmitt Martin HoltkampDas Buch bietet dem Behandler einen Überblick über die gängigen klinisch relevanten Konzepte sowie diagnostischen und therapeutischen Maßnahmen in der Epileptologie. Mit seinem praxisorientierten Aufbau befähigt das Werk dazu, dieses Wissen im klinischen Kontext direkt anzuwenden.Zahlreiche Kasuistiken beantworten über die Kapitel hinweg typische Fragen zu Differenzialdiagnostik, Therapie und sozialmedizinischen Aspekten. Bei den Therapien kommen sowohl medikamentöse als auch operative Ansätze zur Sprache. Ein ballastfreies Buch, geschrieben von Epilepsie-Experten aus Deutschland, Österreich und der Schweiz, das sich den konkreten klinischen Aspekten widmet und dabei die entsprechenden nationalen und internationalen Leitlinien berücksichtigt.
Epistasis: Methods and Protocols (Methods in Molecular Biology #2212)
by Ka-Chun WongThis volume explores methods and protocols for detecting epistasis from genetic data. Chapters provide methods and protocols demonstrating approaches to identify epistasis, genetic epistasis testing, genome-wide epistatic SNP networks, epistasis detection through machine learning, and complex interaction analysis using trigenic synthetic genetic array (τ-SGA). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Epistasis: Methods and Protocols aims to ensure successful results in the further study of this vital field. "Simulating Evolution in Asexual Populations with Epistasis” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Epistemic Justice in Mental Healthcare: Recognising Agency and Promoting Virtues Across the Life Span
by Lisa BortolottiThis open access book explores epistemic justice in mental healthcare, bringing together perspectives from psychologists, psychiatrists, philosophers, activists, and lived experience researchers. Through eight chapters, authors identify threats to the agency of people who hear voices, experience depression, have psychotic symptoms, live with dementia, are diagnosed with personality disorders, and face serious mental health issues while receiving palliative care. Considering the power asymmetries in clinical interactions, where patients are vulnerable and healthcare professionals are uniquely placed to offer support, this book reaffirms the importance of recognizing patients as agents and collaborators. Topics covered include trust in the therapeutic relationship, dignity at the end of life, the social dimension of health, stigma in an acute ward, the harm caused by biases and stereotypes, the role of clinical communication, and the promise of digital health. Students, academic researchers, practitioners, as well as mental health charities will benefit from this timely collection.
Epithelial Cell Culture Protocols
by Clare WiseWell-versed experimenters and clinical researchers share their best methods for establishing and maintaining epithelial cell cultures, for analyzing and studying their characteristics, and for using them to set up models of critical biological systems. The emphasis is on the analysis and assessment of epithelial cells, for example by looking at apoptosis and integrins, or by measuring membrane capacitance and confluence. Also described in step-by-step detail are co-culture techniques valuable in developing models for investigating many different in vitro systems, including the blood-brain barrier, drug uptake, and the interaction of epithelial cells with bacteria. Epithelial Cell Culture Protocols offers a step-by-step guide toward a deeper understanding of cellular and molecular mechanisms, as well as a set of robust techniques for specifically evaluating the nature and behavior of epithelial cells.
Epithelial Morphogenesis in Development and Disease
by Walter BirchmeierBringing together a series of articles on the structural, functional, and developmental characteristics of epithelia, this volume represents a timely and valuable contribution to a growing field of study.
Epitope Mapping Protocols
by Mike Schutkowski Ulrich ReinekeGiven the versatile utility of the determinination of epitopes, beneficial to a wide variety of scientists from immunologists to structural biologists to biotechnologists, the need for a thorough, state-of-the-art collection of experimental protocols is clear. In Epitope Mapping Protocols, Second Edition, expert contributors from a broad spectrum of scientific backgrounds update and expand the successful first edition with cutting-edge techniques and applications, including approaches to both antibody or B-cell epitope mapping and T-cell epitope mapping as well as a new section on the profiling of antibody signatures in biological fluids. Written in the popular Methods in Molecular BiologyTM series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Epitope Mapping Protocols, Second Edition is a reliable and valuable reference for all those who wish to understand and further investigate the diversifying field of epitope mapping.
Epitope Mapping Protocols (Methods in Molecular Biology #2937)
by Johan Rockberg Johan Nilvebrant Magdalena Malm Niklas Berndt ThalénThis detailed new edition explores methodologies for the characterization of antibody-antigen interactions tailored to different applications and requirements. Beginning with an overview of key concepts and definitions related to antibody epitopes, the book continues with sections on structural biology methods, display technologies to analyze libraries of proteins or protein arrays, techniques based on protein labeling, as well as computational approaches and binding assays that rely on binding interactions or competition. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Epitope Mapping Protocols, Fourth Edition serves as an ideal resource for scientists from a wide range of fields involved in critical antibody research. Chapter 19 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Epitranscriptomics: Methods and Protocols (Methods in Molecular Biology #1870)
by Narendra Wajapeyee Romi GuptaThis volume provides readers with the latest technologies to study changes in the epitranscriptome. The protocols described in this book explore both targeted and unbiased high-throughput analysis associated with post-transcriptional RNA modification. The chapters in this book also cover specific topics such as transcriptome-wide detection of 5-methylcytosine; HAMR; iRNA-2OM; genome-wide annotation of circRNAs; immune-northern blotting; and detection and quantification of pseudouridine in RNA. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and comprehensive, Epitranscriptomics: Methods and Protocols is an important resource for both expert and novice scientists who are interested in learning more about this field.
Eponyms and Names in Obstetrics and Gynaecology: Eponyms And Names In Obstetrics And Gynaecology
by Thomas F. BaskettFew specialties have a longer or richer eponymous background than obstetrics and gynaecology. Eponyms add a human side to an increasingly technical profession and represent the historic tradition and language of the speciality. This collection aims to perpetuate the names and contributions of pioneers and offer introductory profiles to the founders in whose steps we follow. This third edition includes 26 new entries, as well as expanded detail, illustration and quotation for existing entries. Biographical data and historical and medical context are discussed for each of the 391 names, with reference to 34 countries, reflecting the field's far reaching origins. More than 1700 original references feature, alongside an extensive bibliography of more than 2500 linked references to assist readers searching for more detailed information. This is a volume for physicians, midwives, medical historians, medical ethicists and all those interested in the history and evolution of obstetrical and gynaecological treatment.
Eponyms in Surgery and Anatomy of the Liver, Bile Ducts and Pancreas
by Mark D StringerFor surgeons, physicians, and anatomists involved in the management and study of disorders of the liver, bile ducts and pancreas, eponyms are part of everyday communication. They help to describe anatomical features, operative procedures, surgical instruments, and diseases. Unfortunately, many have become distorted or are inaccurately applied. Few of us understand their derivation or the remarkable people and controversies behind them.This book explores the origins of seventy eponyms in the field of hepatobiliary and pancreatic surgery and anatomy. Each section is deliberately short and intended for quick reference, providing accurate information about the origin of the eponym and the figure behind it.Meticulously researched, and beautifully illustrated with more than 150 photographs, Eponyms in Surgery and Anatomy of the Liver, Bile Ducts and Pancreas is aimed at surgeons, physicians and anatomists, and is sure to enrich the reader's historical perspective of this fascinating branch of surgery and anatomy.
Epstein Barr Virus
by Hans Helmut Niller Janos MinarovitsThis volume explores data from the applications of molecular biological methods and the applications of recent immunological and cytogenetic methods in Epstein-Barr Virus (EBV) that will offer readers possible new solutions to the unresolved problems in the EBV field. Chapters in this book cover topics such as: viral life cycle, latency, EBV-associated diseases and EBV diagnostics; in vitro methods including organotypic cultures for the analysis of EBV-epithelial cell interactions; identification of the interacting viral and cellular proteins using affinity purification-mass spectrometry methods; 3D telomere FISH; transcription analysis using high-throughput RNA sequencing, qPCR and nuclear run-on assay; analysis of viral and cellular microRNAs; isolation and characterization of exosomes and the assessment of their function; characterization of the viral genome by terminal repeat analysis and sequencing; the use of chromatin immunoprecipitation coupled sequencing (ChIP-Seq) for the analysis of Zta-DNA interactions; epigenetic analysis by bisulfite sequencing and ChIP; novel in vivo models for the study of EBV infection; and how immunological, virological, tissue culture and molecular methods can be combined to yield Good Manufacturing Practice-compliant EBV-specific T cells for the immunotherapy of EBV-associated post-transplant lymphoproliferative diseases (PTLD). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Epstein Barr-Virus: Methods and Protocols is a valuable resource for anyone who is interested in this fascinating and evolving field.
Epstein Barr Virus Volume 2
by Christian MünzEpstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt's lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.
Epstein-Barr Virus
by Martin GardnerFilling a gap in the literature, this guide analyzes EBV infection and all of its associated disorders including infectious mononucleosis, Burkitt lymphoma, and Hodgkin's disease. Opening with a historical introduction, the reference progresses from molecular virology, epidemiology, immunology, and pathology to clinical presentation, diagnosis, dis
Epstein-Barr Virus Protocols
by Joanna B. Wilson Gerhard H. MayJoanna Wilson and Gerhard May have assembled a collection of the key molecular biology protocols used in the analysis of Epstein-Barr virus (EBV), along with a series of valuable immunology, cell biology, and transgenic mouse protocols. These readily reproducible techniques include methods for gene expression with mini-EBV plasmids, for expression analysis by FISH, for EBV detection and quantitation, and for cell proliferation and death assays. In addition, there are EBV-based vectors, an up-to-date map of EBV, a comprehensive table of available latent protein antisera, and assays from in vitro to cell to organ to organism levels. Timely and highly practical, Epstein-Barr Virus Protocols provides powerful tools for elucidating the life cycle of EBV and its host interactions, work that promises the emergence of major new treatments and cures for EBV associated diseases, including several forms of human cancer.
Equal Opportunity and the Case for State Sponsored Ectogenesis
by Evie KendalEctogenesis refers to the artificial gestation of a fetus outside the womb. Despite certain advantages for women's reproductive liberty, feminist groups remain divided regarding this technology. This book argues that reproduction imposes unjust burdens on women, and thus the ideals of equal opportunity demand continued research into ectogenesis.
Equalising Opportunities, Minimising Oppression: A Critical Review of Anti-Discriminatory Policies in Health and Social Welfare
by Dylan Ronald Tomlinson Winston TrewAnti-Racist Practice (ARP), Anti-Discriminatory Practice (ADP) and Anti-Oppressive Practice (AOP) form a trinity of concepts, nested into one another, which have evolved in welfare services over the last fifteen years. They tend to have developed as forms of practice panaceas and as a result have been subject to both unrealistic expectations and, at times, to political ridicule. This book clarifies the distinctions between three key concepts - ARP, ADP and AOP. Critically and constructively analysing these three approaches to practice it reappraises their potential in the light of emerging equality issues in the health service With contributions from leading teachers and practitioners in the field, Equalising Opportunities provides students and practitioners in health and social care with a clear overview of an area where there is much confusion and imperfect understanding.
Equality within Our Lifetimes: How Laws and Policies Can Close—or Widen—Gender Gaps in Economies Worldwide
by Jody Heymann Aleta Sprague Amy RaubA free ebook version of this title is available through Luminos, University of California Press’s Open Access publishing program. Visit www.luminosoa.org to learn more. Well into the twenty-first century, achieving gender equality in the economy remains unfinished business. Worldwide, women’s employment, income, and leadership opportunities lag men’s. Building and using a one-of-a-kind database that covers 193 countries, this book systematically analyzes how far we’ve come and how far we have to go in adopting evidence-based solutions to close the gaps. Spanning topics including girls’ education, employment discrimination of all kinds, sexual harassment, and caregiving needs across the life course, the authors bring the findings to life through global maps, stories of laws’ impact in courts and beyond, and case studies of making change. A powerful call to action, Equality within Our Lifetimes reveals how gender equality is both feasible and urgently needed to address some of the greatest challenges of our generation.
Equine Anesthesia and Co-Existing Disease
by Stuart Clark-Price Khursheed MamaEquine Anesthesia and Co-Existing Disease offers practical guidance on anesthetizing horses with pre-existing diseases or other unique conditions. Filling a significant gap in available literature, this authoritative reference is the ideal companion to existing publications on basic management principles, equipment, and complications in equine anesthesia. Detailed chapters, co-authored by anesthesiologists and other allied specialists, offer a body-system approach to anesthesia considerations in horses presenting with a variety of disease conditions. Each chapter contains foundational knowledge such as pathophysiology or diagnostic techniques, clinical images, practical information for pharmacologic selection, and technical requirements for completion of procedures. The text covers equine anesthesia management relevant to respiratory, neuromuscular, and gastrointestinal diseases, cardiac and orthopedic procedures, diagnostic imaging and unique therapies, and more. Designed to allow quick and easy reference to vital information, this valuable clinical resource: Provides complete coverage of anesthetic management of horses with existing conditions or diseases Describes how pre-existing conditions can affect anesthesia in equine patients Includes coverage of accident and error management, induction, and recovery Discusses how anesthesia management differs for other species such as domesticated donkeys and mules Equine Anesthesia and Co-Existing Disease is a must-have reference and clinical guide for everyone involved in the anesthetization of equine patients, including equine general practitioners, anesthesiologists, specialists in related areas, residents in veterinary anesthesiology, and equine anesthesia technicians.