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Fragment-Based Drug Discovery and X-Ray Crystallography
by Thomas G. Davies Marko HyvönenIntroduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber Targeting Protein-Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyvönen Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan
Fragment-Based Methods in Drug Discovery
by Anthony E. KlonThis volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation. The second part discusses the technical aspects that various methods have used to simulate fragment binding to a target protein by using Monte Carlo, molecular dynamics, and docking algorithms. After simulations, fragments are assembled into molecules using a variety of approaches, which are explored next. A discussion of design strategies and consideration of drug-like properties is included as part of the design process at this stage. Finally, several examples of successful fragment-based drug design projects are presented. Written for the Methods in Molecular Biology series, this work contains the kind of detailed description and implementation advice to encourage success in the lab. Practical and cutting-edge, Fragment-Based Methods in Drug Discovery takes into account the great accomplishments in the field to provide an ideal guide for researchers continuing to investigate this exciting area of pharmacological study.
Fragmente einer Sprache des Essens
by Christoph KlotterDer vorliegende Band beschäftigt sich zum einen mit der Reduktion des Essens auf eine naturwissenschaftliche Perspektive und moralisches Gebot und hebt zum anderen die kulturelle und soziale Bedeutung hervor. Seit der Entstehung der Ernährungswissenschaft Mitte des 19. Jahrhunderts haben wir uns daran gewöhnt, von Vitaminen, Proteinen und Kohlehydraten zu sprechen. Wir betrachten Lebensmittel aus naturwissenschaftlicher Sicht, lösen sie in einzelne Bestandteile auf und quantifizieren diese, um festzustellen, wie viel wir von welchem Inhaltsstoff zu uns nehmen müssen, um uns gesund zu ernähren. Die Ernährung hat dann die primäre Aufgabe, die Gesundheit zu erhalten und das Leben zu verlängern. Wer sich dieser Aufgabe verweigert, wie vermeintlich die Adipösen, darf moralisch verurteilt werden. Ernährung und Gesundheit haben sich so moralisiert. Somit wird mittels der empfohlenen Ernährung ein zentraler abendländischer Wert vermittelt, der der Mäßigung. Von Platon bis zur protestantischen Ethik, die unser Leben heute bestimmt, wird Mäßigung eingefordert, heute über das rigide Schlankheitsideal.
Fragmented Democracy: Medicaid, Federalism, and Unequal Politics
by Jamila MichenerMedicaid is the single largest public health insurer in the United States, covering upward of 70 million Americans. Crucially, Medicaid is also an intergovernmental program that yokes poverty to federalism: the federal government determines its broad contours, while states have tremendous discretion over how it is designed and implemented. Where some locales are generous and openhanded, others are tightfisted and punitive. In Fragmented Democracy, Jamila Michener demonstrates the consequences of such disparities for democratic citizenship. Unpacking how federalism transforms Medicaid beneficiaries’ interpretations of government and structures their participation in politics, this book examines American democracy from the vantage point(s) of those who are living in or near poverty, (disproportionately) black or Latino, and reliant on a federated government for vital resources.
Fragmented: A Doctor's Quest to Piece Together American Health Care
by Ilana Yurkiewicz MDAn award-winning physician-writer exposes how pervasive cracks in the health care system cost us time, energy, and lives—and how we can fix them. There’s an unspoken assumption when we go to see a doctor: the doctor knows our medical story and is making decisions based on that story. But reality frequently falls short. Medical records vanish when we switch doctors. Critical details of life-saving treatment plans get lost in muddled electronic charts. The doctors we see change according to specialty, hospital shifts, or an insurer’s whims. Physician Ilana Yurkiewicz calls this phenomenon fragmentation, and, she argues, it’s the central failure of health care today. In this gripping narrative from medicine’s front lines, Yurkiewicz reveals how a system that doesn’t talk to itself puts insupportable burdens on physicians, patients, and caregivers, forcing them to heroic lengths to hold the pieces together—barely. The stories she tells are at once harrowing and commonplace. A patient narrowly averts an unnecessary, invasive heart procedure by producing a worn rhythm strip he has carried in his pocket for a decade. A man diagnosed with leukemia while visiting from abroad has thirty-one physicians, but no one he can call “his” doctor, with tragic consequences. When Yurkiewicz’s own father falls ill, a culture that incentivizes health care providers to react with quick fixes to the problems immediately before them—often to the neglect of a patient’s overall narrative—leads to weeks of additional suffering and a risky hospital transfer. The system is hanging by a thread, and we need better solutions. Yurkiewicz issues a clear-eyed call for change, naming concrete reforms doctors and policymakers can make, and empowering patients and their loved ones to advocate for themselves in the meantime. Urgent, radiantly humane, and ultimately hopeful, Fragmented a prescription for what really needs fixing in modern medicine.
A Fragmented Feminism: The Life and Letters of Anandibai Joshee
by Meera Kosambi"This book is a search for ‘the real Anandibai Joshee’ —— a search in which the readers are invited to participate." In her short and eventful life, Anandibai Joshee, the first Indian woman to earn a medical degree, broke many stereotypes. Literate at a time when it was taboo for a girl to attend school or even ‘pick up a paper’, she was courageous, articulate, and assertive. And ambitious. Fuelled by a desire to improve the healthcare that was available to Indian women at that time, she travelled across the seas to the United States to study medicine. Meera Kosambi’s biography of Anandibai is more than just a retelling of the life of a woman who was ahead of her times. Drawing on a host of narratives, Kosambi recovers Anandibai’s many voices, which have been submerged in history — that of a conflicted feminist, a nationalist, and a reformer, among others — and her engagement with the world at large. This volume is a testament to Meera Kosambi’s commitment to social history. When she passed away in 2015, she left an incomplete manuscript that has painstakingly been put together by the editors. Drawing on archival research, including a host of Anandibai’s letters, her poems in Marathi, newspaper reports, and rare photographs, this book will be of immense interest to scholars and researchers of modern Indian history, sociology, gender, and South Asian studies.
A Fragmented Landscape: Abortion Governance and Protest Logics in Europe (Protest, Culture & Society #20)
by Lorena Anton Joanna Mishtal Silvia De ZordoSince World War II, abortion policies have remained remarkably varied across European nations, with struggles over abortion rights at the forefront of national politics. This volume analyses European abortion governance and explores how social movements, political groups, and individuals use protests and resistance to influence abortion policy. Drawing on case studies from Italy, Spain, Norway, Poland, Romania, Russia, Sweden, Switzerland, the United Kingdom and the European Union, it analyses the strategies and discourses of groups seeking to liberalise or restrict reproductive rights. It also illuminates the ways that reproductive rights politics intersect with demographic anxieties, as well as the rising nationalisms and xenophobia related to austerity policies, mass migration and the recent terrorist attacks in Europe.�
Fragments
by James N. DavidsonBrilliant psychologists have assembled in a small college town to conduct a revolutionary experiment that challenges the very nature of identity and individuality. Their subjects are savants, mentally and emotionally challenged individuals, each of whom possesses an amazing gift. One person can calculate calendar dates backward and forward, while another can memorize an entire library or assemble jigsaw puzzles at the speed of lightning. . Each of these very special people is flawed and psychologically handicapped, but what if five such savants are cybernetically linked together to create a sixth composite personality? Can this newly created entity be more than the sum of its parts? At first the experiment yields promising results, but a terrifying secret in the past will transform the project in ways the researchers never anticipated-and infect the newborn intelligence with a catastrophic thirst for vengeance. Soon all of them are at risk to become killers or to be killed. Good intentions and care for safety are overwhelmed by escalating powers, and the struggle to contain those lethal powers and to survive. Tension begins early in the book as a man with the secret power to control others insinuates himself in to the experiment. The suspense mounts rapidly to breathtaking levels. Scientific and emotional thinkers combine efforts to stop the destructive rampage they started. The subjects of the experiments, all with one special gift superimposed on limited intellects, are sympathetically and fascinatingly examined. Each has a part to play in this gripping novel about human and superhuman nature.
Fragments: Coping with Attention Deficit Disorder
by Amy E SteinExplore effective alternative approaches to improving the lives of those diagnosed with attention deficit disorder!This remarkable new book offers fresh perspectives on ADD/ADHD. Even more important, it provides new direction for sufferers, introducing an ecologically based lifestyle that focuses on hands-on interactive learning. Fragments: Coping with Attention Deficit Disorder shows how to use environmental education and activities such as organic farming, community service, mission work, art, yoga, meditation, and spirituality to bring about positive change in people diagnosed with ADD or ADHD.From author Amy E. Stein: “This book is about life. It is written for those who think they have no hope, who struggle with life, with decisions, with addiction, and in search of themselves. I do not believe traditional psychotherapy or medication are solutions for those of us who fall under the label of ADD or ADHD.”Candidly written by a woman who, at age 25, was diagnosed as “a textbook case for attention deficit hyperactivity disorder,” this insightful book examines: the pitfalls of traditional psychotherapy and medication for those diagnosed with ADD/ADHD how an interactive hands-on learning environment can markedly improve the educational experience of ADD/ADHD kids how an organic, holistic approach can benefit those diagnosed with ADD/ADHD the correlation between agriculture and ADD/ADHD and the impact of eliminating pesticides and increasing fatty acid intake in the diets of sufferers how incorporating spirituality and faith into ADD/ADHD sufferers&’ lives can help to add discipline and bring greater satisfaction and much more!Five helpful appendices give you easy access to environmental education resources, agricultural resources, a sample agricultural curriculum, a sample ecology curriculum, and an environmental art curriculum.
Fragrance and Wellbeing: Plant Aromatics and Their Influence on the Psyche
by Jennifer Peace RhindFor thousands of years fragrance has been used, across many varied cultures, for altering mental and emotional states, and as part of spiritual practice. This book explores the impact of fragrance on the psyche from biological, anthropological, perfumery and aromatherapy viewpoints. Beginning with an exploration of our olfactory system and a discussion of the language of odour, the book examines the ways in which fragrance can influence our perceptions and experiences. It introduces us to a broad range of fragrance types - woody, resinous, spicy, herbaceous, agrestic, floral and citrus, as well as the attars that form part of Unani Tibb medicine. Traditional and contemporary uses and the mood-enhancing properties of fragrance types are presented. The book then provides an overview of the theoretical and philosophical frameworks that have been used to analyse how and why we choose fragrance. Finally readers are given guidance on how to cultivate their olfactory palate, which reveals a new dimension in the use of fragrance to enhance wellbeing. This book offers a wealth of knowledge on plant aromatics and the powerful influence of fragrance on wellbeing. It will be of particular interest to aromatherapists, perfumers, psychotherapists, ethnobotanists and anthropologists.
Frailty: A Multidisciplinary Approach to Assessment, Management, and Prevention
by Jorge G. Ruiz Olga TheouThis book offers a thorough examination of frailty, covering its complexity through sections on foundational concepts, pathogenesis research, assessment methods, management strategies, care settings, its relation to other chronic conditions, and societal implications. It provides a deep understanding of frailty's scientific basis, advanced assessment tools, innovative management, and prevention approaches, and examines frailty within diverse care settings and in relation to other health conditions. By integrating multidisciplinary insights, it presents a holistic view of frailty, addressing its clinical, societal, and policy-related aspects, aiming to enhance well-being and inform clinical practitioners, educators, and policymakers.This book can serve as a reference guide with up-to-date information on frailty in older adults for geriatric medicine physicians, primary care clinicians, geroscience researchers, nurses, therapists (OT, PT, ST), and social workers.
Frailty and Cardiovascular Diseases: Research into an Elderly Population (Advances in Experimental Medicine and Biology #1216)
by Nicola VeroneseThis book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.
Frailty and Kidney Disease: A Practical Guide to Clinical Management
by Carlos Guido Musso José Ricardo Jauregui Juan Florencio Macías-Núñez Adrian CovicThis unique book reviews the information available in the literature regarding the new syndrome, frailty, in patients with various renal conditions, such as acute kidney injury, chronic kidney disease, as well as dialysis and transplant patients. The topic is of importance in nephrology, specifically nephrogeriatrics, since frailty is a condition affecting many elderly patients and which is becoming increasingly common in medical practice. As such, there is a considerable need for information to assist professionals treating these patients. The book includes chapters on the frailty syndrome (definition, evaluation and treatment), the main geriatric syndromes (gait disorder, falls, incontinence, and delirium), the main renal syndromes (acute renal injury, chronic kidney disease) as well as dialysis and kidney transplant, and the relationship between geriatrics and renal syndromes. Frailty and Kidney Disease: A Practical Guide to Clinical Management is an essential resource for general practitioners, researchers, internal medicine physicians, geriatricians, and nephrologists.
Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future
by Puneeta Tandon Aldo J. Montano-LozaThis book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes.Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treat patients with cirrhosis.
Frailty in Children: From the Perioperative Management to the Multidisciplinary Approach
by Mario Lima Maria Cristina MondardiniThis book focuses on the management strategies of complex conditions of frail pediatric patients. The clinical condition of frailty is usually seen as the physiological and multidimensional decline of organ systems related to age: paradoxically, a frailty condition can also occur in children as a disability resulting from various congenital or acquired diseases. The fragile patients are more vulnerable to developing severe clinical events and often need surgical interventions. Moreover, those patients have significant morbidity and lower quality of life. The improvement in managing fragile patients has improved their life expectancy, but in most health care systems, the passage from childhood to adulthood is a critical point for the lack of medical figures able to provide the continuity of care. The book aims to provide guidance for dealing with medical and surgical emergencies and to develop short and long-term treatment strategies, and will provide an analysis of the different and the most innovative techniques. This book will be an unvaluable tool for Pediatric surgeons, Anesthesiologists, Critical Care Physicians, Hospital and family Pediatricians, nurses, Physiotherapists and Psychologists.
Frailty in Older Adults with Cancer
by Fabio GomesThis book summarizes evidence on frailty and ageing, how this may impact patient outcomes and how frailty can be assessed, managed and incorporated in the decision-making process for older patients with cancer. The book aims to: empower clinical teams to assess and support older cancer patients with frailty, ideally within a multidisciplinary setting; and to improve the selection of older cancer patients to the most appropriate management/treatment strategies in order to improve the outcomes of this group of patients often underrepresented in research. The reader will learn the methods available for assessing frailty, such as screening tools, but also how to perform different geriatric assessments covering the different key components (physical, nutritional, social, psychological, etc.). The book also provides information on how to manage and intervene on frailty with the role of pre-habilitation and re-habilitation, how to set-up specialised teams and pathways within one’s hospital and community for these older cancer patients with frailty. Finally, the management of this challenging group of patients according to the cancer type is discussed in detail, alongside with mapping the unmet research needs and future directions in this field.
Frakturen der Mittelhand und Finger: Eine Übersicht für Ärzte aller Fachgebiete (essentials)
by Adrian Cavalcanti Kußmaul Frank UnglaubFrakturen von Fingern und Mittelhand stellen gemeinsam die häufigsten Frakturen dar. Klinisch kann es neben Schwellungen, Hämatomen und Schmerzen auch zu Funktionseinschränkungen kommen. Die Diagnostik umfasst neben klinischer Untersuchung auch bildgebende Verfahren, insbesondere röntgenologische Untersuchungen. Therapeutisch sollte neben dem Funktionserhalt insbesondere der individuelle Anspruch im Vordergrund stehen.
Fraktursonografie
by Ole AckermannDieses Buch bietet einen Überblick über das Spektrum der diagnostischen Fraktursonografie, die die konventionelle radiologische Bildgebung ergänzen und zum Teil auch ersetzen kann. Vorgestellt werden die apparativen und fachlichen Voraussetzungen, die Indikationen und Abläufe und die möglichen Gefahren. Algorithmen, Pitfalls und Tipps zur rechtssicheren Dokumentation runden die Fraktursonografie in der Praxis ab. Damit bietet das Werk alle relevanten Grundlagen zur Umsetzung in die Praxis.
Frames of Reference for Pediatric Occupational Therapy
by Paula KramerPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Frames of Reference for Pediatric Occupational Therapy, Fourth Edition, uses frames of reference for diagnostic categories (neuro-development, social participation, etc.) as effective blueprints for applying theory to pediatric OT practice. Updated with new chapters, case examples, and a new focus on evidence-based practice. This proven approach helps students understand the “why” of each frame of reference before moving on to the “how” of creating effective treatment programs to help pediatric clients lead richer, fuller lives. The book first covers the foundations of frames reference for pediatric OT (Section I), and then covers commonly used frames of reference such as motor skill acquisition, biomechanical, and sensory integration (Section II). A final section discusses newer focused/specific frames of reference like handwriting skills and social participation. A standardized format within each frame of reference chapter covers the same elements (Theoretical Base, Supporting Evidence, the Function/Dysfunction Continuum, Guide to Evaluation, and Application to Practice) to help students build the knowledge and skills needed for effective practice.
A Framework for Assessing Effects of the Food System
by Malden C. NesheimHow we produce and consume food has a bigger impact on Americans' well-being than any other human activity. The food industry is the largest sector of our economy; food touches everything from our health to the environment, climate change, economic inequality, and the federal budget. From the earliest developments of agriculture, a major goal has been to attain sufficient foods that provide the energy and the nutrients needed for a healthy, active life. Over time, food production, processing, marketing, and consumption have evolved and become highly complex. The challenges of improving the food system in the 21st century will require systemic approaches that take full account of social, economic, ecological, and evolutionary factors. Policy or business interventions involving a segment of the food system often have consequences beyond the original issue the intervention was meant to address. "A Framework for Assessing Effects of the Food System" develops an analytical framework for assessing effects associated with the ways in which food is grown, processed, distributed, marketed, retailed, and consumed in the United States. The framework will allow users to recognize effects across the full food system, consider all domains and dimensions of effects, account for systems dynamics and complexities, and choose appropriate methods for analysis. This report provides example applications of the framework based on complex questions that are currently under debate: consumption of a healthy and safe diet, food security, animal welfare, and preserving the environment and its resources. "A Framework for Assessing Effects of the Food System" describes the U. S. food system and provides a brief history of its evolution into the current system. This report identifies some of the real and potential implications of the current system in terms of its health, environmental, and socioeconomic effects along with a sense for the complexities of the system, potential metrics, and some of the data needs that are required to assess the effects. The overview of the food system and the framework described in this report will be an essential resource for decision makers, researchers, and others to examine the possible impacts of alternative policies or agricultural or food processing practices.
Framework for Dietary Risk Assessment in the WIC Program: Interim Report
by Institute of MedicineThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Frameworks for Internal Medicine
by Andre MansoorPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Introducing an innovative, systematic approach to understanding differential diagnosis, Frameworks for Internal Medicine helps students learn to think like physicians and master the methodology behind diagnosing the most commonly encountered conditions in internal medicine.
Framing Animals as Epidemic Villains: Histories of Non-Human Disease Vectors (Medicine and Biomedical Sciences in Modern History)
by Christos LynterisThis book takes a historical and anthropological approach to understanding how non-human hosts and vectors of diseases are understood, at a time when emerging infectious diseases are one of the central concerns of global health. The volume critically examines the ways in which animals have come to be framed as ‘epidemic villains’ since the turn of the nineteenth century. Providing epistemological and social histories of non-human epidemic blame, as well as ethnographic perspectives on its recent manifestations, the essays explore this cornerstone of modern epidemiology and public health alongside its continuing importance in today’s world. Covering diverse regions, the book argues that framing animals as spreaders and reservoirs of infectious diseases – from plague to rabies to Ebola – is an integral aspect not only to scientific breakthroughs but also to the ideological and biopolitical apparatus of modern medicine. As the first book to consider the impact of the image of non-human disease hosts and vectors on medicine and public health, it offers a major contribution to our understanding of human-animal interaction under the shadow of global epidemic threat.
Framing the Sexual Subject: The Politics of Gender, Sexuality, and Power
by Richard Parker Regina Maria Barbosa Peter AggletonThis collection brings together the work of writers from a range of disciplines and cultural traditions to explore the social and political dimensions of sexuality and sexual experience. The contributors reconfigure existing notions of gender and sexuality, linking them to deeper understandings of power, resistance, and emancipation around the globe. They map areas that are currently at the cutting edge of social science writing on sexuality, as well as the complex interface between theory and practice. Framing the Sexual Subject highlights the extent to which populations and communities that once were the object of scientific scrutiny have increasingly demanded the right to speak on their own behalf, as subjects of their own sexualities and agents of their own sexual histories.
Las francesas no se hacen liftings
by Mireille GuilianoSecretos de belleza y estrategias para envejecer con buena actitud, alegría y sin cirugía. Mireille Guiliano comparte secretos de belleza y estrategias para envejecer con buena actitud y alegría, ofreciendo sus consejos y su humor al tiempo que revela los secretos mejor guardados por las francesas acerca de cómo tener un excelente aspecto y sentirse demaravilla. Encara todos los temas, desde las lociones y las cremas hasta las dietas, la amistad y el amor.Gracias a su característica combinación de ingenio, consejos prácticos y talento narrativo, Guiliano proporciona una encantadora mirada sobre la belleza y el arte de envejecer en nuestra época. Para cualquiera que alguna vez haya gastado el equivalente a una cuota de hipoteca en tratamientos antiedad, se haya vestido de manera inadecuada para sus años, haya aumentado demasiado de peso o accidentalmente haya olvidado cómocoquetear, he aquí una manera proactiva de seguir teniendo un aspecto excelente y encontrarse estupendamente sin declararse enquiebra o recurrir a la cirugía. Reseñas:«Como una estupenda amiga que comparte sus secretos, Mireille Guiliano divulga, anima e inspira. Y lo hace con alegría.»Pamela Druckerman, autora de Cómo ser una mamá cruasán. «Las francesas poseen un estilo y una confianza en sí mismas increíbles. Mireille Guiliano supone una inspiración y sus libros son de lectura imprescindible para cualquier mujerque quiera tener mejor aspecto y, en última instancia, sentirse más bella.»Bobbi Brown, maquilladora y autora de Bobbi Brown Make-Up Manual